Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H701_LEIBR

TriTrypDb:

LbrM.12.0890 , LBRM2903_200076900

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H701

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H701

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.621
CLV_NRD_NRD_1	220	222	PF00675	0.713
CLV_NRD_NRD_1	298	300	PF00675	0.816
CLV_NRD_NRD_1	417	419	PF00675	0.870
CLV_NRD_NRD_1	422	424	PF00675	0.788
CLV_NRD_NRD_1	461	463	PF00675	0.844
CLV_NRD_NRD_1	489	491	PF00675	0.748
CLV_NRD_NRD_1	53	55	PF00675	0.800
CLV_NRD_NRD_1	87	89	PF00675	0.744
CLV_NRD_NRD_1	884	886	PF00675	0.523
CLV_PCSK_FUR_1	415	419	PF00082	0.870
CLV_PCSK_KEX2_1	220	222	PF00082	0.713
CLV_PCSK_KEX2_1	298	300	PF00082	0.816
CLV_PCSK_KEX2_1	415	417	PF00082	0.871
CLV_PCSK_KEX2_1	422	424	PF00082	0.755
CLV_PCSK_KEX2_1	461	463	PF00082	0.844
CLV_PCSK_KEX2_1	489	491	PF00082	0.748
CLV_PCSK_KEX2_1	53	55	PF00082	0.800
CLV_PCSK_KEX2_1	87	89	PF00082	0.744
CLV_PCSK_KEX2_1	886	888	PF00082	0.543
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.531
CLV_PCSK_PC7_1	418	424	PF00082	0.866
CLV_PCSK_SKI1_1	253	257	PF00082	0.749
CLV_PCSK_SKI1_1	340	344	PF00082	0.616
CLV_PCSK_SKI1_1	399	403	PF00082	0.838
CLV_PCSK_SKI1_1	546	550	PF00082	0.824
CLV_PCSK_SKI1_1	732	736	PF00082	0.564
CLV_PCSK_SKI1_1	878	882	PF00082	0.725
DEG_APCC_DBOX_1	460	468	PF00400	0.849
DEG_APCC_DBOX_1	768	776	PF00400	0.672
DEG_COP1_1	302	310	PF00400	0.559
DEG_SCF_FBW7_1	701	708	PF00400	0.591
DEG_SPOP_SBC_1	16	20	PF00917	0.776
DEG_SPOP_SBC_1	430	434	PF00917	0.837
DEG_SPOP_SBC_1	536	540	PF00917	0.829
DEG_SPOP_SBC_1	666	670	PF00917	0.575
DEG_SPOP_SBC_1	819	823	PF00917	0.591
DEG_SPOP_SBC_1	859	863	PF00917	0.569
DOC_ANK_TNKS_1	120	127	PF00023	0.602
DOC_CKS1_1	193	198	PF01111	0.565
DOC_CYCLIN_RxL_1	250	258	PF00134	0.592
DOC_CYCLIN_RxL_1	337	346	PF00134	0.616
DOC_CYCLIN_RxL_1	658	669	PF00134	0.580
DOC_MAPK_gen_1	461	467	PF00069	0.851
DOC_PP1_RVXF_1	659	666	PF00149	0.577
DOC_PP2B_LxvP_1	674	677	PF13499	0.637
DOC_PP4_FxxP_1	519	522	PF00568	0.565
DOC_USP7_MATH_1	16	20	PF00917	0.519
DOC_USP7_MATH_1	219	223	PF00917	0.673
DOC_USP7_MATH_1	281	285	PF00917	0.808
DOC_USP7_MATH_1	328	332	PF00917	0.652
DOC_USP7_MATH_1	362	366	PF00917	0.830
DOC_USP7_MATH_1	430	434	PF00917	0.837
DOC_USP7_MATH_1	44	48	PF00917	0.603
DOC_USP7_MATH_1	456	460	PF00917	0.580
DOC_USP7_MATH_1	522	526	PF00917	0.719
DOC_USP7_MATH_1	642	646	PF00917	0.583
DOC_USP7_MATH_1	649	653	PF00917	0.545
DOC_USP7_MATH_1	666	670	PF00917	0.509
DOC_USP7_MATH_1	7	11	PF00917	0.612
DOC_USP7_MATH_1	705	709	PF00917	0.596
DOC_USP7_MATH_1	714	718	PF00917	0.562
