SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania braziliensis

UniProt:

A4H6Z7_LEIBR

TriTrypDb:

LbrM.12.0850 , LBRM2903_200077400

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006869	lipid transport	5	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0071702	organic substance transport	4	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	559	563	PF00656	0.633
CLV_MEL_PAP_1	409	415	PF00089	0.349
CLV_NRD_NRD_1	219	221	PF00675	0.380
CLV_NRD_NRD_1	28	30	PF00675	0.387
CLV_NRD_NRD_1	291	293	PF00675	0.364
CLV_NRD_NRD_1	43	45	PF00675	0.325
CLV_NRD_NRD_1	447	449	PF00675	0.410
CLV_NRD_NRD_1	584	586	PF00675	0.610
CLV_NRD_NRD_1	649	651	PF00675	0.597
CLV_PCSK_KEX2_1	291	293	PF00082	0.362
CLV_PCSK_KEX2_1	649	651	PF00082	0.528
CLV_PCSK_SKI1_1	329	333	PF00082	0.331
CLV_PCSK_SKI1_1	494	498	PF00082	0.411
CLV_PCSK_SKI1_1	586	590	PF00082	0.434
CLV_PCSK_SKI1_1	85	89	PF00082	0.284
DEG_APCC_DBOX_1	236	244	PF00400	0.602
DEG_Nend_UBRbox_2	1	3	PF02207	0.310
DEG_SCF_FBW7_1	301	308	PF00400	0.516
DOC_ANK_TNKS_1	635	642	PF00023	0.630
DOC_CKS1_1	302	307	PF01111	0.608
DOC_CYCLIN_RxL_1	291	304	PF00134	0.601
DOC_MAPK_DCC_7	418	427	PF00069	0.512
DOC_MAPK_DCC_7	585	595	PF00069	0.621
DOC_MAPK_gen_1	234	243	PF00069	0.645
DOC_MAPK_gen_1	418	427	PF00069	0.512
DOC_MAPK_HePTP_8	401	413	PF00069	0.489
DOC_MAPK_HePTP_8	415	427	PF00069	0.507
DOC_MAPK_MEF2A_6	158	165	PF00069	0.622
DOC_MAPK_MEF2A_6	404	413	PF00069	0.489
DOC_MAPK_MEF2A_6	418	427	PF00069	0.512
DOC_MAPK_MEF2A_6	586	595	PF00069	0.667
DOC_MAPK_NFAT4_5	158	166	PF00069	0.620
DOC_MAPK_NFAT4_5	404	412	PF00069	0.558
DOC_PP1_RVXF_1	327	333	PF00149	0.525
DOC_PP1_RVXF_1	408	414	PF00149	0.551
DOC_PP1_RVXF_1	43	50	PF00149	0.497
DOC_PP1_RVXF_1	435	441	PF00149	0.497
DOC_PP1_RVXF_1	459	465	PF00149	0.568
DOC_PP1_RVXF_1	67	74	PF00149	0.632
DOC_PP4_FxxP_1	509	512	PF00568	0.570
DOC_SPAK_OSR1_1	412	416	PF12202	0.512
DOC_USP7_MATH_1	353	357	PF00917	0.590
DOC_USP7_MATH_1	387	391	PF00917	0.636
DOC_USP7_MATH_1	483	487	PF00917	0.537
DOC_USP7_MATH_1	591	595	PF00917	0.617
DOC_USP7_MATH_1	627	631	PF00917	0.729
DOC_USP7_MATH_1	660	664	PF00917	0.658
DOC_USP7_UBL2_3	347	351	PF12436	0.523
DOC_WW_Pin1_4	301	306	PF00397	0.566
DOC_WW_Pin1_4	580	585	PF00397	0.706
DOC_WW_Pin1_4	586	591	PF00397	0.670
DOC_WW_Pin1_4	613	618	PF00397	0.663
DOC_WW_Pin1_4	666	671	PF00397	0.737
DOC_WW_Pin1_4	673	678	PF00397	0.821
LIG_14-3-3_CanoR_1	151	155	PF00244	0.614
LIG_14-3-3_CanoR_1	223	227	PF00244	0.649
LIG_14-3-3_CanoR_1	336	341	PF00244	0.528
LIG_14-3-3_CanoR_1	354	360	PF00244	0.537
LIG_14-3-3_CanoR_1	538	545	PF00244	0.721
LIG_14-3-3_CanoR_1	603	612	PF00244	0.633
LIG_APCC_ABBA_1	161	166	PF00400	0.612
LIG_APCC_ABBA_1	495	500	PF00400	0.593
LIG_APCC_ABBA_1	511	516	PF00400	0.618
LIG_APCC_ABBAyCdc20_2	364	370	PF00400	0.584
LIG_APCC_ABBAyCdc20_2	494	500	PF00400	0.594
