TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H725_LEIBR

TriTrypDb:

LbrM.13.0170 , LBRM2903_130006900

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H725

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H725

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.717
CLV_C14_Caspase3-7	276	280	PF00656	0.451
CLV_C14_Caspase3-7	294	298	PF00656	0.605
CLV_C14_Caspase3-7	59	63	PF00656	0.752
CLV_NRD_NRD_1	286	288	PF00675	0.601
CLV_NRD_NRD_1	336	338	PF00675	0.392
CLV_NRD_NRD_1	402	404	PF00675	0.535
CLV_NRD_NRD_1	76	78	PF00675	0.403
CLV_PCSK_KEX2_1	286	288	PF00082	0.590
CLV_PCSK_KEX2_1	336	338	PF00082	0.391
CLV_PCSK_KEX2_1	402	404	PF00082	0.535
CLV_PCSK_KEX2_1	76	78	PF00082	0.400
CLV_PCSK_SKI1_1	151	155	PF00082	0.487
CLV_PCSK_SKI1_1	232	236	PF00082	0.430
CLV_PCSK_SKI1_1	261	265	PF00082	0.398
CLV_PCSK_SKI1_1	303	307	PF00082	0.449
CLV_PCSK_SKI1_1	354	358	PF00082	0.401
CLV_PCSK_SKI1_1	368	372	PF00082	0.318
DEG_APCC_DBOX_1	231	239	PF00400	0.426
DEG_SPOP_SBC_1	195	199	PF00917	0.803
DEG_SPOP_SBC_1	410	414	PF00917	0.529
DOC_CKS1_1	175	180	PF01111	0.445
DOC_CKS1_1	383	388	PF01111	0.625
DOC_CYCLIN_RxL_1	226	237	PF00134	0.564
DOC_CYCLIN_RxL_1	363	375	PF00134	0.507
DOC_MAPK_MEF2A_6	261	269	PF00069	0.579
DOC_PP1_RVXF_1	347	354	PF00149	0.240
DOC_PP2B_LxvP_1	117	120	PF13499	0.442
DOC_PP2B_LxvP_1	228	231	PF13499	0.597
DOC_USP7_MATH_1	127	131	PF00917	0.746
DOC_USP7_MATH_1	135	139	PF00917	0.574
DOC_USP7_MATH_1	193	197	PF00917	0.737
DOC_USP7_MATH_1	200	204	PF00917	0.714
DOC_USP7_MATH_1	388	392	PF00917	0.604
DOC_USP7_MATH_1	410	414	PF00917	0.564
DOC_WW_Pin1_4	123	128	PF00397	0.512
DOC_WW_Pin1_4	163	168	PF00397	0.605
DOC_WW_Pin1_4	174	179	PF00397	0.633
DOC_WW_Pin1_4	189	194	PF00397	0.608
DOC_WW_Pin1_4	202	207	PF00397	0.651
DOC_WW_Pin1_4	34	39	PF00397	0.556
DOC_WW_Pin1_4	382	387	PF00397	0.690
DOC_WW_Pin1_4	406	411	PF00397	0.760
LIG_14-3-3_CanoR_1	104	113	PF00244	0.417
LIG_14-3-3_CanoR_1	116	120	PF00244	0.551
LIG_14-3-3_CanoR_1	188	195	PF00244	0.752
LIG_14-3-3_CanoR_1	223	229	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_FHA_1	175	181	PF00498	0.601
LIG_FHA_1	239	245	PF00498	0.530
LIG_FHA_1	262	268	PF00498	0.454
LIG_FHA_1	297	303	PF00498	0.534
LIG_FHA_1	341	347	PF00498	0.492
LIG_FHA_1	83	89	PF00498	0.483
LIG_FHA_2	127	133	PF00498	0.722
LIG_FHA_2	252	258	PF00498	0.308
LIG_FHA_2	379	385	PF00498	0.457
LIG_Integrin_RGD_1	169	171	PF01839	0.641
LIG_LIR_Gen_1	207	218	PF02991	0.466
LIG_LIR_Gen_1	90	100	PF02991	0.494
LIG_LIR_Nem_3	207	213	PF02991	0.457
LIG_LIR_Nem_3	90	96	PF02991	0.479
LIG_LYPXL_SIV_4	148	156	PF13949	0.483
LIG_RPA_C_Fungi	21	33	PF08784	0.521
LIG_SH2_CRK	210	214	PF00017	0.439
LIG_SH2_CRK	93	97	PF00017	0.502
LIG_SH2_NCK_1	10	14	PF00017	0.497
LIG_SH2_NCK_1	247	251	PF00017	0.579
LIG_SH2_SRC	10	13	PF00017	0.499
LIG_SH2_SRC	99	102	PF00017	0.493
LIG_SH2_STAP1	10	14	PF00017	0.298
LIG_SH2_STAP1	210	214	PF00017	0.333
LIG_SH2_STAT5	252	255	PF00017	0.497
LIG_SH2_STAT5	339	342	PF00017	0.341
LIG_SH2_STAT5	99	102	PF00017	0.339
LIG_SH3_1	339	345	PF00018	0.357
