Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H706_LEIBR

TriTrypDb:

LbrM.12.0940 , LBRM2903_200076300

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H706

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H706

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.764
CLV_NRD_NRD_1	152	154	PF00675	0.597
CLV_NRD_NRD_1	156	158	PF00675	0.597
CLV_NRD_NRD_1	161	163	PF00675	0.592
CLV_NRD_NRD_1	340	342	PF00675	0.482
CLV_NRD_NRD_1	392	394	PF00675	0.492
CLV_NRD_NRD_1	415	417	PF00675	0.729
CLV_NRD_NRD_1	9	11	PF00675	0.495
CLV_PCSK_KEX2_1	151	153	PF00082	0.608
CLV_PCSK_KEX2_1	156	158	PF00082	0.596
CLV_PCSK_KEX2_1	161	163	PF00082	0.587
CLV_PCSK_KEX2_1	265	267	PF00082	0.511
CLV_PCSK_KEX2_1	340	342	PF00082	0.482
CLV_PCSK_KEX2_1	392	394	PF00082	0.564
CLV_PCSK_KEX2_1	415	417	PF00082	0.706
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.526
CLV_PCSK_PC7_1	152	158	PF00082	0.621
CLV_PCSK_SKI1_1	128	132	PF00082	0.691
CLV_PCSK_SKI1_1	21	25	PF00082	0.568
CLV_PCSK_SKI1_1	393	397	PF00082	0.536
DEG_APCC_DBOX_1	229	237	PF00400	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.704
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.496
DOC_MAPK_DCC_7	96	106	PF00069	0.521
DOC_MAPK_gen_1	392	399	PF00069	0.532
DOC_MAPK_JIP1_4	393	399	PF00069	0.506
DOC_MAPK_MEF2A_6	21	30	PF00069	0.562
DOC_MAPK_MEF2A_6	392	399	PF00069	0.544
DOC_PP2B_LxvP_1	182	185	PF13499	0.466
DOC_PP2B_LxvP_1	395	398	PF13499	0.504
DOC_USP7_MATH_1	139	143	PF00917	0.651
DOC_USP7_MATH_1	145	149	PF00917	0.614
DOC_USP7_MATH_1	187	191	PF00917	0.585
DOC_USP7_MATH_1	253	257	PF00917	0.468
DOC_USP7_MATH_1	259	263	PF00917	0.390
DOC_USP7_MATH_2	103	109	PF00917	0.524
DOC_WW_Pin1_4	107	112	PF00397	0.718
DOC_WW_Pin1_4	276	281	PF00397	0.362
DOC_WW_Pin1_4	397	402	PF00397	0.549
DOC_WW_Pin1_4	405	410	PF00397	0.548
LIG_14-3-3_CanoR_1	161	169	PF00244	0.617
LIG_14-3-3_CanoR_1	186	192	PF00244	0.548
LIG_14-3-3_CanoR_1	386	395	PF00244	0.377
LIG_BIR_III_2	343	347	PF00653	0.311
LIG_BRCT_BRCA1_1	145	149	PF00533	0.529
LIG_BRCT_BRCA1_1	207	211	PF00533	0.486
LIG_DCNL_PONY_1	1	4	PF03556	0.702
LIG_FHA_1	296	302	PF00498	0.403
LIG_FHA_1	361	367	PF00498	0.496
LIG_FHA_1	79	85	PF00498	0.641
LIG_FHA_2	115	121	PF00498	0.688
LIG_FHA_2	131	137	PF00498	0.756
LIG_FHA_2	306	312	PF00498	0.355
LIG_LIR_Gen_1	18	27	PF02991	0.402
LIG_LIR_Gen_1	195	203	PF02991	0.420
LIG_LIR_Gen_1	208	219	PF02991	0.362
LIG_LIR_Gen_1	40	49	PF02991	0.669
LIG_LIR_Gen_1	63	71	PF02991	0.509
LIG_LIR_LC3C_4	400	404	PF02991	0.435
LIG_LIR_Nem_3	18	22	PF02991	0.423
LIG_LIR_Nem_3	208	214	PF02991	0.432
LIG_LIR_Nem_3	215	221	PF02991	0.381
LIG_LIR_Nem_3	40	45	PF02991	0.667
LIG_NRBOX	25	31	PF00104	0.461
LIG_Pex14_1	378	382	PF04695	0.371
LIG_SH2_CRK	283	287	PF00017	0.331
LIG_SH2_SRC	370	373	PF00017	0.373
LIG_SH2_STAP1	19	23	PF00017	0.411
LIG_SH2_STAP1	240	244	PF00017	0.563
LIG_SH2_STAP1	283	287	PF00017	0.364
LIG_SH2_STAT3	372	375	PF00017	0.360
