N-ethylmaleimide reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-ethylmaleimide reductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H6Z4_LEIBR

TriTrypDb:

LbrM.12.0820 , LBRM2903_200077800

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H6Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0010181	FMN binding	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0032553	ribonucleotide binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.634
CLV_C14_Caspase3-7	267	271	PF00656	0.431
CLV_C14_Caspase3-7	632	636	PF00656	0.532
CLV_C14_Caspase3-7	687	691	PF00656	0.470
CLV_NRD_NRD_1	271	273	PF00675	0.279
CLV_NRD_NRD_1	297	299	PF00675	0.332
CLV_NRD_NRD_1	459	461	PF00675	0.332
CLV_NRD_NRD_1	609	611	PF00675	0.327
CLV_NRD_NRD_1	644	646	PF00675	0.332
CLV_NRD_NRD_1	677	679	PF00675	0.332
CLV_NRD_NRD_1	783	785	PF00675	0.592
CLV_PCSK_KEX2_1	297	299	PF00082	0.332
CLV_PCSK_KEX2_1	459	461	PF00082	0.332
CLV_PCSK_KEX2_1	609	611	PF00082	0.231
CLV_PCSK_KEX2_1	643	645	PF00082	0.332
CLV_PCSK_KEX2_1	726	728	PF00082	0.468
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.468
CLV_PCSK_SKI1_1	171	175	PF00082	0.332
CLV_PCSK_SKI1_1	222	226	PF00082	0.434
CLV_PCSK_SKI1_1	273	277	PF00082	0.293
CLV_PCSK_SKI1_1	343	347	PF00082	0.332
CLV_PCSK_SKI1_1	496	500	PF00082	0.332
CLV_PCSK_SKI1_1	657	661	PF00082	0.332
CLV_PCSK_SKI1_1	727	731	PF00082	0.339
CLV_PCSK_SKI1_1	90	94	PF00082	0.434
DEG_APCC_DBOX_1	174	182	PF00400	0.431
DEG_APCC_DBOX_1	221	229	PF00400	0.532
DEG_COP1_1	38	45	PF00400	0.634
DEG_SCF_FBW7_1	242	249	PF00400	0.532
DOC_ANK_TNKS_1	284	291	PF00023	0.532
DOC_CYCLIN_RxL_1	219	229	PF00134	0.634
DOC_MAPK_gen_1	220	227	PF00069	0.547
DOC_MAPK_gen_1	236	244	PF00069	0.523
DOC_MAPK_gen_1	272	279	PF00069	0.493
DOC_MAPK_gen_1	411	418	PF00069	0.404
DOC_MAPK_gen_1	459	467	PF00069	0.532
DOC_MAPK_gen_1	571	580	PF00069	0.532
DOC_MAPK_gen_1	643	650	PF00069	0.532
DOC_MAPK_gen_1	678	685	PF00069	0.532
DOC_MAPK_MEF2A_6	236	244	PF00069	0.543
DOC_MAPK_MEF2A_6	411	418	PF00069	0.404
DOC_MAPK_MEF2A_6	571	580	PF00069	0.532
DOC_MAPK_MEF2A_6	643	650	PF00069	0.532
DOC_PP1_RVXF_1	270	277	PF00149	0.634
DOC_PP1_RVXF_1	569	575	PF00149	0.532
DOC_PP4_FxxP_1	377	380	PF00568	0.615
DOC_PP4_FxxP_1	873	876	PF00568	0.549
DOC_USP7_MATH_1	169	173	PF00917	0.487
DOC_USP7_MATH_1	218	222	PF00917	0.431
DOC_USP7_MATH_1	414	418	PF00917	0.363
DOC_USP7_MATH_1	686	690	PF00917	0.583
DOC_USP7_MATH_1	758	762	PF00917	0.434
