Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H722_LEIBR

TriTrypDb:

LbrM.13.0140 , LBRM2903_130006600

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H722

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H722

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.589
CLV_NRD_NRD_1	167	169	PF00675	0.565
CLV_NRD_NRD_1	218	220	PF00675	0.517
CLV_NRD_NRD_1	338	340	PF00675	0.479
CLV_PCSK_KEX2_1	154	156	PF00082	0.567
CLV_PCSK_KEX2_1	167	169	PF00082	0.609
CLV_PCSK_KEX2_1	218	220	PF00082	0.535
CLV_PCSK_KEX2_1	338	340	PF00082	0.479
CLV_PCSK_KEX2_1	452	454	PF00082	0.580
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.564
CLV_PCSK_SKI1_1	12	16	PF00082	0.483
CLV_PCSK_SKI1_1	154	158	PF00082	0.648
CLV_PCSK_SKI1_1	429	433	PF00082	0.422
DEG_SCF_FBW7_2	173	178	PF00400	0.424
DEG_SPOP_SBC_1	103	107	PF00917	0.756
DOC_CKS1_1	172	177	PF01111	0.418
DOC_CKS1_1	81	86	PF01111	0.766
DOC_CKS1_1	97	102	PF01111	0.514
DOC_MAPK_gen_1	135	143	PF00069	0.574
DOC_MAPK_gen_1	21	31	PF00069	0.297
DOC_MAPK_MEF2A_6	135	143	PF00069	0.648
DOC_PP4_FxxP_1	303	306	PF00568	0.488
DOC_PP4_FxxP_1	34	37	PF00568	0.429
DOC_USP7_MATH_1	366	370	PF00917	0.599
DOC_USP7_MATH_1	70	74	PF00917	0.715
DOC_WW_Pin1_4	13	18	PF00397	0.312
DOC_WW_Pin1_4	171	176	PF00397	0.513
DOC_WW_Pin1_4	241	246	PF00397	0.450
DOC_WW_Pin1_4	377	382	PF00397	0.458
DOC_WW_Pin1_4	76	81	PF00397	0.695
DOC_WW_Pin1_4	96	101	PF00397	0.587
LIG_14-3-3_CanoR_1	140	144	PF00244	0.647
LIG_14-3-3_CanoR_1	338	343	PF00244	0.607
LIG_14-3-3_CanoR_1	349	358	PF00244	0.481
LIG_14-3-3_CanoR_1	67	73	PF00244	0.733
LIG_APCC_ABBA_1	275	280	PF00400	0.390
LIG_BRCT_BRCA1_1	106	110	PF00533	0.721
LIG_BRCT_BRCA1_1	352	356	PF00533	0.408
LIG_CtBP_PxDLS_1	36	40	PF00389	0.314
LIG_deltaCOP1_diTrp_1	232	239	PF00928	0.567
LIG_EH1_1	355	363	PF00400	0.639
LIG_eIF4E_1	207	213	PF01652	0.408
LIG_eIF4E_1	451	457	PF01652	0.570
LIG_FHA_1	324	330	PF00498	0.430
LIG_FHA_1	405	411	PF00498	0.657
LIG_FHA_1	69	75	PF00498	0.566
LIG_FHA_1	90	96	PF00498	0.709
LIG_FHA_1	97	103	PF00498	0.756
LIG_FHA_2	172	178	PF00498	0.611
LIG_FHA_2	194	200	PF00498	0.561
LIG_GBD_Chelix_1	415	423	PF00786	0.289
LIG_Integrin_RGD_1	54	56	PF01839	0.624
LIG_LIR_Apic_2	171	175	PF02991	0.413
LIG_LIR_Apic_2	301	306	PF02991	0.521
LIG_LIR_Apic_2	32	37	PF02991	0.431
LIG_LIR_Gen_1	196	204	PF02991	0.557
LIG_LIR_Gen_1	236	245	PF02991	0.420
LIG_LIR_Nem_3	150	156	PF02991	0.574
LIG_LIR_Nem_3	196	200	PF02991	0.531
LIG_LIR_Nem_3	203	207	PF02991	0.498
LIG_LIR_Nem_3	236	240	PF02991	0.402
LIG_LIR_Nem_3	460	466	PF02991	0.400
LIG_LIR_Nem_3	56	62	PF02991	0.604
LIG_MYND_1	377	381	PF01753	0.536
LIG_Pex14_2	11	15	PF04695	0.556
LIG_Pex14_2	200	204	PF04695	0.418
LIG_Pex14_2	229	233	PF04695	0.620
LIG_SH2_CRK	153	157	PF00017	0.579
LIG_SH2_CRK	166	170	PF00017	0.500
LIG_SH2_CRK	26	30	PF00017	0.484
LIG_SH2_PTP2	172	175	PF00017	0.409
LIG_SH2_STAP1	278	282	PF00017	0.508
LIG_SH2_STAP1	421	425	PF00017	0.366
