Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Y3_LEIBR

TriTrypDb:

LbrM.12.0700 , LBRM2903_120013000

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A4H6Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.384
CLV_C14_Caspase3-7	649	653	PF00656	0.395
CLV_NRD_NRD_1	268	270	PF00675	0.710
CLV_NRD_NRD_1	52	54	PF00675	0.544
CLV_NRD_NRD_1	790	792	PF00675	0.562
CLV_NRD_NRD_1	807	809	PF00675	0.569
CLV_NRD_NRD_1	836	838	PF00675	0.770
CLV_PCSK_KEX2_1	181	183	PF00082	0.655
CLV_PCSK_KEX2_1	219	221	PF00082	0.647
CLV_PCSK_KEX2_1	33	35	PF00082	0.609
CLV_PCSK_KEX2_1	52	54	PF00082	0.586
CLV_PCSK_KEX2_1	688	690	PF00082	0.634
CLV_PCSK_KEX2_1	707	709	PF00082	0.312
CLV_PCSK_KEX2_1	790	792	PF00082	0.566
CLV_PCSK_KEX2_1	836	838	PF00082	0.764
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.655
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.647
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.609
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.634
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.312
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.764
CLV_PCSK_PC7_1	786	792	PF00082	0.560
CLV_PCSK_SKI1_1	216	220	PF00082	0.621
CLV_PCSK_SKI1_1	476	480	PF00082	0.383
CLV_PCSK_SKI1_1	48	52	PF00082	0.544
CLV_PCSK_SKI1_1	498	502	PF00082	0.443
CLV_PCSK_SKI1_1	536	540	PF00082	0.412
CLV_PCSK_SKI1_1	839	843	PF00082	0.733
CLV_Separin_Metazoa	659	663	PF03568	0.545
DEG_APCC_DBOX_1	790	798	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DEG_ODPH_VHL_1	64	76	PF01847	0.553
DEG_SPOP_SBC_1	160	164	PF00917	0.459
DEG_SPOP_SBC_1	256	260	PF00917	0.555
DOC_CKS1_1	281	286	PF01111	0.609
DOC_CYCLIN_RxL_1	216	224	PF00134	0.536
DOC_CYCLIN_RxL_1	495	502	PF00134	0.333
DOC_CYCLIN_RxL_1	530	540	PF00134	0.485
DOC_MAPK_gen_1	181	188	PF00069	0.524
DOC_MAPK_gen_1	790	796	PF00069	0.687
DOC_MAPK_gen_1	835	843	PF00069	0.509
DOC_MAPK_HePTP_8	573	585	PF00069	0.444
DOC_MAPK_MEF2A_6	576	585	PF00069	0.331
DOC_MAPK_MEF2A_6	754	761	PF00069	0.617
DOC_MAPK_RevD_3	675	689	PF00069	0.356
DOC_USP7_MATH_1	110	114	PF00917	0.401
DOC_USP7_MATH_1	127	131	PF00917	0.536
DOC_USP7_MATH_1	149	153	PF00917	0.762
DOC_USP7_MATH_1	155	159	PF00917	0.647
DOC_USP7_MATH_1	160	164	PF00917	0.515
DOC_USP7_MATH_1	172	176	PF00917	0.347
DOC_USP7_MATH_1	240	244	PF00917	0.655
DOC_USP7_MATH_1	320	324	PF00917	0.521
