Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease

Gene product:

ribonuclease HII, putative

Species:

Leishmania braziliensis

UniProt:

A4H713_LEIBR

TriTrypDb:

LbrM.13.0050 , LBRM2903_130005600

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0032299	ribonuclease H2 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H713

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H713

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	7
GO:0004540	RNA nuclease activity	4	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.434
CLV_C14_Caspase3-7	44	48	PF00656	0.533
CLV_C14_Caspase3-7	57	61	PF00656	0.594
CLV_NRD_NRD_1	157	159	PF00675	0.303
CLV_PCSK_KEX2_1	159	161	PF00082	0.308
CLV_PCSK_KEX2_1	27	29	PF00082	0.213
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.321
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.213
CLV_PCSK_SKI1_1	246	250	PF00082	0.314
CLV_PCSK_SKI1_1	27	31	PF00082	0.394
CLV_PCSK_SKI1_1	51	55	PF00082	0.213
CLV_PCSK_SKI1_1	90	94	PF00082	0.394
DEG_APCC_DBOX_1	70	78	PF00400	0.594
DOC_CKS1_1	119	124	PF01111	0.458
DOC_MAPK_gen_1	194	204	PF00069	0.489
DOC_USP7_MATH_1	187	191	PF00917	0.521
DOC_USP7_UBL2_3	246	250	PF12436	0.314
DOC_WW_Pin1_4	118	123	PF00397	0.521
DOC_WW_Pin1_4	14	19	PF00397	0.484
LIG_14-3-3_CanoR_1	13	21	PF00244	0.521
LIG_14-3-3_CanoR_1	133	139	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_BIR_III_1	1	5	PF00653	0.410
LIG_BIR_III_3	1	5	PF00653	0.410
LIG_Clathr_ClatBox_1	81	85	PF01394	0.413
LIG_FHA_1	122	128	PF00498	0.510
LIG_FHA_1	172	178	PF00498	0.594
LIG_FHA_2	20	26	PF00498	0.434
LIG_FHA_2	55	61	PF00498	0.594
LIG_LIR_Gen_1	110	119	PF02991	0.564
LIG_LIR_Gen_1	235	245	PF02991	0.594
LIG_LIR_Nem_3	110	114	PF02991	0.559
LIG_LIR_Nem_3	164	168	PF02991	0.601
LIG_LIR_Nem_3	235	240	PF02991	0.540
LIG_LIR_Nem_3	241	245	PF02991	0.500
LIG_LYPXL_yS_3	165	168	PF13949	0.594
LIG_PDZ_Class_3	250	255	PF00595	0.340
LIG_SH2_CRK	111	115	PF00017	0.566
LIG_SH2_CRK	242	246	PF00017	0.533
LIG_SH2_SRC	242	245	PF00017	0.572
LIG_SH2_STAT5	200	203	PF00017	0.413
LIG_SH2_STAT5	21	24	PF00017	0.434
LIG_SH2_STAT5	220	223	PF00017	0.521
LIG_SH3_3	160	166	PF00018	0.541
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.521
LIG_SUMO_SIM_par_1	80	85	PF11976	0.594
LIG_TRAF2_1	140	143	PF00917	0.594
LIG_TYR_ITIM	163	168	PF00017	0.594
LIG_TYR_ITIM	240	245	PF00017	0.521
MOD_CDK_SPxK_1	14	20	PF00069	0.530
MOD_CK2_1	137	143	PF00069	0.559
MOD_GlcNHglycan	100	103	PF01048	0.389
MOD_GlcNHglycan	14	17	PF01048	0.321
MOD_GlcNHglycan	31	34	PF01048	0.158
MOD_GlcNHglycan	77	80	PF01048	0.213
MOD_GSK3_1	103	110	PF00069	0.453
MOD_GSK3_1	134	141	PF00069	0.413
MOD_GSK3_1	19	26	PF00069	0.378
MOD_GSK3_1	3	10	PF00069	0.575
MOD_N-GLC_1	93	98	PF02516	0.321
MOD_NEK2_1	171	176	PF00069	0.594
MOD_NEK2_1	29	34	PF00069	0.429
MOD_NEK2_1	53	58	PF00069	0.594
MOD_PKA_2	12	18	PF00069	0.521
MOD_PKA_2	19	25	PF00069	0.521
MOD_Plk_1	179	185	PF00069	0.594
MOD_Plk_1	54	60	PF00069	0.413
MOD_Plk_1	93	99	PF00069	0.486
MOD_Plk_4	103	109	PF00069	0.410
MOD_Plk_4	179	185	PF00069	0.557
MOD_Plk_4	187	193	PF00069	0.391
MOD_Plk_4	200	206	PF00069	0.594
MOD_Plk_4	7	13	PF00069	0.521
MOD_ProDKin_1	118	124	PF00069	0.521
