SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania braziliensis

UniProt:

A4H6Z6_LEIBR

TriTrypDb:

LbrM.12.0840 , LBRM2903_200077500

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H6Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008289	lipid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.592
CLV_NRD_NRD_1	309	311	PF00675	0.557
CLV_NRD_NRD_1	345	347	PF00675	0.553
CLV_NRD_NRD_1	75	77	PF00675	0.359
CLV_PCSK_KEX2_1	309	311	PF00082	0.557
CLV_PCSK_KEX2_1	487	489	PF00082	0.515
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.515
CLV_PCSK_SKI1_1	143	147	PF00082	0.306
CLV_PCSK_SKI1_1	203	207	PF00082	0.395
CLV_PCSK_SKI1_1	208	212	PF00082	0.392
CLV_PCSK_SKI1_1	265	269	PF00082	0.436
CLV_PCSK_SKI1_1	346	350	PF00082	0.652
CLV_PCSK_SKI1_1	496	500	PF00082	0.450
CLV_PCSK_SKI1_1	507	511	PF00082	0.463
CLV_PCSK_SKI1_1	56	60	PF00082	0.527
DEG_APCC_DBOX_1	202	210	PF00400	0.412
DEG_APCC_DBOX_1	75	83	PF00400	0.339
DEG_SCF_FBW7_1	452	459	PF00400	0.547
DEG_SPOP_SBC_1	339	343	PF00917	0.554
DEG_SPOP_SBC_1	456	460	PF00917	0.542
DOC_CDC14_PxL_1	210	218	PF14671	0.336
DOC_CKS1_1	453	458	PF01111	0.547
DOC_MAPK_gen_1	496	504	PF00069	0.467
DOC_MAPK_MEF2A_6	187	195	PF00069	0.327
DOC_MAPK_RevD_3	70	86	PF00069	0.351
DOC_PP4_FxxP_1	240	243	PF00568	0.451
DOC_USP7_MATH_1	115	119	PF00917	0.566
DOC_USP7_MATH_1	241	245	PF00917	0.381
DOC_USP7_MATH_1	249	253	PF00917	0.487
DOC_USP7_MATH_1	278	282	PF00917	0.616
DOC_USP7_MATH_1	327	331	PF00917	0.580
DOC_USP7_MATH_1	390	394	PF00917	0.528
DOC_USP7_MATH_1	462	466	PF00917	0.526
DOC_USP7_MATH_1	486	490	PF00917	0.507
DOC_USP7_MATH_1	494	498	PF00917	0.410
DOC_USP7_UBL2_3	499	503	PF12436	0.456
DOC_USP7_UBL2_3	73	77	PF12436	0.420
DOC_WW_Pin1_4	245	250	PF00397	0.440
DOC_WW_Pin1_4	274	279	PF00397	0.547
DOC_WW_Pin1_4	364	369	PF00397	0.655
DOC_WW_Pin1_4	401	406	PF00397	0.695
DOC_WW_Pin1_4	452	457	PF00397	0.548
LIG_14-3-3_CanoR_1	116	123	PF00244	0.339
LIG_14-3-3_CanoR_1	143	149	PF00244	0.477
LIG_14-3-3_CanoR_1	208	216	PF00244	0.351
LIG_14-3-3_CanoR_1	23	28	PF00244	0.361
LIG_14-3-3_CanoR_1	309	313	PF00244	0.554
LIG_14-3-3_CanoR_1	346	351	PF00244	0.703
LIG_14-3-3_CanoR_1	406	410	PF00244	0.678
LIG_14-3-3_CanoR_1	435	445	PF00244	0.553
LIG_14-3-3_CanoR_1	488	498	PF00244	0.462
LIG_APCC_ABBA_1	226	231	PF00400	0.535
LIG_APCC_ABBA_1	233	238	PF00400	0.437
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.534
LIG_BRCT_BRCA1_1	138	142	PF00533	0.281
