LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
Protein of unknown function (DUF962), putative
Species:
Leishmania braziliensis
UniProt:
A4H6Y5_LEIBR
TriTrypDb:
LbrM.12.0720 , LBRM2903_120013200
Length:
108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4H6Y5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.297
CLV_NRD_NRD_1 32 34 PF00675 0.275
CLV_PCSK_KEX2_1 19 21 PF00082 0.297
CLV_PCSK_KEX2_1 32 34 PF00082 0.275
DOC_PP1_RVXF_1 50 56 PF00149 0.211
DOC_PP4_FxxP_1 84 87 PF00568 0.513
DOC_WW_Pin1_4 2 7 PF00397 0.669
LIG_14-3-3_CanoR_1 79 85 PF00244 0.515
LIG_FHA_1 3 9 PF00498 0.529
LIG_LIR_Apic_2 83 87 PF02991 0.523
LIG_LIR_Gen_1 54 62 PF02991 0.197
LIG_LIR_Nem_3 13 18 PF02991 0.482
LIG_LIR_Nem_3 54 58 PF02991 0.197
LIG_PDZ_Class_3 103 108 PF00595 0.538
LIG_SH2_STAT5 66 69 PF00017 0.377
LIG_TRAF2_1 14 17 PF00917 0.465
LIG_WRC_WIRS_1 1 6 PF05994 0.580
MOD_CK1_1 11 17 PF00069 0.513
MOD_CK1_1 60 66 PF00069 0.273
MOD_CK2_1 11 17 PF00069 0.515
MOD_NEK2_1 36 41 PF00069 0.362
MOD_NEK2_1 58 63 PF00069 0.372
MOD_NEK2_1 8 13 PF00069 0.696
MOD_PKA_2 31 37 PF00069 0.515
MOD_ProDKin_1 2 8 PF00069 0.668
TRG_ER_diArg_1 18 20 PF00400 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C1 Leptomonas seymouri 42% 100%
A0A0N1HYH1 Leptomonas seymouri 55% 100%
A0A0S4IVD1 Bodo saltans 29% 96%
A0A1X0NMC7 Trypanosomatidae 33% 99%
A0A3Q8IHQ7 Leishmania donovani 88% 100%
A0A3R7N4G9 Trypanosoma rangeli 39% 99%
A0A3S5H6L3 Leishmania donovani 39% 100%
A4H6Y4 Leishmania braziliensis 35% 100%
E9AGF8 Leishmania infantum 39% 100%
E9AGF9 Leishmania infantum 87% 100%
E9ANZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
Q4QGM2 Leishmania major 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS