Golgi apparatus membrane protein TVP38

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H703_LEIBR

TriTrypDb:

LbrM.12.0910 , LBRM2903_200076600

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H703

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H703

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.488
CLV_C14_Caspase3-7	263	267	PF00656	0.681
CLV_MEL_PAP_1	215	221	PF00089	0.458
CLV_NRD_NRD_1	263	265	PF00675	0.466
CLV_PCSK_KEX2_1	232	234	PF00082	0.683
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.683
CLV_PCSK_SKI1_1	148	152	PF00082	0.245
CLV_PCSK_SKI1_1	153	157	PF00082	0.272
CLV_PCSK_SKI1_1	16	20	PF00082	0.545
CLV_PCSK_SKI1_1	233	237	PF00082	0.533
DEG_SCF_FBW7_1	234	240	PF00400	0.446
DEG_SPOP_SBC_1	279	283	PF00917	0.534
DOC_CKS1_1	234	239	PF01111	0.420
DOC_MAPK_DCC_7	284	293	PF00069	0.537
DOC_MAPK_MEF2A_6	16	25	PF00069	0.270
DOC_MAPK_MEF2A_6	166	175	PF00069	0.483
DOC_PP2B_LxvP_1	114	117	PF13499	0.262
DOC_PP2B_LxvP_1	194	197	PF13499	0.352
DOC_PP4_FxxP_1	94	97	PF00568	0.356
DOC_USP7_UBL2_3	227	231	PF12436	0.344
DOC_WW_Pin1_4	10	15	PF00397	0.286
DOC_WW_Pin1_4	176	181	PF00397	0.312
DOC_WW_Pin1_4	188	193	PF00397	0.247
DOC_WW_Pin1_4	233	238	PF00397	0.308
LIG_14-3-3_CanoR_1	159	169	PF00244	0.525
LIG_14-3-3_CanoR_1	284	288	PF00244	0.534
LIG_Actin_WH2_2	41	59	PF00022	0.555
LIG_BIR_II_1	1	5	PF00653	0.383
LIG_BIR_III_3	1	5	PF00653	0.341
LIG_eIF4E_1	77	83	PF01652	0.510
LIG_FHA_1	137	143	PF00498	0.533
LIG_FHA_1	177	183	PF00498	0.292
LIG_FHA_1	238	244	PF00498	0.370
LIG_FHA_1	36	42	PF00498	0.334
LIG_FHA_1	91	97	PF00498	0.353
LIG_FHA_2	234	240	PF00498	0.356
LIG_LIR_Apic_2	93	97	PF02991	0.353
LIG_LIR_Gen_1	167	178	PF02991	0.457
LIG_LIR_Gen_1	213	222	PF02991	0.258
LIG_LIR_Gen_1	236	246	PF02991	0.288
LIG_LIR_Gen_1	36	45	PF02991	0.404
LIG_LIR_Gen_1	85	96	PF02991	0.300
LIG_LIR_Nem_3	167	173	PF02991	0.457
LIG_LIR_Nem_3	213	217	PF02991	0.259
LIG_LIR_Nem_3	236	241	PF02991	0.290
LIG_LIR_Nem_3	27	33	PF02991	0.391
LIG_LIR_Nem_3	36	42	PF02991	0.385
LIG_LIR_Nem_3	85	91	PF02991	0.308
LIG_PDZ_Class_2	288	293	PF00595	0.540
LIG_Pex14_2	22	26	PF04695	0.324
LIG_SH2_STAT5	118	121	PF00017	0.319
LIG_SH2_STAT5	131	134	PF00017	0.257
LIG_SH2_STAT5	172	175	PF00017	0.299
LIG_SH2_STAT5	214	217	PF00017	0.247
LIG_SH2_STAT5	34	37	PF00017	0.321
LIG_SH2_STAT5	88	91	PF00017	0.295
LIG_SH3_1	177	183	PF00018	0.299
LIG_SH3_3	177	183	PF00018	0.299
LIG_SH3_3	18	24	PF00018	0.235
LIG_SH3_3	284	290	PF00018	0.653
LIG_SH3_4	227	234	PF00018	0.335
LIG_SUMO_SIM_anti_2	139	146	PF11976	0.526
LIG_SUMO_SIM_anti_2	275	283	PF11976	0.542
