Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6Y2_LEIBR

TriTrypDb:

LbrM.12.0690 , LBRM2903_120012900

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.647
CLV_NRD_NRD_1	149	151	PF00675	0.661
CLV_NRD_NRD_1	31	33	PF00675	0.592
CLV_PCSK_KEX2_1	140	142	PF00082	0.656
CLV_PCSK_KEX2_1	31	33	PF00082	0.592
CLV_PCSK_PC7_1	137	143	PF00082	0.655
CLV_PCSK_SKI1_1	158	162	PF00082	0.664
CLV_PCSK_SKI1_1	52	56	PF00082	0.616
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DOC_CYCLIN_RxL_1	137	149	PF00134	0.482
DOC_MAPK_gen_1	137	145	PF00069	0.458
DOC_MAPK_gen_1	148	155	PF00069	0.346
DOC_MAPK_gen_1	71	80	PF00069	0.476
DOC_MAPK_gen_1	8	16	PF00069	0.501
DOC_MAPK_MEF2A_6	113	120	PF00069	0.430
DOC_MAPK_MEF2A_6	65	72	PF00069	0.501
DOC_PP2B_LxvP_1	78	81	PF13499	0.326
DOC_PP2B_PxIxI_1	88	94	PF00149	0.448
DOC_USP7_MATH_1	122	126	PF00917	0.533
DOC_USP7_MATH_1	59	63	PF00917	0.373
LIG_14-3-3_CanoR_1	150	154	PF00244	0.458
LIG_14-3-3_CanoR_1	41	45	PF00244	0.449
LIG_14-3-3_CanoR_1	74	78	PF00244	0.353
LIG_14-3-3_CterR_2	163	166	PF00244	0.369
LIG_FHA_1	19	25	PF00498	0.415
LIG_FHA_1	41	47	PF00498	0.454
LIG_FHA_2	100	106	PF00498	0.405
LIG_LIR_Gen_1	43	51	PF02991	0.428
LIG_LIR_Gen_1	76	85	PF02991	0.422
LIG_LIR_Nem_3	50	54	PF02991	0.401
LIG_LIR_Nem_3	76	80	PF02991	0.409
LIG_SH2_CRK	51	55	PF00017	0.419
LIG_SH2_STAT5	138	141	PF00017	0.451
LIG_SH2_STAT5	44	47	PF00017	0.391
LIG_SH2_STAT5	77	80	PF00017	0.393
LIG_SUMO_SIM_par_1	89	94	PF11976	0.464
LIG_TYR_ITIM	75	80	PF00017	0.461
MOD_CK1_1	18	24	PF00069	0.378
MOD_CK1_1	40	46	PF00069	0.430
MOD_CK2_1	130	136	PF00069	0.510
MOD_CK2_1	99	105	PF00069	0.363
MOD_GlcNHglycan	17	20	PF01048	0.378
MOD_GSK3_1	107	114	PF00069	0.471
MOD_GSK3_1	124	131	PF00069	0.420
MOD_GSK3_1	15	22	PF00069	0.413
MOD_GSK3_1	30	37	PF00069	0.255
MOD_GSK3_1	99	106	PF00069	0.445
MOD_NEK2_1	130	135	PF00069	0.349
MOD_NEK2_1	30	35	PF00069	0.453
MOD_PIKK_1	103	109	PF00454	0.389
MOD_PIKK_1	122	128	PF00454	0.499
MOD_PKA_2	149	155	PF00069	0.458
MOD_PKA_2	30	36	PF00069	0.418
MOD_PKA_2	40	46	PF00069	0.444
MOD_PKA_2	73	79	PF00069	0.451
MOD_Plk_1	91	97	PF00069	0.453
MOD_Plk_2-3	149	155	PF00069	0.341
MOD_Plk_2-3	73	79	PF00069	0.402
MOD_Plk_4	124	130	PF00069	0.420
MOD_Plk_4	19	25	PF00069	0.389
MOD_Plk_4	40	46	PF00069	0.423
MOD_Plk_4	73	79	PF00069	0.421
MOD_SUMO_rev_2	146	153	PF00179	0.448
TRG_DiLeu_BaEn_1	50	55	PF01217	0.419
TRG_DiLeu_BaEn_4	156	162	PF01217	0.340
TRG_ENDOCYTIC_2	44	47	PF00928	0.379
TRG_ENDOCYTIC_2	51	54	PF00928	0.418
TRG_ENDOCYTIC_2	77	80	PF00928	0.413
TRG_ER_diArg_1	139	142	PF00400	0.464
TRG_ER_diArg_1	30	32	PF00400	0.371
TRG_ER_diArg_1	8	11	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB87	Leptomonas seymouri	80%	96%
A0A0S4JEH6	Bodo saltans	49%	100%
A0A1X0NMA1	Trypanosomatidae	69%	100%
A0A3Q8I877	Leishmania donovani	86%	100%
C9ZHY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	99%
C9ZHZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AGF6	Leishmania infantum	86%	100%
E9ANZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QGM4	Leishmania major	86%	100%