CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Z8_LEIBR

TriTrypDb:

LbrM.12.0860 , LBRM2903_200077300

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.686
CLV_C14_Caspase3-7	122	126	PF00656	0.676
CLV_C14_Caspase3-7	497	501	PF00656	0.693
CLV_C14_Caspase3-7	66	70	PF00656	0.555
CLV_NRD_NRD_1	114	116	PF00675	0.553
CLV_NRD_NRD_1	163	165	PF00675	0.614
CLV_NRD_NRD_1	181	183	PF00675	0.554
CLV_NRD_NRD_1	656	658	PF00675	0.448
CLV_NRD_NRD_1	77	79	PF00675	0.772
CLV_NRD_NRD_1	820	822	PF00675	0.694
CLV_NRD_NRD_1	853	855	PF00675	0.661
CLV_PCSK_KEX2_1	163	165	PF00082	0.618
CLV_PCSK_KEX2_1	180	182	PF00082	0.565
CLV_PCSK_KEX2_1	189	191	PF00082	0.613
CLV_PCSK_KEX2_1	760	762	PF00082	0.524
CLV_PCSK_KEX2_1	77	79	PF00082	0.705
CLV_PCSK_KEX2_1	820	822	PF00082	0.686
CLV_PCSK_KEX2_1	855	857	PF00082	0.637
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.609
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.524
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.637
CLV_PCSK_PC7_1	176	182	PF00082	0.606
CLV_PCSK_SKI1_1	195	199	PF00082	0.625
CLV_PCSK_SKI1_1	216	220	PF00082	0.589
CLV_PCSK_SKI1_1	339	343	PF00082	0.540
CLV_PCSK_SKI1_1	444	448	PF00082	0.440
CLV_PCSK_SKI1_1	761	765	PF00082	0.485
CLV_PCSK_SKI1_1	78	82	PF00082	0.678
CLV_PCSK_SKI1_1	8	12	PF00082	0.575
CLV_PCSK_SKI1_1	855	859	PF00082	0.625
DEG_SCF_FBW7_2	307	313	PF00400	0.522
DEG_SCF_TRCP1_1	840	846	PF00400	0.527
DEG_SPOP_SBC_1	673	677	PF00917	0.691
DOC_CKS1_1	307	312	PF01111	0.578
DOC_CKS1_1	787	792	PF01111	0.351
DOC_CYCLIN_RxL_1	75	83	PF00134	0.689
DOC_CYCLIN_yClb1_LxF_4	804	810	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	397	400	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	562	565	PF00134	0.412
DOC_MAPK_gen_1	760	769	PF00069	0.506
DOC_PP1_RVXF_1	604	610	PF00149	0.327
DOC_PP2B_LxvP_1	185	188	PF13499	0.522
DOC_PP2B_LxvP_1	397	400	PF13499	0.493
DOC_PP2B_LxvP_1	456	459	PF13499	0.325
DOC_PP2B_LxvP_1	562	565	PF13499	0.414
DOC_PP2B_LxvP_1	667	670	PF13499	0.586
DOC_PP4_FxxP_1	421	424	PF00568	0.468
DOC_SPAK_OSR1_1	176	180	PF12202	0.531
DOC_USP7_MATH_1	147	151	PF00917	0.644
DOC_USP7_MATH_1	275	279	PF00917	0.567
DOC_USP7_MATH_1	322	326	PF00917	0.746
DOC_USP7_MATH_1	501	505	PF00917	0.625
DOC_USP7_MATH_1	508	512	PF00917	0.571
DOC_USP7_MATH_1	576	580	PF00917	0.348
DOC_USP7_MATH_1	674	678	PF00917	0.740
DOC_USP7_MATH_1	688	692	PF00917	0.593
DOC_USP7_MATH_1	699	703	PF00917	0.692
DOC_USP7_MATH_1	843	847	PF00917	0.678
DOC_USP7_UBL2_3	4	8	PF12436	0.578
DOC_USP7_UBL2_3	760	764	PF12436	0.487