LIG_BRCT_BRCA1_1	18	22	PF00533	0.264
LIG_BRCT_BRCA1_1	250	254	PF00533	0.599
LIG_CaM_NSCaTE_8	297	304	PF13499	0.564
LIG_Clathr_ClatBox_1	240	244	PF01394	0.604
LIG_Clathr_ClatBox_1	712	716	PF01394	0.611
LIG_FHA_1	288	294	PF00498	0.534
LIG_FHA_1	445	451	PF00498	0.580
LIG_FHA_1	463	469	PF00498	0.584
LIG_FHA_1	666	672	PF00498	0.706
LIG_FHA_1	90	96	PF00498	0.542
LIG_FHA_2	101	107	PF00498	0.624
LIG_FHA_2	217	223	PF00498	0.719
LIG_FHA_2	337	343	PF00498	0.596
LIG_FHA_2	393	399	PF00498	0.542
LIG_GBD_Chelix_1	488	496	PF00786	0.323
LIG_HP1_1	591	595	PF01393	0.617
LIG_Integrin_isoDGR_2	232	234	PF01839	0.401
LIG_LIR_Apic_2	507	512	PF02991	0.558
LIG_LIR_Gen_1	19	28	PF02991	0.467
LIG_LIR_Gen_1	295	305	PF02991	0.511
LIG_LIR_Gen_1	307	318	PF02991	0.534
LIG_LIR_Gen_1	321	331	PF02991	0.461
LIG_LIR_Gen_1	396	407	PF02991	0.501
LIG_LIR_Gen_1	48	57	PF02991	0.631
LIG_LIR_Gen_1	589	600	PF02991	0.716
LIG_LIR_Nem_3	143	148	PF02991	0.624
LIG_LIR_Nem_3	19	25	PF02991	0.387
LIG_LIR_Nem_3	279	284	PF02991	0.542
LIG_LIR_Nem_3	295	300	PF02991	0.496
LIG_LIR_Nem_3	307	313	PF02991	0.576
LIG_LIR_Nem_3	321	326	PF02991	0.532
LIG_LIR_Nem_3	396	402	PF02991	0.505
LIG_LIR_Nem_3	414	420	PF02991	0.493
LIG_LIR_Nem_3	48	52	PF02991	0.623
LIG_LIR_Nem_3	589	595	PF02991	0.715
LIG_LIR_Nem_3	8	14	PF02991	0.308
LIG_NRBOX	339	345	PF00104	0.547
LIG_PCNA_yPIPBox_3	319	329	PF02747	0.521
LIG_Pex14_2	24	28	PF04695	0.426
LIG_PTB_Apo_2	202	209	PF02174	0.554
LIG_SH2_CRK	11	15	PF00017	0.418
LIG_SH2_CRK	145	149	PF00017	0.608
LIG_SH2_STAT5	227	230	PF00017	0.609
LIG_SH3_1	695	701	PF00018	0.633
LIG_SH3_2	681	686	PF14604	0.751
LIG_SH3_3	381	387	PF00018	0.574
LIG_SH3_3	438	444	PF00018	0.530
LIG_SH3_3	452	458	PF00018	0.565
LIG_SH3_3	585	591	PF00018	0.768
LIG_SH3_3	615	621	PF00018	0.731
LIG_SH3_3	678	684	PF00018	0.703
LIG_SH3_3	695	701	PF00018	0.706
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.288
LIG_SUMO_SIM_par_1	2	8	PF11976	0.288
LIG_TRAF2_1	204	207	PF00917	0.641
LIG_TYR_ITIM	415	420	PF00017	0.513
LIG_TYR_ITSM	141	148	PF00017	0.629
LIG_UBA3_1	23	30	PF00899	0.358
LIG_UBA3_1	425	430	PF00899	0.552
LIG_UBA3_1	481	487	PF00899	0.607
LIG_WRC_WIRS_1	6	11	PF05994	0.320
LIG_WW_3	617	621	PF00397	0.659
LIG_WW_3	680	684	PF00397	0.734
MOD_CDK_SPK_2	580	585	PF00069	0.628
MOD_CDK_SPxK_1	580	586	PF00069	0.684
MOD_CDK_SPxxK_3	613	620	PF00069	0.666
MOD_CK1_1	225	231	PF00069	0.752
MOD_CK1_1	382	388	PF00069	0.583
MOD_CK1_1	392	398	PF00069	0.538
MOD_CK1_1	547	553	PF00069	0.721
MOD_CK1_1	564	570	PF00069	0.732
MOD_CK1_1	580	586	PF00069	0.709
MOD_CK1_1	594	600	PF00069	0.658
MOD_CK1_1	604	610	PF00069	0.598
MOD_CK1_1	626	632	PF00069	0.729
MOD_CK1_1	652	658	PF00069	0.710
MOD_CK2_1	216	222	PF00069	0.716
MOD_CK2_1	526	532	PF00069	0.671
MOD_Cter_Amidation	647	650	PF01082	0.434
MOD_GlcNHglycan	206	211	PF01048	0.349