DOC_USP7_MATH_1	741	745	PF00917	0.701
DOC_USP7_MATH_1	795	799	PF00917	0.708
DOC_USP7_MATH_1	828	832	PF00917	0.593
DOC_USP7_MATH_1	842	846	PF00917	0.510
DOC_USP7_MATH_1	852	856	PF00917	0.685
DOC_WW_Pin1_4	149	154	PF00397	0.595
DOC_WW_Pin1_4	163	168	PF00397	0.752
DOC_WW_Pin1_4	192	197	PF00397	0.689
DOC_WW_Pin1_4	207	212	PF00397	0.644
DOC_WW_Pin1_4	309	314	PF00397	0.621
DOC_WW_Pin1_4	324	329	PF00397	0.761
DOC_WW_Pin1_4	399	404	PF00397	0.842
DOC_WW_Pin1_4	417	422	PF00397	0.552
DOC_WW_Pin1_4	426	431	PF00397	0.697
DOC_WW_Pin1_4	480	485	PF00397	0.824
DOC_WW_Pin1_4	541	546	PF00397	0.824
DOC_WW_Pin1_4	607	612	PF00397	0.618
DOC_WW_Pin1_4	655	660	PF00397	0.617
DOC_WW_Pin1_4	699	704	PF00397	0.609
DOC_WW_Pin1_4	847	852	PF00397	0.598
LIG_14-3-3_CanoR_1	138	143	PF00244	0.599
LIG_14-3-3_CanoR_1	192	196	PF00244	0.687
LIG_14-3-3_CanoR_1	228	234	PF00244	0.755
LIG_14-3-3_CanoR_1	293	298	PF00244	0.739
LIG_14-3-3_CanoR_1	299	304	PF00244	0.745
LIG_14-3-3_CanoR_1	351	356	PF00244	0.600
LIG_14-3-3_CanoR_1	415	421	PF00244	0.866
LIG_14-3-3_CanoR_1	461	465	PF00244	0.837
LIG_14-3-3_CanoR_1	508	517	PF00244	0.567
LIG_14-3-3_CanoR_1	87	97	PF00244	0.759
LIG_14-3-3_CterR_2	885	890	PF00244	0.787
LIG_Actin_WH2_2	621	638	PF00022	0.575
LIG_AP2alpha_2	80	82	PF02296	0.542
LIG_APCC_Cbox_2	69	75	PF00515	0.559
LIG_BIR_III_2	409	413	PF00653	0.595
LIG_BIR_III_2	631	635	PF00653	0.555
LIG_BRCT_BRCA1_1	17	21	PF00533	0.678
LIG_BRCT_BRCA1_1	299	303	PF00533	0.817
LIG_BRCT_BRCA1_1	836	840	PF00533	0.559
LIG_BRCT_BRCA1_1	854	858	PF00533	0.510
LIG_CSL_BTD_1	656	659	PF09270	0.577
LIG_CtBP_PxDLS_1	484	488	PF00389	0.627
LIG_DLG_GKlike_1	299	307	PF00625	0.816
LIG_DLG_GKlike_1	351	359	PF00625	0.585
LIG_FHA_1	166	172	PF00498	0.651
LIG_FHA_1	302	308	PF00498	0.711
LIG_FHA_1	33	39	PF00498	0.566
LIG_FHA_1	334	340	PF00498	0.630
LIG_FHA_1	350	356	PF00498	0.842
LIG_FHA_1	430	436	PF00498	0.839
LIG_FHA_1	619	625	PF00498	0.816
LIG_FHA_1	666	672	PF00498	0.795
LIG_FHA_1	678	684	PF00498	0.639
LIG_FHA_1	740	746	PF00498	0.744
LIG_FHA_1	96	102	PF00498	0.826
LIG_FHA_2	467	473	PF00498	0.855
LIG_FHA_2	537	543	PF00498	0.825
LIG_FHA_2	598	604	PF00498	0.772
LIG_FHA_2	733	739	PF00498	0.651
LIG_FHA_2	812	818	PF00498	0.566
LIG_FHA_2	870	876	PF00498	0.613
LIG_LIR_Apic_2	409	414	PF02991	0.836
LIG_LIR_Gen_1	312	322	PF02991	0.561
LIG_LIR_Gen_1	622	633	PF02991	0.579
LIG_LIR_Gen_1	95	102	PF02991	0.786
LIG_LIR_Nem_3	312	318	PF02991	0.600
LIG_LIR_Nem_3	622	628	PF02991	0.586
LIG_LIR_Nem_3	95	100	PF02991	0.788
LIG_NRBOX	338	344	PF00104	0.578
LIG_PTAP_UEV_1	750	755	PF05743	0.581
LIG_SH2_CRK	162	166	PF00017	0.574
