Putative MOZ/SAS family acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MOZ/SAS family acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H724_LEIBR

TriTrypDb:

LbrM.13.0160 , LBRM2903_130006800

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H724

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H724

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051252	regulation of RNA metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:2001141	regulation of RNA biosynthetic process	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004402	histone acetyltransferase activity	4	11
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0034212	peptide N-acetyltransferase activity	7	11
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	539	543	PF00656	0.801
CLV_NRD_NRD_1	347	349	PF00675	0.442
CLV_NRD_NRD_1	440	442	PF00675	0.325
CLV_NRD_NRD_1	455	457	PF00675	0.554
CLV_NRD_NRD_1	527	529	PF00675	0.796
CLV_NRD_NRD_1	530	532	PF00675	0.782
CLV_NRD_NRD_1	69	71	PF00675	0.654
CLV_PCSK_FUR_1	528	532	PF00082	0.596
CLV_PCSK_FUR_1	67	71	PF00082	0.649
CLV_PCSK_KEX2_1	347	349	PF00082	0.442
CLV_PCSK_KEX2_1	440	442	PF00082	0.325
CLV_PCSK_KEX2_1	455	457	PF00082	0.633
CLV_PCSK_KEX2_1	527	529	PF00082	0.797
CLV_PCSK_KEX2_1	530	532	PF00082	0.760
CLV_PCSK_KEX2_1	602	604	PF00082	0.693
CLV_PCSK_KEX2_1	69	71	PF00082	0.654
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.737
CLV_PCSK_SKI1_1	269	273	PF00082	0.360
CLV_PCSK_SKI1_1	296	300	PF00082	0.313
CLV_PCSK_SKI1_1	391	395	PF00082	0.358
CLV_PCSK_SKI1_1	440	444	PF00082	0.335
CLV_PCSK_SKI1_1	486	490	PF00082	0.543
DEG_APCC_DBOX_1	313	321	PF00400	0.454
DEG_APCC_DBOX_1	440	448	PF00400	0.564
DEG_APCC_DBOX_1	465	473	PF00400	0.592
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DEG_SPOP_SBC_1	522	526	PF00917	0.674
DOC_CKS1_1	252	257	PF01111	0.552
DOC_MAPK_MEF2A_6	459	467	PF00069	0.673
DOC_MAPK_MEF2A_6	473	480	PF00069	0.428
DOC_PP2B_LxvP_1	214	217	PF13499	0.552
DOC_PP4_FxxP_1	204	207	PF00568	0.415
DOC_PP4_FxxP_1	496	499	PF00568	0.684
DOC_USP7_MATH_1	137	141	PF00917	0.722
DOC_USP7_MATH_1	146	150	PF00917	0.671
DOC_USP7_MATH_1	19	23	PF00917	0.673
DOC_USP7_MATH_1	313	317	PF00917	0.415
DOC_USP7_MATH_1	323	327	PF00917	0.522
DOC_USP7_MATH_1	340	344	PF00917	0.393
DOC_USP7_MATH_1	522	526	PF00917	0.650
DOC_USP7_MATH_1	551	555	PF00917	0.768
DOC_USP7_MATH_1	556	560	PF00917	0.763
DOC_USP7_UBL2_3	588	592	PF12436	0.519
DOC_WW_Pin1_4	230	235	PF00397	0.376
DOC_WW_Pin1_4	251	256	PF00397	0.525
DOC_WW_Pin1_4	425	430	PF00397	0.496
