Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Y7_LEIBR

TriTrypDb:

LbrM.12.0740 , LBRM2903_120013400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.610
CLV_NRD_NRD_1	229	231	PF00675	0.562
CLV_NRD_NRD_1	318	320	PF00675	0.681
CLV_NRD_NRD_1	394	396	PF00675	0.639
CLV_PCSK_KEX2_1	229	231	PF00082	0.562
CLV_PCSK_KEX2_1	243	245	PF00082	0.601
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.596
CLV_PCSK_SKI1_1	34	38	PF00082	0.453
CLV_PCSK_SKI1_1	395	399	PF00082	0.648
CLV_Separin_Metazoa	226	230	PF03568	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DOC_CYCLIN_RxL_1	392	402	PF00134	0.662
DOC_MAPK_gen_1	319	327	PF00069	0.731
DOC_MAPK_gen_1	34	44	PF00069	0.556
DOC_MAPK_gen_1	8	18	PF00069	0.642
DOC_MAPK_MEF2A_6	11	18	PF00069	0.591
DOC_PP4_FxxP_1	148	151	PF00568	0.538
DOC_USP7_MATH_1	321	325	PF00917	0.710
DOC_USP7_MATH_1	426	430	PF00917	0.682
DOC_USP7_UBL2_3	257	261	PF12436	0.451
DOC_WW_Pin1_4	10	15	PF00397	0.556
DOC_WW_Pin1_4	103	108	PF00397	0.547
DOC_WW_Pin1_4	352	357	PF00397	0.655
DOC_WW_Pin1_4	422	427	PF00397	0.539
DOC_WW_Pin1_4	61	66	PF00397	0.548
LIG_14-3-3_CanoR_1	3	10	PF00244	0.492
LIG_14-3-3_CanoR_1	312	321	PF00244	0.510
LIG_BRCT_BRCA1_1	323	327	PF00533	0.713
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.639
LIG_EVH1_1	148	152	PF00568	0.540
LIG_EVH1_2	29	33	PF00568	0.519
LIG_FHA_1	11	17	PF00498	0.614
LIG_FHA_1	243	249	PF00498	0.602
LIG_FHA_1	407	413	PF00498	0.571
LIG_FHA_2	328	334	PF00498	0.598
LIG_FHA_2	353	359	PF00498	0.503
LIG_FHA_2	55	61	PF00498	0.391
LIG_LIR_Apic_2	146	151	PF02991	0.555
LIG_LIR_Apic_2	250	255	PF02991	0.616
LIG_LIR_Apic_2	299	303	PF02991	0.610
LIG_LIR_Apic_2	59	65	PF02991	0.537
LIG_LIR_Apic_2	93	97	PF02991	0.566
LIG_LIR_Gen_1	236	247	PF02991	0.589
LIG_LIR_Gen_1	289	300	PF02991	0.557
LIG_LIR_Nem_3	182	188	PF02991	0.528
LIG_LIR_Nem_3	236	242	PF02991	0.602
LIG_LIR_Nem_3	289	295	PF02991	0.538
LIG_LIR_Nem_3	31	36	PF02991	0.613
LIG_LIR_Nem_3	310	314	PF02991	0.640
LIG_LIR_Nem_3	358	364	PF02991	0.474
LIG_LIR_Nem_3	85	90	PF02991	0.558
LIG_PCNA_PIPBox_1	116	125	PF02747	0.624
LIG_Pex14_2	327	331	PF04695	0.753
LIG_PTAP_UEV_1	407	412	PF05743	0.478
LIG_SH2_CRK	292	296	PF00017	0.561
LIG_SH2_CRK	87	91	PF00017	0.563
LIG_SH2_NCK_1	292	296	PF00017	0.589
LIG_SH2_PTP2	300	303	PF00017	0.635
LIG_SH2_SRC	124	127	PF00017	0.380
LIG_SH2_SRC	300	303	PF00017	0.635
LIG_SH2_SRC	364	367	PF00017	0.635
LIG_SH2_STAT3	70	73	PF00017	0.542
LIG_SH2_STAT5	124	127	PF00017	0.380
LIG_SH2_STAT5	174	177	PF00017	0.419
LIG_SH2_STAT5	300	303	PF00017	0.635
LIG_SH2_STAT5	56	59	PF00017	0.469
LIG_SH2_STAT5	70	73	PF00017	0.568
LIG_SH2_STAT5	9	12	PF00017	0.427
LIG_SH2_STAT5	94	97	PF00017	0.568
LIG_SH3_1	420	426	PF00018	0.734
LIG_SH3_3	135	141	PF00018	0.570