LIG_SH2_STAT3	382	385	PF00017	0.366
LIG_SH2_STAT5	191	194	PF00017	0.335
LIG_SH2_STAT5	338	341	PF00017	0.356
LIG_SH2_STAT5	370	373	PF00017	0.382
LIG_SH2_STAT5	382	385	PF00017	0.405
LIG_SH3_1	11	17	PF00018	0.650
LIG_SH3_3	11	17	PF00018	0.650
LIG_SH3_3	233	239	PF00018	0.482
LIG_SH3_3	395	401	PF00018	0.518
LIG_SH3_3	97	103	PF00018	0.613
LIG_SUMO_SIM_par_1	102	108	PF11976	0.523
LIG_SUMO_SIM_par_1	28	37	PF11976	0.534
LIG_SUMO_SIM_par_1	400	408	PF11976	0.405
LIG_TRAF2_1	71	74	PF00917	0.518
LIG_WRC_WIRS_1	61	66	PF05994	0.539
MOD_CDK_SPK_2	107	112	PF00069	0.526
MOD_CK1_1	110	116	PF00069	0.656
MOD_CK1_1	126	132	PF00069	0.712
MOD_CK1_1	143	149	PF00069	0.743
MOD_CK1_1	163	169	PF00069	0.637
MOD_CK1_1	205	211	PF00069	0.503
MOD_CK1_1	34	40	PF00069	0.560
MOD_CK1_1	53	59	PF00069	0.588
MOD_CK2_1	131	137	PF00069	0.690
MOD_CK2_1	171	177	PF00069	0.576
MOD_CK2_1	358	364	PF00069	0.453
MOD_CK2_1	385	391	PF00069	0.328
MOD_Cter_Amidation	263	266	PF01082	0.478
MOD_GlcNHglycan	165	168	PF01048	0.666
MOD_GlcNHglycan	182	185	PF01048	0.669
MOD_GlcNHglycan	54	58	PF01048	0.638
MOD_GlcNHglycan	96	99	PF01048	0.599
MOD_GSK3_1	110	117	PF00069	0.696
MOD_GSK3_1	126	133	PF00069	0.760
MOD_GSK3_1	135	142	PF00069	0.688
MOD_GSK3_1	143	150	PF00069	0.712
MOD_GSK3_1	163	170	PF00069	0.591
MOD_GSK3_1	33	40	PF00069	0.527
MOD_GSK3_1	43	50	PF00069	0.611
MOD_LATS_1	114	120	PF00433	0.718
MOD_LATS_1	159	165	PF00433	0.673
MOD_N-GLC_1	203	208	PF02516	0.305
MOD_NEK2_1	123	128	PF00069	0.719
MOD_NEK2_1	130	135	PF00069	0.714
MOD_NEK2_1	202	207	PF00069	0.411
MOD_NEK2_1	252	257	PF00069	0.386
MOD_NEK2_1	28	33	PF00069	0.540
MOD_NEK2_1	305	310	PF00069	0.338
MOD_NEK2_2	333	338	PF00069	0.406
MOD_PKA_1	161	167	PF00069	0.541
MOD_PKA_2	160	166	PF00069	0.714
MOD_PKA_2	385	391	PF00069	0.454
MOD_Plk_1	17	23	PF00069	0.594
MOD_Plk_1	34	40	PF00069	0.623
MOD_Plk_2-3	358	364	PF00069	0.480
MOD_Plk_4	187	193	PF00069	0.481
MOD_Plk_4	28	34	PF00069	0.524
MOD_Plk_4	297	303	PF00069	0.395
MOD_Plk_4	333	339	PF00069	0.367
MOD_Plk_4	44	50	PF00069	0.572
MOD_ProDKin_1	107	113	PF00069	0.715
MOD_ProDKin_1	276	282	PF00069	0.361
MOD_ProDKin_1	397	403	PF00069	0.550
MOD_ProDKin_1	405	411	PF00069	0.563
TRG_DiLeu_BaEn_1	362	367	PF01217	0.301
TRG_DiLeu_BaEn_2	17	23	PF01217	0.569
TRG_ENDOCYTIC_2	19	22	PF00928	0.418
TRG_ENDOCYTIC_2	221	224	PF00928	0.400
TRG_ENDOCYTIC_2	283	286	PF00928	0.317
TRG_ER_diArg_1	151	153	PF00400	0.603
TRG_ER_diArg_1	275	278	PF00400	0.512
TRG_ER_diArg_1	339	341	PF00400	0.456
TRG_ER_diArg_1	392	394	PF00400	0.408
TRG_NLS_MonoExtC_3	9	14	PF00514	0.639
TRG_NLS_MonoExtN_4	8	14	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W8	Leptomonas seymouri	55%	95%
A0A1X0NMC5	Trypanosomatidae	39%	88%
A0A3R7L7Q9	Trypanosoma rangeli	34%	96%
A0A3S7WS83	Leishmania donovani	75%	97%
E9AGI8	Leishmania infantum	75%	97%
E9AP26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%
Q4QGG3	Leishmania major	75%	100%
V5DFZ8	Trypanosoma cruzi	36%	96%