RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H704_LEIBR

TriTrypDb:

LbrM.12.0920 , LBRM2903_200076500

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H704

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H704

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.470
CLV_NRD_NRD_1	174	176	PF00675	0.499
CLV_NRD_NRD_1	302	304	PF00675	0.559
CLV_NRD_NRD_1	348	350	PF00675	0.617
CLV_NRD_NRD_1	36	38	PF00675	0.553
CLV_NRD_NRD_1	399	401	PF00675	0.525
CLV_NRD_NRD_1	492	494	PF00675	0.454
CLV_NRD_NRD_1	524	526	PF00675	0.491
CLV_NRD_NRD_1	719	721	PF00675	0.441
CLV_PCSK_FUR_1	522	526	PF00082	0.490
CLV_PCSK_KEX2_1	174	176	PF00082	0.517
CLV_PCSK_KEX2_1	302	304	PF00082	0.559
CLV_PCSK_KEX2_1	350	352	PF00082	0.621
CLV_PCSK_KEX2_1	36	38	PF00082	0.553
CLV_PCSK_KEX2_1	399	401	PF00082	0.525
CLV_PCSK_KEX2_1	418	420	PF00082	0.383
CLV_PCSK_KEX2_1	492	494	PF00082	0.436
CLV_PCSK_KEX2_1	524	526	PF00082	0.491
CLV_PCSK_KEX2_1	721	723	PF00082	0.464
CLV_PCSK_KEX2_1	759	761	PF00082	0.654
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.621
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.480
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.443
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.654
CLV_PCSK_SKI1_1	110	114	PF00082	0.553
CLV_PCSK_SKI1_1	174	178	PF00082	0.499
CLV_PCSK_SKI1_1	217	221	PF00082	0.518
CLV_PCSK_SKI1_1	254	258	PF00082	0.523
CLV_PCSK_SKI1_1	302	306	PF00082	0.399
CLV_PCSK_SKI1_1	399	403	PF00082	0.428
CLV_PCSK_SKI1_1	446	450	PF00082	0.524
CLV_PCSK_SKI1_1	463	467	PF00082	0.396
CLV_PCSK_SKI1_1	512	516	PF00082	0.443
CLV_PCSK_SKI1_1	534	538	PF00082	0.598
CLV_PCSK_SKI1_1	623	627	PF00082	0.399
CLV_PCSK_SKI1_1	721	725	PF00082	0.441
DEG_APCC_DBOX_1	348	356	PF00400	0.624
DEG_APCC_DBOX_1	462	470	PF00400	0.398
DEG_APCC_DBOX_1	586	594	PF00400	0.405
DEG_Nend_UBRbox_3	1	3	PF02207	0.475
DOC_MAPK_gen_1	337	346	PF00069	0.451
DOC_MAPK_gen_1	758	766	PF00069	0.502
DOC_MAPK_MEF2A_6	463	470	PF00069	0.512
DOC_MAPK_MEF2A_6	758	766	PF00069	0.502
DOC_MAPK_NFAT4_5	463	471	PF00069	0.396
DOC_PP1_RVXF_1	301	308	PF00149	0.463
DOC_USP7_MATH_1	181	185	PF00917	0.558
DOC_USP7_MATH_1	289	293	PF00917	0.562
DOC_USP7_MATH_1	327	331	PF00917	0.427
DOC_USP7_MATH_1	547	551	PF00917	0.443
DOC_USP7_MATH_1	645	649	PF00917	0.499
DOC_USP7_MATH_1	681	685	PF00917	0.440
DOC_USP7_MATH_1	737	741	PF00917	0.455
DOC_USP7_MATH_1	87	91	PF00917	0.497
DOC_USP7_UBL2_3	754	758	PF12436	0.543
DOC_WW_Pin1_4	721	726	PF00397	0.622
LIG_14-3-3_CanoR_1	217	224	PF00244	0.432
LIG_14-3-3_CanoR_1	512	520	PF00244	0.449
