Putative carboxypeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E) Family M32

Species:

Leishmania braziliensis

UniProt:

A4H716_LEIBR

TriTrypDb:

LbrM.13.0080 , LBRM2903_130006000

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H716

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H716

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.321
CLV_C14_Caspase3-7	208	212	PF00656	0.208
CLV_NRD_NRD_1	118	120	PF00675	0.448
CLV_NRD_NRD_1	137	139	PF00675	0.448
CLV_NRD_NRD_1	496	498	PF00675	0.391
CLV_NRD_NRD_1	86	88	PF00675	0.351
CLV_PCSK_KEX2_1	118	120	PF00082	0.208
CLV_PCSK_KEX2_1	496	498	PF00082	0.364
CLV_PCSK_KEX2_1	86	88	PF00082	0.357
CLV_PCSK_SKI1_1	186	190	PF00082	0.474
CLV_PCSK_SKI1_1	258	262	PF00082	0.412
CLV_PCSK_SKI1_1	61	65	PF00082	0.409
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DOC_ANK_TNKS_1	39	46	PF00023	0.208
DOC_CYCLIN_RxL_1	183	194	PF00134	0.227
DOC_CYCLIN_RxL_1	255	263	PF00134	0.405
DOC_CYCLIN_yClb5_NLxxxL_5	13	21	PF00134	0.270
DOC_MAPK_gen_1	103	112	PF00069	0.450
DOC_MAPK_gen_1	341	349	PF00069	0.246
DOC_MAPK_gen_1	387	394	PF00069	0.369
DOC_PP4_FxxP_1	315	318	PF00568	0.303
DOC_USP7_UBL2_3	459	463	PF12436	0.343
LIG_14-3-3_CanoR_1	105	111	PF00244	0.494
LIG_14-3-3_CanoR_1	246	253	PF00244	0.480
LIG_14-3-3_CanoR_1	308	316	PF00244	0.208
LIG_14-3-3_CanoR_1	336	344	PF00244	0.278
LIG_14-3-3_CanoR_1	86	96	PF00244	0.402
LIG_APCC_ABBA_1	347	352	PF00400	0.269
LIG_BIR_III_4	211	215	PF00653	0.208
LIG_BRCT_BRCA1_1	308	312	PF00533	0.321
LIG_CtBP_PxDLS_1	278	282	PF00389	0.397
LIG_deltaCOP1_diTrp_1	407	415	PF00928	0.369
LIG_eIF4E_1	356	362	PF01652	0.284
LIG_eIF4E_1	471	477	PF01652	0.476
LIG_FHA_1	107	113	PF00498	0.284
LIG_FHA_1	236	242	PF00498	0.294
LIG_FHA_1	255	261	PF00498	0.484
LIG_FHA_1	372	378	PF00498	0.313
LIG_FHA_1	418	424	PF00498	0.326
LIG_FHA_1	471	477	PF00498	0.359
LIG_FHA_1	58	64	PF00498	0.436
LIG_FHA_2	127	133	PF00498	0.405
LIG_FHA_2	247	253	PF00498	0.394
LIG_FHA_2	261	267	PF00498	0.420
LIG_FHA_2	60	66	PF00498	0.356
LIG_LIR_Apic_2	314	318	PF02991	0.369
LIG_LIR_Gen_1	122	130	PF02991	0.465
LIG_LIR_Gen_1	170	181	PF02991	0.253
LIG_LIR_Gen_1	18	27	PF02991	0.303
LIG_LIR_Gen_1	299	306	PF02991	0.346
LIG_LIR_Gen_1	98	106	PF02991	0.250
LIG_LIR_Nem_3	122	126	PF02991	0.342
LIG_LIR_Nem_3	154	160	PF02991	0.457
LIG_LIR_Nem_3	170	176	PF02991	0.199
LIG_LIR_Nem_3	18	23	PF02991	0.376
LIG_LIR_Nem_3	299	304	PF02991	0.425
LIG_LIR_Nem_3	309	315	PF02991	0.353
LIG_LIR_Nem_3	98	102	PF02991	0.250
LIG_PCNA_PIPBox_1	210	219	PF02747	0.381
LIG_PCNA_yPIPBox_3	382	392	PF02747	0.364
LIG_Pex14_1	221	225	PF04695	0.269
LIG_Pex14_2	346	350	PF04695	0.208
LIG_PTB_Apo_2	483	490	PF02174	0.369
LIG_PTB_Phospho_1	483	489	PF10480	0.369
LIG_SH2_STAP1	153	157	PF00017	0.354
LIG_SH2_STAP1	89	93	PF00017	0.284
LIG_SH2_STAT3	89	92	PF00017	0.284
LIG_SH2_STAT5	22	25	PF00017	0.208
LIG_SH2_STAT5	391	394	PF00017	0.315
LIG_SH2_STAT5	417	420	PF00017	0.363
LIG_SH2_STAT5	421	424	PF00017	0.379
LIG_SH2_STAT5	433	436	PF00017	0.208
LIG_SH2_STAT5	489	492	PF00017	0.460
LIG_SH2_STAT5	493	496	PF00017	0.481
LIG_SH2_STAT5	498	501	PF00017	0.342
LIG_SH3_3	198	204	PF00018	0.262
LIG_SH3_3	351	357	PF00018	0.361
LIG_UBA3_1	183	192	PF00899	0.323
