LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4H707_LEIBR
TriTrypDb:
LbrM.12.0950 , LBRM2903_120010700 *
Length:
782

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H707
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H707

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 170 174 PF00656 0.714
CLV_C14_Caspase3-7 231 235 PF00656 0.613
CLV_C14_Caspase3-7 705 709 PF00656 0.912
CLV_NRD_NRD_1 113 115 PF00675 0.850
CLV_NRD_NRD_1 33 35 PF00675 0.594
CLV_NRD_NRD_1 338 340 PF00675 0.646
CLV_NRD_NRD_1 373 375 PF00675 0.859
CLV_NRD_NRD_1 447 449 PF00675 0.614
CLV_NRD_NRD_1 544 546 PF00675 0.606
CLV_NRD_NRD_1 563 565 PF00675 0.567
CLV_NRD_NRD_1 593 595 PF00675 0.769
CLV_PCSK_FUR_1 111 115 PF00082 0.602
CLV_PCSK_KEX2_1 111 113 PF00082 0.826
CLV_PCSK_KEX2_1 33 35 PF00082 0.594
CLV_PCSK_KEX2_1 338 340 PF00082 0.646
CLV_PCSK_KEX2_1 373 375 PF00082 0.870
CLV_PCSK_KEX2_1 447 449 PF00082 0.617
CLV_PCSK_KEX2_1 544 546 PF00082 0.606
CLV_PCSK_KEX2_1 563 565 PF00082 0.615
CLV_PCSK_KEX2_1 593 595 PF00082 0.756
CLV_PCSK_PC7_1 589 595 PF00082 0.769
CLV_PCSK_SKI1_1 117 121 PF00082 0.855
CLV_PCSK_SKI1_1 534 538 PF00082 0.776
CLV_PCSK_SKI1_1 618 622 PF00082 0.592
CLV_PCSK_SKI1_1 65 69 PF00082 0.806
DEG_APCC_DBOX_1 111 119 PF00400 0.604
DEG_Kelch_Keap1_1 510 515 PF01344 0.841
DEG_Nend_UBRbox_3 1 3 PF02207 0.840
DEG_SCF_FBW7_1 483 490 PF00400 0.819
DEG_SIAH_1 211 219 PF03145 0.629
DEG_SPOP_SBC_1 552 556 PF00917 0.581
DOC_CDC14_PxL_1 104 112 PF14671 0.588
DOC_CKS1_1 279 284 PF01111 0.699
DOC_CKS1_1 484 489 PF01111 0.700
DOC_CKS1_1 621 626 PF01111 0.613
DOC_CKS1_1 673 678 PF01111 0.662
DOC_CKS1_1 752 757 PF01111 0.627
DOC_CYCLIN_RxL_1 613 625 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.581
DOC_CYCLIN_yCln2_LP_2 492 498 PF00134 0.618
DOC_CYCLIN_yCln2_LP_2 93 99 PF00134 0.566
DOC_MAPK_DCC_7 111 120 PF00069 0.605
DOC_MAPK_DCC_7 684 694 PF00069 0.638
DOC_MAPK_gen_1 111 120 PF00069 0.827
DOC_MAPK_MEF2A_6 111 120 PF00069 0.605
DOC_PP1_RVXF_1 193 200 PF00149 0.619
DOC_PP2B_LxvP_1 205 208 PF13499 0.867
DOC_PP2B_LxvP_1 492 495 PF13499 0.612
DOC_PP2B_LxvP_1 536 539 PF13499 0.692
DOC_PP2B_LxvP_1 93 96 PF13499 0.568
DOC_PP4_FxxP_1 242 245 PF00568 0.610
DOC_PP4_FxxP_1 272 275 PF00568 0.853
DOC_PP4_FxxP_1 549 552 PF00568 0.611
DOC_USP7_MATH_1 119 123 PF00917 0.851
DOC_USP7_MATH_1 291 295 PF00917 0.628
DOC_USP7_MATH_1 363 367 PF00917 0.608
DOC_USP7_MATH_1 500 504 PF00917 0.698
DOC_USP7_MATH_1 524 528 PF00917 0.785
DOC_USP7_MATH_1 552 556 PF00917 0.606
DOC_USP7_MATH_1 744 748 PF00917 0.848
DOC_USP7_MATH_1 778 782 PF00917 0.599
DOC_USP7_MATH_1 80 84 PF00917 0.833
DOC_WW_Pin1_4 147 152 PF00397 0.868