LIG_SUMO_SIM_par_1	139	146	PF11976	0.544
LIG_WRC_WIRS_1	118	123	PF05994	0.194
LIG_WRC_WIRS_1	198	203	PF05994	0.297
LIG_WRC_WIRS_1	91	96	PF05994	0.356
MOD_CDK_SPxK_1	10	16	PF00069	0.282
MOD_CK1_1	278	284	PF00069	0.712
MOD_CK1_1	40	46	PF00069	0.452
MOD_CK1_1	55	61	PF00069	0.472
MOD_CK2_1	137	143	PF00069	0.533
MOD_CK2_1	6	12	PF00069	0.321
MOD_GlcNHglycan	224	227	PF01048	0.618
MOD_GlcNHglycan	57	60	PF01048	0.372
MOD_GSK3_1	117	124	PF00069	0.314
MOD_GSK3_1	160	167	PF00069	0.520
MOD_GSK3_1	218	225	PF00069	0.285
MOD_GSK3_1	233	240	PF00069	0.272
MOD_GSK3_1	275	282	PF00069	0.618
MOD_GSK3_1	33	40	PF00069	0.401
MOD_GSK3_1	51	58	PF00069	0.582
MOD_GSK3_1	6	13	PF00069	0.372
MOD_GSK3_1	83	90	PF00069	0.415
MOD_NEK2_1	121	126	PF00069	0.297
MOD_NEK2_1	222	227	PF00069	0.430
MOD_NEK2_1	82	87	PF00069	0.332
MOD_PIKK_1	6	12	PF00454	0.321
MOD_PKA_2	283	289	PF00069	0.533
MOD_Plk_1	51	57	PF00069	0.576
MOD_Plk_4	109	115	PF00069	0.244
MOD_Plk_4	117	123	PF00069	0.325
MOD_Plk_4	137	143	PF00069	0.316
MOD_Plk_4	210	216	PF00069	0.247
MOD_Plk_4	237	243	PF00069	0.351
MOD_Plk_4	283	289	PF00069	0.533
MOD_Plk_4	83	89	PF00069	0.338
MOD_Plk_4	96	102	PF00069	0.269
MOD_ProDKin_1	10	16	PF00069	0.282
MOD_ProDKin_1	176	182	PF00069	0.312
MOD_ProDKin_1	188	194	PF00069	0.247
MOD_ProDKin_1	233	239	PF00069	0.308
MOD_SUMO_rev_2	225	234	PF00179	0.492
TRG_AP2beta_CARGO_1	168	177	PF09066	0.458
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.172
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.536
TRG_ENDOCYTIC_2	118	121	PF00928	0.333
TRG_ENDOCYTIC_2	172	175	PF00928	0.299
TRG_ENDOCYTIC_2	214	217	PF00928	0.247
TRG_ENDOCYTIC_2	77	80	PF00928	0.525
TRG_ENDOCYTIC_2	88	91	PF00928	0.235
TRG_NLS_MonoExtN_4	255	261	PF00514	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM9	Leptomonas seymouri	76%	100%
A0A0S4JD94	Bodo saltans	56%	98%
A0A1X0NMH8	Trypanosomatidae	58%	96%
A0A3Q8I9D7	Leishmania donovani	80%	89%
A0A422NV37	Trypanosoma rangeli	54%	100%
A4II98	Xenopus tropicalis	30%	100%
C9ZI22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9AGI5	Leishmania infantum	81%	100%
E9AP23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	89%
O62126	Caenorhabditis elegans	30%	100%
Q08D99	Bos taurus	32%	100%
Q4QGG6	Leishmania major	79%	100%
Q5BJD5	Homo sapiens	29%	100%
Q5FVN2	Rattus norvegicus	29%	100%
Q5RBZ8	Pongo abelii	29%	100%
Q5U4K5	Xenopus laevis	29%	100%
Q5ZIL6	Gallus gallus	30%	100%
Q6NV38	Danio rerio	32%	100%
Q8K1A5	Mus musculus	30%	100%
Q96HV5	Homo sapiens	31%	100%
Q9D8U2	Mus musculus	32%	100%
Q9VX39	Drosophila melanogaster	31%	92%
V5BJQ3	Trypanosoma cruzi	56%	100%