LIG_SH2_CRK	193	197	PF00017	0.569
LIG_SH2_CRK	625	629	PF00017	0.683
LIG_SH2_NCK_1	162	166	PF00017	0.574
LIG_SH2_NCK_1	193	197	PF00017	0.569
LIG_SH2_NCK_1	510	514	PF00017	0.562
LIG_SH2_SRC	779	782	PF00017	0.416
LIG_SH2_STAP1	492	496	PF00017	0.697
LIG_SH2_STAP1	500	504	PF00017	0.750
LIG_SH2_STAP1	510	514	PF00017	0.595
LIG_SH2_STAP1	779	783	PF00017	0.517
LIG_SH2_STAT3	623	626	PF00017	0.687
LIG_SH2_STAT5	623	626	PF00017	0.726
LIG_SH3_2	216	221	PF14604	0.857
LIG_SH3_3	114	120	PF00018	0.600
LIG_SH3_3	164	170	PF00018	0.797
LIG_SH3_3	210	216	PF00018	0.680
LIG_SH3_3	275	281	PF00018	0.600
LIG_SH3_3	285	291	PF00018	0.505
LIG_SH3_3	365	371	PF00018	0.684
LIG_SH3_3	386	392	PF00018	0.778
LIG_SH3_3	424	430	PF00018	0.853
LIG_SH3_3	585	591	PF00018	0.794
LIG_SH3_3	612	618	PF00018	0.667
LIG_SH3_3	627	633	PF00018	0.787
LIG_SH3_3	643	649	PF00018	0.560
LIG_SH3_3	695	701	PF00018	0.647
LIG_SH3_3	748	754	PF00018	0.777
LIG_SH3_3	75	81	PF00018	0.588
LIG_SH3_3	836	842	PF00018	0.618
LIG_SUMO_SIM_par_1	463	469	PF11976	0.852
LIG_TYR_ITIM	777	782	PF00017	0.427
LIG_WW_3	412	416	PF00397	0.854
MOD_CDC14_SPxK_1	658	661	PF00782	0.579
MOD_CDK_SPK_2	417	422	PF00069	0.866
MOD_CDK_SPK_2	541	546	PF00069	0.824
MOD_CDK_SPK_2	701	706	PF00069	0.589
MOD_CDK_SPxK_1	417	423	PF00069	0.866
MOD_CDK_SPxK_1	655	661	PF00069	0.580
MOD_CDK_SPxxK_3	699	706	PF00069	0.589
MOD_CK1_1	110	116	PF00069	0.541
MOD_CK1_1	15	21	PF00069	0.546
MOD_CK1_1	152	158	PF00069	0.656
MOD_CK1_1	166	172	PF00069	0.585
MOD_CK1_1	194	200	PF00069	0.690
MOD_CK1_1	224	230	PF00069	0.606
MOD_CK1_1	234	240	PF00069	0.671
MOD_CK1_1	245	251	PF00069	0.655
MOD_CK1_1	302	308	PF00069	0.744
MOD_CK1_1	309	315	PF00069	0.504
MOD_CK1_1	327	333	PF00069	0.681
MOD_CK1_1	354	360	PF00069	0.833
MOD_CK1_1	361	367	PF00069	0.716
MOD_CK1_1	429	435	PF00069	0.839
MOD_CK1_1	438	444	PF00069	0.588
MOD_CK1_1	457	463	PF00069	0.524
MOD_CK1_1	499	505	PF00069	0.666
MOD_CK1_1	535	541	PF00069	0.827
MOD_CK1_1	544	550	PF00069	0.675
MOD_CK1_1	593	599	PF00069	0.834
MOD_CK1_1	670	676	PF00069	0.802
MOD_CK1_1	717	723	PF00069	0.590
MOD_CK1_1	798	804	PF00069	0.608
MOD_CK1_1	8	14	PF00069	0.580
MOD_CK1_1	821	827	PF00069	0.693
MOD_CK1_1	831	837	PF00069	0.767
MOD_CK1_1	857	863	PF00069	0.800
MOD_CK1_1	92	98	PF00069	0.763
MOD_CK2_1	466	472	PF00069	0.651
MOD_CK2_1	536	542	PF00069	0.827
MOD_CK2_1	548	554	PF00069	0.631
MOD_CK2_1	649	655	PF00069	0.694
MOD_CK2_1	706	712	PF00069	0.615
MOD_CK2_1	811	817	PF00069	0.560
MOD_CK2_1	858	864	PF00069	0.570
MOD_DYRK1A_RPxSP_1	324	328	PF00069	0.817
MOD_GlcNHglycan	102	105	PF01048	0.566
MOD_GlcNHglycan	109	112	PF01048	0.552
MOD_GlcNHglycan	14	17	PF01048	0.583
