Protein kinase A regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase A regulatory subunit

Species:

Leishmania braziliensis

UniProt:

A4H723_LEIBR

TriTrypDb:

LbrM.13.0150 , LBRM2903_130006700

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4H723

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H723

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	5
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0016310	phosphorylation	5	4
GO:0044237	cellular metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.645
CLV_NRD_NRD_1	122	124	PF00675	0.447
CLV_NRD_NRD_1	203	205	PF00675	0.599
CLV_NRD_NRD_1	351	353	PF00675	0.488
CLV_NRD_NRD_1	460	462	PF00675	0.355
CLV_NRD_NRD_1	475	477	PF00675	0.402
CLV_PCSK_FUR_1	201	205	PF00082	0.667
CLV_PCSK_KEX2_1	203	205	PF00082	0.595
CLV_PCSK_KEX2_1	302	304	PF00082	0.249
CLV_PCSK_KEX2_1	350	352	PF00082	0.485
CLV_PCSK_KEX2_1	460	462	PF00082	0.355
CLV_PCSK_KEX2_1	475	477	PF00082	0.508
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.249
CLV_PCSK_SKI1_1	123	127	PF00082	0.438
CLV_PCSK_SKI1_1	152	156	PF00082	0.497
CLV_PCSK_SKI1_1	251	255	PF00082	0.524
CLV_PCSK_SKI1_1	53	57	PF00082	0.427
DEG_APCC_DBOX_1	133	141	PF00400	0.576
DEG_APCC_DBOX_1	52	60	PF00400	0.418
DOC_CDC14_PxL_1	359	367	PF14671	0.456
DOC_CKS1_1	20	25	PF01111	0.602
DOC_CKS1_1	315	320	PF01111	0.355
DOC_CYCLIN_RxL_1	120	127	PF00134	0.470
DOC_MAPK_gen_1	201	209	PF00069	0.715
DOC_MAPK_gen_1	302	308	PF00069	0.249
DOC_PP1_RVXF_1	142	148	PF00149	0.462
DOC_PP1_RVXF_1	24	31	PF00149	0.582
DOC_USP7_MATH_1	379	383	PF00917	0.465
DOC_USP7_UBL2_3	294	298	PF12436	0.368
DOC_WW_Pin1_4	19	24	PF00397	0.481
DOC_WW_Pin1_4	3	8	PF00397	0.606
DOC_WW_Pin1_4	314	319	PF00397	0.355
LIG_14-3-3_CanoR_1	123	129	PF00244	0.544
LIG_14-3-3_CanoR_1	203	208	PF00244	0.600
LIG_Actin_WH2_2	278	296	PF00022	0.249
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	381	385	PF00533	0.478
LIG_CSL_BTD_1	184	187	PF09270	0.495
LIG_eIF4E_1	120	126	PF01652	0.436
LIG_FHA_1	189	195	PF00498	0.740
LIG_FHA_1	204	210	PF00498	0.617
LIG_FHA_1	230	236	PF00498	0.471
LIG_FHA_1	315	321	PF00498	0.355
LIG_FHA_1	325	331	PF00498	0.355
LIG_FHA_1	406	412	PF00498	0.376
LIG_FHA_1	453	459	PF00498	0.372
LIG_FHA_2	141	147	PF00498	0.460
LIG_FHA_2	379	385	PF00498	0.533
LIG_FHA_2	441	447	PF00498	0.446
LIG_FHA_2	479	485	PF00498	0.375
LIG_FHA_2	90	96	PF00498	0.339
LIG_LIR_Apic_2	312	318	PF02991	0.355
LIG_LIR_Gen_1	35	45	PF02991	0.573
LIG_LIR_Gen_1	353	363	PF02991	0.458
LIG_LIR_Gen_1	369	379	PF02991	0.425
LIG_LIR_Gen_1	397	405	PF02991	0.355
LIG_LIR_Gen_1	484	490	PF02991	0.502
LIG_LIR_Nem_3	338	343	PF02991	0.352
LIG_LIR_Nem_3	35	40	PF02991	0.576
LIG_LIR_Nem_3	397	403	PF02991	0.355
LIG_LIR_Nem_3	480	486	PF02991	0.481
LIG_PCNA_yPIPBox_3	21	31	PF02747	0.520
LIG_PCNA_yPIPBox_3	46	59	PF02747	0.356
LIG_Rb_pABgroove_1	309	317	PF01858	0.371
LIG_SH2_CRK	315	319	PF00017	0.355
LIG_SH2_CRK	340	344	PF00017	0.371
LIG_SH2_CRK	486	490	PF00017	0.483
LIG_SH2_NCK_1	315	319	PF00017	0.440
LIG_SH2_PTP2	220	223	PF00017	0.562
LIG_SH2_PTP2	402	405	PF00017	0.432
LIG_SH2_SRC	390	393	PF00017	0.390
LIG_SH2_SRC	402	405	PF00017	0.390