LIG_14-3-3_CanoR_1	629	639	PF00244	0.425
LIG_14-3-3_CanoR_1	682	689	PF00244	0.548
LIG_Actin_WH2_2	231	246	PF00022	0.467
LIG_APCC_ABBA_1	102	107	PF00400	0.416
LIG_BIR_III_4	438	442	PF00653	0.399
LIG_EH1_1	95	103	PF00400	0.421
LIG_eIF4E_1	672	678	PF01652	0.385
LIG_FHA_1	183	189	PF00498	0.579
LIG_FHA_1	294	300	PF00498	0.551
LIG_FHA_1	385	391	PF00498	0.403
LIG_FHA_1	497	503	PF00498	0.579
LIG_FHA_1	513	519	PF00498	0.440
LIG_FHA_1	544	550	PF00498	0.439
LIG_FHA_1	658	664	PF00498	0.371
LIG_FHA_1	9	15	PF00498	0.690
LIG_FHA_1	97	103	PF00498	0.417
LIG_FHA_2	185	191	PF00498	0.578
LIG_FHA_2	218	224	PF00498	0.488
LIG_FHA_2	232	238	PF00498	0.396
LIG_FHA_2	269	275	PF00498	0.396
LIG_FHA_2	619	625	PF00498	0.538
LIG_FHA_2	739	745	PF00498	0.484
LIG_LIR_Apic_2	657	662	PF02991	0.465
LIG_LIR_Gen_1	121	129	PF02991	0.400
LIG_LIR_Gen_1	271	280	PF02991	0.403
LIG_LIR_Gen_1	444	454	PF02991	0.407
LIG_LIR_Gen_1	544	553	PF02991	0.582
LIG_LIR_Nem_3	107	112	PF02991	0.526
LIG_LIR_Nem_3	121	126	PF02991	0.408
LIG_LIR_Nem_3	271	275	PF02991	0.399
LIG_LIR_Nem_3	544	548	PF02991	0.578
LIG_LIR_Nem_3	624	628	PF02991	0.638
LIG_MYND_1	163	167	PF01753	0.470
LIG_NRBOX	465	471	PF00104	0.395
LIG_PCNA_yPIPBox_3	89	102	PF02747	0.445
LIG_Rb_LxCxE_1	724	744	PF01857	0.503
LIG_SH2_CRK	659	663	PF00017	0.385
LIG_SH2_STAT5	164	167	PF00017	0.474
LIG_SH2_STAT5	206	209	PF00017	0.568
LIG_SH2_STAT5	659	662	PF00017	0.463
LIG_SH2_STAT5	672	675	PF00017	0.527
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.518
LIG_SUMO_SIM_anti_2	761	766	PF11976	0.516
LIG_TRAF2_1	245	248	PF00917	0.551
LIG_TRAF2_1	340	343	PF00917	0.507
LIG_TRAF2_1	600	603	PF00917	0.508
LIG_TRAF2_1	71	74	PF00917	0.416
MOD_CDK_SPK_2	721	726	PF00069	0.444
MOD_CK1_1	184	190	PF00069	0.577
MOD_CK1_1	427	433	PF00069	0.460
MOD_CK1_1	434	440	PF00069	0.464
MOD_CK1_1	630	636	PF00069	0.361
MOD_CK1_1	684	690	PF00069	0.564
MOD_CK1_1	691	697	PF00069	0.615
MOD_CK2_1	184	190	PF00069	0.577
MOD_CK2_1	217	223	PF00069	0.488
MOD_CK2_1	231	237	PF00069	0.398
MOD_CK2_1	268	274	PF00069	0.396
MOD_CK2_1	288	294	PF00069	0.523
MOD_CK2_1	322	328	PF00069	0.555
MOD_CK2_1	641	647	PF00069	0.486
MOD_CK2_1	697	703	PF00069	0.673
MOD_CK2_1	738	744	PF00069	0.493
MOD_CK2_1	87	93	PF00069	0.425
MOD_GlcNHglycan	178	182	PF01048	0.483
MOD_GlcNHglycan	24	27	PF01048	0.618
MOD_GlcNHglycan	254	257	PF01048	0.418
MOD_GlcNHglycan	371	374	PF01048	0.431
MOD_GlcNHglycan	433	436	PF01048	0.544
MOD_GlcNHglycan	539	542	PF01048	0.429
MOD_GlcNHglycan	61	64	PF01048	0.420
MOD_GlcNHglycan	643	646	PF01048	0.459