DOC_WW_Pin1_4	514	519	PF00397	0.768
DOC_WW_Pin1_4	77	82	PF00397	0.499
LIG_14-3-3_CanoR_1	283	288	PF00244	0.496
LIG_14-3-3_CanoR_1	314	318	PF00244	0.443
LIG_14-3-3_CanoR_1	347	353	PF00244	0.371
LIG_14-3-3_CanoR_1	391	396	PF00244	0.561
LIG_14-3-3_CanoR_1	456	465	PF00244	0.658
LIG_14-3-3_CanoR_1	466	470	PF00244	0.605
LIG_14-3-3_CanoR_1	535	541	PF00244	0.770
LIG_14-3-3_CanoR_1	571	577	PF00244	0.624
LIG_APCC_ABBA_1	40	45	PF00400	0.553
LIG_APCC_ABBA_1	427	432	PF00400	0.405
LIG_APCC_ABBA_1	478	483	PF00400	0.438
LIG_BIR_III_4	354	358	PF00653	0.374
LIG_BRCT_BRCA1_1	232	236	PF00533	0.472
LIG_BRCT_BRCA1_1	342	346	PF00533	0.380
LIG_BRCT_BRCA1_1	423	427	PF00533	0.496
LIG_BRCT_BRCA1_1	99	103	PF00533	0.375
LIG_CSL_BTD_1	202	205	PF09270	0.506
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.440
LIG_EH1_1	30	38	PF00400	0.442
LIG_eIF4E_1	438	444	PF01652	0.562
LIG_FHA_1	164	170	PF00498	0.474
LIG_FHA_1	32	38	PF00498	0.553
LIG_FHA_1	392	398	PF00498	0.539
LIG_FHA_1	480	486	PF00498	0.547
LIG_FHA_1	571	577	PF00498	0.650
LIG_FHA_1	578	584	PF00498	0.587
LIG_FHA_2	149	155	PF00498	0.763
LIG_FHA_2	326	332	PF00498	0.684
LIG_FHA_2	347	353	PF00498	0.371
LIG_FHA_2	466	472	PF00498	0.563
LIG_FHA_2	55	61	PF00498	0.517
LIG_FHA_2	579	585	PF00498	0.635
LIG_LIR_Apic_2	493	499	PF02991	0.667
LIG_LIR_Gen_1	114	125	PF02991	0.444
LIG_LIR_Gen_1	212	221	PF02991	0.458
LIG_LIR_Gen_1	239	249	PF02991	0.526
LIG_LIR_Gen_1	303	313	PF02991	0.471
LIG_LIR_Nem_3	114	120	PF02991	0.440
LIG_LIR_Nem_3	192	198	PF02991	0.370
LIG_LIR_Nem_3	212	216	PF02991	0.462
LIG_LIR_Nem_3	239	245	PF02991	0.480
LIG_LIR_Nem_3	248	252	PF02991	0.506
LIG_LIR_Nem_3	265	271	PF02991	0.562
LIG_LIR_Nem_3	303	308	PF02991	0.471
LIG_LIR_Nem_3	45	51	PF02991	0.559
LIG_LIR_Nem_3	453	457	PF02991	0.664
LIG_LIR_Nem_3	492	497	PF02991	0.574
LIG_MLH1_MIPbox_1	232	236	PF16413	0.505
LIG_NRBOX	484	490	PF00104	0.424
LIG_Pex14_1	116	120	PF04695	0.546
LIG_Pex14_1	48	52	PF04695	0.550
LIG_Pex14_2	200	204	PF04695	0.447
LIG_Pex14_2	600	604	PF04695	0.602
LIG_PTB_Apo_2	25	32	PF02174	0.446
LIG_REV1ctd_RIR_1	233	242	PF16727	0.538
LIG_SH2_CRK	249	253	PF00017	0.542
LIG_SH2_CRK	454	458	PF00017	0.439
LIG_SH2_CRK	497	501	PF00017	0.593
LIG_SH2_CRK	615	619	PF00017	0.741
LIG_SH2_PTP2	242	245	PF00017	0.547
LIG_SH2_PTP2	307	310	PF00017	0.562
LIG_SH2_SRC	305	308	PF00017	0.562
LIG_SH2_SRC	319	322	PF00017	0.587
LIG_SH2_SRC	497	500	PF00017	0.689
LIG_SH2_STAP1	117	121	PF00017	0.426
LIG_SH2_STAP1	305	309	PF00017	0.482
LIG_SH2_STAP1	572	576	PF00017	0.625
LIG_SH2_STAP1	613	617	PF00017	0.516
LIG_SH2_STAT3	198	201	PF00017	0.473