DOC_WW_Pin1_4 208 213 PF00397 0.623
DOC_WW_Pin1_4 253 258 PF00397 0.855
DOC_WW_Pin1_4 263 268 PF00397 0.683
DOC_WW_Pin1_4 278 283 PF00397 0.716
DOC_WW_Pin1_4 306 311 PF00397 0.640
DOC_WW_Pin1_4 39 44 PF00397 0.670
DOC_WW_Pin1_4 405 410 PF00397 0.880
DOC_WW_Pin1_4 433 438 PF00397 0.875
DOC_WW_Pin1_4 483 488 PF00397 0.701
DOC_WW_Pin1_4 620 625 PF00397 0.612
DOC_WW_Pin1_4 672 677 PF00397 0.643
DOC_WW_Pin1_4 695 700 PF00397 0.779
DOC_WW_Pin1_4 711 716 PF00397 0.768
DOC_WW_Pin1_4 751 756 PF00397 0.628
LIG_14-3-3_CanoR_1 192 198 PF00244 0.826
LIG_14-3-3_CanoR_1 238 245 PF00244 0.850
LIG_14-3-3_CanoR_1 314 319 PF00244 0.606
LIG_14-3-3_CanoR_1 33 39 PF00244 0.652
LIG_14-3-3_CanoR_1 338 346 PF00244 0.887
LIG_14-3-3_CanoR_1 373 379 PF00244 0.704
LIG_14-3-3_CanoR_1 417 422 PF00244 0.767
LIG_14-3-3_CanoR_1 447 456 PF00244 0.739
LIG_14-3-3_CanoR_1 534 539 PF00244 0.774
LIG_14-3-3_CanoR_1 65 70 PF00244 0.806
LIG_14-3-3_CanoR_1 756 762 PF00244 0.758
LIG_14-3-3_CterR_2 779 782 PF00244 0.594
LIG_BRCT_BRCA1_1 239 243 PF00533 0.606
LIG_BRCT_BRCA1_1 58 62 PF00533 0.587
LIG_BRCT_BRCA1_1 93 97 PF00533 0.571
LIG_Clathr_ClatBox_1 749 753 PF01394 0.635
LIG_DLG_GKlike_1 374 382 PF00625 0.615
LIG_EVH1_2 151 155 PF00568 0.612
LIG_EVH1_2 494 498 PF00568 0.620
LIG_EVH1_2 665 669 PF00568 0.630
LIG_FHA_1 151 157 PF00498 0.632
LIG_FHA_1 211 217 PF00498 0.754
LIG_FHA_1 56 62 PF00498 0.640
LIG_FHA_1 621 627 PF00498 0.642
LIG_FHA_1 684 690 PF00498 0.628
LIG_FHA_1 7 13 PF00498 0.592
LIG_FHA_2 499 505 PF00498 0.633
LIG_FHA_2 696 702 PF00498 0.795
LIG_LIR_Apic_2 240 245 PF02991 0.608
LIG_LIR_Apic_2 435 441 PF02991 0.861
LIG_LIR_Apic_2 546 552 PF02991 0.845
LIG_LIR_Gen_1 94 104 PF02991 0.565
LIG_LIR_Nem_3 153 158 PF02991 0.613
LIG_LIR_Nem_3 419 424 PF02991 0.615
LIG_LIR_Nem_3 63 67 PF02991 0.587
LIG_LIR_Nem_3 668 672 PF02991 0.628
LIG_LIR_Nem_3 94 100 PF02991 0.562
LIG_MLH1_MIPbox_1 239 243 PF16413 0.606
LIG_Pex14_2 97 101 PF04695 0.562
LIG_PTB_Apo_2 7 14 PF02174 0.591
LIG_SH2_CRK 438 442 PF00017 0.876
LIG_SH2_NCK_1 438 442 PF00017 0.876
LIG_SH2_STAP1 295 299 PF00017 0.801
LIG_SH2_STAP1 496 500 PF00017 0.700
LIG_SH2_STAP1 568 572 PF00017 0.539
LIG_SH2_STAP1 770 774 PF00017 0.805
LIG_SH2_STAT5 378 381 PF00017 0.861
LIG_SH2_STAT5 438 441 PF00017 0.834
LIG_SH3_3 264 270 PF00018 0.779
LIG_SH3_3 276 282 PF00018 0.622
LIG_SH3_3 488 494 PF00018 0.818
LIG_SH3_3 621 627 PF00018 0.682
LIG_SH3_3 660 666 PF00018 0.668
LIG_SH3_3 689 695 PF00018 0.651
LIG_SH3_3 709 715 PF00018 0.829
LIG_SUMO_SIM_anti_2 635 642 PF11976 0.625
LIG_SUMO_SIM_par_1 635 642 PF11976 0.821
LIG_SxIP_EBH_1 522 534 PF03271 0.601
LIG_WRC_WIRS_1 168 173 PF05994 0.624