MOD_ProDKin_1	14	20	PF00069	0.484
TRG_ENDOCYTIC_2	111	114	PF00928	0.594
TRG_ENDOCYTIC_2	165	168	PF00928	0.594
TRG_ENDOCYTIC_2	242	245	PF00928	0.572
TRG_ER_diArg_1	158	161	PF00400	0.508
TRG_NES_CRM1_1	72	85	PF08389	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU4	Leptomonas seymouri	59%	89%
A0A0S4J8A1	Bodo saltans	27%	100%
A0A3S7WSB6	Leishmania donovani	80%	95%
A0JXT5	Arthrobacter sp. (strain FB24)	32%	100%
A0L4Z0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	29%	100%
A0M5H5	Gramella forsetii (strain KT0803)	27%	100%
A0Q7F9	Francisella tularensis subsp. novicida (strain U112)	29%	100%
A1V554	Burkholderia mallei (strain SAVP1)	34%	100%
A1VN54	Polaromonas naphthalenivorans (strain CJ2)	34%	100%
A1W904	Acidovorax sp. (strain JS42)	35%	100%
A2SB87	Burkholderia mallei (strain NCTC 10229)	34%	100%
A2SH85	Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)	31%	100%
A3MKS8	Burkholderia mallei (strain NCTC 10247)	34%	100%
A3NAT3	Burkholderia pseudomallei (strain 668)	34%	100%
A3NWL6	Burkholderia pseudomallei (strain 1106a)	34%	100%
A3QG89	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	31%	100%
A4HVE1	Leishmania infantum	80%	95%
A4IX19	Francisella tularensis subsp. tularensis (strain WY96-3418)	30%	100%
A4VJT5	Pseudomonas stutzeri (strain A1501)	30%	100%
A4XLE8	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)	28%	100%
A4XWS7	Pseudomonas mendocina (strain ymp)	31%	100%
A5FIL7	Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101)	28%	100%
A5VF46	Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1)	29%	100%
A5W836	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	30%	100%
A5WDY2	Psychrobacter sp. (strain PRwf-1)	35%	84%
A6GYW0	Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86)	32%	100%
A6V1E6	Pseudomonas aeruginosa (strain PA7)	31%	100%
A7HQZ3	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	28%	95%
A7NCM0	Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)	29%	100%
B0KSB3	Pseudomonas putida (strain GB-1)	30%	100%
B0RW80	Xanthomonas campestris pv. campestris (strain B100)	34%	100%
B0SZF7	Caulobacter sp. (strain K31)	31%	100%
B0TYD6	Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036)	30%	100%
B0U235	Xylella fastidiosa (strain M12)	32%	100%
B1GZ18	Endomicrobium trichonymphae	28%	100%
B1JBP6	Pseudomonas putida (strain W619)	30%	100%
B2I7N7	Xylella fastidiosa (strain M23)	32%	100%
B2SGW7	Francisella tularensis subsp. mediasiatica (strain FSC147)	30%	100%
B2UBB5	Ralstonia pickettii (strain 12J)	33%	100%
B3CM59	Wolbachia pipientis subsp. Culex pipiens (strain wPip)	26%	100%
B3QQY0	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	33%	100%
B3QRP3	Chloroherpeton thalassium (strain ATCC 35110 / GB-78)	32%	100%
B4SAK8	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	29%	100%
B5EBC6	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	30%	100%
B7V7U6	Pseudomonas aeruginosa (strain LESB58)	31%	100%
B9MGN1	Acidovorax ebreus (strain TPSY)	35%	100%
C1DST2	Azotobacter vinelandii (strain DJ / ATCC BAA-1303)	32%	100%
E9AP39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%
Q02RB4	Pseudomonas aeruginosa (strain UCBPP-PA14)	31%	100%