DOC_WW_Pin1_4	104	109	PF00397	0.543
DOC_WW_Pin1_4	132	137	PF00397	0.722
DOC_WW_Pin1_4	306	311	PF00397	0.579
DOC_WW_Pin1_4	420	425	PF00397	0.473
DOC_WW_Pin1_4	510	515	PF00397	0.641
DOC_WW_Pin1_4	544	549	PF00397	0.592
DOC_WW_Pin1_4	658	663	PF00397	0.557
DOC_WW_Pin1_4	736	741	PF00397	0.567
DOC_WW_Pin1_4	786	791	PF00397	0.346
LIG_14-3-3_CanoR_1	195	204	PF00244	0.589
LIG_14-3-3_CanoR_1	339	345	PF00244	0.563
LIG_14-3-3_CanoR_1	606	610	PF00244	0.483
LIG_14-3-3_CanoR_1	657	662	PF00244	0.492
LIG_14-3-3_CanoR_1	664	668	PF00244	0.582
LIG_14-3-3_CanoR_1	768	774	PF00244	0.446
LIG_Actin_WH2_2	438	455	PF00022	0.458
LIG_Actin_WH2_2	586	604	PF00022	0.514
LIG_APCC_ABBA_1	865	870	PF00400	0.617
LIG_BIR_III_4	500	504	PF00653	0.534
LIG_Clathr_ClatBox_1	253	257	PF01394	0.515
LIG_deltaCOP1_diTrp_1	643	651	PF00928	0.484
LIG_EVH1_1	456	460	PF00568	0.336
LIG_FHA_1	309	315	PF00498	0.553
LIG_FHA_1	433	439	PF00498	0.333
LIG_FHA_1	487	493	PF00498	0.551
LIG_FHA_1	545	551	PF00498	0.528
LIG_FHA_1	583	589	PF00498	0.564
LIG_FHA_1	702	708	PF00498	0.548
LIG_FHA_1	709	715	PF00498	0.451
LIG_FHA_1	737	743	PF00498	0.530
LIG_FHA_1	87	93	PF00498	0.711
LIG_FHA_2	196	202	PF00498	0.709
LIG_FHA_2	208	214	PF00498	0.471
LIG_FHA_2	388	394	PF00498	0.599
LIG_FHA_2	495	501	PF00498	0.667
LIG_FHA_2	564	570	PF00498	0.548
LIG_FHA_2	799	805	PF00498	0.483
LIG_FHA_2	843	849	PF00498	0.503
LIG_Integrin_isoDGR_2	621	623	PF01839	0.596
LIG_LIR_Apic_2	643	649	PF02991	0.482
LIG_LIR_Gen_1	12	23	PF02991	0.578
LIG_LIR_Gen_1	441	450	PF02991	0.441
LIG_LIR_Nem_3	12	18	PF02991	0.558
LIG_LIR_Nem_3	159	165	PF02991	0.612
LIG_LIR_Nem_3	219	224	PF02991	0.389
LIG_LIR_Nem_3	243	247	PF02991	0.496
LIG_LIR_Nem_3	272	276	PF02991	0.525
LIG_LIR_Nem_3	441	445	PF02991	0.370
LIG_LIR_Nem_3	645	650	PF02991	0.491
LIG_LYPXL_yS_3	873	876	PF13949	0.621
LIG_PALB2_WD40_1	642	650	PF16756	0.482
LIG_Pex14_2	11	15	PF04695	0.560
LIG_Pex14_2	647	651	PF04695	0.498
LIG_SH2_NCK_1	146	150	PF00017	0.644
LIG_SH2_STAT5	224	227	PF00017	0.392
LIG_SH2_STAT5	344	347	PF00017	0.547
LIG_SH2_STAT5	406	409	PF00017	0.476
LIG_SH2_STAT5	451	454	PF00017	0.485
LIG_SH2_STAT5	710	713	PF00017	0.496
LIG_SH2_STAT5	725	728	PF00017	0.346
LIG_SH2_STAT5	782	785	PF00017	0.485
LIG_SH3_1	668	674	PF00018	0.686
LIG_SH3_1	98	104	PF00018	0.532
LIG_SH3_3	290	296	PF00018	0.533
LIG_SH3_3	454	460	PF00018	0.525
LIG_SH3_3	502	508	PF00018	0.643
LIG_SH3_3	558	564	PF00018	0.585
LIG_SH3_3	646	652	PF00018	0.503
LIG_SH3_3	666	672	PF00018	0.601
LIG_SH3_3	693	699	PF00018	0.687
LIG_SH3_3	98	104	PF00018	0.583