MOD_CDC14_SPxK_1 256 259 PF00782 0.815
MOD_CDC14_SPxK_1 42 45 PF00782 0.577
MOD_CDK_SPK_2 751 756 PF00069 0.628
MOD_CDK_SPxK_1 253 259 PF00069 0.815
MOD_CDK_SPxK_1 39 45 PF00069 0.584
MOD_CDK_SPxxK_3 278 285 PF00069 0.596
MOD_CDK_SPxxK_3 711 718 PF00069 0.780
MOD_CDK_SPxxK_3 751 758 PF00069 0.627
MOD_CK1_1 137 143 PF00069 0.794
MOD_CK1_1 176 182 PF00069 0.664
MOD_CK1_1 219 225 PF00069 0.634
MOD_CK1_1 227 233 PF00069 0.591
MOD_CK1_1 253 259 PF00069 0.728
MOD_CK1_1 289 295 PF00069 0.705
MOD_CK1_1 300 306 PF00069 0.791
MOD_CK1_1 377 383 PF00069 0.860
MOD_CK1_1 416 422 PF00069 0.793
MOD_CK1_1 427 433 PF00069 0.612
MOD_CK1_1 450 456 PF00069 0.746
MOD_CK1_1 485 491 PF00069 0.717
MOD_CK1_1 553 559 PF00069 0.562
MOD_CK1_1 562 568 PF00069 0.477
MOD_CK1_1 646 652 PF00069 0.876
MOD_CK1_1 697 703 PF00069 0.895
MOD_CK1_1 711 717 PF00069 0.654
MOD_CK1_1 757 763 PF00069 0.867
MOD_CK1_1 766 772 PF00069 0.745
MOD_CK2_1 386 392 PF00069 0.626
MOD_CK2_1 498 504 PF00069 0.631
MOD_CK2_1 622 628 PF00069 0.746
MOD_CK2_1 695 701 PF00069 0.797
MOD_CK2_1 711 717 PF00069 0.740
MOD_CK2_1 737 743 PF00069 0.899
MOD_GlcNHglycan 121 124 PF01048 0.856
MOD_GlcNHglycan 136 139 PF01048 0.650
MOD_GlcNHglycan 17 20 PF01048 0.726
MOD_GlcNHglycan 218 221 PF01048 0.720
MOD_GlcNHglycan 224 229 PF01048 0.615
MOD_GlcNHglycan 342 345 PF01048 0.869
MOD_GlcNHglycan 365 368 PF01048 0.686
MOD_GlcNHglycan 369 372 PF01048 0.678
MOD_GlcNHglycan 379 382 PF01048 0.762
MOD_GlcNHglycan 421 424 PF01048 0.709
MOD_GlcNHglycan 450 453 PF01048 0.659
MOD_GlcNHglycan 498 501 PF01048 0.724
MOD_GlcNHglycan 526 529 PF01048 0.752
MOD_GlcNHglycan 58 61 PF01048 0.686
MOD_GlcNHglycan 632 635 PF01048 0.643
MOD_GlcNHglycan 645 648 PF01048 0.799
MOD_GlcNHglycan 722 726 PF01048 0.907
MOD_GlcNHglycan 746 749 PF01048 0.680
MOD_GlcNHglycan 82 85 PF01048 0.657
MOD_GSK3_1 102 109 PF00069 0.681
MOD_GSK3_1 146 153 PF00069 0.623
MOD_GSK3_1 173 180 PF00069 0.658
MOD_GSK3_1 243 250 PF00069 0.799
MOD_GSK3_1 289 296 PF00069 0.655
MOD_GSK3_1 297 304 PF00069 0.627
MOD_GSK3_1 314 321 PF00069 0.645
MOD_GSK3_1 353 360 PF00069 0.773
MOD_GSK3_1 363 370 PF00069 0.682
MOD_GSK3_1 373 380 PF00069 0.781
MOD_GSK3_1 384 391 PF00069 0.692
MOD_GSK3_1 4 11 PF00069 0.711
MOD_GSK3_1 412 419 PF00069 0.831
MOD_GSK3_1 424 431 PF00069 0.676
MOD_GSK3_1 432 439 PF00069 0.801
MOD_GSK3_1 443 450 PF00069 0.701
MOD_GSK3_1 483 490 PF00069 0.773
MOD_GSK3_1 496 503 PF00069 0.663
MOD_GSK3_1 51 58 PF00069 0.691
MOD_GSK3_1 524 531 PF00069 0.717
MOD_GSK3_1 534 541 PF00069 0.745
MOD_GSK3_1 642 649 PF00069 0.872
MOD_GSK3_1 65 72 PF00069 0.732
MOD_GSK3_1 759 766 PF00069 0.863
MOD_GSK3_1 91 98 PF00069 0.753