MOD_GlcNHglycan	203	206	PF01048	0.835
MOD_GlcNHglycan	22	25	PF01048	0.656
MOD_GlcNHglycan	223	226	PF01048	0.531
MOD_GlcNHglycan	237	240	PF01048	0.629
MOD_GlcNHglycan	244	247	PF01048	0.613
MOD_GlcNHglycan	283	286	PF01048	0.546
MOD_GlcNHglycan	304	307	PF01048	0.750
MOD_GlcNHglycan	308	311	PF01048	0.687
MOD_GlcNHglycan	360	363	PF01048	0.827
MOD_GlcNHglycan	424	427	PF01048	0.782
MOD_GlcNHglycan	456	459	PF01048	0.776
MOD_GlcNHglycan	46	49	PF01048	0.668
MOD_GlcNHglycan	496	499	PF01048	0.566
MOD_GlcNHglycan	503	507	PF01048	0.570
MOD_GlcNHglycan	539	542	PF01048	0.828
MOD_GlcNHglycan	550	553	PF01048	0.643
MOD_GlcNHglycan	646	649	PF01048	0.807
MOD_GlcNHglycan	651	654	PF01048	0.773
MOD_GlcNHglycan	66	69	PF01048	0.599
MOD_GlcNHglycan	709	712	PF01048	0.613
MOD_GlcNHglycan	751	754	PF01048	0.581
MOD_GlcNHglycan	759	762	PF01048	0.482
MOD_GlcNHglycan	797	800	PF01048	0.623
MOD_GlcNHglycan	830	833	PF01048	0.631
MOD_GlcNHglycan	844	847	PF01048	0.762
MOD_GlcNHglycan	854	857	PF01048	0.665
MOD_GSK3_1	1	8	PF00069	0.585
MOD_GSK3_1	12	19	PF00069	0.555
MOD_GSK3_1	194	201	PF00069	0.717
MOD_GSK3_1	203	210	PF00069	0.626
MOD_GSK3_1	22	29	PF00069	0.559
MOD_GSK3_1	220	227	PF00069	0.546
MOD_GSK3_1	231	238	PF00069	0.627
MOD_GSK3_1	241	248	PF00069	0.595
MOD_GSK3_1	251	258	PF00069	0.640
MOD_GSK3_1	289	296	PF00069	0.661
MOD_GSK3_1	297	304	PF00069	0.751
MOD_GSK3_1	324	331	PF00069	0.761
MOD_GSK3_1	351	358	PF00069	0.834
MOD_GSK3_1	362	369	PF00069	0.646
MOD_GSK3_1	391	398	PF00069	0.664
MOD_GSK3_1	422	429	PF00069	0.857
MOD_GSK3_1	431	438	PF00069	0.639
MOD_GSK3_1	456	463	PF00069	0.600
MOD_GSK3_1	466	473	PF00069	0.599
MOD_GSK3_1	490	497	PF00069	0.644
MOD_GSK3_1	531	538	PF00069	0.758
MOD_GSK3_1	544	551	PF00069	0.573
MOD_GSK3_1	593	600	PF00069	0.792
MOD_GSK3_1	603	610	PF00069	0.628
MOD_GSK3_1	644	651	PF00069	0.817
MOD_GSK3_1	666	673	PF00069	0.681
MOD_GSK3_1	701	708	PF00069	0.748
MOD_GSK3_1	714	721	PF00069	0.657
MOD_GSK3_1	795	802	PF00069	0.651
MOD_GSK3_1	818	825	PF00069	0.785
MOD_GSK3_1	830	837	PF00069	0.650
MOD_GSK3_1	854	861	PF00069	0.674
MOD_GSK3_1	865	872	PF00069	0.438
MOD_GSK3_1	88	95	PF00069	0.793
MOD_GSK3_1	881	888	PF00069	0.508
MOD_GSK3_1	96	103	PF00069	0.669
MOD_LATS_1	218	224	PF00433	0.862
MOD_LATS_1	349	355	PF00433	0.842
MOD_LATS_1	94	100	PF00433	0.827
MOD_N-GLC_1	144	149	PF02516	0.558
MOD_N-GLC_1	799	804	PF02516	0.537
MOD_N-GLC_1	842	847	PF02516	0.813
MOD_N-GLC_1	865	870	PF02516	0.523
MOD_NEK2_1	199	204	PF00069	0.688
MOD_NEK2_1	255	260	PF00069	0.600
MOD_NEK2_1	297	302	PF00069	0.815
MOD_NEK2_1	355	360	PF00069	0.580
MOD_NEK2_1	393	398	PF00069	0.814