LIG_SH2_STAT5	195	198	PF00017	0.356
LIG_SH2_STAT5	213	216	PF00017	0.463
LIG_SH2_STAT5	226	229	PF00017	0.377
LIG_SH2_STAT5	242	245	PF00017	0.324
LIG_SH2_STAT5	249	252	PF00017	0.406
LIG_SH2_STAT5	307	310	PF00017	0.526
LIG_SH2_STAT5	319	322	PF00017	0.413
LIG_SH2_STAT5	366	369	PF00017	0.483
LIG_SH2_STAT5	53	56	PF00017	0.392
LIG_SH2_STAT5	572	575	PF00017	0.686
LIG_SH2_STAT6	267	271	PF00017	0.562
LIG_SH3_3	149	155	PF00018	0.675
LIG_SH3_3	199	205	PF00018	0.502
LIG_SH3_3	307	313	PF00018	0.496
LIG_SH3_3	315	321	PF00018	0.467
LIG_SH3_3	379	385	PF00018	0.534
LIG_SH3_3	423	429	PF00018	0.496
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.470
LIG_SUMO_SIM_par_1	486	493	PF11976	0.558
LIG_SUMO_SIM_par_1	573	581	PF11976	0.661
LIG_TRAF2_1	329	332	PF00917	0.443
LIG_TRAF2_1	468	471	PF00917	0.347
LIG_TRFH_1	120	124	PF08558	0.553
LIG_TYR_ITIM	211	216	PF00017	0.519
LIG_WRC_WIRS_1	392	397	PF05994	0.562
MOD_CDK_SPxxK_3	251	258	PF00069	0.529
MOD_CK1_1	102	108	PF00069	0.541
MOD_CK1_1	140	146	PF00069	0.755
MOD_CK1_1	165	171	PF00069	0.690
MOD_CK1_1	326	332	PF00069	0.684
MOD_CK1_1	503	509	PF00069	0.716
MOD_CK1_1	517	523	PF00069	0.760
MOD_CK1_1	543	549	PF00069	0.663
MOD_CK1_1	596	602	PF00069	0.476
MOD_CK2_1	148	154	PF00069	0.743
MOD_CK2_1	325	331	PF00069	0.666
MOD_CK2_1	465	471	PF00069	0.560
MOD_CK2_1	54	60	PF00069	0.557
MOD_CK2_1	578	584	PF00069	0.581
MOD_CK2_1	89	95	PF00069	0.658
MOD_DYRK1A_RPxSP_1	425	429	PF00069	0.496
MOD_GlcNHglycan	125	128	PF01048	0.640
MOD_GlcNHglycan	139	142	PF01048	0.726
MOD_GlcNHglycan	148	151	PF01048	0.716
MOD_GlcNHglycan	328	331	PF01048	0.685
MOD_GlcNHglycan	418	421	PF01048	0.381
MOD_GlcNHglycan	502	505	PF01048	0.668
MOD_GlcNHglycan	512	517	PF01048	0.714
MOD_GlcNHglycan	545	548	PF01048	0.719
MOD_GlcNHglycan	558	561	PF01048	0.649
MOD_GlcNHglycan	565	568	PF01048	0.480
MOD_GlcNHglycan	608	613	PF01048	0.560
MOD_GlcNHglycan	77	80	PF01048	0.695
MOD_GlcNHglycan	86	89	PF01048	0.684
MOD_GlcNHglycan	99	102	PF01048	0.455
MOD_GSK3_1	13	20	PF00069	0.598
MOD_GSK3_1	132	139	PF00069	0.693
MOD_GSK3_1	230	237	PF00069	0.386
MOD_GSK3_1	335	342	PF00069	0.429
MOD_GSK3_1	376	383	PF00069	0.477
MOD_GSK3_1	421	428	PF00069	0.489
MOD_GSK3_1	430	437	PF00069	0.465
MOD_GSK3_1	500	507	PF00069	0.652
MOD_GSK3_1	514	521	PF00069	0.690
MOD_GSK3_1	536	543	PF00069	0.712
MOD_GSK3_1	73	80	PF00069	0.595
MOD_GSK3_1	99	106	PF00069	0.505
MOD_N-GLC_1	132	137	PF02516	0.754
MOD_NEK2_1	103	108	PF00069	0.525
MOD_NEK2_1	196	201	PF00069	0.404
MOD_NEK2_1	292	297	PF00069	0.487
MOD_NEK2_1	31	36	PF00069	0.570
