Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H712_LEIBR

TriTrypDb:

LbrM.13.0040 , LBRM2903_130005500

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H712

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H712

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.566
CLV_NRD_NRD_1	108	110	PF00675	0.495
CLV_NRD_NRD_1	148	150	PF00675	0.484
CLV_NRD_NRD_1	179	181	PF00675	0.413
CLV_NRD_NRD_1	225	227	PF00675	0.539
CLV_PCSK_FUR_1	177	181	PF00082	0.423
CLV_PCSK_KEX2_1	108	110	PF00082	0.678
CLV_PCSK_KEX2_1	148	150	PF00082	0.467
CLV_PCSK_KEX2_1	179	181	PF00082	0.537
CLV_PCSK_KEX2_1	201	203	PF00082	0.614
CLV_PCSK_KEX2_1	225	227	PF00082	0.539
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.614
CLV_PCSK_SKI1_1	131	135	PF00082	0.372
CLV_PCSK_SKI1_1	171	175	PF00082	0.520
CLV_PCSK_SKI1_1	30	34	PF00082	0.707
CLV_PCSK_SKI1_1	339	343	PF00082	0.498
DEG_APCC_DBOX_1	168	176	PF00400	0.450
DOC_CYCLIN_RxL_1	223	234	PF00134	0.353
DOC_MAPK_gen_1	179	188	PF00069	0.510
DOC_PP4_FxxP_1	273	276	PF00568	0.527
DOC_USP7_MATH_1	207	211	PF00917	0.572
DOC_USP7_MATH_1	276	280	PF00917	0.383
DOC_USP7_MATH_1	88	92	PF00917	0.655
DOC_WW_Pin1_4	208	213	PF00397	0.747
DOC_WW_Pin1_4	303	308	PF00397	0.482
LIG_14-3-3_CanoR_1	116	120	PF00244	0.517
LIG_14-3-3_CanoR_1	12	18	PF00244	0.591
LIG_14-3-3_CanoR_1	258	267	PF00244	0.545
LIG_14-3-3_CanoR_1	268	276	PF00244	0.625
LIG_14-3-3_CanoR_1	283	287	PF00244	0.475
LIG_14-3-3_CanoR_1	339	346	PF00244	0.469
LIG_FHA_1	148	154	PF00498	0.541
LIG_FHA_1	181	187	PF00498	0.637
LIG_FHA_1	216	222	PF00498	0.485
LIG_FHA_1	230	236	PF00498	0.401
LIG_FHA_1	27	33	PF00498	0.480
LIG_FHA_2	101	107	PF00498	0.648
LIG_FHA_2	260	266	PF00498	0.558
LIG_FHA_2	320	326	PF00498	0.493
LIG_LIR_Apic_2	270	276	PF02991	0.549
LIG_LIR_Gen_1	321	332	PF02991	0.620
LIG_LIR_Nem_3	321	327	PF02991	0.634
LIG_PTAP_UEV_1	345	350	PF05743	0.474
LIG_SH2_GRB2like	217	220	PF00017	0.538
LIG_SH2_STAP1	217	221	PF00017	0.535
LIG_SH2_STAT5	217	220	PF00017	0.538
LIG_SH3_1	201	207	PF00018	0.472
LIG_SH3_3	201	207	PF00018	0.499
LIG_SH3_3	343	349	PF00018	0.499
LIG_SH3_3	93	99	PF00018	0.521
LIG_SUMO_SIM_par_1	289	295	PF11976	0.332
LIG_TRAF2_1	301	304	PF00917	0.482
MOD_CK1_1	306	312	PF00069	0.482
MOD_CK1_1	58	64	PF00069	0.529
MOD_GlcNHglycan	193	196	PF01048	0.690
MOD_GlcNHglycan	253	256	PF01048	0.492
MOD_GlcNHglycan	26	29	PF01048	0.492
MOD_GlcNHglycan	294	297	PF01048	0.413
MOD_GSK3_1	111	118	PF00069	0.558
MOD_GSK3_1	12	19	PF00069	0.572
MOD_GSK3_1	143	150	PF00069	0.510
MOD_GSK3_1	186	193	PF00069	0.512
MOD_GSK3_1	26	33	PF00069	0.436
MOD_GSK3_1	61	68	PF00069	0.455
MOD_N-GLC_1	318	323	PF02516	0.368
MOD_NEK2_1	235	240	PF00069	0.514
MOD_NEK2_1	26	31	PF00069	0.461
MOD_NEK2_1	354	359	PF00069	0.599
MOD_NEK2_1	55	60	PF00069	0.550
MOD_PIKK_1	109	115	PF00454	0.673
MOD_PIKK_1	2	8	PF00454	0.575
MOD_PIKK_1	235	241	PF00454	0.461
MOD_PIKK_1	61	67	PF00454	0.567
MOD_PKA_1	108	114	PF00069	0.460
MOD_PKA_1	180	186	PF00069	0.451
MOD_PKA_2	108	114	PF00069	0.729
MOD_PKA_2	11	17	PF00069	0.567
MOD_PKA_2	115	121	PF00069	0.583
MOD_PKA_2	147	153	PF00069	0.433
MOD_PKA_2	215	221	PF00069	0.507
MOD_PKA_2	267	273	PF00069	0.659
MOD_PKA_2	282	288	PF00069	0.474
MOD_PKA_2	70	76	PF00069	0.450
MOD_Plk_1	235	241	PF00069	0.483
MOD_Plk_1	276	282	PF00069	0.503
MOD_Plk_1	318	324	PF00069	0.370
MOD_Plk_2-3	97	103	PF00069	0.518
MOD_Plk_4	115	121	PF00069	0.590
MOD_Plk_4	282	288	PF00069	0.474
MOD_Plk_4	319	325	PF00069	0.518
MOD_Plk_4	349	355	PF00069	0.574
MOD_Plk_4	65	71	PF00069	0.571
MOD_ProDKin_1	208	214	PF00069	0.743
MOD_ProDKin_1	303	309	PF00069	0.481
MOD_SUMO_for_1	124	127	PF00179	0.365
MOD_SUMO_rev_2	152	158	PF00179	0.485
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.623
TRG_ER_diArg_1	147	149	PF00400	0.490
TRG_ER_diArg_1	164	167	PF00400	0.374
TRG_ER_diArg_1	168	171	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V4	Leptomonas seymouri	50%	100%
A0A3Q8IBM3	Leishmania donovani	70%	100%
A4HVE0	Leishmania infantum	70%	100%
E9AP38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QGF0	Leishmania major	69%	96%
V5ATU2	Trypanosoma cruzi	30%	70%