MOD_GlcNHglycan	647	650	PF01048	0.420
MOD_GlcNHglycan	694	697	PF01048	0.627
MOD_GlcNHglycan	703	707	PF01048	0.544
MOD_GlcNHglycan	735	738	PF01048	0.462
MOD_GSK3_1	177	184	PF00069	0.546
MOD_GSK3_1	284	291	PF00069	0.525
MOD_GSK3_1	365	372	PF00069	0.495
MOD_GSK3_1	427	434	PF00069	0.422
MOD_GSK3_1	497	504	PF00069	0.439
MOD_GSK3_1	543	550	PF00069	0.436
MOD_GSK3_1	623	630	PF00069	0.407
MOD_GSK3_1	641	648	PF00069	0.460
MOD_GSK3_1	681	688	PF00069	0.460
MOD_GSK3_1	698	705	PF00069	0.612
MOD_GSK3_1	733	740	PF00069	0.487
MOD_GSK3_1	96	103	PF00069	0.420
MOD_LATS_1	494	500	PF00433	0.582
MOD_N-GLC_1	496	501	PF02516	0.554
MOD_NEK2_1	176	181	PF00069	0.592
MOD_NEK2_1	231	236	PF00069	0.429
MOD_NEK2_1	355	360	PF00069	0.624
MOD_NEK2_1	537	542	PF00069	0.437
MOD_NEK2_1	618	623	PF00069	0.537
MOD_NEK2_1	689	694	PF00069	0.515
MOD_NEK2_2	100	105	PF00069	0.418
MOD_PIKK_1	118	124	PF00454	0.544
MOD_PIKK_1	355	361	PF00454	0.622
MOD_PIKK_1	497	503	PF00454	0.572
MOD_PIKK_1	5	11	PF00454	0.569
MOD_PIKK_1	618	624	PF00454	0.538
MOD_PIKK_1	657	663	PF00454	0.243
MOD_PK_1	10	16	PF00069	0.561
MOD_PK_1	758	764	PF00069	0.364
MOD_PKA_1	399	405	PF00069	0.430
MOD_PKA_1	758	764	PF00069	0.506
MOD_PKA_2	22	28	PF00069	0.564
MOD_PKA_2	399	405	PF00069	0.520
MOD_PKA_2	497	503	PF00069	0.437
MOD_PKA_2	628	634	PF00069	0.368
MOD_PKA_2	681	687	PF00069	0.405
MOD_Plk_1	322	328	PF00069	0.555
MOD_Plk_1	53	59	PF00069	0.441
MOD_Plk_1	543	549	PF00069	0.436
MOD_Plk_1	623	629	PF00069	0.394
MOD_Plk_1	684	690	PF00069	0.556
MOD_Plk_1	702	708	PF00069	0.450
MOD_Plk_2-3	424	430	PF00069	0.411
MOD_Plk_4	184	190	PF00069	0.522
MOD_Plk_4	427	433	PF00069	0.411
MOD_Plk_4	738	744	PF00069	0.554
MOD_ProDKin_1	721	727	PF00069	0.615
MOD_SUMO_for_1	600	603	PF00179	0.412
MOD_SUMO_rev_2	227	234	PF00179	0.423
MOD_SUMO_rev_2	343	352	PF00179	0.583
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.494
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.465
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.553
TRG_ER_diArg_1	174	176	PF00400	0.562
TRG_ER_diArg_1	241	244	PF00400	0.484
TRG_ER_diArg_1	278	281	PF00400	0.411
TRG_ER_diArg_1	302	304	PF00400	0.559
TRG_ER_diArg_1	349	352	PF00400	0.623
TRG_ER_diArg_1	35	37	PF00400	0.551
TRG_ER_diArg_1	399	401	PF00400	0.521
TRG_ER_diArg_1	522	525	PF00400	0.555
TRG_ER_diArg_1	586	589	PF00400	0.433
TRG_ER_diArg_1	719	722	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB7	Leishmania donovani	64%	89%
E9AGI6	Leishmania infantum	64%	89%
E9AP24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	89%
Q4QGG5	Leishmania major	66%	100%