LIG_SH3_5	142	146	PF00018	0.545
LIG_SUMO_SIM_anti_2	393	399	PF11976	0.512
LIG_SUMO_SIM_par_1	252	257	PF11976	0.510
LIG_TRAF2_1	566	569	PF00917	0.547
LIG_TRFH_1	695	699	PF08558	0.518
LIG_WW_1	143	146	PF00397	0.708
MOD_CDK_SPxK_1	658	664	PF00069	0.518
MOD_CK1_1	132	138	PF00069	0.700
MOD_CK1_1	150	156	PF00069	0.597
MOD_CK1_1	157	163	PF00069	0.587
MOD_CK1_1	263	269	PF00069	0.592
MOD_CK1_1	306	312	PF00069	0.522
MOD_CK1_1	343	349	PF00069	0.536
MOD_CK1_1	364	370	PF00069	0.511
MOD_CK1_1	475	481	PF00069	0.635
MOD_CK1_1	510	516	PF00069	0.643
MOD_CK1_1	579	585	PF00069	0.578
MOD_CK1_1	65	71	PF00069	0.580
MOD_CK1_1	675	681	PF00069	0.755
MOD_CK1_1	702	708	PF00069	0.588
MOD_CK2_1	195	201	PF00069	0.712
MOD_CK2_1	207	213	PF00069	0.485
MOD_CK2_1	27	33	PF00069	0.628
MOD_CK2_1	275	281	PF00069	0.623
MOD_CK2_1	387	393	PF00069	0.568
MOD_CK2_1	563	569	PF00069	0.560
MOD_CK2_1	798	804	PF00069	0.510
MOD_CK2_1	842	848	PF00069	0.506
MOD_Cter_Amidation	655	658	PF01082	0.435
MOD_GlcNHglycan	137	140	PF01048	0.673
MOD_GlcNHglycan	149	152	PF01048	0.551
MOD_GlcNHglycan	233	237	PF01048	0.392
MOD_GlcNHglycan	265	268	PF01048	0.674
MOD_GlcNHglycan	273	276	PF01048	0.614
MOD_GlcNHglycan	277	280	PF01048	0.621
MOD_GlcNHglycan	320	323	PF01048	0.671
MOD_GlcNHglycan	324	327	PF01048	0.645
MOD_GlcNHglycan	328	331	PF01048	0.611
MOD_GlcNHglycan	345	348	PF01048	0.544
MOD_GlcNHglycan	352	355	PF01048	0.618
MOD_GlcNHglycan	359	362	PF01048	0.652
MOD_GlcNHglycan	363	366	PF01048	0.597
MOD_GlcNHglycan	38	42	PF01048	0.492
MOD_GlcNHglycan	45	48	PF01048	0.616
MOD_GlcNHglycan	477	480	PF01048	0.583
MOD_GlcNHglycan	523	526	PF01048	0.665
MOD_GlcNHglycan	54	57	PF01048	0.693
MOD_GlcNHglycan	582	585	PF01048	0.564
MOD_GlcNHglycan	65	68	PF01048	0.580
MOD_GlcNHglycan	690	693	PF01048	0.610
MOD_GlcNHglycan	701	704	PF01048	0.537
MOD_GlcNHglycan	729	734	PF01048	0.641
MOD_GlcNHglycan	790	793	PF01048	0.351
MOD_GlcNHglycan	82	85	PF01048	0.492
MOD_GlcNHglycan	834	837	PF01048	0.663
MOD_GlcNHglycan	840	843	PF01048	0.586
MOD_GlcNHglycan	845	848	PF01048	0.540
MOD_GSK3_1	147	154	PF00069	0.690
MOD_GSK3_1	23	30	PF00069	0.636
MOD_GSK3_1	259	266	PF00069	0.635
MOD_GSK3_1	271	278	PF00069	0.576
MOD_GSK3_1	299	306	PF00069	0.652
MOD_GSK3_1	318	325	PF00069	0.693
MOD_GSK3_1	342	349	PF00069	0.552
MOD_GSK3_1	350	357	PF00069	0.551
MOD_GSK3_1	434	441	PF00069	0.470
MOD_GSK3_1	482	489	PF00069	0.746
MOD_GSK3_1	510	517	PF00069	0.531
MOD_GSK3_1	576	583	PF00069	0.599
MOD_GSK3_1	58	65	PF00069	0.613
MOD_GSK3_1	605	612	PF00069	0.511
MOD_GSK3_1	698	705	PF00069	0.666