MOD_NEK2_1	435	440	PF00069	0.836
MOD_NEK2_1	496	501	PF00069	0.567
MOD_NEK2_1	548	553	PF00069	0.799
MOD_NEK2_1	684	689	PF00069	0.583
MOD_NEK2_1	820	825	PF00069	0.744
MOD_NEK2_1	858	863	PF00069	0.657
MOD_NEK2_1	881	886	PF00069	0.497
MOD_NEK2_2	362	367	PF00069	0.735
MOD_NEK2_2	835	840	PF00069	0.559
MOD_PIKK_1	391	397	PF00454	0.810
MOD_PIKK_1	466	472	PF00454	0.856
MOD_PK_1	96	102	PF00069	0.826
MOD_PKA_1	220	226	PF00069	0.709
MOD_PKA_1	416	422	PF00069	0.867
MOD_PKA_2	137	143	PF00069	0.560
MOD_PKA_2	191	197	PF00069	0.784
MOD_PKA_2	219	225	PF00069	0.712
MOD_PKA_2	227	233	PF00069	0.683
MOD_PKA_2	289	295	PF00069	0.693
MOD_PKA_2	297	303	PF00069	0.785
MOD_PKA_2	366	372	PF00069	0.830
MOD_PKA_2	416	422	PF00069	0.867
MOD_PKA_2	460	466	PF00069	0.596
MOD_PKA_2	8	14	PF00069	0.794
MOD_PKA_2	95	101	PF00069	0.728
MOD_Plk_1	144	150	PF00069	0.573
MOD_Plk_1	715	721	PF00069	0.594
MOD_Plk_1	790	796	PF00069	0.546
MOD_Plk_1	799	805	PF00069	0.500
MOD_Plk_1	92	98	PF00069	0.788
MOD_Plk_4	1	7	PF00069	0.798
MOD_Plk_4	17	23	PF00069	0.513
MOD_Plk_4	203	209	PF00069	0.742
MOD_Plk_4	251	257	PF00069	0.807
MOD_Plk_4	619	625	PF00069	0.675
MOD_Plk_4	679	685	PF00069	0.738
MOD_Plk_4	835	841	PF00069	0.589
MOD_Plk_4	854	860	PF00069	0.504
MOD_Plk_4	96	102	PF00069	0.826
MOD_ProDKin_1	149	155	PF00069	0.594
MOD_ProDKin_1	163	169	PF00069	0.754
MOD_ProDKin_1	192	198	PF00069	0.685
MOD_ProDKin_1	207	213	PF00069	0.644
MOD_ProDKin_1	309	315	PF00069	0.624
MOD_ProDKin_1	324	330	PF00069	0.760
MOD_ProDKin_1	399	405	PF00069	0.843
MOD_ProDKin_1	417	423	PF00069	0.552
MOD_ProDKin_1	426	432	PF00069	0.698
MOD_ProDKin_1	480	486	PF00069	0.823
MOD_ProDKin_1	541	547	PF00069	0.820
MOD_ProDKin_1	607	613	PF00069	0.618
MOD_ProDKin_1	655	661	PF00069	0.618
MOD_ProDKin_1	699	705	PF00069	0.609
MOD_ProDKin_1	847	853	PF00069	0.598
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.564
TRG_ENDOCYTIC_2	161	164	PF00928	0.573
TRG_ENDOCYTIC_2	315	318	PF00928	0.609
TRG_ENDOCYTIC_2	625	628	PF00928	0.800
TRG_ENDOCYTIC_2	779	782	PF00928	0.683
TRG_ER_diArg_1	120	123	PF00400	0.638
TRG_ER_diArg_1	219	221	PF00400	0.715
TRG_ER_diArg_1	297	299	PF00400	0.819
TRG_ER_diArg_1	414	417	PF00400	0.867
TRG_ER_diArg_1	421	423	PF00400	0.755
TRG_ER_diArg_1	489	491	PF00400	0.742
TRG_ER_diArg_1	53	56	PF00400	0.821
TRG_ER_diArg_1	766	769	PF00400	0.693
TRG_ER_diArg_1	86	88	PF00400	0.793
TRG_NLS_MonoExtN_4	883	889	PF00514	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WS93	Leishmania donovani	59%	88%
E9AGH4	Leishmania infantum	60%	99%
E9AP21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	89%
Q4QGG8	Leishmania major	57%	100%