Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H720_LEIBR

TriTrypDb:

LbrM.13.0120 , LBRM2903_130006400

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097542	ciliary tip	2	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H720

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H720

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007019	microtubule depolymerization	5	1
GO:0010938	cytoplasmic microtubule depolymerization	5	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0044782	cilium organization	5	1
GO:0051261	protein depolymerization	6	1
GO:0060271	cilium assembly	6	1
GO:0060404	axonemal microtubule depolymerization	6	1
GO:0061523	cilium disassembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903008	organelle disassembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008270	zinc ion binding	6	11
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.295
CLV_C14_Caspase3-7	578	582	PF00656	0.481
CLV_NRD_NRD_1	206	208	PF00675	0.310
CLV_NRD_NRD_1	228	230	PF00675	0.328
CLV_NRD_NRD_1	363	365	PF00675	0.233
CLV_NRD_NRD_1	432	434	PF00675	0.396
CLV_NRD_NRD_1	435	437	PF00675	0.413
CLV_NRD_NRD_1	557	559	PF00675	0.543
CLV_NRD_NRD_1	564	566	PF00675	0.540
CLV_NRD_NRD_1	635	637	PF00675	0.486
CLV_PCSK_FUR_1	433	437	PF00082	0.522
CLV_PCSK_KEX2_1	206	208	PF00082	0.300
CLV_PCSK_KEX2_1	230	232	PF00082	0.300
CLV_PCSK_KEX2_1	314	316	PF00082	0.564
CLV_PCSK_KEX2_1	363	365	PF00082	0.255
CLV_PCSK_KEX2_1	434	436	PF00082	0.458
CLV_PCSK_KEX2_1	557	559	PF00082	0.549
CLV_PCSK_KEX2_1	564	566	PF00082	0.540
CLV_PCSK_KEX2_1	635	637	PF00082	0.500
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.325
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.564
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.477
CLV_PCSK_PC7_1	310	316	PF00082	0.554
CLV_PCSK_PC7_1	553	559	PF00082	0.484
CLV_PCSK_SKI1_1	214	218	PF00082	0.266
CLV_PCSK_SKI1_1	281	285	PF00082	0.476
CLV_PCSK_SKI1_1	408	412	PF00082	0.278
DEG_APCC_DBOX_1	68	76	PF00400	0.331
DEG_Nend_UBRbox_1	1	4	PF02207	0.373
DEG_SCF_FBW7_1	452	458	PF00400	0.679
DEG_SCF_FBW7_2	3	10	PF00400	0.453
DEG_SPOP_SBC_1	463	467	PF00917	0.539
DOC_CKS1_1	452	457	PF01111	0.680
DOC_CYCLIN_RxL_1	211	221	PF00134	0.281
DOC_CYCLIN_yClb5_NLxxxL_5	600	609	PF00134	0.421
DOC_MAPK_gen_1	158	168	PF00069	0.300
DOC_MAPK_gen_1	229	235	PF00069	0.276
