LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H709_LEIBR

TriTrypDb:

LbrM.13.0010 , LBRM2903_130005200

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0016604	nuclear body	2	2
GO:0016607	nuclear speck	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A4H709

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H709

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	5
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	5
GO:0000398	mRNA splicing, via spliceosome	8	5
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006397	mRNA processing	7	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0008380	RNA splicing	7	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0016071	mRNA metabolic process	6	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.655
CLV_NRD_NRD_1	369	371	PF00675	0.567
CLV_NRD_NRD_1	75	77	PF00675	0.457
CLV_PCSK_KEX2_1	257	259	PF00082	0.652
CLV_PCSK_KEX2_1	362	364	PF00082	0.514
CLV_PCSK_KEX2_1	369	371	PF00082	0.532
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.375
CLV_PCSK_SKI1_1	104	108	PF00082	0.591
CLV_PCSK_SKI1_1	153	157	PF00082	0.405
CLV_PCSK_SKI1_1	20	24	PF00082	0.728
CLV_PCSK_SKI1_1	96	100	PF00082	0.530
DEG_APCC_DBOX_1	515	523	PF00400	0.537
DEG_APCC_DBOX_1	75	83	PF00400	0.437
DEG_ODPH_VHL_1	297	308	PF01847	0.622
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.550
DOC_MAPK_MEF2A_6	38	46	PF00069	0.458
DOC_PP1_RVXF_1	372	379	PF00149	0.501
DOC_PP2B_LxvP_1	267	270	PF13499	0.646
DOC_PP2B_LxvP_1	330	333	PF13499	0.489
DOC_PP2B_PxIxI_1	279	285	PF00149	0.510
DOC_USP7_MATH_1	106	110	PF00917	0.577
DOC_USP7_MATH_1	15	19	PF00917	0.725
DOC_USP7_MATH_1	180	184	PF00917	0.594
DOC_USP7_MATH_1	270	274	PF00917	0.595
DOC_USP7_MATH_1	398	402	PF00917	0.380
DOC_USP7_MATH_1	5	9	PF00917	0.741
DOC_USP7_MATH_1	94	98	PF00917	0.491
DOC_USP7_UBL2_3	100	104	PF12436	0.581
DOC_USP7_UBL2_3	108	112	PF12436	0.689
DOC_WW_Pin1_4	114	119	PF00397	0.678
DOC_WW_Pin1_4	21	26	PF00397	0.643
DOC_WW_Pin1_4	490	495	PF00397	0.433
DOC_WW_Pin1_4	502	507	PF00397	0.368
DOC_WW_Pin1_4	543	548	PF00397	0.626
LIG_14-3-3_CanoR_1	258	267	PF00244	0.568
LIG_14-3-3_CanoR_1	291	295	PF00244	0.631
LIG_14-3-3_CanoR_1	463	469	PF00244	0.511
LIG_14-3-3_CanoR_1	545	551	PF00244	0.476
LIG_14-3-3_CanoR_1	617	625	PF00244	0.456
LIG_14-3-3_CanoR_1	76	80	PF00244	0.490
LIG_Actin_RPEL_3	31	50	PF02755	0.571
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BIR_III_4	14	18	PF00653	0.775
LIG_BRCT_BRCA1_1	124	128	PF00533	0.486
LIG_BRCT_BRCA1_1	506	510	PF00533	0.554
LIG_CSL_BTD_1	330	333	PF09270	0.466
LIG_CtBP_PxDLS_1	228	232	PF00389	0.654
LIG_EH1_1	453	461	PF00400	0.502
LIG_FHA_1	169	175	PF00498	0.544
LIG_FHA_1	191	197	PF00498	0.506
LIG_FHA_1	230	236	PF00498	0.644
LIG_FHA_1	24	30	PF00498	0.692
LIG_FHA_1	284	290	PF00498	0.510
LIG_FHA_1	324	330	PF00498	0.459
LIG_FHA_1	332	338	PF00498	0.534