Q0A7J3	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	30%	100%
Q0BLL3	Francisella tularensis subsp. holarctica (strain OSU18)	29%	100%
Q0BYK9	Hyphomonas neptunium (strain ATCC 15444)	31%	100%
Q12A45	Polaromonas sp. (strain JS666 / ATCC BAA-500)	33%	100%
Q14GW0	Francisella tularensis subsp. tularensis (strain FSC 198)	30%	100%
Q18BC9	Clostridioides difficile (strain 630)	26%	100%
Q1GUJ1	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	28%	100%
Q1I640	Pseudomonas entomophila (strain L48)	30%	100%
Q1QAL9	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	36%	89%
Q21HI6	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	31%	100%
Q21WX6	Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)	28%	100%
Q2A337	Francisella tularensis subsp. holarctica (strain LVS)	29%	100%
Q2GFP8	Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)	26%	100%
Q2NCP5	Erythrobacter litoralis (strain HTCC2594)	33%	100%
Q2P4B9	Xanthomonas oryzae pv. oryzae (strain MAFF 311018)	34%	100%
Q3AP34	Chlorobium chlorochromatii (strain CaD3)	33%	100%
Q3JR43	Burkholderia pseudomallei (strain 1710b)	34%	100%
Q3KH98	Pseudomonas fluorescens (strain Pf0-1)	30%	100%
Q3MDN0	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	26%	100%
Q3YST1	Ehrlichia canis (strain Jake)	25%	100%
Q470F1	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	28%	100%
Q47F78	Dechloromonas aromatica (strain RCB)	33%	100%
Q48F73	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	35%	100%
Q4FPF7	Pelagibacter ubique (strain HTCC1062)	28%	100%
Q4FT93	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	34%	89%
Q4KHG2	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	30%	100%
Q4QGE9	Leishmania major	80%	100%
Q4USP6	Xanthomonas campestris pv. campestris (strain 8004)	34%	100%
Q4ZWR4	Pseudomonas syringae pv. syringae (strain B728a)	35%	100%
Q50412	Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)	31%	100%
Q5H1F4	Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)	34%	100%
Q5L0P0	Geobacillus kaustophilus (strain HTA426)	30%	98%
Q5NFF8	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)	30%	100%
Q5QZK7	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	27%	100%
Q62JD8	Burkholderia mallei (strain ATCC 23344)	34%	100%
Q63T26	Burkholderia pseudomallei (strain K96243)	34%	100%
Q6MLA0	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	28%	100%
Q72DU5	Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)	33%	100%
Q82U06	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	32%	100%
Q87EI6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	32%	100%
Q886M9	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	34%	100%
Q88MG6	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	30%	100%
Q8KAA5	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	31%	100%
Q8PAW7	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	34%	100%
Q8PML9	Xanthomonas axonopodis pv. citri (strain 306)	34%	100%
Q8RDX3	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	27%	100%
Q986D0	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	34%	100%
Q9HXY9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%
Q9PEI7	Xylella fastidiosa (strain 9a5c)	32%	100%
Q9Z962	Chlamydia pneumoniae	29%	100%