Bardet-Biedl syndrome 5 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 5 protein

Species:

Leishmania braziliensis

UniProt:

A4H6Y1_LEIBR

TriTrypDb:

LbrM.12.0680 , LBRM2903_120012800

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005815	microtubule organizing center	2	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0031253	cell projection membrane	4	12
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0060170	ciliary membrane	5	12
GO:0098588	bounding membrane of organelle	4	12
GO:0098590	plasma membrane region	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4H6Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y1

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0032266	phosphatidylinositol-3-phosphate binding	6	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.260
CLV_NRD_NRD_1	150	152	PF00675	0.323
CLV_NRD_NRD_1	350	352	PF00675	0.150
CLV_NRD_NRD_1	381	383	PF00675	0.184
CLV_NRD_NRD_1	396	398	PF00675	0.201
CLV_NRD_NRD_1	82	84	PF00675	0.184
CLV_PCSK_KEX2_1	124	126	PF00082	0.142
CLV_PCSK_KEX2_1	149	151	PF00082	0.326
CLV_PCSK_KEX2_1	350	352	PF00082	0.180
CLV_PCSK_KEX2_1	381	383	PF00082	0.221
CLV_PCSK_KEX2_1	82	84	PF00082	0.224
CLV_PCSK_SKI1_1	17	21	PF00082	0.380
CLV_PCSK_SKI1_1	301	305	PF00082	0.296
CLV_PCSK_SKI1_1	307	311	PF00082	0.269
CLV_PCSK_SKI1_1	398	402	PF00082	0.206
DOC_MAPK_gen_1	124	131	PF00069	0.467
DOC_MAPK_gen_1	82	90	PF00069	0.435
DOC_MAPK_MEF2A_6	301	310	PF00069	0.423
DOC_MAPK_MEF2A_6	382	391	PF00069	0.421
DOC_MAPK_MEF2A_6	82	90	PF00069	0.470
DOC_PP1_RVXF_1	226	233	PF00149	0.397
DOC_PP1_RVXF_1	27	34	PF00149	0.421
DOC_PP1_RVXF_1	73	79	PF00149	0.464
DOC_USP7_MATH_1	172	176	PF00917	0.408
DOC_USP7_MATH_1	207	211	PF00917	0.396
DOC_USP7_MATH_1	322	326	PF00917	0.342
DOC_USP7_UBL2_3	17	21	PF12436	0.394
DOC_WW_Pin1_4	141	146	PF00397	0.404
DOC_WW_Pin1_4	343	348	PF00397	0.449
LIG_14-3-3_CanoR_1	296	304	PF00244	0.546
LIG_14-3-3_CanoR_1	350	359	PF00244	0.342
LIG_Clathr_ClatBox_1	194	198	PF01394	0.443
LIG_FHA_1	110	116	PF00498	0.427
LIG_FHA_1	204	210	PF00498	0.540
LIG_FHA_1	219	225	PF00498	0.375
LIG_FHA_1	298	304	PF00498	0.486
LIG_FHA_1	314	320	PF00498	0.392
LIG_FHA_1	44	50	PF00498	0.493
LIG_FHA_1	66	72	PF00498	0.443
LIG_FHA_2	154	160	PF00498	0.431
LIG_FHA_2	97	103	PF00498	0.443
LIG_HCF-1_HBM_1	47	50	PF13415	0.501
LIG_LIR_Gen_1	123	131	PF02991	0.398
LIG_LIR_Gen_1	161	169	PF02991	0.353
LIG_LIR_Gen_1	241	250	PF02991	0.421
LIG_LIR_Gen_1	286	294	PF02991	0.504
LIG_LIR_Gen_1	47	56	PF02991	0.501
LIG_LIR_LC3C_4	221	224	PF02991	0.342
LIG_LIR_Nem_3	123	129	PF02991	0.407
LIG_LIR_Nem_3	161	166	PF02991	0.404
LIG_LIR_Nem_3	176	182	PF02991	0.431
LIG_LIR_Nem_3	241	247	PF02991	0.407
LIG_LIR_Nem_3	286	291	PF02991	0.467
LIG_LIR_Nem_3	365	370	PF02991	0.395
LIG_LIR_Nem_3	47	53	PF02991	0.501
LIG_LIR_Nem_3	89	95	PF02991	0.421
LIG_Pex14_2	126	130	PF04695	0.409
LIG_Pex14_2	272	276	PF04695	0.484
LIG_SH2_CRK	163	167	PF00017	0.499
LIG_SH2_NCK_1	288	292	PF00017	0.501
LIG_SH2_SRC	385	388	PF00017	0.448
LIG_SH2_STAT3	93	96	PF00017	0.431
LIG_SH2_STAT5	163	166	PF00017	0.342
LIG_SH2_STAT5	244	247	PF00017	0.466
LIG_SH2_STAT5	288	291	PF00017	0.390
LIG_SH2_STAT5	357	360	PF00017	0.489
LIG_SH2_STAT5	93	96	PF00017	0.503
LIG_SH3_3	237	243	PF00018	0.439
LIG_SH3_3	381	387	PF00018	0.464
LIG_SUMO_SIM_par_1	193	198	PF11976	0.513
LIG_SUMO_SIM_par_1	220	225	PF11976	0.363