MOD_GlcNHglycan	250	253	PF01048	0.559
MOD_GlcNHglycan	256	259	PF01048	0.471
MOD_GlcNHglycan	268	271	PF01048	0.459
MOD_GlcNHglycan	391	394	PF01048	0.372
MOD_GlcNHglycan	520	526	PF01048	0.524
MOD_GlcNHglycan	528	531	PF01048	0.478
MOD_GlcNHglycan	549	552	PF01048	0.552
MOD_GlcNHglycan	574	578	PF01048	0.610
MOD_GlcNHglycan	579	582	PF01048	0.496
MOD_GlcNHglycan	596	599	PF01048	0.395
MOD_GlcNHglycan	602	606	PF01048	0.539
MOD_GlcNHglycan	625	628	PF01048	0.574
MOD_GlcNHglycan	629	632	PF01048	0.539
MOD_GlcNHglycan	646	649	PF01048	0.421
MOD_GlcNHglycan	89	92	PF01048	0.300
MOD_GSK3_1	244	251	PF00069	0.685
MOD_GSK3_1	300	307	PF00069	0.603
MOD_GSK3_1	332	339	PF00069	0.583
MOD_GSK3_1	483	490	PF00069	0.537
MOD_GSK3_1	540	547	PF00069	0.733
MOD_GSK3_1	560	567	PF00069	0.838
MOD_GSK3_1	573	580	PF00069	0.657
MOD_GSK3_1	604	611	PF00069	0.678
MOD_GSK3_1	623	630	PF00069	0.728
MOD_GSK3_1	644	651	PF00069	0.713
MOD_N-GLC_1	382	387	PF02516	0.356
MOD_N-GLC_1	538	543	PF02516	0.445
MOD_NEK2_1	254	259	PF00069	0.742
MOD_NEK2_1	300	305	PF00069	0.641
MOD_NEK2_1	332	337	PF00069	0.530
MOD_NEK2_1	35	40	PF00069	0.572
MOD_NEK2_1	545	550	PF00069	0.713
MOD_PIKK_1	276	282	PF00454	0.518
MOD_PIKK_1	305	311	PF00454	0.512
MOD_PIKK_1	462	468	PF00454	0.595
MOD_PIKK_1	575	581	PF00454	0.638
MOD_PIKK_1	604	610	PF00454	0.633
MOD_PIKK_1	650	656	PF00454	0.664
MOD_PKA_1	649	655	PF00069	0.797
MOD_PKA_2	130	136	PF00069	0.575
MOD_PKA_2	150	156	PF00069	0.645
MOD_PKA_2	222	228	PF00069	0.596
MOD_PKA_2	353	359	PF00069	0.593
MOD_PKA_2	411	417	PF00069	0.552
MOD_PKA_2	537	543	PF00069	0.704
MOD_PKA_2	648	654	PF00069	0.703
MOD_PKB_1	195	203	PF00069	0.604
MOD_PKB_1	558	566	PF00069	0.687
MOD_Plk_4	150	156	PF00069	0.573
MOD_Plk_4	167	173	PF00069	0.652
MOD_Plk_4	188	194	PF00069	0.545
MOD_Plk_4	2	8	PF00069	0.391
MOD_Plk_4	222	228	PF00069	0.640
MOD_ProDKin_1	301	307	PF00069	0.566
MOD_ProDKin_1	580	586	PF00069	0.707
MOD_ProDKin_1	613	619	PF00069	0.661
MOD_ProDKin_1	666	672	PF00069	0.737
MOD_ProDKin_1	673	679	PF00069	0.817
MOD_SUMO_for_1	62	65	PF00179	0.594
MOD_SUMO_rev_2	206	215	PF00179	0.607
MOD_SUMO_rev_2	342	348	PF00179	0.592
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.534
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.617
TRG_ENDOCYTIC_2	11	14	PF00928	0.342
TRG_ENDOCYTIC_2	145	148	PF00928	0.611
TRG_ENDOCYTIC_2	226	229	PF00928	0.608
TRG_ENDOCYTIC_2	417	420	PF00928	0.524
TRG_ER_diArg_1	291	293	PF00400	0.601
TRG_NLS_MonoExtN_4	347	353	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	662	667	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN3	Leptomonas seymouri	65%	98%
A0A1X0NNZ4	Trypanosomatidae	42%	100%
A0A3S5H6M5	Leishmania donovani	65%	100%
E9AGI1	Leishmania infantum	66%	100%
E9AP17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QGH2	Leishmania major	70%	100%
V5DG13	Trypanosoma cruzi	29%	100%