Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease

Gene product:

ribonuclease HII, putative

Species:

Leishmania braziliensis

UniProt:

A4H713_LEIBR

TriTrypDb:

LbrM.13.0050 , LBRM2903_130005600

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0032299	ribonuclease H2 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	7
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

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Expansion

Sequence features

A4H713

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H713

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	7
GO:0004540	RNA nuclease activity	4	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.434
CLV_C14_Caspase3-7	44	48	PF00656	0.533
CLV_C14_Caspase3-7	57	61	PF00656	0.594
CLV_NRD_NRD_1	157	159	PF00675	0.303
CLV_PCSK_KEX2_1	159	161	PF00082	0.308
CLV_PCSK_KEX2_1	27	29	PF00082	0.213
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.321
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.213
CLV_PCSK_SKI1_1	246	250	PF00082	0.314
CLV_PCSK_SKI1_1	27	31	PF00082	0.394

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU4	Leptomonas seymouri	59%	89%
A0A0S4J8A1	Bodo saltans	27%	100%
A0A3S7WSB6	Leishmania donovani	80%	95%
A0JXT5	Arthrobacter sp. (strain FB24)	32%	100%
A0L4Z0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	29%	100%
A0M5H5	Gramella forsetii (strain KT0803)	27%	100%
A0Q7F9	Francisella tularensis subsp. novicida (strain U112)	29%	100%
A1V554	Burkholderia mallei (strain SAVP1)	34%	100%
A1VN54	Polaromonas naphthalenivorans (strain CJ2)	34%	100%
A1W904	Acidovorax sp. (strain JS42)	35%	100%

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