Putative NADH:flavin oxidoreductase/NADH oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH:flavin oxidoreductase/NADH oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Z3_LEIBR

TriTrypDb:

LbrM.12.0810 , LBRM2903_200077900

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H6Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0010181	FMN binding	4	12
GO:0016491	oxidoreductase activity	2	12
GO:0032553	ribonucleotide binding	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.578
CLV_C14_Caspase3-7	83	87	PF00656	0.548
CLV_NRD_NRD_1	88	90	PF00675	0.348
CLV_PCSK_SKI1_1	217	221	PF00082	0.378
CLV_PCSK_SKI1_1	89	93	PF00082	0.381
DEG_COP1_1	37	44	PF00400	0.566
DOC_CKS1_1	343	348	PF01111	0.477
DOC_CKS1_1	41	46	PF01111	0.453
DOC_CYCLIN_RxL_1	214	224	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.462
DOC_MAPK_gen_1	232	239	PF00069	0.600
DOC_MAPK_MEF2A_6	232	239	PF00069	0.578
DOC_MAPK_MEF2A_6	53	60	PF00069	0.614
DOC_MAPK_NFAT4_5	53	61	PF00069	0.614
DOC_PP1_RVXF_1	265	272	PF00149	0.614
DOC_PP2B_LxvP_1	20	23	PF13499	0.445
DOC_USP7_MATH_1	2	6	PF00917	0.724
DOC_USP7_MATH_1	241	245	PF00917	0.584
DOC_USP7_MATH_1	373	377	PF00917	0.673
DOC_WW_Pin1_4	237	242	PF00397	0.511
DOC_WW_Pin1_4	342	347	PF00397	0.555
DOC_WW_Pin1_4	40	45	PF00397	0.453
LIG_14-3-3_CanoR_1	111	115	PF00244	0.564
LIG_14-3-3_CanoR_1	267	272	PF00244	0.519
LIG_14-3-3_CanoR_1	53	57	PF00244	0.524
LIG_Actin_WH2_2	223	240	PF00022	0.536
LIG_FHA_1	255	261	PF00498	0.536
LIG_FHA_1	323	329	PF00498	0.614
LIG_FHA_1	90	96	PF00498	0.554
LIG_FHA_2	131	137	PF00498	0.471
LIG_FHA_2	155	161	PF00498	0.504
LIG_FHA_2	62	68	PF00498	0.461
LIG_Integrin_RGD_1	276	278	PF01839	0.328
LIG_IRF3_LxIS_1	235	240	PF10401	0.554
LIG_LIR_Gen_1	270	279	PF02991	0.590
LIG_LIR_Gen_1	67	76	PF02991	0.453
LIG_LIR_Nem_3	270	274	PF02991	0.531
LIG_LIR_Nem_3	292	297	PF02991	0.555
LIG_LIR_Nem_3	356	362	PF02991	0.490
LIG_LIR_Nem_3	67	73	PF02991	0.453
LIG_LIR_Nem_3	86	91	PF02991	0.537
LIG_LYPXL_yS_3	362	365	PF13949	0.485
LIG_SH2_NCK_1	168	172	PF00017	0.578
LIG_SH2_PTP2	164	167	PF00017	0.548
LIG_SH2_STAP1	168	172	PF00017	0.578
LIG_SH2_STAP1	50	54	PF00017	0.522
LIG_SH2_STAT5	164	167	PF00017	0.627
LIG_SH2_STAT5	191	194	PF00017	0.540
LIG_SH2_STAT5	259	262	PF00017	0.559
LIG_SH3_3	24	30	PF00018	0.546
LIG_SH3_3	38	44	PF00018	0.546
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.453
LIG_UBA3_1	219	228	PF00899	0.571
LIG_WRC_WIRS_1	242	247	PF05994	0.643
LIG_WRC_WIRS_1	70	75	PF05994	0.608
MOD_CK1_1	244	250	PF00069	0.453
MOD_CK1_1	364	370	PF00069	0.497
MOD_CK2_1	130	136	PF00069	0.471
MOD_CK2_1	350	356	PF00069	0.634
MOD_CK2_1	61	67	PF00069	0.467
MOD_GlcNHglycan	127	130	PF01048	0.336
MOD_GlcNHglycan	314	317	PF01048	0.366
MOD_GlcNHglycan	370	373	PF01048	0.624
MOD_GSK3_1	198	205	PF00069	0.533
MOD_GSK3_1	237	244	PF00069	0.554
MOD_GSK3_1	259	266	PF00069	0.469
MOD_GSK3_1	347	354	PF00069	0.607
MOD_GSK3_1	361	368	PF00069	0.383
MOD_N-GLC_1	267	272	PF02516	0.253
MOD_N-GLC_2	214	216	PF02516	0.348
MOD_NEK2_1	167	172	PF00069	0.516
MOD_NEK2_1	196	201	PF00069	0.515
MOD_NEK2_1	365	370	PF00069	0.737
MOD_PIKK_1	244	250	PF00454	0.569
MOD_PIKK_1	259	265	PF00454	0.649
MOD_PIKK_1	278	284	PF00454	0.426
MOD_PIKK_1	61	67	PF00454	0.566
MOD_PKA_1	89	95	PF00069	0.578
MOD_PKA_2	110	116	PF00069	0.614
MOD_PKA_2	52	58	PF00069	0.557
MOD_Plk_1	267	273	PF00069	0.453
MOD_Plk_1	61	67	PF00069	0.562
MOD_Plk_4	347	353	PF00069	0.596
MOD_Plk_4	361	367	PF00069	0.609
MOD_ProDKin_1	237	243	PF00069	0.511
MOD_ProDKin_1	342	348	PF00069	0.559
MOD_ProDKin_1	40	46	PF00069	0.453
TRG_DiLeu_BaEn_1	97	102	PF01217	0.453
TRG_ENDOCYTIC_2	164	167	PF00928	0.572
TRG_ENDOCYTIC_2	294	297	PF00928	0.554
TRG_ENDOCYTIC_2	362	365	PF00928	0.569
TRG_ENDOCYTIC_2	70	73	PF00928	0.523
TRG_ER_diArg_1	215	218	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2A2	Leptomonas seymouri	72%	100%
A0A0N0P2S0	Leptomonas seymouri	33%	100%
A0A0N1HZB3	Leptomonas seymouri	40%	68%
A0A0S4IVY9	Bodo saltans	33%	100%
A0A0S4IYW9	Bodo saltans	44%	100%
A0A0S4JST7	Bodo saltans	30%	67%
A0A1D8PPK1	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	94%
A0A1U8QTA2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	98%
A0A1X0P653	Trypanosomatidae	49%	100%
A0A3Q8ICQ9	Leishmania donovani	81%	99%
A0A422NKC3	Trypanosoma rangeli	47%	100%
A0A482NAR8	Talaromyces variabilis	28%	94%
A0ALF5	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	29%	100%
A2TBU0	Epichloe festucae var. lolii	36%	100%
A4IQK7	Geobacillus thermodenitrificans (strain NG80-2)	34%	100%
A7GNY4	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	28%	100%
A8C7R3	Claviceps fusiformis	33%	100%
B7HJE9	Bacillus cereus (strain B4264)	28%	100%
B8DBP0	Listeria monocytogenes serotype 4a (strain HCC23)	28%	100%
B8N8Q9	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	92%
B8NWW6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	35%	100%
B9FFD2	Oryza sativa subsp. japonica	39%	94%
B9FFD3	Oryza sativa subsp. japonica	38%	100%
B9FSC8	Oryza sativa subsp. japonica	38%	100%
C1KYN8	Listeria monocytogenes serotype 4b (strain CLIP80459)	28%	100%
C5D427	Geobacillus sp. (strain WCH70)	34%	100%
C5H429	Artemisia annua	37%	98%
E9AGH7	Leishmania infantum	84%	100%
E9AP13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
G0REX8	Hypocrea jecorina (strain QM6a)	26%	95%
I1RV17	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	30%	92%
M1W0Y0	Claviceps purpurea (strain 20.1)	34%	100%
O94467	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	97%
P0DI08	Arabidopsis thaliana	39%	100%
P0DI09	Arabidopsis thaliana	39%	100%
P40952	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	96%
P41816	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
P43084	Candida albicans	33%	94%
P54524	Bacillus subtilis (strain 168)	30%	100%
P54550	Bacillus subtilis (strain 168)	31%	100%
P77258	Escherichia coli (strain K12)	38%	100%
Q02899	Saccharomyces pastorianus	35%	96%
Q03558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	96%
Q09670	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q09671	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q0E0C6	Oryza sativa subsp. japonica	37%	94%
Q4QGH6	Leishmania major	82%	100%
Q4WZ70	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	100%
Q5KXG9	Geobacillus kaustophilus (strain HTA426)	35%	100%
Q69TH4	Oryza sativa subsp. japonica	39%	100%
Q69TH6	Oryza sativa subsp. japonica	39%	100%
Q69TH8	Oryza sativa subsp. japonica	37%	100%
Q69TI0	Oryza sativa subsp. japonica	38%	100%
Q69TI2	Oryza sativa subsp. japonica	38%	98%
Q6HJU1	Bacillus thuringiensis subsp. konkukian (strain 97-27)	28%	100%
Q6UEF0	Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)	27%	86%
Q6Z965	Oryza sativa subsp. japonica	39%	97%
Q6ZXC1	Claviceps purpurea	34%	100%
Q71WV6	Listeria monocytogenes serotype 4b (strain F2365)	28%	100%
Q81EF6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	28%	100%
Q84QK0	Oryza sativa subsp. japonica	39%	100%
Q8GYA3	Arabidopsis thaliana	36%	100%
Q8GYB8	Arabidopsis thaliana	39%	100%
Q8LAH7	Arabidopsis thaliana	39%	100%
Q8Y4H1	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	29%	100%
Q928C2	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	28%	100%
Q97E86	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	29%	100%
Q9FEW9	Solanum lycopersicum	36%	96%
Q9FEX0	Solanum lycopersicum	34%	100%
Q9FUP0	Arabidopsis thaliana	38%	98%
Q9XG54	Solanum lycopersicum	38%	100%
V5BT91	Trypanosoma cruzi	45%	100%
W6Q2D7	Penicillium roqueforti (strain FM164)	39%	100%
W6Q9S9	Penicillium roqueforti (strain FM164)	37%	100%