DOC_USP7_MATH_1	792	796	PF00917	0.662
DOC_USP7_MATH_1	833	837	PF00917	0.575
DOC_USP7_MATH_1	868	872	PF00917	0.534
DOC_WW_Pin1_4	112	117	PF00397	0.532
DOC_WW_Pin1_4	159	164	PF00397	0.431
DOC_WW_Pin1_4	242	247	PF00397	0.634
DOC_WW_Pin1_4	345	350	PF00397	0.449
DOC_WW_Pin1_4	539	544	PF00397	0.431
DOC_WW_Pin1_4	619	624	PF00397	0.532
DOC_WW_Pin1_4	648	653	PF00397	0.532
DOC_WW_Pin1_4	821	826	PF00397	0.599
DOC_WW_Pin1_4	841	846	PF00397	0.501
LIG_14-3-3_CanoR_1	112	116	PF00244	0.634
LIG_14-3-3_CanoR_1	297	301	PF00244	0.532
LIG_14-3-3_CanoR_1	402	409	PF00244	0.597
LIG_14-3-3_CanoR_1	413	419	PF00244	0.371
LIG_14-3-3_CanoR_1	459	464	PF00244	0.532
LIG_14-3-3_CanoR_1	54	58	PF00244	0.634
LIG_14-3-3_CanoR_1	727	736	PF00244	0.316
LIG_14-3-3_CanoR_1	839	845	PF00244	0.557
LIG_Actin_WH2_2	558	575	PF00022	0.522
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BRCT_BRCA1_1	9	13	PF00533	0.366
LIG_CaMK_CASK_1	293	298	PF00069	0.532
LIG_deltaCOP1_diTrp_1	293	300	PF00928	0.532
LIG_FHA_1	260	266	PF00498	0.634
LIG_FHA_1	497	503	PF00498	0.532
LIG_FHA_1	529	535	PF00498	0.497
LIG_FHA_1	60	66	PF00498	0.532
LIG_FHA_1	666	672	PF00498	0.431
LIG_FHA_1	728	734	PF00498	0.327
LIG_FHA_1	91	97	PF00498	0.634
LIG_FHA_2	118	124	PF00498	0.439
LIG_FHA_2	160	166	PF00498	0.564
LIG_FHA_2	243	249	PF00498	0.532
LIG_FHA_2	309	315	PF00498	0.517
LIG_FHA_2	612	618	PF00498	0.532
LIG_FHA_2	660	666	PF00498	0.532
LIG_FHA_2	777	783	PF00498	0.531
LIG_FHA_2	89	95	PF00498	0.485
LIG_Integrin_RGD_1	281	283	PF01839	0.426
LIG_LIR_Apic_2	376	380	PF02991	0.587
LIG_LIR_Apic_2	690	696	PF02991	0.521
LIG_LIR_Apic_2	870	876	PF02991	0.547
LIG_LIR_Gen_1	307	316	PF02991	0.431
LIG_LIR_Gen_1	7	15	PF02991	0.359
LIG_LIR_Gen_1	779	787	PF02991	0.547
LIG_LIR_Nem_3	307	313	PF02991	0.487
LIG_LIR_Nem_3	339	345	PF02991	0.542
LIG_LIR_Nem_3	363	369	PF02991	0.596
LIG_LIR_Nem_3	462	466	PF02991	0.530
LIG_LIR_Nem_3	7	12	PF02991	0.364
LIG_LIR_Nem_3	771	777	PF02991	0.593
LIG_LIR_Nem_3	87	92	PF02991	0.578
LIG_LYPXL_yS_3	154	157	PF13949	0.431
LIG_REV1ctd_RIR_1	356	365	PF16727	0.463
LIG_RPA_C_Fungi	454	466	PF08784	0.385
LIG_SH2_CRK	463	467	PF00017	0.385
LIG_SH2_CRK	510	514	PF00017	0.385
LIG_SH2_CRK	693	697	PF00017	0.507
LIG_SH2_PTP2	415	418	PF00017	0.346
LIG_SH2_PTP2	682	685	PF00017	0.363
LIG_SH2_SRC	76	79	PF00017	0.385
LIG_SH2_STAP1	457	461	PF00017	0.320
LIG_SH2_STAP1	774	778	PF00017	0.447
LIG_SH2_STAP1	9	13	PF00017	0.473
