Putative surface antigen protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Y9_LEIBR

TriTrypDb:

LbrM.12.0760

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.820
CLV_NRD_NRD_1	246	248	PF00675	0.684
CLV_NRD_NRD_1	264	266	PF00675	0.463
CLV_NRD_NRD_1	298	300	PF00675	0.879
CLV_NRD_NRD_1	336	338	PF00675	0.678
CLV_PCSK_KEX2_1	246	248	PF00082	0.684
CLV_PCSK_KEX2_1	264	266	PF00082	0.463
CLV_PCSK_KEX2_1	298	300	PF00082	0.879
CLV_PCSK_KEX2_1	336	338	PF00082	0.678
CLV_Separin_Metazoa	125	129	PF03568	0.792
DEG_ODPH_VHL_1	322	335	PF01847	0.841
DEG_SPOP_SBC_1	357	361	PF00917	0.666
DEG_SPOP_SBC_1	63	67	PF00917	0.876
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.878
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.657
DOC_MAPK_gen_1	336	343	PF00069	0.864
DOC_MAPK_HePTP_8	333	349	PF00069	0.700
DOC_MAPK_MEF2A_6	108	115	PF00069	0.842
DOC_MAPK_MEF2A_6	336	343	PF00069	0.864
DOC_PP1_RVXF_1	223	229	PF00149	0.747
DOC_PP2B_LxvP_1	329	332	PF13499	0.874
DOC_PP2B_LxvP_1	381	384	PF13499	0.643
DOC_PP2B_LxvP_1	60	63	PF13499	0.867
DOC_USP7_MATH_1	117	121	PF00917	0.823
DOC_USP7_MATH_1	19	23	PF00917	0.772
DOC_USP7_MATH_1	192	196	PF00917	0.600
DOC_USP7_MATH_1	315	319	PF00917	0.600
DOC_USP7_MATH_1	47	51	PF00917	0.858
DOC_USP7_MATH_1	63	67	PF00917	0.675
DOC_USP7_MATH_1	83	87	PF00917	0.630
DOC_USP7_MATH_1	9	13	PF00917	0.885
DOC_USP7_MATH_1	94	98	PF00917	0.741
DOC_WW_Pin1_4	15	20	PF00397	0.894
DOC_WW_Pin1_4	250	255	PF00397	0.875
DOC_WW_Pin1_4	358	363	PF00397	0.664
DOC_WW_Pin1_4	374	379	PF00397	0.461
DOC_WW_Pin1_4	64	69	PF00397	0.874
DOC_WW_Pin1_4	90	95	PF00397	0.871
DOC_WW_Pin1_4	98	103	PF00397	0.764
LIG_14-3-3_CanoR_1	145	149	PF00244	0.600
LIG_14-3-3_CanoR_1	246	250	PF00244	0.881
LIG_14-3-3_CanoR_1	293	301	PF00244	0.681
LIG_14-3-3_CterR_2	411	413	PF00244	0.828
LIG_Actin_WH2_2	395	413	PF00022	0.600
LIG_CtBP_PxDLS_1	346	350	PF00389	0.600
LIG_FHA_1	128	134	PF00498	0.775
LIG_FHA_1	158	164	PF00498	0.538
LIG_FHA_1	188	194	PF00498	0.500
LIG_FHA_1	204	210	PF00498	0.410
LIG_FHA_1	324	330	PF00498	0.600
LIG_FHA_1	53	59	PF00498	0.866
LIG_FHA_2	206	212	PF00498	0.761
LIG_FHA_2	222	228	PF00498	0.539
LIG_FHA_2	236	242	PF00498	0.639
LIG_FHA_2	325	331	PF00498	0.600
LIG_FHA_2	358	364	PF00498	0.666
LIG_GBD_Chelix_1	402	410	PF00786	0.600
LIG_LIR_Gen_1	120	127	PF02991	0.808
LIG_LIR_Gen_1	130	140	PF02991	0.575
LIG_LIR_Gen_1	217	226	PF02991	0.747
LIG_LIR_Gen_1	227	235	PF02991	0.646
LIG_LIR_Gen_1	73	83	PF02991	0.880
LIG_LIR_Nem_3	107	113	PF02991	0.845
LIG_LIR_Nem_3	120	126	PF02991	0.648
LIG_LIR_Nem_3	130	135	PF02991	0.646
LIG_LIR_Nem_3	185	189	PF02991	0.542
LIG_LIR_Nem_3	217	221	PF02991	0.754
LIG_LIR_Nem_3	73	79	PF02991	0.880
LIG_LYPXL_yS_3	110	113	PF13949	0.842
LIG_SH2_CRK	218	222	PF00017	0.748
LIG_SH2_CRK	76	80	PF00017	0.884
LIG_SH2_GRB2like	218	221	PF00017	0.752
LIG_SH2_SRC	218	221	PF00017	0.752
LIG_SH2_STAP1	218	222	PF00017	0.748
LIG_SH2_STAT5	205	208	PF00017	0.764
LIG_SH3_1	336	342	PF00018	0.864
LIG_SH3_3	207	213	PF00018	0.757
LIG_SH3_3	318	324	PF00018	0.600
LIG_SH3_3	336	342	PF00018	0.638
LIG_SH3_3	36	42	PF00018	0.872
LIG_SH3_3	365	371	PF00018	0.659
LIG_SH3_3	65	71	PF00018	0.872
LIG_SH3_3	85	91	PF00018	0.625
LIG_SH3_3	99	105	PF00018	0.681
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.538
LIG_TYR_ITIM	216	221	PF00017	0.751
LIG_WRC_WIRS_1	310	315	PF05994	0.600
MOD_CK1_1	176	182	PF00069	0.563
MOD_CK1_1	23	29	PF00069	0.893
MOD_CK1_1	259	265	PF00069	0.867
MOD_CK1_1	278	284	PF00069	0.267
MOD_CK1_1	98	104	PF00069	0.863
MOD_CK2_1	205	211	PF00069	0.764
MOD_CK2_1	324	330	PF00069	0.600
MOD_CK2_1	357	363	PF00069	0.663
MOD_Cter_Amidation	296	299	PF01082	0.883
MOD_GlcNHglycan	178	181	PF01048	0.759
MOD_GlcNHglycan	22	25	PF01048	0.513
MOD_GlcNHglycan	235	238	PF01048	0.599
MOD_GlcNHglycan	294	297	PF01048	0.885
MOD_GlcNHglycan	315	318	PF01048	0.600
MOD_GlcNHglycan	386	389	PF01048	0.829
MOD_GlcNHglycan	7	10	PF01048	0.692
MOD_GSK3_1	146	153	PF00069	0.753
MOD_GSK3_1	15	22	PF00069	0.770
MOD_GSK3_1	174	181	PF00069	0.558
MOD_GSK3_1	187	194	PF00069	0.337
MOD_GSK3_1	235	242	PF00069	0.808
MOD_GSK3_1	245	252	PF00069	0.753
MOD_GSK3_1	255	262	PF00069	0.607
MOD_GSK3_1	283	290	PF00069	0.600
MOD_GSK3_1	309	316	PF00069	0.600
MOD_GSK3_1	370	377	PF00069	0.662
MOD_GSK3_1	384	391	PF00069	0.455
MOD_GSK3_1	5	12	PF00069	0.888
MOD_GSK3_1	90	97	PF00069	0.874
MOD_NEK2_1	127	132	PF00069	0.783
MOD_NEK2_1	174	179	PF00069	0.554
MOD_NEK2_1	20	25	PF00069	0.902
MOD_NEK2_1	226	231	PF00069	0.752
MOD_NEK2_1	235	240	PF00069	0.687
MOD_NEK2_1	249	254	PF00069	0.697
MOD_NEK2_1	255	260	PF00069	0.605
MOD_NEK2_1	283	288	PF00069	0.600
MOD_NEK2_1	95	100	PF00069	0.883
MOD_NEK2_2	117	122	PF00069	0.824
MOD_NEK2_2	192	197	PF00069	0.600
MOD_NEK2_2	54	59	PF00069	0.867
MOD_OFUCOSY	184	191	PF10250	0.742
MOD_OFUCOSY	80	85	PF10250	0.683
MOD_PK_1	337	343	PF00069	0.860
MOD_PKA_2	127	133	PF00069	0.780
MOD_PKA_2	144	150	PF00069	0.302
MOD_PKA_2	24	30	PF00069	0.888
MOD_PKA_2	245	251	PF00069	0.882
MOD_PKA_2	292	298	PF00069	0.856
MOD_PKB_1	267	275	PF00069	0.892
MOD_Plk_1	226	232	PF00069	0.761
MOD_Plk_4	278	284	PF00069	0.600
MOD_Plk_4	287	293	PF00069	0.442
MOD_Plk_4	309	315	PF00069	0.600
MOD_Plk_4	345	351	PF00069	0.600
MOD_ProDKin_1	15	21	PF00069	0.895
MOD_ProDKin_1	250	256	PF00069	0.871
MOD_ProDKin_1	358	364	PF00069	0.666
MOD_ProDKin_1	374	380	PF00069	0.458
MOD_ProDKin_1	64	70	PF00069	0.876
MOD_ProDKin_1	90	96	PF00069	0.873
MOD_ProDKin_1	98	104	PF00069	0.763
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.872
TRG_ENDOCYTIC_2	110	113	PF00928	0.842
TRG_ENDOCYTIC_2	218	221	PF00928	0.752
TRG_ENDOCYTIC_2	76	79	PF00928	0.884
TRG_ER_diArg_1	264	267	PF00400	0.889
TRG_ER_diArg_1	335	337	PF00400	0.885
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P21978	LEIAM	62%	87%