LIG_UBA3_1	431	437	PF00899	0.476
LIG_WRC_WIRS_1	123	128	PF05994	0.400
MOD_CK1_1	145	151	PF00069	0.387
MOD_CK1_1	171	177	PF00069	0.267
MOD_CK1_1	245	251	PF00069	0.284
MOD_CK1_1	34	40	PF00069	0.346
MOD_CK1_1	59	65	PF00069	0.216
MOD_CK2_1	126	132	PF00069	0.398
MOD_CK2_1	260	266	PF00069	0.490
MOD_CK2_1	267	273	PF00069	0.523
MOD_GlcNHglycan	144	147	PF01048	0.342
MOD_GlcNHglycan	226	229	PF01048	0.337
MOD_GlcNHglycan	231	235	PF01048	0.250
MOD_GlcNHglycan	309	312	PF01048	0.293
MOD_GlcNHglycan	36	39	PF01048	0.289
MOD_GlcNHglycan	89	92	PF01048	0.489
MOD_GSK3_1	122	129	PF00069	0.455
MOD_GSK3_1	171	178	PF00069	0.450
MOD_GSK3_1	242	249	PF00069	0.492
MOD_GSK3_1	260	267	PF00069	0.503
MOD_GSK3_1	27	34	PF00069	0.439
MOD_GSK3_1	53	60	PF00069	0.359
MOD_LATS_1	269	275	PF00433	0.284
MOD_N-GLC_1	15	20	PF02516	0.208
MOD_NEK2_1	106	111	PF00069	0.436
MOD_NEK2_1	230	235	PF00069	0.217
MOD_NEK2_1	260	265	PF00069	0.386
MOD_NEK2_1	405	410	PF00069	0.338
MOD_NEK2_1	431	436	PF00069	0.289
MOD_NEK2_1	439	444	PF00069	0.269
MOD_NEK2_1	74	79	PF00069	0.512
MOD_PIKK_1	294	300	PF00454	0.420
MOD_PIKK_1	336	342	PF00454	0.308
MOD_PIKK_1	74	80	PF00454	0.225
MOD_PIKK_1	8	14	PF00454	0.425
MOD_PKA_2	104	110	PF00069	0.473
MOD_PKA_2	245	251	PF00069	0.359
MOD_PKA_2	307	313	PF00069	0.208
MOD_Plk_1	15	21	PF00069	0.208
MOD_Plk_1	242	248	PF00069	0.467
MOD_Plk_1	440	446	PF00069	0.284
MOD_Plk_1	97	103	PF00069	0.253
MOD_Plk_4	122	128	PF00069	0.465
MOD_Plk_4	168	174	PF00069	0.374
MOD_Plk_4	175	181	PF00069	0.372
MOD_Plk_4	27	33	PF00069	0.384
MOD_Plk_4	422	428	PF00069	0.361
MOD_Plk_4	59	65	PF00069	0.381
MOD_SUMO_for_1	435	438	PF00179	0.284
MOD_SUMO_for_1	70	73	PF00179	0.361
MOD_SUMO_rev_2	170	178	PF00179	0.412
TRG_DiLeu_BaEn_1	333	338	PF01217	0.284
TRG_DiLeu_BaEn_1	46	51	PF01217	0.436
TRG_DiLeu_BaEn_1	472	477	PF01217	0.348
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.284
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.405
TRG_ENDOCYTIC_2	153	156	PF00928	0.361
TRG_ENDOCYTIC_2	391	394	PF00928	0.364
TRG_ENDOCYTIC_2	4	7	PF00928	0.413
TRG_ER_diArg_1	341	344	PF00400	0.338
TRG_ER_diArg_1	496	498	PF00400	0.364
TRG_ER_diArg_1	85	87	PF00400	0.351
TRG_NES_CRM1_1	12	27	PF08389	0.238
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	46%	100%
A0A1X0NY67	Trypanosomatidae	52%	99%
A0A1X0P441	Trypanosomatidae	55%	100%
A0A1X0P598	Trypanosomatidae	56%	100%
A0A3Q8IBW2	Leishmania donovani	54%	100%
A0A3Q8IJY8	Leishmania donovani	49%	100%
A0A3Q8IU74	Leishmania donovani	55%	100%
A0A3S7WSA3	Leishmania donovani	81%	100%
A0A422P042	Trypanosoma rangeli	55%	100%
A0A422P4R1	Trypanosoma rangeli	52%	100%
A4HLW4	Leishmania braziliensis	54%	100%
A4HVE5	Leishmania infantum	81%	100%
A4HVW0	Leishmania infantum	54%	100%
A4I993	Leishmania infantum	55%	100%
A4IC85	Leishmania infantum	49%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
P42663	Thermus aquaticus	34%	98%
P50848	Bacillus subtilis (strain 168)	34%	100%
Q4Q0D4	Leishmania major	49%	100%
Q4Q3T3	Leishmania major	54%	100%
Q4QFW7	Leishmania major	55%	100%
Q4QGE5	Leishmania major	80%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	35%	99%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	35%	100%
V5DQA0	Trypanosoma cruzi	56%	100%