LIG_SH2_STAT5	196	199	PF00017	0.527
LIG_SH2_STAT5	264	267	PF00017	0.517
LIG_SH2_STAT5	310	313	PF00017	0.363
LIG_SH2_STAT5	366	369	PF00017	0.545
LIG_SH2_STAT5	415	418	PF00017	0.488
LIG_SH2_STAT5	480	483	PF00017	0.385
LIG_SH2_STAT5	510	513	PF00017	0.385
LIG_SH2_STAT5	579	582	PF00017	0.385
LIG_SH2_STAT5	602	605	PF00017	0.385
LIG_SH2_STAT5	682	685	PF00017	0.375
LIG_SH2_STAT5	777	780	PF00017	0.440
LIG_SH3_3	123	129	PF00018	0.385
LIG_SH3_3	15	21	PF00018	0.446
LIG_SH3_3	25	31	PF00018	0.429
LIG_SH3_3	415	421	PF00018	0.494
LIG_SH3_3	431	437	PF00018	0.237
LIG_SUMO_SIM_par_1	223	229	PF11976	0.385
LIG_SUMO_SIM_par_1	563	568	PF11976	0.243
LIG_TRAF2_2	439	444	PF00917	0.385
LIG_TYR_ITIM	508	513	PF00017	0.385
LIG_TYR_ITIM	680	685	PF00017	0.385
LIG_WRC_WIRS_1	170	175	PF05994	0.320
LIG_WRC_WIRS_1	198	203	PF05994	0.385
LIG_WRC_WIRS_1	247	252	PF05994	0.527
MOD_CDK_SPxxK_3	345	352	PF00069	0.243
MOD_CDK_SPxxK_3	539	546	PF00069	0.243
MOD_CDK_SPxxK_3	619	626	PF00069	0.385
MOD_CK1_1	390	396	PF00069	0.551
MOD_CK1_1	53	59	PF00069	0.385
MOD_CK1_1	776	782	PF00069	0.521
MOD_CK1_1	824	830	PF00069	0.547
MOD_CK1_1	838	844	PF00069	0.535
MOD_CK1_1	88	94	PF00069	0.243
MOD_CK2_1	159	165	PF00069	0.396
MOD_CK2_1	253	259	PF00069	0.363
MOD_CK2_1	308	314	PF00069	0.243
MOD_CK2_1	373	379	PF00069	0.467
MOD_CK2_1	659	665	PF00069	0.243
MOD_CK2_1	717	723	PF00069	0.475
MOD_CK2_1	776	782	PF00069	0.542
MOD_CK2_1	88	94	PF00069	0.320
MOD_Cter_Amidation	641	644	PF01082	0.385
MOD_DYRK1A_RPxSP_1	112	116	PF00069	0.385
MOD_GlcNHglycan	1	4	PF01048	0.756
MOD_GlcNHglycan	120	123	PF01048	0.385
MOD_GlcNHglycan	129	132	PF01048	0.454
MOD_GlcNHglycan	290	293	PF01048	0.325
MOD_GlcNHglycan	526	529	PF01048	0.279
MOD_GlcNHglycan	567	570	PF01048	0.385
MOD_GlcNHglycan	686	689	PF01048	0.448
MOD_GlcNHglycan	71	74	PF01048	0.393
MOD_GlcNHglycan	794	797	PF01048	0.660
MOD_GlcNHglycan	798	801	PF01048	0.611
MOD_GlcNHglycan	81	84	PF01048	0.295
MOD_GlcNHglycan	818	821	PF01048	0.486
MOD_GlcNHglycan	835	838	PF01048	0.524
MOD_GlcNHglycan	870	873	PF01048	0.556
MOD_GSK3_1	203	210	PF00069	0.363
MOD_GSK3_1	242	249	PF00069	0.527
MOD_GSK3_1	304	311	PF00069	0.276
MOD_GSK3_1	524	531	PF00069	0.307
MOD_GSK3_1	697	704	PF00069	0.318
MOD_GSK3_1	758	765	PF00069	0.441
MOD_GSK3_1	792	799	PF00069	0.552
MOD_GSK3_1	823	830	PF00069	0.552
MOD_GSK3_1	868	875	PF00069	0.539
MOD_N-GLC_1	117	122	PF02516	0.385
MOD_N-GLC_1	218	223	PF02516	0.385
