Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H700_LEIBR

TriTrypDb:

LbrM.12.0880 , LBRM2903_200077100

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H700

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H700

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.491
CLV_NRD_NRD_1	126	128	PF00675	0.591
CLV_NRD_NRD_1	250	252	PF00675	0.401
CLV_NRD_NRD_1	29	31	PF00675	0.545
CLV_NRD_NRD_1	424	426	PF00675	0.596
CLV_NRD_NRD_1	95	97	PF00675	0.663
CLV_PCSK_KEX2_1	250	252	PF00082	0.460
CLV_PCSK_KEX2_1	29	31	PF00082	0.545
CLV_PCSK_KEX2_1	423	425	PF00082	0.595
CLV_PCSK_KEX2_1	77	79	PF00082	0.432
CLV_PCSK_KEX2_1	95	97	PF00082	0.620
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.432
CLV_PCSK_SKI1_1	115	119	PF00082	0.497
CLV_PCSK_SKI1_1	427	431	PF00082	0.729
CLV_PCSK_SKI1_1	46	50	PF00082	0.487
CLV_PCSK_SKI1_1	77	81	PF00082	0.432
CLV_PCSK_SKI1_1	96	100	PF00082	0.531
DEG_APCC_DBOX_1	94	102	PF00400	0.669
DEG_SCF_FBW7_1	17	24	PF00400	0.520
DOC_CKS1_1	193	198	PF01111	0.578
DOC_CYCLIN_RxL_1	111	119	PF00134	0.473
DOC_CYCLIN_RxL_1	75	86	PF00134	0.669
DOC_CYCLIN_RxL_1	92	103	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.581
DOC_MAPK_gen_1	127	135	PF00069	0.470
DOC_MAPK_gen_1	92	101	PF00069	0.645
DOC_PP2B_LxvP_1	197	200	PF13499	0.681
DOC_PP2B_LxvP_1	397	400	PF13499	0.584
DOC_PP2B_LxvP_1	453	456	PF13499	0.506
DOC_USP7_MATH_1	308	312	PF00917	0.441
DOC_USP7_MATH_1	414	418	PF00917	0.647
DOC_USP7_MATH_1	444	448	PF00917	0.514
DOC_USP7_MATH_1	64	68	PF00917	0.453
DOC_USP7_UBL2_3	111	115	PF12436	0.468
DOC_WW_Pin1_4	17	22	PF00397	0.633
DOC_WW_Pin1_4	192	197	PF00397	0.562
LIG_14-3-3_CanoR_1	206	211	PF00244	0.543
LIG_14-3-3_CanoR_1	29	34	PF00244	0.611
LIG_14-3-3_CanoR_1	314	323	PF00244	0.486
LIG_14-3-3_CanoR_1	36	41	PF00244	0.506
LIG_14-3-3_CanoR_1	410	418	PF00244	0.544
LIG_14-3-3_CanoR_1	459	466	PF00244	0.592
LIG_BIR_III_2	9	13	PF00653	0.502
LIG_BIR_III_4	370	374	PF00653	0.503
LIG_BRCT_BRCA1_1	139	143	PF00533	0.505
LIG_BRCT_BRCA1_1	145	149	PF00533	0.511
LIG_CtBP_PxDLS_1	435	439	PF00389	0.458
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.451
LIG_DLG_GKlike_1	36	43	PF00625	0.523
LIG_FHA_1	151	157	PF00498	0.522
LIG_FHA_1	345	351	PF00498	0.526
LIG_FHA_1	352	358	PF00498	0.500
LIG_FHA_1	429	435	PF00498	0.552
LIG_FHA_1	448	454	PF00498	0.745
LIG_FHA_1	461	467	PF00498	0.508
LIG_FHA_2	214	220	PF00498	0.555
LIG_FHA_2	234	240	PF00498	0.482
LIG_FHA_2	428	434	PF00498	0.471
LIG_LIR_Apic_2	67	73	PF02991	0.440
LIG_LIR_Gen_1	233	242	PF02991	0.488
LIG_LIR_Gen_1	317	328	PF02991	0.482
LIG_LIR_Gen_1	38	48	PF02991	0.553
LIG_LIR_Gen_1	52	63	PF02991	0.437
LIG_LIR_Nem_3	233	237	PF02991	0.554
LIG_LIR_Nem_3	257	263	PF02991	0.461
LIG_LIR_Nem_3	309	315	PF02991	0.511
LIG_LIR_Nem_3	317	323	PF02991	0.499
LIG_LIR_Nem_3	38	43	PF02991	0.558
LIG_LIR_Nem_3	52	58	PF02991	0.445
LIG_Pex14_1	252	256	PF04695	0.470
LIG_Rb_LxCxE_1	354	374	PF01857	0.458
LIG_REV1ctd_RIR_1	329	338	PF16727	0.580
LIG_SH2_CRK	70	74	PF00017	0.438
LIG_SH2_NCK_1	70	74	PF00017	0.438
LIG_SH2_STAP1	353	357	PF00017	0.398
LIG_SH2_STAP1	460	464	PF00017	0.552
LIG_SH2_STAT3	104	107	PF00017	0.448
LIG_SH2_STAT3	353	356	PF00017	0.391
LIG_SH2_STAT5	104	107	PF00017	0.503
LIG_SH2_STAT5	255	258	PF00017	0.475
