Alkyl transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alkyl transferase

Gene product:

cis-prenyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H710_LEIBR

TriTrypDb:

LbrM.13.0020 , LBRM2903_130005300

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H710

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H710

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016093	polyprenol metabolic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0002094	polyprenyltransferase activity	5	1
GO:0004659	prenyltransferase activity	4	5
GO:0008834	di-trans,poly-cis-decaprenylcistransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.299
CLV_C14_Caspase3-7	160	164	PF00656	0.212
CLV_C14_Caspase3-7	26	30	PF00656	0.506
CLV_NRD_NRD_1	102	104	PF00675	0.489
CLV_NRD_NRD_1	106	108	PF00675	0.529
CLV_NRD_NRD_1	260	262	PF00675	0.441
CLV_NRD_NRD_1	286	288	PF00675	0.477
CLV_NRD_NRD_1	390	392	PF00675	0.416
CLV_NRD_NRD_1	69	71	PF00675	0.689
CLV_PCSK_FUR_1	387	391	PF00082	0.408
CLV_PCSK_KEX2_1	102	104	PF00082	0.489
CLV_PCSK_KEX2_1	106	108	PF00082	0.529
CLV_PCSK_KEX2_1	151	153	PF00082	0.501
CLV_PCSK_KEX2_1	260	262	PF00082	0.422
CLV_PCSK_KEX2_1	286	288	PF00082	0.452
CLV_PCSK_KEX2_1	389	391	PF00082	0.406
CLV_PCSK_KEX2_1	69	71	PF00082	0.689
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.512
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.480
CLV_PCSK_PC7_1	102	108	PF00082	0.555
CLV_PCSK_PC7_1	282	288	PF00082	0.512
CLV_PCSK_SKI1_1	21	25	PF00082	0.338
CLV_PCSK_SKI1_1	220	224	PF00082	0.451
CLV_PCSK_SKI1_1	225	229	PF00082	0.415
CLV_PCSK_SKI1_1	261	265	PF00082	0.477
CLV_PCSK_SKI1_1	314	318	PF00082	0.401
CLV_PCSK_SKI1_1	74	78	PF00082	0.653
CLV_Separin_Metazoa	311	315	PF03568	0.275
DEG_APCC_DBOX_1	20	28	PF00400	0.533
DOC_MAPK_gen_1	260	268	PF00069	0.225
DOC_MAPK_MEF2A_6	260	268	PF00069	0.222
DOC_PP1_RVXF_1	240	247	PF00149	0.255
DOC_WW_Pin1_4	81	86	PF00397	0.405
LIG_14-3-3_CanoR_1	144	154	PF00244	0.284
LIG_14-3-3_CanoR_1	230	236	PF00244	0.257
LIG_Actin_WH2_2	326	344	PF00022	0.257
LIG_eIF4E_1	58	64	PF01652	0.166
LIG_FHA_1	1	7	PF00498	0.644
LIG_FHA_1	252	258	PF00498	0.303
LIG_FHA_1	40	46	PF00498	0.382
LIG_FHA_1	76	82	PF00498	0.469
LIG_FHA_2	132	138	PF00498	0.354
LIG_FHA_2	158	164	PF00498	0.161
LIG_FHA_2	24	30	PF00498	0.588
LIG_FHA_2	302	308	PF00498	0.257
LIG_FHA_2	315	321	PF00498	0.195
LIG_FHA_2	341	347	PF00498	0.208
LIG_FHA_2	366	372	PF00498	0.209
LIG_LIR_Apic_2	194	200	PF02991	0.275
LIG_LIR_Gen_1	356	365	PF02991	0.211
LIG_LIR_Nem_3	147	153	PF02991	0.219
LIG_LIR_Nem_3	350	355	PF02991	0.219
LIG_LIR_Nem_3	356	362	PF02991	0.208
LIG_LIR_Nem_3	368	372	PF02991	0.208
LIG_LIR_Nem_3	42	46	PF02991	0.335
LIG_LIR_Nem_3	54	58	PF02991	0.244
LIG_Pex14_2	211	215	PF04695	0.208
LIG_REV1ctd_RIR_1	211	221	PF16727	0.233
LIG_RPA_C_Fungi	277	289	PF08784	0.388
LIG_SH2_NCK_1	355	359	PF00017	0.258
LIG_SH2_PTP2	58	61	PF00017	0.166
LIG_SH2_STAP1	355	359	PF00017	0.246
LIG_SH2_STAT3	270	273	PF00017	0.388
LIG_SH2_STAT5	58	61	PF00017	0.229
LIG_SH3_3	112	118	PF00018	0.327
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.236
LIG_SUMO_SIM_par_1	2	8	PF11976	0.630
LIG_SUMO_SIM_par_1	32	38	PF11976	0.476
LIG_TYR_ITIM	56	61	PF00017	0.166