LIG_SH3_3	146	152	PF00018	0.551
LIG_SH3_3	186	192	PF00018	0.561
LIG_SH3_3	23	29	PF00018	0.508
LIG_SH3_3	245	251	PF00018	0.605
LIG_SH3_3	342	348	PF00018	0.641
LIG_SH3_3	402	408	PF00018	0.670
LIG_SH3_3	420	426	PF00018	0.724
LIG_TRAF2_1	20	23	PF00917	0.642
LIG_TRAF2_1	386	389	PF00917	0.407
LIG_TRAF2_1	65	68	PF00917	0.640
LIG_UBA3_1	130	134	PF00899	0.515
MOD_CDC14_SPxK_1	106	109	PF00782	0.521
MOD_CDK_SPK_2	352	357	PF00069	0.648
MOD_CDK_SPxK_1	103	109	PF00069	0.542
MOD_CDK_SPxxK_3	10	17	PF00069	0.583
MOD_CK1_1	431	437	PF00069	0.722
MOD_CK2_1	158	164	PF00069	0.563
MOD_CK2_1	352	358	PF00069	0.505
MOD_CK2_1	383	389	PF00069	0.566
MOD_CK2_1	54	60	PF00069	0.387
MOD_GlcNHglycan	368	371	PF01048	0.452
MOD_GlcNHglycan	400	404	PF01048	0.670
MOD_GlcNHglycan	84	87	PF01048	0.549
MOD_GSK3_1	422	429	PF00069	0.549
MOD_GSK3_1	99	106	PF00069	0.564
MOD_N-GLC_1	103	108	PF02516	0.432
MOD_N-GLC_1	166	171	PF02516	0.372
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	314	319	PF00069	0.620
MOD_NEK2_1	327	332	PF00069	0.725
MOD_NEK2_1	398	403	PF00069	0.631
MOD_NEK2_1	99	104	PF00069	0.575
MOD_NEK2_2	166	171	PF00069	0.374
MOD_PKA_2	2	8	PF00069	0.475
MOD_Plk_1	158	164	PF00069	0.563
MOD_Plk_1	166	172	PF00069	0.505
MOD_Plk_1	383	389	PF00069	0.510
MOD_ProDKin_1	10	16	PF00069	0.559
MOD_ProDKin_1	103	109	PF00069	0.542
MOD_ProDKin_1	352	358	PF00069	0.651
MOD_ProDKin_1	422	428	PF00069	0.541
MOD_ProDKin_1	61	67	PF00069	0.552
TRG_DiLeu_BaEn_4	223	229	PF01217	0.433
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.586
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.569
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.573
TRG_ENDOCYTIC_2	176	179	PF00928	0.560
TRG_ENDOCYTIC_2	292	295	PF00928	0.549
TRG_ENDOCYTIC_2	87	90	PF00928	0.565
TRG_ER_diArg_1	228	230	PF00400	0.567
TRG_ER_diArg_1	48	51	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.670
TRG_PTS2	1	48	PF00400	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	89%	99%
A0A0S4IRN8	Bodo saltans	80%	100%
A0A1X0NP12	Trypanosomatidae	81%	100%
A0A381ME06	Leishmania infantum	84%	100%
A0A3Q8IHT5	Leishmania donovani	84%	100%
A0A3S7WS51	Leishmania donovani	84%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AGG3	Leishmania infantum	84%	100%
E9AGG8	Leishmania infantum	84%	100%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGI1	Leishmania major	83%	100%
Q4QGI3	Leishmania major	82%	100%
Q4QGJ1	Leishmania major	87%	100%
Q4QGJ3	Leishmania major	82%	100%
Q4QGJ5	Leishmania major	81%	100%
Q4QGJ8	Leishmania major	82%	100%
Q4QGK3	Leishmania major	82%	100%
Q4QGK5	Leishmania major	82%	100%
Q4QGK7	Leishmania major	82%	100%
Q4QGL3	Leishmania major	82%	100%
Q4QGL6	Leishmania major	81%	100%
Q4QGM0	Leishmania major	81%	100%
V5BF60	Trypanosoma cruzi	80%	89%