DOC_MAPK_MEF2A_6	161	170	PF00069	0.281
DOC_PP1_RVXF_1	181	187	PF00149	0.411
DOC_PP1_SILK_1	485	490	PF00149	0.533
DOC_USP7_MATH_1	262	266	PF00917	0.314
DOC_USP7_MATH_1	359	363	PF00917	0.189
DOC_USP7_MATH_1	464	468	PF00917	0.661
DOC_USP7_MATH_1	495	499	PF00917	0.751
DOC_USP7_MATH_1	501	505	PF00917	0.726
DOC_USP7_MATH_1	510	514	PF00917	0.554
DOC_USP7_MATH_1	534	538	PF00917	0.768
DOC_WW_Pin1_4	258	263	PF00397	0.266
DOC_WW_Pin1_4	3	8	PF00397	0.452
DOC_WW_Pin1_4	339	344	PF00397	0.566
DOC_WW_Pin1_4	451	456	PF00397	0.567
DOC_WW_Pin1_4	537	542	PF00397	0.644
LIG_14-3-3_CanoR_1	158	168	PF00244	0.352
LIG_14-3-3_CanoR_1	183	187	PF00244	0.281
LIG_14-3-3_CanoR_1	224	229	PF00244	0.325
LIG_14-3-3_CanoR_1	251	260	PF00244	0.325
LIG_14-3-3_CanoR_1	456	463	PF00244	0.745
LIG_14-3-3_CanoR_1	543	551	PF00244	0.737
LIG_14-3-3_CterR_2	653	656	PF00244	0.421
LIG_Actin_WH2_2	133	150	PF00022	0.348
LIG_APCC_ABBA_1	620	625	PF00400	0.458
LIG_BRCT_BRCA1_1	546	550	PF00533	0.677
LIG_FHA_1	125	131	PF00498	0.331
LIG_FHA_1	239	245	PF00498	0.266
LIG_FHA_1	252	258	PF00498	0.266
LIG_FHA_1	4	10	PF00498	0.446
LIG_FHA_1	524	530	PF00498	0.630
LIG_FHA_1	76	82	PF00498	0.386
LIG_FHA_2	183	189	PF00498	0.274
LIG_FHA_2	203	209	PF00498	0.360
LIG_FHA_2	23	29	PF00498	0.360
LIG_FHA_2	386	392	PF00498	0.460
LIG_FHA_2	464	470	PF00498	0.691
LIG_FHA_2	576	582	PF00498	0.586
LIG_FHA_2	80	86	PF00498	0.432
LIG_GBD_Chelix_1	605	613	PF00786	0.547
LIG_LIR_Apic_2	592	597	PF02991	0.585
LIG_LIR_Gen_1	116	126	PF02991	0.368
LIG_LIR_Gen_1	13	20	PF02991	0.305
LIG_LIR_Gen_1	185	190	PF02991	0.313
LIG_LIR_Gen_1	476	483	PF02991	0.472
LIG_LIR_Nem_3	116	121	PF02991	0.316
LIG_LIR_Nem_3	13	19	PF02991	0.340
LIG_LIR_Nem_3	185	189	PF02991	0.313
LIG_LIR_Nem_3	476	481	PF02991	0.475
LIG_LIR_Nem_3	92	97	PF02991	0.272
LIG_NRBOX	100	106	PF00104	0.266
LIG_PCNA_yPIPBox_3	626	638	PF02747	0.490
LIG_SH2_CRK	102	106	PF00017	0.411
LIG_SH2_CRK	118	122	PF00017	0.366
LIG_SH2_CRK	478	482	PF00017	0.472
LIG_SH2_CRK	594	598	PF00017	0.528
LIG_SH2_GRB2like	118	121	PF00017	0.435
LIG_SH2_NCK_1	16	20	PF00017	0.411
LIG_SH2_NCK_1	478	482	PF00017	0.472
LIG_SH2_SRC	118	121	PF00017	0.411
LIG_SH2_SRC	16	19	PF00017	0.411
LIG_SH2_STAP1	16	20	PF00017	0.411
LIG_SH2_STAP1	276	280	PF00017	0.266
LIG_SH2_STAP1	623	627	PF00017	0.434
LIG_SH2_STAP1	73	77	PF00017	0.411
LIG_SH2_STAT5	348	351	PF00017	0.447
LIG_SH2_STAT5	401	404	PF00017	0.442