DOC_USP7_MATH_1	419	423	PF00917	0.715
DOC_USP7_MATH_1	559	563	PF00917	0.387
DOC_USP7_MATH_1	803	807	PF00917	0.655
DOC_USP7_MATH_1	827	831	PF00917	0.656
DOC_USP7_UBL2_3	832	836	PF12436	0.620
DOC_USP7_UBL2_3	838	842	PF12436	0.645
DOC_WW_Pin1_4	231	236	PF00397	0.772
DOC_WW_Pin1_4	242	247	PF00397	0.611
DOC_WW_Pin1_4	258	263	PF00397	0.808
DOC_WW_Pin1_4	26	31	PF00397	0.640
DOC_WW_Pin1_4	280	285	PF00397	0.601
DOC_WW_Pin1_4	450	455	PF00397	0.787
DOC_WW_Pin1_4	514	519	PF00397	0.444
LIG_14-3-3_CanoR_1	161	167	PF00244	0.652
LIG_14-3-3_CanoR_1	293	297	PF00244	0.558
LIG_14-3-3_CanoR_1	34	44	PF00244	0.564
LIG_14-3-3_CanoR_1	689	696	PF00244	0.380
LIG_14-3-3_CanoR_1	725	733	PF00244	0.640
LIG_14-3-3_CanoR_1	814	822	PF00244	0.578
LIG_14-3-3_CanoR_1	837	842	PF00244	0.625
LIG_Actin_WH2_2	289	306	PF00022	0.530
LIG_Actin_WH2_2	668	683	PF00022	0.340
LIG_Actin_WH2_2	69	86	PF00022	0.459
LIG_Actin_WH2_2	9	24	PF00022	0.450
LIG_BRCT_BRCA1_1	124	128	PF00533	0.522
LIG_Clathr_ClatBox_1	73	77	PF01394	0.543
LIG_EH_1	225	229	PF12763	0.615
LIG_eIF4E_1	665	671	PF01652	0.468
LIG_FHA_1	116	122	PF00498	0.595
LIG_FHA_1	137	143	PF00498	0.671
LIG_FHA_1	16	22	PF00498	0.581
LIG_FHA_1	27	33	PF00498	0.578
LIG_FHA_1	35	41	PF00498	0.338
LIG_FHA_1	350	356	PF00498	0.588
LIG_FHA_1	412	418	PF00498	0.715
LIG_FHA_1	430	436	PF00498	0.671
LIG_FHA_1	441	447	PF00498	0.707
LIG_FHA_1	477	483	PF00498	0.616
LIG_FHA_1	551	557	PF00498	0.320
LIG_FHA_1	813	819	PF00498	0.701
LIG_FHA_2	100	106	PF00498	0.579
LIG_FHA_2	36	42	PF00498	0.560
LIG_FHA_2	393	399	PF00498	0.555
LIG_FHA_2	644	650	PF00498	0.384
LIG_FHA_2	696	702	PF00498	0.621
LIG_LIR_Gen_1	608	613	PF02991	0.444
LIG_LIR_Nem_3	608	612	PF02991	0.371
LIG_MYND_1	455	459	PF01753	0.541
LIG_NRBOX	286	292	PF00104	0.402
LIG_NRBOX	465	471	PF00104	0.424
LIG_NRBOX	533	539	PF00104	0.485
LIG_PDZ_Class_2	838	843	PF00595	0.502
LIG_SH2_CRK	2	6	PF00017	0.592
LIG_SH2_GRB2like	166	169	PF00017	0.643
LIG_SH2_GRB2like	196	199	PF00017	0.529
LIG_SH2_SRC	166	169	PF00017	0.643
LIG_SH2_STAP1	17	21	PF00017	0.533
LIG_SH2_STAP1	36	40	PF00017	0.547
LIG_SH2_STAT3	196	199	PF00017	0.629
LIG_SH2_STAT3	726	729	PF00017	0.588
LIG_SH2_STAT5	166	169	PF00017	0.555
LIG_SH2_STAT5	17	20	PF00017	0.480
LIG_SH2_STAT5	196	199	PF00017	0.603
LIG_SH2_STAT5	36	39	PF00017	0.328
LIG_SH2_STAT5	428	431	PF00017	0.532
LIG_SH2_STAT5	726	729	PF00017	0.588