MOD_GSK3_1	769	776	PF00069	0.463
MOD_GSK3_1	782	789	PF00069	0.335
MOD_GSK3_1	838	845	PF00069	0.509
MOD_GSK3_1	92	99	PF00069	0.623
MOD_N-GLC_1	195	200	PF02516	0.589
MOD_N-GLC_1	485	490	PF02516	0.585
MOD_N-GLC_1	501	506	PF02516	0.586
MOD_N-GLC_1	798	803	PF02516	0.561
MOD_NEK2_1	129	134	PF00069	0.613
MOD_NEK2_1	23	28	PF00069	0.638
MOD_NEK2_1	240	245	PF00069	0.478
MOD_NEK2_1	260	265	PF00069	0.565
MOD_NEK2_1	342	347	PF00069	0.537
MOD_NEK2_1	37	42	PF00069	0.468
MOD_NEK2_1	43	48	PF00069	0.478
MOD_NEK2_1	440	445	PF00069	0.423
MOD_NEK2_1	580	585	PF00069	0.507
MOD_NEK2_1	609	614	PF00069	0.510
MOD_NEK2_1	690	695	PF00069	0.559
MOD_NEK2_1	731	736	PF00069	0.469
MOD_NEK2_1	769	774	PF00069	0.463
MOD_NEK2_2	663	668	PF00069	0.565
MOD_PIKK_1	346	352	PF00454	0.594
MOD_PK_1	472	478	PF00069	0.506
MOD_PK_1	96	102	PF00069	0.583
MOD_PKA_1	657	663	PF00069	0.498
MOD_PKA_2	302	308	PF00069	0.546
MOD_PKA_2	531	537	PF00069	0.545
MOD_PKA_2	605	611	PF00069	0.483
MOD_PKA_2	656	662	PF00069	0.484
MOD_PKA_2	663	669	PF00069	0.547
MOD_PKA_2	708	714	PF00069	0.498
MOD_Plk_1	280	286	PF00069	0.628
MOD_Plk_1	303	309	PF00069	0.542
MOD_Plk_1	337	343	PF00069	0.537
MOD_Plk_1	642	648	PF00069	0.471
MOD_Plk_1	798	804	PF00069	0.573
MOD_Plk_2-3	798	804	PF00069	0.510
MOD_Plk_4	151	157	PF00069	0.589
MOD_Plk_4	488	494	PF00069	0.608
MOD_Plk_4	576	582	PF00069	0.497
MOD_Plk_4	605	611	PF00069	0.483
MOD_Plk_4	642	648	PF00069	0.481
MOD_Plk_4	745	751	PF00069	0.470
MOD_Plk_4	782	788	PF00069	0.475
MOD_ProDKin_1	104	110	PF00069	0.546
MOD_ProDKin_1	132	138	PF00069	0.724
MOD_ProDKin_1	306	312	PF00069	0.578
MOD_ProDKin_1	420	426	PF00069	0.480
MOD_ProDKin_1	510	516	PF00069	0.643
MOD_ProDKin_1	544	550	PF00069	0.600
MOD_ProDKin_1	658	664	PF00069	0.567
MOD_ProDKin_1	736	742	PF00069	0.554
MOD_ProDKin_1	786	792	PF00069	0.348
MOD_SUMO_for_1	31	34	PF00179	0.624
MOD_SUMO_rev_2	848	857	PF00179	0.659
TRG_DiLeu_BaEn_1	393	398	PF01217	0.517
TRG_DiLeu_BaEn_1	861	866	PF01217	0.611
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.680
TRG_DiLeu_BaLyEn_6	620	625	PF01217	0.605
TRG_ENDOCYTIC_2	873	876	PF00928	0.621
TRG_ER_diArg_1	162	164	PF00400	0.623
TRG_ER_diArg_1	179	182	PF00400	0.565
TRG_ER_diArg_1	76	78	PF00400	0.709
TRG_ER_diArg_1	819	821	PF00400	0.697
TRG_ER_diArg_1	854	857	PF00400	0.620
TRG_NLS_MonoExtN_4	854	859	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHU8	Leishmania donovani	69%	100%
E9AGI2	Leishmania infantum	69%	100%
E9AP18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QGH1	Leishmania major	68%	100%