LIG_SH3_3	283	289	PF00018	0.607
LIG_SH3_3	442	448	PF00018	0.434
LIG_SH3_3	488	494	PF00018	0.616
LIG_SH3_3	584	590	PF00018	0.544
LIG_SUMO_SIM_anti_2	457	467	PF11976	0.675
LIG_SUMO_SIM_par_1	215	221	PF11976	0.281
LIG_TRAF2_1	25	28	PF00917	0.331
LIG_TRAF2_1	388	391	PF00917	0.478
LIG_TRAF2_2	380	385	PF00917	0.478
LIG_UBA3_1	216	220	PF00899	0.281
MOD_CDC14_SPxK_1	342	345	PF00782	0.440
MOD_CDC14_SPxK_1	540	543	PF00782	0.490
MOD_CDK_SPK_2	451	456	PF00069	0.675
MOD_CDK_SPxK_1	339	345	PF00069	0.437
MOD_CDK_SPxK_1	537	543	PF00069	0.491
MOD_CK1_1	12	18	PF00069	0.360
MOD_CK1_1	159	165	PF00069	0.291
MOD_CK1_1	238	244	PF00069	0.266
MOD_CK1_1	467	473	PF00069	0.634
MOD_CK1_1	476	482	PF00069	0.617
MOD_CK1_1	499	505	PF00069	0.704
MOD_CK1_1	536	542	PF00069	0.691
MOD_CK1_1	546	552	PF00069	0.648
MOD_CK1_1	57	63	PF00069	0.281
MOD_CK1_1	647	653	PF00069	0.607
MOD_CK1_1	87	93	PF00069	0.331
MOD_CK2_1	172	178	PF00069	0.364
MOD_CK2_1	202	208	PF00069	0.360
MOD_CK2_1	22	28	PF00069	0.331
MOD_CK2_1	262	268	PF00069	0.314
MOD_CK2_1	385	391	PF00069	0.489
MOD_CK2_1	79	85	PF00069	0.388
MOD_CK2_1	89	95	PF00069	0.266
MOD_Cter_Amidation	562	565	PF01082	0.535
MOD_GlcNHglycan	512	515	PF01048	0.743
MOD_GlcNHglycan	546	549	PF01048	0.651
MOD_GlcNHglycan	56	59	PF01048	0.281
MOD_GlcNHglycan	583	586	PF01048	0.590
MOD_GSK3_1	189	196	PF00069	0.322
MOD_GSK3_1	198	205	PF00069	0.308
MOD_GSK3_1	258	265	PF00069	0.282
MOD_GSK3_1	353	360	PF00069	0.491
MOD_GSK3_1	451	458	PF00069	0.591
MOD_GSK3_1	463	470	PF00069	0.586
MOD_GSK3_1	473	480	PF00069	0.609
MOD_GSK3_1	495	502	PF00069	0.689
MOD_GSK3_1	5	12	PF00069	0.210
MOD_GSK3_1	506	513	PF00069	0.459
MOD_GSK3_1	525	532	PF00069	0.707
MOD_GSK3_1	533	540	PF00069	0.669
MOD_GSK3_1	542	549	PF00069	0.604
MOD_GSK3_1	59	66	PF00069	0.456
MOD_GSK3_1	643	650	PF00069	0.541
MOD_GSK3_1	71	78	PF00069	0.235
MOD_GSK3_1	81	88	PF00069	0.265
MOD_N-GLC_1	212	217	PF02516	0.266
MOD_N-GLC_1	448	453	PF02516	0.515
MOD_N-GLC_1	581	586	PF02516	0.501
MOD_N-GLC_1	609	614	PF02516	0.326
MOD_N-GLC_2	567	569	PF02516	0.478
MOD_NEK2_1	172	177	PF00069	0.389
MOD_NEK2_1	235	240	PF00069	0.272
MOD_NEK2_1	244	249	PF00069	0.256
MOD_NEK2_1	37	42	PF00069	0.260
MOD_NEK2_1	468	473	PF00069	0.612
MOD_NEK2_1	474	479	PF00069	0.564
MOD_NEK2_1	52	57	PF00069	0.295
MOD_NEK2_1	544	549	PF00069	0.640
MOD_NEK2_1	609	614	PF00069	0.582
MOD_NEK2_1	89	94	PF00069	0.279