LIG_SH2_STAT3	283	286	PF00017	0.355
LIG_SH2_STAT3	485	488	PF00017	0.609
LIG_SH2_STAT5	220	223	PF00017	0.503
LIG_SH2_STAT5	283	286	PF00017	0.355
LIG_SH2_STAT5	355	358	PF00017	0.421
LIG_SH2_STAT5	390	393	PF00017	0.371
LIG_SH2_STAT5	402	405	PF00017	0.371
LIG_SH3_3	17	23	PF00018	0.474
LIG_SUMO_SIM_anti_2	310	317	PF11976	0.355
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.371
LIG_SUMO_SIM_par_1	136	143	PF11976	0.546
LIG_SUMO_SIM_par_1	38	44	PF11976	0.561
LIG_SUMO_SIM_par_1	446	452	PF11976	0.475
LIG_SUMO_SIM_par_1	54	60	PF11976	0.272
LIG_TRAF2_1	167	170	PF00917	0.538
LIG_UBA3_1	244	251	PF00899	0.494
LIG_WRC_WIRS_1	244	249	PF05994	0.352
MOD_CDK_SPxxK_3	19	26	PF00069	0.628
MOD_CK1_1	326	332	PF00069	0.288
MOD_CK1_1	33	39	PF00069	0.520
MOD_CK1_1	501	507	PF00069	0.523
MOD_CK2_1	36	42	PF00069	0.497
MOD_CK2_1	378	384	PF00069	0.461
MOD_CK2_1	478	484	PF00069	0.593
MOD_Cter_Amidation	121	124	PF01082	0.443
MOD_GlcNHglycan	1	4	PF01048	0.668
MOD_GlcNHglycan	286	289	PF01048	0.390
MOD_GlcNHglycan	427	430	PF01048	0.502
MOD_GlcNHglycan	493	496	PF01048	0.688
MOD_GSK3_1	106	113	PF00069	0.567
MOD_GSK3_1	188	195	PF00069	0.671
MOD_GSK3_1	225	232	PF00069	0.501
MOD_GSK3_1	243	250	PF00069	0.338
MOD_GSK3_1	319	326	PF00069	0.475
MOD_GSK3_1	448	455	PF00069	0.355
MOD_N-GLC_1	140	145	PF02516	0.474
MOD_N-GLC_1	418	423	PF02516	0.443
MOD_NEK2_1	110	115	PF00069	0.439
MOD_NEK2_1	179	184	PF00069	0.647
MOD_NEK2_1	478	483	PF00069	0.487
MOD_NEK2_2	319	324	PF00069	0.412
MOD_PIKK_1	185	191	PF00454	0.677
MOD_PIKK_1	225	231	PF00454	0.618
MOD_PKA_1	203	209	PF00069	0.589
MOD_PKA_1	351	357	PF00069	0.459
MOD_PKA_2	203	209	PF00069	0.579
MOD_PKA_2	336	342	PF00069	0.365
MOD_PKA_2	351	357	PF00069	0.470
MOD_PKA_2	498	504	PF00069	0.514
MOD_PKB_1	201	209	PF00069	0.651
MOD_Plk_1	140	146	PF00069	0.476
MOD_Plk_1	192	198	PF00069	0.595
MOD_Plk_1	229	235	PF00069	0.480
MOD_Plk_4	230	236	PF00069	0.551
MOD_Plk_4	326	332	PF00069	0.288
MOD_Plk_4	351	357	PF00069	0.471
MOD_Plk_4	36	42	PF00069	0.556
MOD_Plk_4	6	12	PF00069	0.404
MOD_Plk_4	89	95	PF00069	0.357
MOD_ProDKin_1	19	25	PF00069	0.487
MOD_ProDKin_1	3	9	PF00069	0.599
MOD_ProDKin_1	314	320	PF00069	0.355
MOD_SUMO_for_1	266	269	PF00179	0.470
MOD_SUMO_for_1	301	304	PF00179	0.355
TRG_DiLeu_BaEn_4	396	402	PF01217	0.371
TRG_ENDOCYTIC_2	340	343	PF00928	0.351
TRG_ENDOCYTIC_2	355	358	PF00928	0.407
TRG_ENDOCYTIC_2	371	374	PF00928	0.431
TRG_ENDOCYTIC_2	402	405	PF00928	0.360
TRG_ENDOCYTIC_2	486	489	PF00928	0.480
TRG_ER_diArg_1	201	204	PF00400	0.602
TRG_ER_diArg_1	349	352	PF00400	0.488
TRG_ER_diArg_1	474	476	PF00400	0.387
TRG_NES_CRM1_1	399	415	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P645	Leptomonas seymouri	79%	100%
A0A0S4JEQ3	Bodo saltans	60%	100%
A0A1X0NNW8	Trypanosomatidae	64%	100%
A0A3S7WSB4	Leishmania donovani	88%	100%
A0A422NNY9	Trypanosoma rangeli	62%	100%
A4HVF2	Leishmania infantum	88%	100%
D0A6V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AP50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q13237	Homo sapiens	24%	67%
Q4QGD8	Leishmania major	87%	100%
Q5ZM91	Gallus gallus	33%	100%
Q61410	Mus musculus	23%	67%
V5BIC8	Trypanosoma cruzi	63%	100%