LIG_SH2_STAT5	172	175	PF00017	0.582
LIG_SH2_STAT5	195	198	PF00017	0.673
LIG_SH2_STAT5	390	393	PF00017	0.399
LIG_SH3_3	11	17	PF00018	0.558
LIG_SH3_3	111	117	PF00018	0.388
LIG_SH3_3	325	331	PF00018	0.398
LIG_SH3_3	375	381	PF00018	0.413
LIG_SH3_3	91	97	PF00018	0.756
LIG_SUMO_SIM_par_1	70	76	PF11976	0.472
LIG_TRAF2_1	174	177	PF00917	0.572
LIG_TYR_ITAM	150	169	PF00017	0.403
LIG_WRC_WIRS_1	31	36	PF05994	0.279
MOD_CDK_SPK_2	241	246	PF00069	0.309
MOD_CDK_SPxxK_3	241	248	PF00069	0.494
MOD_CK1_1	104	110	PF00069	0.706
MOD_CK1_1	16	22	PF00069	0.293
MOD_CK1_1	193	199	PF00069	0.585
MOD_CK1_1	320	326	PF00069	0.591
MOD_CK1_1	438	444	PF00069	0.473
MOD_CK1_1	73	79	PF00069	0.499
MOD_CK2_1	171	177	PF00069	0.604
MOD_GlcNHglycan	209	212	PF01048	0.498
MOD_GlcNHglycan	252	255	PF01048	0.579
MOD_GlcNHglycan	322	325	PF01048	0.605
MOD_GlcNHglycan	352	355	PF01048	0.531
MOD_GSK3_1	276	283	PF00069	0.548
MOD_GSK3_1	320	327	PF00069	0.594
MOD_GSK3_1	42	49	PF00069	0.462
MOD_GSK3_1	76	83	PF00069	0.598
MOD_N-GLC_1	280	285	PF02516	0.459
MOD_N-GLC_1	318	323	PF02516	0.535
MOD_N-GLC_1	404	409	PF02516	0.676
MOD_NEK2_1	101	106	PF00069	0.753
MOD_NEK2_1	200	205	PF00069	0.668
MOD_NEK2_1	240	245	PF00069	0.522
MOD_NEK2_1	350	355	PF00069	0.464
MOD_NEK2_1	43	48	PF00069	0.442
MOD_PIKK_1	392	398	PF00454	0.538
MOD_PKA_1	154	160	PF00069	0.657
MOD_PKA_1	338	344	PF00069	0.507
MOD_PKA_2	139	145	PF00069	0.570
MOD_PKA_2	154	160	PF00069	0.573
MOD_PKA_2	207	213	PF00069	0.530
MOD_PKA_2	338	344	PF00069	0.598
MOD_PKA_2	441	447	PF00069	0.503
MOD_Plk_1	283	289	PF00069	0.582
MOD_Plk_1	366	372	PF00069	0.594
MOD_Plk_4	225	231	PF00069	0.657
MOD_Plk_4	30	36	PF00069	0.469
MOD_Plk_4	324	330	PF00069	0.560
MOD_Plk_4	357	363	PF00069	0.576
MOD_Plk_4	421	427	PF00069	0.375
MOD_ProDKin_1	13	19	PF00069	0.304
MOD_ProDKin_1	171	177	PF00069	0.511
MOD_ProDKin_1	241	247	PF00069	0.441
MOD_ProDKin_1	377	383	PF00069	0.449
MOD_ProDKin_1	76	82	PF00069	0.695
MOD_ProDKin_1	96	102	PF00069	0.588
MOD_SUMO_rev_2	428	436	PF00179	0.319
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.526
TRG_ENDOCYTIC_2	153	156	PF00928	0.609
TRG_ENDOCYTIC_2	166	169	PF00928	0.496
TRG_ENDOCYTIC_2	197	200	PF00928	0.541
TRG_ENDOCYTIC_2	26	29	PF00928	0.426
TRG_ENDOCYTIC_2	390	393	PF00928	0.512
TRG_ER_diArg_1	153	155	PF00400	0.680
TRG_ER_diArg_1	160	163	PF00400	0.611
TRG_ER_diArg_1	166	168	PF00400	0.605
TRG_ER_diArg_1	217	219	PF00400	0.527
TRG_ER_diArg_1	337	339	PF00400	0.469
TRG_ER_diArg_1	51	54	PF00400	0.572
TRG_NLS_MonoExtN_4	135	141	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I6	Leptomonas seymouri	57%	100%
A0A0S4JBB6	Bodo saltans	25%	96%
A0A1X0NPY5	Trypanosomatidae	37%	100%
A0A3R7KWR6	Trypanosoma rangeli	39%	100%
A0A3S7WSC4	Leishmania donovani	82%	100%
A4HVF1	Leishmania infantum	82%	100%
D0A6V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AP49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QGD9	Leishmania major	83%	100%
V5BDY2	Trypanosoma cruzi	38%	100%