MOD_NEK2_2	525	530	PF00069	0.493
MOD_PIKK_1	238	244	PF00454	0.274
MOD_PIKK_1	385	391	PF00454	0.579
MOD_PIKK_1	468	474	PF00454	0.741
MOD_PKA_2	157	163	PF00069	0.340
MOD_PKA_2	182	188	PF00069	0.274
MOD_PKA_2	193	199	PF00069	0.252
MOD_PKA_2	235	241	PF00069	0.266
MOD_PKA_2	244	250	PF00069	0.266
MOD_PKA_2	385	391	PF00069	0.439
MOD_PKA_2	455	461	PF00069	0.675
MOD_PKA_2	499	505	PF00069	0.732
MOD_PKA_2	506	512	PF00069	0.711
MOD_PKA_2	542	548	PF00069	0.592
MOD_Plk_1	173	179	PF00069	0.339
MOD_Plk_1	212	218	PF00069	0.266
MOD_Plk_1	267	273	PF00069	0.266
MOD_Plk_1	448	454	PF00069	0.591
MOD_Plk_1	609	615	PF00069	0.479
MOD_Plk_1	84	90	PF00069	0.331
MOD_Plk_2-3	575	581	PF00069	0.482
MOD_Plk_2-3	79	85	PF00069	0.331
MOD_Plk_4	212	218	PF00069	0.266
MOD_Plk_4	244	250	PF00069	0.287
MOD_Plk_4	458	464	PF00069	0.482
MOD_Plk_4	515	521	PF00069	0.490
MOD_Plk_4	546	552	PF00069	0.634
MOD_Plk_4	59	65	PF00069	0.266
MOD_Plk_4	609	615	PF00069	0.487
MOD_Plk_4	618	624	PF00069	0.414
MOD_Plk_4	89	95	PF00069	0.270
MOD_ProDKin_1	258	264	PF00069	0.266
MOD_ProDKin_1	3	9	PF00069	0.453
MOD_ProDKin_1	339	345	PF00069	0.567
MOD_ProDKin_1	451	457	PF00069	0.572
MOD_ProDKin_1	537	543	PF00069	0.647
MOD_SUMO_rev_2	107	114	PF00179	0.360
MOD_SUMO_rev_2	162	170	PF00179	0.325
MOD_SUMO_rev_2	196	205	PF00179	0.364
MOD_SUMO_rev_2	278	286	PF00179	0.331
MOD_SUMO_rev_2	391	397	PF00179	0.478
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.281
TRG_ENDOCYTIC_2	102	105	PF00928	0.437
TRG_ENDOCYTIC_2	118	121	PF00928	0.366
TRG_ENDOCYTIC_2	16	19	PF00928	0.432
TRG_ENDOCYTIC_2	478	481	PF00928	0.475
TRG_ER_diArg_1	228	231	PF00400	0.325
TRG_ER_diArg_1	432	435	PF00400	0.447
TRG_ER_diArg_1	564	566	PF00400	0.604
TRG_ER_diArg_1	634	636	PF00400	0.500
TRG_NES_CRM1_1	180	193	PF08389	0.331
TRG_NES_CRM1_1	611	625	PF08389	0.345
TRG_NLS_MonoCore_2	432	437	PF00514	0.516
TRG_NLS_MonoExtC_3	432	438	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P647	Leptomonas seymouri	70%	89%
A0A0S4IJP8	Bodo saltans	50%	88%
A0A1X0NNY0	Trypanosomatidae	63%	100%
A0A1X0NQ03	Trypanosomatidae	25%	79%
A0A3S7WS99	Leishmania donovani	86%	90%
A0A422NBP2	Trypanosoma rangeli	53%	100%
A4HVE9	Leishmania infantum	86%	90%
D0A6W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	95%
E9AP47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	90%
Q4QGE1	Leishmania major	85%	100%