LIG_SH3_1	278	284	PF00018	0.662
LIG_SH3_2	455	460	PF14604	0.538
LIG_SH3_3	278	284	PF00018	0.641
LIG_SH3_3	452	458	PF00018	0.796
LIG_SUMO_SIM_anti_2	463	470	PF11976	0.443
LIG_SUMO_SIM_anti_2	792	798	PF11976	0.438
LIG_SUMO_SIM_par_1	184	191	PF11976	0.527
LIG_SUMO_SIM_par_1	205	210	PF11976	0.586
LIG_TRAF2_1	562	565	PF00917	0.233
LIG_TRAF2_1	799	802	PF00917	0.623
LIG_WW_3	457	461	PF00397	0.616
MOD_CDK_SPxxK_3	26	33	PF00069	0.635
MOD_CK1_1	115	121	PF00069	0.695
MOD_CK1_1	122	128	PF00069	0.726
MOD_CK1_1	130	136	PF00069	0.563
MOD_CK1_1	162	168	PF00069	0.419
MOD_CK1_1	258	264	PF00069	0.795
MOD_CK1_1	453	459	PF00069	0.700
MOD_CK1_1	499	505	PF00069	0.553
MOD_CK1_1	830	836	PF00069	0.666
MOD_CK2_1	187	193	PF00069	0.688
MOD_CK2_1	257	263	PF00069	0.740
MOD_CK2_1	35	41	PF00069	0.560
MOD_CK2_1	392	398	PF00069	0.527
MOD_CK2_1	559	565	PF00069	0.272
MOD_CK2_1	643	649	PF00069	0.381
MOD_CK2_1	680	686	PF00069	0.362
MOD_GlcNHglycan	121	124	PF01048	0.717
MOD_GlcNHglycan	151	154	PF01048	0.770
MOD_GlcNHglycan	157	160	PF01048	0.707
MOD_GlcNHglycan	174	177	PF01048	0.472
MOD_GlcNHglycan	222	226	PF01048	0.586
MOD_GlcNHglycan	235	238	PF01048	0.637
MOD_GlcNHglycan	240	243	PF01048	0.650
MOD_GlcNHglycan	355	358	PF01048	0.585
MOD_GlcNHglycan	376	380	PF01048	0.569
MOD_GlcNHglycan	421	424	PF01048	0.641
MOD_GlcNHglycan	463	466	PF01048	0.594
MOD_GlcNHglycan	539	542	PF01048	0.485
MOD_GSK3_1	1	8	PF00069	0.487
MOD_GSK3_1	111	118	PF00069	0.649
MOD_GSK3_1	119	126	PF00069	0.718
MOD_GSK3_1	155	162	PF00069	0.498
MOD_GSK3_1	238	245	PF00069	0.634
MOD_GSK3_1	251	258	PF00069	0.733
MOD_GSK3_1	292	299	PF00069	0.431
MOD_GSK3_1	302	309	PF00069	0.495
MOD_GSK3_1	330	337	PF00069	0.298
MOD_GSK3_1	349	356	PF00069	0.387
MOD_GSK3_1	375	382	PF00069	0.477
MOD_GSK3_1	419	426	PF00069	0.725
MOD_GSK3_1	488	495	PF00069	0.543
MOD_GSK3_1	827	834	PF00069	0.733
MOD_LATS_1	474	480	PF00433	0.385
MOD_N-GLC_1	587	592	PF02516	0.339
MOD_N-GLC_1	643	648	PF02516	0.629
MOD_NEK2_1	1	6	PF00069	0.500
MOD_NEK2_1	214	219	PF00069	0.540
MOD_NEK2_1	221	226	PF00069	0.460
MOD_NEK2_1	291	296	PF00069	0.513
MOD_NEK2_1	329	334	PF00069	0.416
MOD_NEK2_1	35	40	PF00069	0.543
MOD_NEK2_1	360	365	PF00069	0.671
MOD_NEK2_1	488	493	PF00069	0.543
MOD_NEK2_1	496	501	PF00069	0.424
MOD_NEK2_1	524	529	PF00069	0.507
MOD_NEK2_1	537	542	PF00069	0.344
MOD_NEK2_1	60	65	PF00069	0.525
MOD_NEK2_1	612	617	PF00069	0.419
