Cytochrome c oxidase subunit IV

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit IV, putative

Species:

Leishmania braziliensis

UniProt:

A4H6Y0_LEIBR

TriTrypDb:

LbrM.12.0670 , LBRM2903_120012700

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6Y0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016491	oxidoreductase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.673
CLV_NRD_NRD_1	124	126	PF00675	0.610
CLV_NRD_NRD_1	233	235	PF00675	0.508
CLV_NRD_NRD_1	243	245	PF00675	0.370
CLV_NRD_NRD_1	26	28	PF00675	0.581
CLV_NRD_NRD_1	333	335	PF00675	0.511
CLV_NRD_NRD_1	4	6	PF00675	0.588
CLV_NRD_NRD_1	96	98	PF00675	0.577
CLV_PCSK_KEX2_1	233	235	PF00082	0.412
CLV_PCSK_KEX2_1	26	28	PF00082	0.573
CLV_PCSK_KEX2_1	4	6	PF00082	0.588
CLV_PCSK_SKI1_1	155	159	PF00082	0.547
CLV_PCSK_SKI1_1	234	238	PF00082	0.504
CLV_PCSK_SKI1_1	275	279	PF00082	0.443
CLV_PCSK_SKI1_1	335	339	PF00082	0.618
CLV_PCSK_SKI1_1	69	73	PF00082	0.521
DEG_APCC_DBOX_1	233	241	PF00400	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.600
DEG_SPOP_SBC_1	17	21	PF00917	0.694
DOC_CYCLIN_yClb5_NLxxxL_5	187	194	PF00134	0.679
DOC_MAPK_DCC_7	69	77	PF00069	0.541
DOC_MAPK_gen_1	233	239	PF00069	0.511
DOC_MAPK_MEF2A_6	69	77	PF00069	0.541
DOC_USP7_MATH_1	133	137	PF00917	0.568
DOC_USP7_MATH_1	17	21	PF00917	0.696
DOC_USP7_MATH_1	6	10	PF00917	0.562
DOC_USP7_UBL2_3	56	60	PF12436	0.700
DOC_WW_Pin1_4	175	180	PF00397	0.578
LIG_14-3-3_CanoR_1	205	211	PF00244	0.498
LIG_14-3-3_CanoR_1	275	280	PF00244	0.498
LIG_14-3-3_CanoR_1	58	67	PF00244	0.568
LIG_APCC_ABBA_1	71	76	PF00400	0.542
LIG_CSL_BTD_1	208	211	PF09270	0.495
LIG_FHA_1	205	211	PF00498	0.498
LIG_FHA_1	272	278	PF00498	0.528
LIG_FHA_2	127	133	PF00498	0.676
LIG_FHA_2	261	267	PF00498	0.536
LIG_FHA_2	59	65	PF00498	0.535
LIG_LIR_Gen_1	212	222	PF02991	0.525
LIG_LIR_Gen_1	79	88	PF02991	0.525
LIG_LIR_Nem_3	212	217	PF02991	0.508
LIG_LIR_Nem_3	220	225	PF02991	0.504
LIG_LIR_Nem_3	332	336	PF02991	0.550
LIG_LIR_Nem_3	79	84	PF02991	0.520
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.405
LIG_SH2_CRK	214	218	PF00017	0.512
LIG_SH2_NCK_1	311	315	PF00017	0.417
LIG_SH2_STAP1	247	251	PF00017	0.470
LIG_SH2_STAP1	256	260	PF00017	0.442
LIG_SH2_STAP1	311	315	PF00017	0.417
LIG_SH2_STAP1	81	85	PF00017	0.531
LIG_SH2_STAT5	156	159	PF00017	0.563
LIG_SH2_STAT5	218	221	PF00017	0.533
LIG_SH2_STAT5	247	250	PF00017	0.638
LIG_SUMO_SIM_anti_2	235	242	PF11976	0.534
LIG_SUMO_SIM_par_1	235	242	PF11976	0.563
LIG_TRAF2_1	61	64	PF00917	0.563
MOD_CK1_1	178	184	PF00069	0.561
MOD_CK1_1	20	26	PF00069	0.646
MOD_CK2_1	178	184	PF00069	0.561
MOD_CK2_1	260	266	PF00069	0.505
MOD_CK2_1	58	64	PF00069	0.547
MOD_CK2_1	76	82	PF00069	0.543
MOD_GlcNHglycan	8	11	PF01048	0.629
MOD_GSK3_1	16	23	PF00069	0.612
MOD_GSK3_1	271	278	PF00069	0.441
MOD_GSK3_1	58	65	PF00069	0.552
MOD_N-GLC_1	227	232	PF02516	0.519
MOD_NEK2_1	18	23	PF00069	0.692
MOD_NEK2_1	260	265	PF00069	0.577
MOD_NEK2_1	67	72	PF00069	0.501
MOD_PKA_2	204	210	PF00069	0.500
MOD_PKA_2	260	266	PF00069	0.557
MOD_Plk_1	183	189	PF00069	0.563
MOD_Plk_4	50	56	PF00069	0.595
MOD_Plk_4	67	73	PF00069	0.512
MOD_ProDKin_1	175	181	PF00069	0.568
MOD_SUMO_for_1	59	62	PF00179	0.667
MOD_SUMO_rev_2	147	157	PF00179	0.551
TRG_DiLeu_BaEn_1	322	327	PF01217	0.528
TRG_ENDOCYTIC_2	214	217	PF00928	0.501
TRG_ENDOCYTIC_2	81	84	PF00928	0.531
TRG_ER_diArg_1	26	28	PF00400	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRY9	Leptomonas seymouri	89%	100%
A0A0S4JH93	Bodo saltans	71%	98%
A0A1X0NMQ0	Trypanosomatidae	78%	99%
A0A3R7NBF6	Trypanosoma rangeli	75%	100%
A0A3S5H6L2	Leishmania donovani	91%	99%
C9ZHY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	96%
E9AGF4	Leishmania infantum	91%	99%
E9ANZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGM6	Leishmania major	91%	100%
V5BF65	Trypanosoma cruzi	76%	100%