MOD_N-GLC_1	4	9	PF02516	0.436
MOD_N-GLC_1	523	528	PF02516	0.363
MOD_N-GLC_1	69	74	PF02516	0.331
MOD_N-GLC_1	717	722	PF02516	0.473
MOD_N-GLC_1	816	821	PF02516	0.541
MOD_NEK2_1	197	202	PF00069	0.499
MOD_NEK2_1	424	429	PF00069	0.315
MOD_NEK2_1	701	706	PF00069	0.291
MOD_NEK2_2	4	9	PF00069	0.436
MOD_NEK2_2	425	430	PF00069	0.385
MOD_PIKK_1	416	422	PF00454	0.487
MOD_PKA_1	459	465	PF00069	0.385
MOD_PKA_1	609	615	PF00069	0.385
MOD_PKA_2	111	117	PF00069	0.527
MOD_PKA_2	202	208	PF00069	0.243
MOD_PKA_2	296	302	PF00069	0.385
MOD_PKA_2	360	366	PF00069	0.478
MOD_PKA_2	396	402	PF00069	0.688
MOD_PKA_2	459	465	PF00069	0.382
MOD_PKA_2	53	59	PF00069	0.527
MOD_PKA_2	609	615	PF00069	0.243
MOD_PKA_2	792	798	PF00069	0.660
MOD_PKA_2	838	844	PF00069	0.566
MOD_Plk_1	218	224	PF00069	0.385
MOD_Plk_1	4	10	PF00069	0.426
MOD_Plk_1	717	723	PF00069	0.471
MOD_Plk_2-3	373	379	PF00069	0.561
MOD_Plk_2-3	717	723	PF00069	0.475
MOD_Plk_4	197	203	PF00069	0.385
MOD_Plk_4	354	360	PF00069	0.638
MOD_Plk_4	4	10	PF00069	0.426
MOD_Plk_4	476	482	PF00069	0.385
MOD_Plk_4	61	67	PF00069	0.243
MOD_Plk_4	697	703	PF00069	0.400
MOD_Plk_4	762	768	PF00069	0.587
MOD_Plk_4	773	779	PF00069	0.485
MOD_ProDKin_1	112	118	PF00069	0.385
MOD_ProDKin_1	159	165	PF00069	0.243
MOD_ProDKin_1	242	248	PF00069	0.527
MOD_ProDKin_1	345	351	PF00069	0.269
MOD_ProDKin_1	539	545	PF00069	0.243
MOD_ProDKin_1	619	625	PF00069	0.385
MOD_ProDKin_1	648	654	PF00069	0.385
MOD_ProDKin_1	821	827	PF00069	0.599
MOD_ProDKin_1	841	847	PF00069	0.504
MOD_SUMO_rev_2	146	151	PF00179	0.385
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.385
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.385
TRG_ENDOCYTIC_2	154	157	PF00928	0.276
TRG_ENDOCYTIC_2	310	313	PF00928	0.336
TRG_ENDOCYTIC_2	415	418	PF00928	0.488
TRG_ENDOCYTIC_2	463	466	PF00928	0.385
TRG_ENDOCYTIC_2	510	513	PF00928	0.385
TRG_ENDOCYTIC_2	682	685	PF00928	0.385
TRG_ENDOCYTIC_2	71	74	PF00928	0.527
TRG_ENDOCYTIC_2	780	783	PF00928	0.581
TRG_ENDOCYTIC_2	9	12	PF00928	0.476
TRG_ER_diArg_1	220	223	PF00400	0.527
TRG_ER_diArg_1	296	298	PF00400	0.385
TRG_ER_diArg_1	439	442	PF00400	0.385
TRG_ER_diArg_1	608	610	PF00400	0.257
TRG_ER_diArg_1	626	629	PF00400	0.346
TRG_ER_diArg_1	643	645	PF00400	0.227
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8C3	Leishmania donovani	81%	100%
E9AGH8	Leishmania infantum	81%	100%
E9AP14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QGH5	Leishmania major	81%	100%