LIG_FHA_1	371	377	PF00498	0.512
LIG_FHA_1	381	387	PF00498	0.491
LIG_FHA_1	422	428	PF00498	0.587
LIG_FHA_1	432	438	PF00498	0.389
LIG_FHA_1	45	51	PF00498	0.327
LIG_FHA_1	474	480	PF00498	0.415
LIG_FHA_1	482	488	PF00498	0.403
LIG_FHA_1	507	513	PF00498	0.466
LIG_FHA_1	525	531	PF00498	0.362
LIG_FHA_2	176	182	PF00498	0.538
LIG_FHA_2	35	41	PF00498	0.519
LIG_FHA_2	534	540	PF00498	0.619
LIG_FHA_2	551	557	PF00498	0.450
LIG_LIR_Gen_1	147	155	PF02991	0.541
LIG_LIR_Gen_1	165	174	PF02991	0.339
LIG_LIR_Gen_1	2	7	PF02991	0.514
LIG_LIR_Gen_1	242	253	PF02991	0.493
LIG_LIR_Gen_1	278	289	PF02991	0.582
LIG_LIR_Gen_1	444	451	PF02991	0.473
LIG_LIR_Nem_3	147	151	PF02991	0.538
LIG_LIR_Nem_3	165	170	PF02991	0.338
LIG_LIR_Nem_3	183	189	PF02991	0.467
LIG_LIR_Nem_3	2	6	PF02991	0.515
LIG_LIR_Nem_3	211	217	PF02991	0.600
LIG_LIR_Nem_3	242	248	PF02991	0.490
LIG_LIR_Nem_3	278	284	PF02991	0.582
LIG_LIR_Nem_3	292	297	PF02991	0.619
LIG_LIR_Nem_3	444	450	PF02991	0.477
LIG_MYND_1	295	299	PF01753	0.582
LIG_NRBOX	169	175	PF00104	0.432
LIG_PCNA_yPIPBox_3	453	463	PF02747	0.445
LIG_PDZ_Class_1	645	650	PF00595	0.444
LIG_Pex14_2	239	243	PF04695	0.614
LIG_REV1ctd_RIR_1	148	156	PF16727	0.422
LIG_SH2_GRB2like	214	217	PF00017	0.703
LIG_SH2_STAP1	447	451	PF00017	0.566
LIG_SH2_STAP1	609	613	PF00017	0.588
LIG_SH2_STAT3	596	599	PF00017	0.762
LIG_SH2_STAT3	609	612	PF00017	0.445
LIG_SH2_STAT5	172	175	PF00017	0.444
LIG_SH2_STAT5	217	220	PF00017	0.583
LIG_SH2_STAT5	468	471	PF00017	0.368
LIG_SH2_STAT5	567	570	PF00017	0.427
LIG_SH2_STAT5	596	599	PF00017	0.716
LIG_SH2_STAT5	74	77	PF00017	0.570
LIG_SH3_2	580	585	PF14604	0.651
LIG_SH3_3	220	226	PF00018	0.727
LIG_SH3_3	330	336	PF00018	0.551
LIG_SH3_3	577	583	PF00018	0.729
LIG_SH3_3	622	628	PF00018	0.550
LIG_SUMO_SIM_anti_2	635	642	PF11976	0.294
LIG_SUMO_SIM_par_1	227	232	PF11976	0.662
LIG_SUMO_SIM_par_1	26	32	PF11976	0.586
LIG_SUMO_SIM_par_1	423	428	PF11976	0.569
LIG_SUMO_SIM_par_1	478	484	PF11976	0.431
LIG_TRAF2_1	85	88	PF00917	0.545
MOD_CK1_1	283	289	PF00069	0.561
MOD_CK1_1	340	346	PF00069	0.514
MOD_CK1_1	380	386	PF00069	0.521
MOD_CK1_1	431	437	PF00069	0.354
MOD_CK1_1	490	496	PF00069	0.475
MOD_CK1_1	505	511	PF00069	0.301
MOD_CK1_1	546	552	PF00069	0.549
MOD_CK1_1	90	96	PF00069	0.589
MOD_CK2_1	175	181	PF00069	0.548
MOD_CK2_1	34	40	PF00069	0.523
MOD_CK2_1	533	539	PF00069	0.593
MOD_CK2_1	550	556	PF00069	0.608
MOD_CK2_1	629	635	PF00069	0.530
MOD_GlcNHglycan	108	111	PF01048	0.504
MOD_GlcNHglycan	17	20	PF01048	0.700
MOD_GlcNHglycan	267	270	PF01048	0.646
MOD_GlcNHglycan	285	289	PF01048	0.363
MOD_GlcNHglycan	341	345	PF01048	0.575
MOD_GlcNHglycan	558	561	PF01048	0.451
MOD_GlcNHglycan	56	59	PF01048	0.428
MOD_GlcNHglycan	591	594	PF01048	0.694
MOD_GlcNHglycan	8	11	PF01048	0.718
MOD_GlcNHglycan	92	95	PF01048	0.536
MOD_GSK3_1	100	107	PF00069	0.462
MOD_GSK3_1	168	175	PF00069	0.497