LIG_BRCT_BRCA1_1	177	181	PF00533	0.335
LIG_BRCT_BRCA1_1	384	388	PF00533	0.680
LIG_BRCT_BRCA1_1	54	58	PF00533	0.334
LIG_BRCT_BRCA1_1	83	87	PF00533	0.408
LIG_Clathr_ClatBox_1	162	166	PF01394	0.284
LIG_FHA_1	166	172	PF00498	0.304
LIG_FHA_1	219	225	PF00498	0.343
LIG_FHA_1	334	340	PF00498	0.688
LIG_FHA_2	347	353	PF00498	0.540
LIG_LIR_Apic_2	238	243	PF02991	0.442
LIG_LIR_Gen_1	126	131	PF02991	0.364
LIG_LIR_Gen_1	135	146	PF02991	0.392
LIG_LIR_Gen_1	22	31	PF02991	0.347
LIG_LIR_Gen_1	252	261	PF02991	0.612
LIG_LIR_Gen_1	65	75	PF02991	0.489
LIG_LIR_Gen_1	7	15	PF02991	0.567
LIG_LIR_Nem_3	126	130	PF02991	0.368
LIG_LIR_Nem_3	135	141	PF02991	0.395
LIG_LIR_Nem_3	147	151	PF02991	0.421
LIG_LIR_Nem_3	22	27	PF02991	0.352
LIG_LIR_Nem_3	252	256	PF02991	0.463
LIG_LIR_Nem_3	65	70	PF02991	0.497
LIG_LIR_Nem_3	7	11	PF02991	0.643
LIG_LRP6_Inhibitor_1	219	225	PF00058	0.296
LIG_MLH1_MIPbox_1	138	142	PF16413	0.281
LIG_MLH1_MIPbox_1	54	58	PF16413	0.334
LIG_NRBOX	497	503	PF00104	0.449
LIG_Pex14_2	138	142	PF04695	0.281
LIG_Pex14_2	53	57	PF04695	0.312
LIG_REV1ctd_RIR_1	139	147	PF16727	0.294
LIG_SH2_CRK	148	152	PF00017	0.366
LIG_SH2_STAP1	40	44	PF00017	0.344
LIG_SH2_STAP1	448	452	PF00017	0.559
LIG_SH2_STAT5	148	151	PF00017	0.494
LIG_SH2_STAT5	227	230	PF00017	0.353
LIG_SH3_3	109	115	PF00018	0.547
LIG_SH3_3	243	249	PF00018	0.435
LIG_SH3_3	393	399	PF00018	0.532
LIG_SH3_3	419	425	PF00018	0.617
LIG_SH3_3	450	456	PF00018	0.552
LIG_SUMO_SIM_par_1	161	168	PF11976	0.313
LIG_SUMO_SIM_par_1	398	404	PF11976	0.547
LIG_TYR_ITIM	146	151	PF00017	0.422
LIG_UBA3_1	27	32	PF00899	0.366
LIG_UBA3_1	71	77	PF00899	0.323
LIG_WRC_WIRS_1	312	317	PF05994	0.551
MOD_CDK_SPK_2	245	250	PF00069	0.452
MOD_CDK_SPK_2	401	406	PF00069	0.554
MOD_CDK_SPxK_1	274	280	PF00069	0.551
MOD_CK1_1	110	116	PF00069	0.436
MOD_CK1_1	281	287	PF00069	0.680
MOD_CK1_1	311	317	PF00069	0.542
MOD_CK1_1	330	336	PF00069	0.554
MOD_CK1_1	338	344	PF00069	0.631
MOD_CK1_1	353	359	PF00069	0.618
MOD_CK1_1	369	375	PF00069	0.707
MOD_CK1_1	384	390	PF00069	0.456
MOD_CK1_1	404	410	PF00069	0.665
MOD_CK1_1	482	488	PF00069	0.526
MOD_CK1_1	489	495	PF00069	0.425
MOD_CK2_1	301	307	PF00069	0.612
MOD_Cter_Amidation	307	310	PF01082	0.567
MOD_GlcNHglycan	117	120	PF01048	0.361
MOD_GlcNHglycan	200	203	PF01048	0.414
MOD_GlcNHglycan	216	219	PF01048	0.309
MOD_GlcNHglycan	269	272	PF01048	0.528
MOD_GlcNHglycan	28	31	PF01048	0.429
MOD_GlcNHglycan	280	283	PF01048	0.575