LIG_WRC_WIRS_1	52	57	PF05994	0.166
LIG_WW_3	239	243	PF00397	0.388
MOD_CK1_1	185	191	PF00069	0.296
MOD_CK1_1	271	277	PF00069	0.388
MOD_CK2_1	314	320	PF00069	0.265
MOD_CK2_1	340	346	PF00069	0.243
MOD_CK2_1	365	371	PF00069	0.194
MOD_Cter_Amidation	104	107	PF01082	0.442
MOD_GlcNHglycan	137	140	PF01048	0.542
MOD_GlcNHglycan	270	273	PF01048	0.272
MOD_GlcNHglycan	343	346	PF01048	0.243
MOD_GSK3_1	131	138	PF00069	0.570
MOD_GSK3_1	140	147	PF00069	0.418
MOD_GSK3_1	23	30	PF00069	0.490
MOD_GSK3_1	35	42	PF00069	0.271
MOD_N-GLC_1	27	32	PF02516	0.548
MOD_N-GLC_1	365	370	PF02516	0.272
MOD_N-GLC_1	81	86	PF02516	0.652
MOD_N-GLC_2	177	179	PF02516	0.272
MOD_N-GLC_2	265	267	PF02516	0.243
MOD_NEK2_1	312	317	PF00069	0.243
MOD_NEK2_1	365	370	PF00069	0.232
MOD_NEK2_1	5	10	PF00069	0.612
MOD_NEK2_1	51	56	PF00069	0.433
MOD_NEK2_2	145	150	PF00069	0.236
MOD_PIKK_1	314	320	PF00454	0.248
MOD_PIKK_1	370	376	PF00454	0.394
MOD_PKA_2	140	146	PF00069	0.409
MOD_PKA_2	182	188	PF00069	0.251
MOD_PKA_2	288	294	PF00069	0.308
MOD_PKA_2	341	347	PF00069	0.243
MOD_PKB_1	287	295	PF00069	0.308
MOD_Plk_1	331	337	PF00069	0.309
MOD_Plk_1	365	371	PF00069	0.202
MOD_Plk_4	185	191	PF00069	0.258
MOD_Plk_4	46	52	PF00069	0.197
MOD_ProDKin_1	81	87	PF00069	0.511
TRG_DiLeu_BaEn_1	203	208	PF01217	0.243
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.192
TRG_ENDOCYTIC_2	150	153	PF00928	0.379
TRG_ENDOCYTIC_2	359	362	PF00928	0.243
TRG_ENDOCYTIC_2	58	61	PF00928	0.215
TRG_ER_diArg_1	102	104	PF00400	0.356
TRG_ER_diArg_1	12	15	PF00400	0.539
TRG_ER_diArg_1	259	261	PF00400	0.260
TRG_ER_diArg_1	286	289	PF00400	0.341
TRG_NES_CRM1_1	170	181	PF08389	0.166
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P394	Leptomonas seymouri	58%	100%
A0A0S4JA70	Bodo saltans	46%	89%
A0A1X0NGI2	Trypanosomatidae	49%	97%
A0A3S7WSB2	Leishmania donovani	78%	100%
A0A422NM12	Trypanosoma rangeli	50%	95%
A4HVD8	Leishmania infantum	78%	100%
B8XA40	Solanum habrochaites	25%	100%
C1K5M2	Solanum lycopersicum	25%	100%
C9ZTQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	94%
E9AP36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
K4CA50	Solanum lycopersicum	28%	100%
K4D3U9	Solanum lycopersicum	28%	100%
K7W9N9	Solanum lycopersicum	25%	100%
K7WQ45	Solanum lycopersicum	25%	100%
K7X479	Solanum lycopersicum	27%	100%
O59258	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	100%
O80458	Arabidopsis thaliana	23%	100%
P35196	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QGF2	Leishmania major	76%	100%
Q570Q8	Arabidopsis thaliana	24%	100%
Q5V1I1	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	24%	100%
Q82TZ9	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	26%	100%
Q86SQ9	Homo sapiens	25%	100%
Q8G7Y3	Bifidobacterium longum (strain NCC 2705)	23%	100%
Q8GY03	Arabidopsis thaliana	25%	100%
Q8KFQ5	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	25%	100%
Q8RX73	Arabidopsis thaliana	25%	100%
Q8S2T1	Arabidopsis thaliana	23%	100%
Q8U0I8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
Q99KU1	Mus musculus	24%	100%
Q9HP68	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	25%	100%
Q9RRP1	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	28%	100%
V5BT78	Trypanosoma cruzi	48%	95%