MOD_GSK3_1	204	211	PF00069	0.544
MOD_GSK3_1	259	266	PF00069	0.594
MOD_GSK3_1	280	287	PF00069	0.545
MOD_GSK3_1	398	405	PF00069	0.401
MOD_GSK3_1	421	428	PF00069	0.447
MOD_GSK3_1	469	476	PF00069	0.426
MOD_GSK3_1	481	488	PF00069	0.402
MOD_GSK3_1	498	505	PF00069	0.268
MOD_GSK3_1	535	542	PF00069	0.619
MOD_GSK3_1	546	553	PF00069	0.459
MOD_GSK3_1	6	13	PF00069	0.596
MOD_GSK3_1	641	648	PF00069	0.448
MOD_GSK3_1	86	93	PF00069	0.535
MOD_N-GLC_1	370	375	PF02516	0.506
MOD_N-GLC_1	440	445	PF02516	0.315
MOD_N-GLC_1	461	466	PF02516	0.439
MOD_N-GLC_2	216	218	PF02516	0.694
MOD_N-GLC_2	222	224	PF02516	0.635
MOD_NEK2_1	113	118	PF00069	0.577
MOD_NEK2_1	122	127	PF00069	0.450
MOD_NEK2_1	151	156	PF00069	0.446
MOD_NEK2_1	158	163	PF00069	0.416
MOD_NEK2_1	239	244	PF00069	0.500
MOD_NEK2_1	289	294	PF00069	0.547
MOD_NEK2_1	425	430	PF00069	0.428
MOD_NEK2_1	440	445	PF00069	0.362
MOD_NEK2_1	461	466	PF00069	0.587
MOD_NEK2_1	487	492	PF00069	0.419
MOD_NEK2_1	511	516	PF00069	0.393
MOD_NEK2_1	54	59	PF00069	0.439
MOD_NEK2_1	595	600	PF00069	0.673
MOD_NEK2_1	641	646	PF00069	0.586
MOD_NEK2_1	75	80	PF00069	0.557
MOD_NEK2_2	172	177	PF00069	0.428
MOD_NEK2_2	234	239	PF00069	0.536
MOD_NEK2_2	94	99	PF00069	0.557
MOD_PIKK_1	204	210	PF00454	0.521
MOD_PIKK_1	270	276	PF00454	0.557
MOD_PIKK_1	595	601	PF00454	0.697
MOD_PIKK_1	64	70	PF00454	0.550
MOD_PKA_2	260	266	PF00069	0.637
MOD_PKA_2	290	296	PF00069	0.586
MOD_PKA_2	533	539	PF00069	0.573
MOD_PKA_2	575	581	PF00069	0.630
MOD_PKA_2	75	81	PF00069	0.490
MOD_Plk_1	158	164	PF00069	0.563
MOD_Plk_1	284	290	PF00069	0.582
MOD_Plk_1	86	92	PF00069	0.588
MOD_Plk_2-3	87	93	PF00069	0.594
MOD_Plk_4	168	174	PF00069	0.552
MOD_Plk_4	234	240	PF00069	0.479
MOD_Plk_4	24	30	PF00069	0.591
MOD_Plk_4	380	386	PF00069	0.460
MOD_Plk_4	44	50	PF00069	0.411
MOD_Plk_4	455	461	PF00069	0.485
MOD_Plk_4	464	470	PF00069	0.516
MOD_Plk_4	487	493	PF00069	0.521
MOD_Plk_4	506	512	PF00069	0.233
MOD_ProDKin_1	114	120	PF00069	0.664
MOD_ProDKin_1	21	27	PF00069	0.633
MOD_ProDKin_1	490	496	PF00069	0.445
MOD_ProDKin_1	502	508	PF00069	0.367
MOD_ProDKin_1	543	549	PF00069	0.617
MOD_SUMO_for_1	111	114	PF00179	0.456
MOD_SUMO_for_1	623	626	PF00179	0.589
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.421
TRG_ENDOCYTIC_2	135	138	PF00928	0.522
TRG_ENDOCYTIC_2	245	248	PF00928	0.511
TRG_ENDOCYTIC_2	447	450	PF00928	0.525
TRG_ER_diArg_1	256	258	PF00400	0.633
TRG_ER_diArg_1	368	370	PF00400	0.555
TRG_ER_diArg_1	571	574	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V3	Leptomonas seymouri	68%	97%
A0A1X0NHC6	Trypanosomatidae	38%	98%
A0A3R7RLK0	Trypanosoma rangeli	43%	98%
A0A3S7WS82	Leishmania donovani	88%	100%
A4HVD7	Leishmania infantum	88%	100%
C9ZTR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	87%
E9AP35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGF3	Leishmania major	87%	100%
V5BXX9	Trypanosoma cruzi	41%	98%