LIG_SUMO_SIM_par_1	66	72	PF11976	0.440
LIG_TRAF2_1	99	102	PF00917	0.501
LIG_TYR_ITIM	90	95	PF00017	0.421
LIG_UBA3_1	303	307	PF00899	0.545
MOD_CDK_SPxxK_3	343	350	PF00069	0.449
MOD_CK1_1	10	16	PF00069	0.582
MOD_CK1_1	144	150	PF00069	0.536
MOD_CK1_1	153	159	PF00069	0.517
MOD_CK1_1	201	207	PF00069	0.480
MOD_CK1_1	210	216	PF00069	0.467
MOD_CK1_1	252	258	PF00069	0.494
MOD_CK1_1	346	352	PF00069	0.397
MOD_CK2_1	210	216	PF00069	0.461
MOD_CK2_1	322	328	PF00069	0.545
MOD_CK2_1	96	102	PF00069	0.501
MOD_CMANNOS	295	298	PF00535	0.221
MOD_GlcNHglycan	117	120	PF01048	0.282
MOD_GlcNHglycan	12	15	PF01048	0.621
MOD_GlcNHglycan	185	188	PF01048	0.342
MOD_GlcNHglycan	35	38	PF01048	0.178
MOD_GlcNHglycan	65	68	PF01048	0.221
MOD_GlcNHglycan	79	82	PF01048	0.206
MOD_GSK3_1	109	116	PF00069	0.475
MOD_GSK3_1	137	144	PF00069	0.516
MOD_GSK3_1	158	165	PF00069	0.414
MOD_GSK3_1	17	24	PF00069	0.402
MOD_GSK3_1	203	210	PF00069	0.513
MOD_GSK3_1	218	225	PF00069	0.401
MOD_GSK3_1	286	293	PF00069	0.503
MOD_GSK3_1	346	353	PF00069	0.431
MOD_GSK3_1	401	408	PF00069	0.423
MOD_GSK3_1	6	13	PF00069	0.632
MOD_GSK3_1	65	72	PF00069	0.492
MOD_N-GLC_1	238	243	PF02516	0.197
MOD_N-GLC_1	312	317	PF02516	0.142
MOD_N-GLC_1	86	91	PF02516	0.208
MOD_NEK2_1	162	167	PF00069	0.439
MOD_NEK2_1	222	227	PF00069	0.425
MOD_NEK2_1	238	243	PF00069	0.429
MOD_NEK2_1	294	299	PF00069	0.505
MOD_NEK2_1	33	38	PF00069	0.378
MOD_NEK2_1	405	410	PF00069	0.580
MOD_NEK2_1	69	74	PF00069	0.408
MOD_NEK2_1	76	81	PF00069	0.397
MOD_PIKK_1	137	143	PF00454	0.454
MOD_PIKK_1	249	255	PF00454	0.501
MOD_PKA_1	150	156	PF00069	0.442
MOD_PKA_1	350	356	PF00069	0.342
MOD_PKA_2	150	156	PF00069	0.478
MOD_PKA_2	350	356	PF00069	0.382
MOD_Plk_1	158	164	PF00069	0.473
MOD_Plk_1	173	179	PF00069	0.408
MOD_Plk_1	238	244	PF00069	0.399
MOD_Plk_1	263	269	PF00069	0.465
MOD_Plk_1	289	295	PF00069	0.439
MOD_Plk_1	406	412	PF00069	0.652
MOD_Plk_1	86	92	PF00069	0.408
MOD_Plk_4	158	164	PF00069	0.395
MOD_Plk_4	198	204	PF00069	0.496
MOD_Plk_4	218	224	PF00069	0.436
MOD_Plk_4	290	296	PF00069	0.397
MOD_Plk_4	401	407	PF00069	0.464
MOD_Plk_4	65	71	PF00069	0.443
MOD_ProDKin_1	141	147	PF00069	0.404
MOD_ProDKin_1	343	349	PF00069	0.449
MOD_SUMO_rev_2	279	284	PF00179	0.443
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.443
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.464
TRG_ENDOCYTIC_2	163	166	PF00928	0.479
TRG_ENDOCYTIC_2	179	182	PF00928	0.325
TRG_ENDOCYTIC_2	244	247	PF00928	0.454
TRG_ENDOCYTIC_2	288	291	PF00928	0.501
TRG_ENDOCYTIC_2	50	53	PF00928	0.501
TRG_ENDOCYTIC_2	92	95	PF00928	0.408
TRG_ER_diArg_1	124	126	PF00400	0.342
TRG_ER_diArg_1	148	151	PF00400	0.528
TRG_ER_diArg_1	182	185	PF00400	0.434
TRG_ER_diArg_1	381	383	PF00400	0.421
TRG_NES_CRM1_1	253	264	PF08389	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P9	Leptomonas seymouri	60%	99%
A0A0S4JE34	Bodo saltans	42%	100%
A0A1X0NMY8	Trypanosomatidae	40%	100%
A0A3Q8ICM0	Leishmania donovani	69%	95%
A0A3R7K3V6	Trypanosoma rangeli	40%	100%
C9ZHY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AGF5	Leishmania infantum	68%	95%
E9ANZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q21626	Caenorhabditis elegans	34%	100%
Q4QGM5	Leishmania major	70%	100%
Q4R649	Macaca fascicularis	37%	100%
Q66IS6	Xenopus laevis	38%	100%
Q7ZWB7	Danio rerio	38%	100%
Q8N3I7	Homo sapiens	37%	100%
Q9CZQ9	Mus musculus	39%	100%
V5BJR9	Trypanosoma cruzi	39%	100%