LIG_SH2_STAT5	260	263	PF00017	0.440
LIG_SH2_STAT5	342	345	PF00017	0.467
LIG_SH2_STAT5	353	356	PF00017	0.478
LIG_SH2_STAT5	55	58	PF00017	0.468
LIG_SH3_3	193	199	PF00018	0.581
LIG_SUMO_SIM_par_1	241	246	PF11976	0.447
LIG_SUMO_SIM_par_1	97	103	PF11976	0.496
LIG_TRAF2_1	221	224	PF00917	0.639
LIG_TRAF2_1	389	392	PF00917	0.588
LIG_TRAF2_1	430	433	PF00917	0.466
MOD_CDK_SPxK_1	17	23	PF00069	0.519
MOD_CDK_SPxK_1	192	198	PF00069	0.643
MOD_CK1_1	213	219	PF00069	0.543
MOD_CK1_1	275	281	PF00069	0.533
MOD_CK1_1	32	38	PF00069	0.625
MOD_CK1_1	409	415	PF00069	0.566
MOD_CK1_1	41	47	PF00069	0.558
MOD_CK1_1	447	453	PF00069	0.480
MOD_CK1_1	86	92	PF00069	0.483
MOD_CK2_1	123	129	PF00069	0.497
MOD_CK2_1	213	219	PF00069	0.570
MOD_CK2_1	280	286	PF00069	0.552
MOD_CK2_1	386	392	PF00069	0.618
MOD_CK2_1	414	420	PF00069	0.500
MOD_CK2_1	427	433	PF00069	0.480
MOD_CK2_1	44	50	PF00069	0.487
MOD_CMANNOS	249	252	PF00535	0.454
MOD_GlcNHglycan	169	172	PF01048	0.568
MOD_GlcNHglycan	212	215	PF01048	0.700
MOD_GlcNHglycan	274	277	PF01048	0.515
MOD_GlcNHglycan	293	296	PF01048	0.577
MOD_GlcNHglycan	317	320	PF01048	0.507
MOD_GlcNHglycan	412	415	PF01048	0.544
MOD_GlcNHglycan	446	449	PF01048	0.514
MOD_GlcNHglycan	66	69	PF01048	0.595
MOD_GlcNHglycan	88	91	PF01048	0.487
MOD_GSK3_1	137	144	PF00069	0.682
MOD_GSK3_1	17	24	PF00069	0.597
MOD_GSK3_1	201	208	PF00069	0.658
MOD_GSK3_1	209	216	PF00069	0.651
MOD_GSK3_1	25	32	PF00069	0.620
MOD_GSK3_1	272	279	PF00069	0.510
MOD_GSK3_1	287	294	PF00069	0.567
MOD_GSK3_1	304	311	PF00069	0.476
MOD_GSK3_1	332	339	PF00069	0.507
MOD_GSK3_1	38	45	PF00069	0.574
MOD_GSK3_1	406	413	PF00069	0.702
MOD_GSK3_1	465	472	PF00069	0.602
MOD_GSK3_1	82	89	PF00069	0.490
MOD_N-GLC_2	136	138	PF02516	0.495
MOD_NEK2_1	143	148	PF00069	0.693
MOD_NEK2_1	210	215	PF00069	0.539
MOD_NEK2_1	306	311	PF00069	0.498
MOD_NEK2_1	315	320	PF00069	0.406
MOD_NEK2_1	469	474	PF00069	0.744
MOD_NEK2_1	49	54	PF00069	0.529
MOD_NEK2_1	82	87	PF00069	0.488
MOD_NEK2_2	157	162	PF00069	0.443
MOD_NEK2_2	201	206	PF00069	0.536
MOD_PIKK_1	116	122	PF00454	0.639
MOD_PIKK_1	306	312	PF00454	0.495
MOD_PKA_1	29	35	PF00069	0.543
MOD_PKA_2	205	211	PF00069	0.591
MOD_PKA_2	29	35	PF00069	0.572
MOD_PKA_2	313	319	PF00069	0.526
MOD_PKA_2	344	350	PF00069	0.514
MOD_PKA_2	409	415	PF00069	0.587
MOD_PKA_2	458	464	PF00069	0.582
MOD_PKA_2	86	92	PF00069	0.424
MOD_Plk_1	336	342	PF00069	0.503
MOD_Plk_1	4	10	PF00069	0.491
MOD_Plk_2-3	129	135	PF00069	0.461
MOD_Plk_2-3	233	239	PF00069	0.488
MOD_Plk_2-3	280	286	PF00069	0.536
MOD_Plk_4	137	143	PF00069	0.527
MOD_Plk_4	308	314	PF00069	0.503
MOD_ProDKin_1	17	23	PF00069	0.634
MOD_ProDKin_1	192	198	PF00069	0.567
MOD_SUMO_rev_2	385	394	PF00179	0.530
TRG_DiLeu_BaEn_2	229	235	PF01217	0.492
TRG_ENDOCYTIC_2	312	315	PF00928	0.441
TRG_ENDOCYTIC_2	320	323	PF00928	0.527
TRG_ENDOCYTIC_2	40	43	PF00928	0.508
TRG_ENDOCYTIC_2	55	58	PF00928	0.468
TRG_ER_diArg_1	215	218	PF00400	0.543
TRG_ER_diArg_1	249	251	PF00400	0.402
TRG_ER_diArg_1	422	425	PF00400	0.592
TRG_ER_diArg_1	94	96	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY24	Leptomonas seymouri	44%	83%
A0A3Q8I9I2	Leishmania donovani	51%	85%
E9AGI4	Leishmania infantum	51%	100%
E9AP20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	89%
Q4QGG9	Leishmania major	50%	100%