MOD_NEK2_1	346	351	PF00069	0.449
MOD_NEK2_1	434	439	PF00069	0.492
MOD_NEK2_1	443	448	PF00069	0.500
MOD_NEK2_1	540	545	PF00069	0.777
MOD_NEK2_1	578	583	PF00069	0.557
MOD_NEK2_1	75	80	PF00069	0.725
MOD_NEK2_2	86	91	PF00069	0.713
MOD_PIKK_1	14	20	PF00454	0.490
MOD_PKA_1	455	461	PF00069	0.660
MOD_PKA_1	531	537	PF00069	0.547
MOD_PKA_2	185	191	PF00069	0.492
MOD_PKA_2	313	319	PF00069	0.440
MOD_PKA_2	346	352	PF00069	0.368
MOD_PKA_2	455	461	PF00069	0.638
MOD_PKA_2	465	471	PF00069	0.604
MOD_PKA_2	570	576	PF00069	0.656
MOD_PKB_1	389	397	PF00069	0.558
MOD_Plk_1	335	341	PF00069	0.530
MOD_Plk_1	374	380	PF00069	0.562
MOD_Plk_1	578	584	PF00069	0.614
MOD_Plk_1	608	614	PF00069	0.636
MOD_Plk_4	165	171	PF00069	0.470
MOD_Plk_4	221	227	PF00069	0.480
MOD_Plk_4	283	289	PF00069	0.497
MOD_Plk_4	391	397	PF00069	0.562
MOD_Plk_4	430	436	PF00069	0.507
MOD_Plk_4	484	490	PF00069	0.519
MOD_Plk_4	572	578	PF00069	0.537
MOD_Plk_4	99	105	PF00069	0.526
MOD_ProDKin_1	230	236	PF00069	0.377
MOD_ProDKin_1	251	257	PF00069	0.527
MOD_ProDKin_1	425	431	PF00069	0.496
MOD_ProDKin_1	514	520	PF00069	0.769
MOD_ProDKin_1	77	83	PF00069	0.497
MOD_SUMO_for_1	606	609	PF00179	0.479
MOD_SUMO_rev_2	483	488	PF00179	0.292
MOD_SUMO_rev_2	539	546	PF00179	0.538
TRG_DiLeu_BaEn_1	294	299	PF01217	0.405
TRG_DiLeu_BaEn_1	46	51	PF01217	0.306
TRG_DiLeu_BaEn_1	471	476	PF01217	0.571
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.562
TRG_DiLeu_LyEn_5	46	51	PF01217	0.306
TRG_ENDOCYTIC_2	117	120	PF00928	0.451
TRG_ENDOCYTIC_2	208	211	PF00928	0.432
TRG_ENDOCYTIC_2	213	216	PF00928	0.438
TRG_ENDOCYTIC_2	242	245	PF00928	0.446
TRG_ENDOCYTIC_2	249	252	PF00928	0.435
TRG_ENDOCYTIC_2	268	271	PF00928	0.560
TRG_ENDOCYTIC_2	305	308	PF00928	0.471
TRG_ENDOCYTIC_2	454	457	PF00928	0.444
TRG_ENDOCYTIC_2	497	500	PF00928	0.592
TRG_ER_diArg_1	346	348	PF00400	0.424
TRG_ER_diArg_1	389	392	PF00400	0.581
TRG_ER_diArg_1	407	410	PF00400	0.421
TRG_ER_diArg_1	439	441	PF00400	0.496
TRG_ER_diArg_1	454	456	PF00400	0.568
TRG_ER_diArg_1	527	530	PF00400	0.694
TRG_ER_diArg_1	6	9	PF00400	0.566
TRG_ER_diArg_1	67	70	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	603	608	PF00026	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4F2	Leptomonas seymouri	55%	100%
A0A0S4JFL5	Bodo saltans	30%	100%
A0A1X0NNC2	Trypanosomatidae	42%	100%
A0A3R7KIN4	Trypanosoma rangeli	40%	100%
A0A3S7WSE3	Leishmania donovani	81%	100%
A4HVF3	Leishmania infantum	81%	100%
E9AP51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QGD7	Leishmania major	80%	100%
V5B9B5	Trypanosoma cruzi	42%	100%