LIG_SH3_3	339	345	PF00018	0.341
LIG_SH3_3	380	386	PF00018	0.608
LIG_SUMO_SIM_anti_2	85	90	PF11976	0.415
LIG_SUMO_SIM_par_1	177	184	PF11976	0.472
LIG_SUMO_SIM_par_1	84	90	PF11976	0.417
LIG_SxIP_EBH_1	188	200	PF03271	0.798
LIG_TRAF2_1	130	133	PF00917	0.450
LIG_TRAF2_1	28	31	PF00917	0.572
LIG_TRAF2_1	291	294	PF00917	0.527
LIG_TRFH_1	34	38	PF08558	0.368
LIG_TYR_ITSM	206	213	PF00017	0.362
LIG_WW_3	229	233	PF00397	0.578
MOD_CDC14_SPxK_1	166	169	PF00782	0.599
MOD_CDK_SPK_2	34	39	PF00069	0.386
MOD_CDK_SPxK_1	163	169	PF00069	0.578
MOD_CK1_1	126	132	PF00069	0.640
MOD_CK1_1	165	171	PF00069	0.622
MOD_CK1_1	196	202	PF00069	0.647
MOD_CK1_1	296	302	PF00069	0.436
MOD_CK1_1	4	10	PF00069	0.566
MOD_CK1_1	409	415	PF00069	0.558
MOD_CK1_1	60	66	PF00069	0.702
MOD_CK2_1	126	132	PF00069	0.654
MOD_CK2_1	24	30	PF00069	0.415
MOD_CK2_1	251	257	PF00069	0.315
MOD_CK2_1	288	294	PF00069	0.640
MOD_CK2_1	378	384	PF00069	0.531
MOD_DYRK1A_RPxSP_1	123	127	PF00069	0.520
MOD_GlcNHglycan	26	29	PF01048	0.440
MOD_GlcNHglycan	289	293	PF01048	0.633
MOD_GlcNHglycan	374	377	PF01048	0.438
MOD_GlcNHglycan	390	393	PF01048	0.596
MOD_GlcNHglycan	41	44	PF01048	0.517
MOD_GlcNHglycan	58	62	PF01048	0.505
MOD_GSK3_1	115	122	PF00069	0.704
MOD_GSK3_1	123	130	PF00069	0.621
MOD_GSK3_1	159	166	PF00069	0.479
MOD_GSK3_1	189	196	PF00069	0.670
MOD_GSK3_1	205	212	PF00069	0.544
MOD_GSK3_1	328	335	PF00069	0.417
MOD_GSK3_1	372	379	PF00069	0.240
MOD_GSK3_1	404	411	PF00069	0.651
MOD_GSK3_1	412	419	PF00069	0.679
MOD_N-GLC_1	273	278	PF02516	0.393
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	159	164	PF00069	0.435
MOD_NEK2_1	224	229	PF00069	0.512
MOD_NEK2_1	328	333	PF00069	0.447
MOD_NEK2_1	361	366	PF00069	0.468
MOD_NEK2_1	417	422	PF00069	0.588
MOD_NEK2_1	82	87	PF00069	0.447
MOD_PIKK_1	68	74	PF00454	0.678
MOD_PKA_2	115	121	PF00069	0.666
MOD_PKA_2	187	193	PF00069	0.757
MOD_PKA_2	372	378	PF00069	0.442
MOD_PKB_1	273	281	PF00069	0.400
MOD_Plk_2-3	319	325	PF00069	0.492
MOD_Plk_4	205	211	PF00069	0.463
MOD_Plk_4	82	88	PF00069	0.419
MOD_ProDKin_1	123	129	PF00069	0.509
MOD_ProDKin_1	163	169	PF00069	0.611
MOD_ProDKin_1	174	180	PF00069	0.630
MOD_ProDKin_1	189	195	PF00069	0.609
MOD_ProDKin_1	202	208	PF00069	0.640
MOD_ProDKin_1	34	40	PF00069	0.572
MOD_ProDKin_1	382	388	PF00069	0.690
MOD_ProDKin_1	406	412	PF00069	0.763
MOD_SUMO_rev_2	296	305	PF00179	0.563
TRG_DiLeu_BaEn_1	101	106	PF01217	0.432
TRG_DiLeu_BaEn_1	324	329	PF01217	0.391
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.438
TRG_DiLeu_LyEn_5	101	106	PF01217	0.480
TRG_ENDOCYTIC_2	210	213	PF00928	0.445
TRG_ENDOCYTIC_2	315	318	PF00928	0.381
TRG_ENDOCYTIC_2	93	96	PF00928	0.492
TRG_ER_diArg_1	285	287	PF00400	0.554
TRG_ER_diArg_1	401	403	PF00400	0.509
TRG_ER_FFAT_2	248	257	PF00635	0.321
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN7	Leptomonas seymouri	42%	100%
A0A0S4JF77	Bodo saltans	32%	88%
A0A1X0NNA0	Trypanosomatidae	31%	100%
A0A3S7WSE7	Leishmania donovani	78%	100%
A4HVF4	Leishmania infantum	78%	100%
E9AP52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%
Q4QGD6	Leishmania major	78%	100%