MOD_GlcNHglycan	316	319	PF01048	0.656
MOD_GlcNHglycan	329	332	PF01048	0.596
MOD_GlcNHglycan	371	374	PF01048	0.702
MOD_GlcNHglycan	384	387	PF01048	0.633
MOD_GlcNHglycan	448	451	PF01048	0.559
MOD_GlcNHglycan	459	462	PF01048	0.490
MOD_GlcNHglycan	470	473	PF01048	0.485
MOD_GlcNHglycan	484	487	PF01048	0.478
MOD_GlcNHglycan	488	491	PF01048	0.479
MOD_GSK3_1	165	172	PF00069	0.291
MOD_GSK3_1	214	221	PF00069	0.415
MOD_GSK3_1	241	248	PF00069	0.414
MOD_GSK3_1	274	281	PF00069	0.637
MOD_GSK3_1	335	342	PF00069	0.639
MOD_GSK3_1	346	353	PF00069	0.712
MOD_GSK3_1	401	408	PF00069	0.671
MOD_GSK3_1	444	451	PF00069	0.556
MOD_GSK3_1	452	459	PF00069	0.519
MOD_GSK3_1	482	489	PF00069	0.540
MOD_GSK3_1	510	517	PF00069	0.520
MOD_N-GLC_1	110	115	PF02516	0.426
MOD_N-GLC_1	214	219	PF02516	0.337
MOD_N-GLC_1	390	395	PF02516	0.525
MOD_N-GLC_1	462	467	PF02516	0.526
MOD_N-GLC_1	468	473	PF02516	0.504
MOD_N-GLC_1	474	479	PF02516	0.479
MOD_N-GLC_1	65	70	PF02516	0.337
MOD_NEK2_1	101	106	PF00069	0.355
MOD_NEK2_1	144	149	PF00069	0.326
MOD_NEK2_1	165	170	PF00069	0.302
MOD_NEK2_1	350	355	PF00069	0.619
MOD_NEK2_1	52	57	PF00069	0.370
MOD_NEK2_2	136	141	PF00069	0.289
MOD_NEK2_2	462	467	PF00069	0.526
MOD_NEK2_2	494	499	PF00069	0.442
MOD_PIKK_1	101	107	PF00454	0.329
MOD_PIKK_1	291	297	PF00454	0.575
MOD_PIKK_1	355	361	PF00454	0.576
MOD_PKA_1	346	352	PF00069	0.553
MOD_PKA_2	115	121	PF00069	0.349
MOD_PKA_2	308	314	PF00069	0.552
MOD_PKA_2	405	411	PF00069	0.556
MOD_PKA_2	510	516	PF00069	0.541
MOD_Plk_1	165	171	PF00069	0.293
MOD_Plk_1	351	357	PF00069	0.554
MOD_Plk_1	390	396	PF00069	0.525
MOD_Plk_1	431	437	PF00069	0.566
MOD_Plk_1	462	468	PF00069	0.526
MOD_Plk_1	479	485	PF00069	0.472
MOD_Plk_2-3	335	341	PF00069	0.557
MOD_Plk_4	23	29	PF00069	0.475
MOD_Plk_4	241	247	PF00069	0.408
MOD_Plk_4	346	352	PF00069	0.640
MOD_Plk_4	462	468	PF00069	0.526
MOD_ProDKin_1	245	251	PF00069	0.437
MOD_ProDKin_1	274	280	PF00069	0.551
MOD_ProDKin_1	364	370	PF00069	0.651
MOD_ProDKin_1	401	407	PF00069	0.696
MOD_ProDKin_1	452	458	PF00069	0.548
MOD_SUMO_for_1	13	16	PF00179	0.359
MOD_SUMO_for_1	473	476	PF00179	0.523
MOD_SUMO_rev_2	284	294	PF00179	0.568
TRG_ENDOCYTIC_2	148	151	PF00928	0.446
TRG_ER_diArg_1	256	259	PF00400	0.450
TRG_ER_diArg_1	433	436	PF00400	0.596
TRG_ER_diLys_1	518	521	PF00400	0.556
TRG_NES_CRM1_1	493	508	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4QGH2	Leishmania major	34%	72%
V5DG13	Trypanosoma cruzi	43%	78%