MOD_N-GLC_1 134 139 PF02516 0.842
MOD_N-GLC_1 173 178 PF02516 0.654
MOD_N-GLC_1 286 291 PF02516 0.802
MOD_N-GLC_1 374 379 PF02516 0.616
MOD_N-GLC_1 4 9 PF02516 0.579
MOD_N-GLC_1 413 418 PF02516 0.825
MOD_NEK2_1 118 123 PF00069 0.606
MOD_NEK2_1 353 358 PF00069 0.733
MOD_NEK2_1 384 389 PF00069 0.849
MOD_NEK2_1 4 9 PF00069 0.632
MOD_NEK2_1 413 418 PF00069 0.829
MOD_NEK2_1 443 448 PF00069 0.692
MOD_NEK2_1 456 461 PF00069 0.557
MOD_NEK2_1 498 503 PF00069 0.630
MOD_OFUCOSY 290 297 PF10250 0.595
MOD_PIKK_1 129 135 PF00454 0.639
MOD_PIKK_1 173 179 PF00454 0.657
MOD_PIKK_1 301 307 PF00454 0.639
MOD_PIKK_1 338 344 PF00454 0.808
MOD_PIKK_1 485 491 PF00454 0.816
MOD_PIKK_1 730 736 PF00454 0.807
MOD_PKA_1 338 344 PF00069 0.644
MOD_PKA_1 373 379 PF00069 0.864
MOD_PKA_1 447 453 PF00069 0.640
MOD_PKA_2 15 21 PF00069 0.719
MOD_PKA_2 237 243 PF00069 0.613
MOD_PKA_2 313 319 PF00069 0.779
MOD_PKA_2 338 344 PF00069 0.756
MOD_PKA_2 373 379 PF00069 0.864
MOD_PKA_2 416 422 PF00069 0.820
MOD_PKA_2 447 453 PF00069 0.624
MOD_PKA_2 51 57 PF00069 0.601
MOD_PKA_2 562 568 PF00069 0.618
MOD_PKA_2 683 689 PF00069 0.872
MOD_PKA_2 737 743 PF00069 0.899
MOD_PKA_2 744 750 PF00069 0.782
MOD_PKA_2 757 763 PF00069 0.538
MOD_Plk_1 374 380 PF00069 0.615
MOD_Plk_1 4 10 PF00069 0.582
MOD_Plk_1 721 727 PF00069 0.903
MOD_Plk_2-3 167 173 PF00069 0.807
MOD_Plk_4 102 108 PF00069 0.577
MOD_Plk_4 124 130 PF00069 0.605
MOD_Plk_4 151 157 PF00069 0.609
MOD_Plk_4 318 324 PF00069 0.618
MOD_Plk_4 374 380 PF00069 0.862
MOD_Plk_4 458 464 PF00069 0.678
MOD_Plk_4 675 681 PF00069 0.622
MOD_Plk_4 8 14 PF00069 0.594
MOD_ProDKin_1 147 153 PF00069 0.867
MOD_ProDKin_1 208 214 PF00069 0.623
MOD_ProDKin_1 253 259 PF00069 0.858
MOD_ProDKin_1 263 269 PF00069 0.675
MOD_ProDKin_1 278 284 PF00069 0.716
MOD_ProDKin_1 306 312 PF00069 0.634
MOD_ProDKin_1 39 45 PF00069 0.670
MOD_ProDKin_1 405 411 PF00069 0.880
MOD_ProDKin_1 433 439 PF00069 0.876
MOD_ProDKin_1 483 489 PF00069 0.701
MOD_ProDKin_1 620 626 PF00069 0.612
MOD_ProDKin_1 672 678 PF00069 0.643
MOD_ProDKin_1 695 701 PF00069 0.780
MOD_ProDKin_1 711 717 PF00069 0.765
MOD_ProDKin_1 751 757 PF00069 0.626
MOD_SUMO_rev_2 640 646 PF00179 0.734
TRG_DiLeu_BaLyEn_6 531 536 PF01217 0.774
TRG_DiLeu_BaLyEn_6 668 673 PF01217 0.792
TRG_ENDOCYTIC_2 64 67 PF00928 0.586
TRG_ER_diArg_1 110 113 PF00400 0.824
TRG_ER_diArg_1 592 594 PF00400 0.757
TRG_ER_diArg_1 755 758 PF00400 0.724

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I9B3 Leishmania donovani 59% 100%
E9AGD4 Leishmania infantum 59% 100%
E9ANX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
Q4QGP6 Leishmania major 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS