J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Z1_LEIBR

TriTrypDb:

LbrM.12.0780 , LBRM2903_200078300

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Z1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0035966	response to topologically incorrect protein	3	1
GO:0035967	cellular response to topologically incorrect protein	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0051788	response to misfolded protein	4	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071218	cellular response to misfolded protein	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.430
CLV_NRD_NRD_1	115	117	PF00675	0.361
CLV_NRD_NRD_1	118	120	PF00675	0.361
CLV_NRD_NRD_1	153	155	PF00675	0.376
CLV_NRD_NRD_1	220	222	PF00675	0.666
CLV_NRD_NRD_1	263	265	PF00675	0.526
CLV_NRD_NRD_1	392	394	PF00675	0.659
CLV_NRD_NRD_1	55	57	PF00675	0.503
CLV_NRD_NRD_1	568	570	PF00675	0.415
CLV_NRD_NRD_1	633	635	PF00675	0.386
CLV_NRD_NRD_1	727	729	PF00675	0.460
CLV_PCSK_FUR_1	261	265	PF00082	0.522
CLV_PCSK_FUR_1	553	557	PF00082	0.526
CLV_PCSK_FUR_1	630	634	PF00082	0.351
CLV_PCSK_KEX2_1	115	117	PF00082	0.308
CLV_PCSK_KEX2_1	152	154	PF00082	0.308
CLV_PCSK_KEX2_1	220	222	PF00082	0.666
CLV_PCSK_KEX2_1	263	265	PF00082	0.526
CLV_PCSK_KEX2_1	392	394	PF00082	0.659
CLV_PCSK_KEX2_1	55	57	PF00082	0.503
CLV_PCSK_KEX2_1	555	557	PF00082	0.511
CLV_PCSK_KEX2_1	568	570	PF00082	0.395
CLV_PCSK_KEX2_1	632	634	PF00082	0.390
CLV_PCSK_KEX2_1	727	729	PF00082	0.471
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.220
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.428
CLV_PCSK_SKI1_1	120	124	PF00082	0.312
CLV_PCSK_SKI1_1	203	207	PF00082	0.451
CLV_PCSK_SKI1_1	45	49	PF00082	0.417
CLV_PCSK_SKI1_1	487	491	PF00082	0.565
CLV_PCSK_SKI1_1	568	572	PF00082	0.376
CLV_PCSK_SKI1_1	84	88	PF00082	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.465
DEG_SPOP_SBC_1	163	167	PF00917	0.515
DEG_SPOP_SBC_1	313	317	PF00917	0.502
DEG_SPOP_SBC_1	488	492	PF00917	0.558
DEG_SPOP_SBC_1	684	688	PF00917	0.546
DOC_CKS1_1	716	721	PF01111	0.467
DOC_CKS1_1	85	90	PF01111	0.420
DOC_CYCLIN_RxL_1	115	128	PF00134	0.400
DOC_CYCLIN_RxL_1	200	209	PF00134	0.465
DOC_CYCLIN_RxL_1	630	640	PF00134	0.335
DOC_CYCLIN_yClb1_LxF_4	68	73	PF00134	0.515
DOC_MAPK_gen_1	115	125	PF00069	0.308
DOC_MAPK_gen_1	382	390	PF00069	0.543
DOC_MAPK_gen_1	630	637	PF00069	0.335
DOC_PP1_RVXF_1	631	638	PF00149	0.341
DOC_PP4_FxxP_1	32	35	PF00568	0.438
DOC_PP4_FxxP_1	73	76	PF00568	0.494
DOC_USP7_MATH_1	163	167	PF00917	0.674
DOC_USP7_MATH_1	225	229	PF00917	0.706
DOC_USP7_MATH_1	290	294	PF00917	0.635
DOC_USP7_MATH_1	311	315	PF00917	0.663
DOC_USP7_MATH_1	330	334	PF00917	0.674
DOC_USP7_MATH_1	370	374	PF00917	0.650
DOC_USP7_MATH_1	430	434	PF00917	0.601
DOC_USP7_MATH_1	488	492	PF00917	0.630
DOC_USP7_MATH_1	509	513	PF00917	0.612
DOC_USP7_MATH_1	544	548	PF00917	0.558
DOC_USP7_MATH_1	588	592	PF00917	0.479
DOC_USP7_MATH_1	677	681	PF00917	0.602
DOC_USP7_MATH_1	709	713	PF00917	0.590
DOC_USP7_MATH_1	714	718	PF00917	0.508
DOC_USP7_MATH_1	89	93	PF00917	0.371
DOC_USP7_MATH_2	335	341	PF00917	0.546
DOC_USP7_UBL2_3	461	465	PF12436	0.546
DOC_WW_Pin1_4	164	169	PF00397	0.672
DOC_WW_Pin1_4	192	197	PF00397	0.610
DOC_WW_Pin1_4	282	287	PF00397	0.698
DOC_WW_Pin1_4	331	336	PF00397	0.537
DOC_WW_Pin1_4	540	545	PF00397	0.522
DOC_WW_Pin1_4	578	583	PF00397	0.576
DOC_WW_Pin1_4	62	67	PF00397	0.616
DOC_WW_Pin1_4	665	670	PF00397	0.595
DOC_WW_Pin1_4	715	720	PF00397	0.526
DOC_WW_Pin1_4	84	89	PF00397	0.438
LIG_14-3-3_CanoR_1	305	313	PF00244	0.691
LIG_14-3-3_CanoR_1	410	419	PF00244	0.628
LIG_14-3-3_CanoR_1	5	11	PF00244	0.549
LIG_14-3-3_CanoR_1	634	644	PF00244	0.316
LIG_14-3-3_CanoR_1	697	707	PF00244	0.732
LIG_14-3-3_CanoR_1	98	104	PF00244	0.359
LIG_APCC_ABBA_1	123	128	PF00400	0.309
LIG_BRCT_BRCA1_1	293	297	PF00533	0.664
LIG_BRCT_BRCA1_1	415	419	PF00533	0.490
LIG_eIF4E_1	118	124	PF01652	0.308
LIG_eIF4E_1	43	49	PF01652	0.423
LIG_EVH1_1	32	36	PF00568	0.435
LIG_EVH1_1	71	75	PF00568	0.497
LIG_FHA_1	100	106	PF00498	0.379
LIG_FHA_1	12	18	PF00498	0.450
LIG_FHA_1	348	354	PF00498	0.539
LIG_FHA_1	419	425	PF00498	0.674
LIG_FHA_1	432	438	PF00498	0.678
LIG_FHA_1	66	72	PF00498	0.514
LIG_FHA_2	199	205	PF00498	0.594
LIG_FHA_2	461	467	PF00498	0.618
LIG_FHA_2	488	494	PF00498	0.588
LIG_FHA_2	56	62	PF00498	0.511
LIG_FHA_2	85	91	PF00498	0.427
LIG_Integrin_RGD_1	234	236	PF01839	0.553
LIG_LIR_Gen_1	25	35	PF02991	0.427
LIG_LIR_Gen_1	603	614	PF02991	0.375
LIG_LIR_Gen_1	676	684	PF02991	0.593
LIG_LIR_Nem_3	135	140	PF02991	0.299
LIG_LIR_Nem_3	25	30	PF02991	0.419
LIG_LIR_Nem_3	574	578	PF02991	0.417
LIG_LIR_Nem_3	676	681	PF02991	0.513
LIG_LIR_Nem_3	97	103	PF02991	0.308
LIG_NRBOX	721	727	PF00104	0.460
LIG_SH2_CRK	100	104	PF00017	0.308
LIG_SH2_CRK	27	31	PF00017	0.427
LIG_SH2_SRC	144	147	PF00017	0.379
LIG_SH2_STAP1	144	148	PF00017	0.308
LIG_SH2_STAP1	275	279	PF00017	0.544
LIG_SH2_STAT5	43	46	PF00017	0.431
LIG_SH2_STAT5	575	578	PF00017	0.540
LIG_SH2_STAT5	580	583	PF00017	0.628
LIG_SH2_STAT5	596	599	PF00017	0.347
LIG_SH3_1	666	672	PF00018	0.541
LIG_SH3_1	713	719	PF00018	0.478
LIG_SH3_3	187	193	PF00018	0.650
LIG_SH3_3	30	36	PF00018	0.521
LIG_SH3_3	60	66	PF00018	0.610
LIG_SH3_3	666	672	PF00018	0.567
LIG_SH3_3	69	75	PF00018	0.567
LIG_SH3_3	713	719	PF00018	0.504
LIG_SH3_3	82	88	PF00018	0.427
LIG_TRAF2_1	76	79	PF00917	0.489
LIG_TYR_ITSM	23	30	PF00017	0.416
LIG_WRC_WIRS_1	23	28	PF05994	0.412
LIG_WRC_WIRS_1	49	54	PF05994	0.438
MOD_CK1_1	166	172	PF00069	0.619
MOD_CK1_1	195	201	PF00069	0.646
MOD_CK1_1	249	255	PF00069	0.572
MOD_CK1_1	293	299	PF00069	0.690
MOD_CK1_1	314	320	PF00069	0.655
MOD_CK1_1	323	329	PF00069	0.607
MOD_CK1_1	413	419	PF00069	0.613
MOD_CK1_1	428	434	PF00069	0.627
MOD_CK1_1	448	454	PF00069	0.759
MOD_CK1_1	50	56	PF00069	0.464
MOD_CK1_1	500	506	PF00069	0.650
MOD_CK1_1	516	522	PF00069	0.496
MOD_CK1_1	524	530	PF00069	0.527
MOD_CK1_1	65	71	PF00069	0.577
MOD_CK1_1	651	657	PF00069	0.512
MOD_CK1_1	687	693	PF00069	0.534
MOD_CK1_1	699	705	PF00069	0.566
MOD_CK2_1	198	204	PF00069	0.633
MOD_CK2_1	270	276	PF00069	0.600
MOD_CK2_1	331	337	PF00069	0.771
MOD_CK2_1	395	401	PF00069	0.544
MOD_CK2_1	460	466	PF00069	0.591
MOD_CK2_1	588	594	PF00069	0.456
MOD_CK2_1	597	603	PF00069	0.434
MOD_CK2_1	640	646	PF00069	0.387
MOD_CK2_1	676	682	PF00069	0.773
MOD_CK2_1	84	90	PF00069	0.442
MOD_DYRK1A_RPxSP_1	62	66	PF00069	0.522
MOD_GlcNHglycan	169	172	PF01048	0.548
MOD_GlcNHglycan	248	251	PF01048	0.555
MOD_GlcNHglycan	272	275	PF01048	0.782
MOD_GlcNHglycan	276	280	PF01048	0.648
MOD_GlcNHglycan	307	310	PF01048	0.572
MOD_GlcNHglycan	370	373	PF01048	0.572
MOD_GlcNHglycan	376	380	PF01048	0.573
MOD_GlcNHglycan	396	400	PF01048	0.626
MOD_GlcNHglycan	447	450	PF01048	0.683
MOD_GlcNHglycan	497	502	PF01048	0.691
MOD_GlcNHglycan	506	509	PF01048	0.621
MOD_GlcNHglycan	515	518	PF01048	0.507
MOD_GlcNHglycan	523	526	PF01048	0.577
MOD_GlcNHglycan	557	560	PF01048	0.492
MOD_GlcNHglycan	57	61	PF01048	0.518
MOD_GlcNHglycan	650	653	PF01048	0.428
MOD_GlcNHglycan	673	676	PF01048	0.608
MOD_GlcNHglycan	687	690	PF01048	0.493
MOD_GSK3_1	162	169	PF00069	0.656
MOD_GSK3_1	18	25	PF00069	0.452
MOD_GSK3_1	194	201	PF00069	0.528
MOD_GSK3_1	226	233	PF00069	0.646
MOD_GSK3_1	234	241	PF00069	0.573
MOD_GSK3_1	270	277	PF00069	0.577
MOD_GSK3_1	293	300	PF00069	0.684
MOD_GSK3_1	347	354	PF00069	0.559
MOD_GSK3_1	406	413	PF00069	0.537
MOD_GSK3_1	426	433	PF00069	0.564
MOD_GSK3_1	444	451	PF00069	0.628
MOD_GSK3_1	460	467	PF00069	0.578
MOD_GSK3_1	500	507	PF00069	0.562
MOD_GSK3_1	509	516	PF00069	0.544
MOD_GSK3_1	540	547	PF00069	0.521
MOD_GSK3_1	673	680	PF00069	0.675
MOD_GSK3_1	683	690	PF00069	0.564
MOD_GSK3_1	695	702	PF00069	0.522
MOD_GSK3_1	714	721	PF00069	0.495
MOD_LATS_1	303	309	PF00433	0.531
MOD_LATS_1	408	414	PF00433	0.473
MOD_LATS_1	54	60	PF00433	0.500
MOD_N-GLC_1	17	22	PF02516	0.397
MOD_N-GLC_1	445	450	PF02516	0.560
MOD_N-GLC_2	245	247	PF02516	0.657
MOD_NEK2_1	17	22	PF00069	0.435
MOD_NEK2_1	206	211	PF00069	0.683
MOD_NEK2_1	297	302	PF00069	0.612
MOD_NEK2_1	445	450	PF00069	0.702
MOD_NEK2_1	48	53	PF00069	0.430
MOD_NEK2_1	597	602	PF00069	0.502
MOD_NEK2_1	635	640	PF00069	0.461
MOD_NEK2_1	700	705	PF00069	0.660
MOD_PIKK_1	285	291	PF00454	0.616
MOD_PIKK_1	314	320	PF00454	0.545
MOD_PIKK_1	410	416	PF00454	0.543
MOD_PIKK_1	89	95	PF00454	0.378
MOD_PKA_1	464	470	PF00069	0.625
MOD_PKA_1	55	61	PF00069	0.506
MOD_PKA_1	555	561	PF00069	0.411
MOD_PKA_2	225	231	PF00069	0.611
MOD_PKA_2	304	310	PF00069	0.710
MOD_PKA_2	347	353	PF00069	0.541
MOD_PKA_2	55	61	PF00069	0.519
MOD_PKA_2	555	561	PF00069	0.426
MOD_PKA_2	615	621	PF00069	0.522
MOD_PKA_2	693	699	PF00069	0.691
MOD_Plk_1	17	23	PF00069	0.443
MOD_Plk_2-3	238	244	PF00069	0.594
MOD_Plk_2-3	337	343	PF00069	0.705
MOD_Plk_4	18	24	PF00069	0.491
MOD_Plk_4	25	31	PF00069	0.462
MOD_Plk_4	320	326	PF00069	0.507
MOD_ProDKin_1	164	170	PF00069	0.671
MOD_ProDKin_1	192	198	PF00069	0.607
MOD_ProDKin_1	282	288	PF00069	0.698
MOD_ProDKin_1	331	337	PF00069	0.541
MOD_ProDKin_1	540	546	PF00069	0.517
MOD_ProDKin_1	578	584	PF00069	0.575
MOD_ProDKin_1	62	68	PF00069	0.615
MOD_ProDKin_1	665	671	PF00069	0.598
MOD_ProDKin_1	715	721	PF00069	0.527
MOD_ProDKin_1	84	90	PF00069	0.430
MOD_SUMO_for_1	453	456	PF00179	0.556
MOD_SUMO_rev_2	455	463	PF00179	0.548
MOD_SUMO_rev_2	77	86	PF00179	0.482
TRG_DiLeu_BaEn_1	135	140	PF01217	0.225
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.418
TRG_ENDOCYTIC_2	100	103	PF00928	0.312
TRG_ENDOCYTIC_2	144	147	PF00928	0.332
TRG_ENDOCYTIC_2	27	30	PF00928	0.426
TRG_ENDOCYTIC_2	606	609	PF00928	0.381
TRG_ER_diArg_1	114	116	PF00400	0.337
TRG_ER_diArg_1	262	264	PF00400	0.523
TRG_ER_diArg_1	392	394	PF00400	0.653
TRG_ER_diArg_1	568	570	PF00400	0.434
TRG_ER_diArg_1	629	632	PF00400	0.328
TRG_ER_diArg_1	633	635	PF00400	0.362
TRG_ER_diArg_1	726	728	PF00400	0.451
TRG_NLS_MonoExtN_4	116	123	PF00514	0.225
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC79	Leptomonas seymouri	38%	100%
A0A3S7WS81	Leishmania donovani	61%	100%
E9AGH2	Leishmania infantum	61%	100%
E9AP11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QGH8	Leishmania major	60%	100%