MOD_NEK2_1	624	629	PF00069	0.460
MOD_NEK2_1	680	685	PF00069	0.591
MOD_PIKK_1	379	385	PF00454	0.496
MOD_PIKK_1	803	809	PF00454	0.625
MOD_PK_1	837	843	PF00069	0.506
MOD_PKA_1	688	694	PF00069	0.379
MOD_PKA_1	837	843	PF00069	0.719
MOD_PKA_2	160	166	PF00069	0.690
MOD_PKA_2	21	27	PF00069	0.581
MOD_PKA_2	292	298	PF00069	0.545
MOD_PKA_2	350	356	PF00069	0.456
MOD_PKA_2	385	391	PF00069	0.790
MOD_PKA_2	638	644	PF00069	0.525
MOD_PKA_2	680	686	PF00069	0.362
MOD_PKA_2	688	694	PF00069	0.348
MOD_PKA_2	724	730	PF00069	0.639
MOD_PKA_2	813	819	PF00069	0.564
MOD_Plk_1	123	129	PF00069	0.716
MOD_Plk_1	397	403	PF00069	0.572
MOD_Plk_1	559	565	PF00069	0.250
MOD_Plk_1	587	593	PF00069	0.339
MOD_Plk_4	112	118	PF00069	0.648
MOD_Plk_4	162	168	PF00069	0.598
MOD_Plk_4	363	369	PF00069	0.553
MOD_Plk_4	488	494	PF00069	0.547
MOD_Plk_4	568	574	PF00069	0.416
MOD_Plk_4	69	75	PF00069	0.546
MOD_ProDKin_1	231	237	PF00069	0.775
MOD_ProDKin_1	242	248	PF00069	0.612
MOD_ProDKin_1	258	264	PF00069	0.809
MOD_ProDKin_1	26	32	PF00069	0.634
MOD_ProDKin_1	280	286	PF00069	0.601
MOD_ProDKin_1	450	456	PF00069	0.786
MOD_ProDKin_1	514	520	PF00069	0.444
MOD_SUMO_for_1	656	659	PF00179	0.597
MOD_SUMO_for_1	731	734	PF00179	0.575
MOD_SUMO_for_1	738	741	PF00179	0.585
MOD_SUMO_rev_2	26	35	PF00179	0.597
MOD_SUMO_rev_2	41	50	PF00179	0.573
MOD_SUMO_rev_2	682	690	PF00179	0.540
MOD_SUMO_rev_2	723	731	PF00179	0.546
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.491
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.573
TRG_ENDOCYTIC_2	13	16	PF00928	0.458
TRG_ENDOCYTIC_2	2	5	PF00928	0.566
TRG_ENDOCYTIC_2	668	671	PF00928	0.466
TRG_ER_diArg_1	348	351	PF00400	0.481
TRG_ER_diArg_1	51	53	PF00400	0.575
TRG_ER_diArg_1	633	636	PF00400	0.477
TRG_NES_CRM1_1	199	210	PF08389	0.646
TRG_NES_CRM1_1	747	760	PF08389	0.580
TRG_NLS_MonoCore_2	834	839	PF00514	0.744
TRG_NLS_MonoExtC_3	834	839	PF00514	0.675
TRG_NLS_MonoExtN_4	832	839	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.728
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P337	Leptomonas seymouri	57%	94%
A0A1X0NMB3	Trypanosomatidae	32%	100%
A0A3Q8IBH7	Leishmania donovani	78%	99%
A0A3R7RCX5	Trypanosoma rangeli	31%	100%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGF7	Leishmania infantum	78%	99%
E9ANZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QGM3	Leishmania major	79%	100%