Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6X9_LEIBR

TriTrypDb:

LbrM.12.0660 , LBRM2903_120012500

Length:

899

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0004722	protein serine/threonine phosphatase activity	4	13
GO:0005488	binding	1	9
GO:0005509	calcium ion binding	5	9
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0017018	myosin phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	550	554	PF00656	0.717
CLV_MEL_PAP_1	273	279	PF00089	0.561
CLV_NRD_NRD_1	126	128	PF00675	0.666
CLV_NRD_NRD_1	14	16	PF00675	0.531
CLV_NRD_NRD_1	409	411	PF00675	0.350
CLV_NRD_NRD_1	499	501	PF00675	0.334
CLV_NRD_NRD_1	592	594	PF00675	0.537
CLV_NRD_NRD_1	609	611	PF00675	0.305
CLV_NRD_NRD_1	820	822	PF00675	0.524
CLV_NRD_NRD_1	860	862	PF00675	0.592
CLV_PCSK_KEX2_1	126	128	PF00082	0.666
CLV_PCSK_KEX2_1	198	200	PF00082	0.612
CLV_PCSK_KEX2_1	408	410	PF00082	0.330
CLV_PCSK_KEX2_1	59	61	PF00082	0.609
CLV_PCSK_KEX2_1	592	594	PF00082	0.525
CLV_PCSK_KEX2_1	609	611	PF00082	0.307
CLV_PCSK_KEX2_1	860	862	PF00082	0.622
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.645
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.529
CLV_PCSK_PC7_1	605	611	PF00082	0.396
CLV_PCSK_SKI1_1	106	110	PF00082	0.555
CLV_PCSK_SKI1_1	153	157	PF00082	0.527
CLV_PCSK_SKI1_1	233	237	PF00082	0.467
CLV_PCSK_SKI1_1	251	255	PF00082	0.272
CLV_PCSK_SKI1_1	32	36	PF00082	0.427
CLV_PCSK_SKI1_1	346	350	PF00082	0.370
CLV_PCSK_SKI1_1	376	380	PF00082	0.336
CLV_PCSK_SKI1_1	500	504	PF00082	0.391
CLV_PCSK_SKI1_1	587	591	PF00082	0.662
CLV_PCSK_SKI1_1	638	642	PF00082	0.415
CLV_PCSK_SKI1_1	822	826	PF00082	0.514
DEG_APCC_DBOX_1	650	658	PF00400	0.526
DEG_APCC_DBOX_1	787	795	PF00400	0.509
DEG_SPOP_SBC_1	211	215	PF00917	0.591
DOC_ANK_TNKS_1	126	133	PF00023	0.622
DOC_CYCLIN_RxL_1	497	507	PF00134	0.429
DOC_CYCLIN_RxL_1	584	594	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	643	649	PF00134	0.446
DOC_MAPK_gen_1	236	244	PF00069	0.539
DOC_MAPK_gen_1	408	414	PF00069	0.336
DOC_MAPK_gen_1	419	428	PF00069	0.336
DOC_MAPK_gen_1	622	630	PF00069	0.305
DOC_MAPK_MEF2A_6	326	335	PF00069	0.323
DOC_MAPK_MEF2A_6	638	645	PF00069	0.435
DOC_MAPK_NFAT4_5	638	646	PF00069	0.453
DOC_MAPK_RevD_3	848	861	PF00069	0.292
DOC_PP2B_LxvP_1	643	646	PF13499	0.438
DOC_PP4_FxxP_1	128	131	PF00568	0.646
DOC_USP7_MATH_1	197	201	PF00917	0.616
DOC_USP7_MATH_1	2	6	PF00917	0.589
DOC_USP7_MATH_1	211	215	PF00917	0.525
DOC_USP7_MATH_1	275	279	PF00917	0.569
DOC_USP7_MATH_1	311	315	PF00917	0.391
DOC_USP7_MATH_1	841	845	PF00917	0.465
DOC_USP7_UBL2_3	16	20	PF12436	0.552
DOC_USP7_UBL2_3	184	188	PF12436	0.609
DOC_USP7_UBL2_3	802	806	PF12436	0.423
DOC_WW_Pin1_4	203	208	PF00397	0.499
DOC_WW_Pin1_4	267	272	PF00397	0.457
DOC_WW_Pin1_4	563	568	PF00397	0.532
DOC_WW_Pin1_4	889	894	PF00397	0.614
LIG_14-3-3_CanoR_1	199	204	PF00244	0.671
LIG_14-3-3_CanoR_1	251	260	PF00244	0.378
LIG_14-3-3_CanoR_1	685	689	PF00244	0.497
LIG_14-3-3_CanoR_1	821	827	PF00244	0.552
LIG_14-3-3_CanoR_1	860	864	PF00244	0.630
LIG_14-3-3_CanoR_1	886	891	PF00244	0.690
LIG_Actin_WH2_2	291	308	PF00022	0.445
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	115	119	PF00533	0.564
LIG_BRCT_BRCA1_1	214	218	PF00533	0.488
LIG_BRCT_BRCA1_1	705	709	PF00533	0.525
LIG_BRCT_BRCA1_2	705	711	PF00533	0.545
LIG_CaM_IQ_9	145	160	PF13499	0.489
LIG_Clathr_ClatBox_1	654	658	PF01394	0.520
LIG_deltaCOP1_diTrp_1	644	649	PF00928	0.450
LIG_deltaCOP1_diTrp_1	678	684	PF00928	0.520
LIG_EH1_1	228	236	PF00400	0.537
LIG_eIF4E_1	543	549	PF01652	0.622
LIG_eIF4E_1	870	876	PF01652	0.368
LIG_FHA_1	119	125	PF00498	0.512
LIG_FHA_1	470	476	PF00498	0.387
LIG_FHA_1	845	851	PF00498	0.390
LIG_FHA_2	370	376	PF00498	0.331
LIG_FHA_2	592	598	PF00498	0.422
LIG_FHA_2	727	733	PF00498	0.412
LIG_FHA_2	796	802	PF00498	0.581
LIG_Integrin_isoDGR_2	279	281	PF01839	0.561
LIG_Integrin_isoDGR_2	895	897	PF01839	0.538
LIG_LIR_Apic_2	442	448	PF02991	0.348
LIG_LIR_Apic_2	509	514	PF02991	0.449
LIG_LIR_Gen_1	178	185	PF02991	0.568
LIG_LIR_Gen_1	437	448	PF02991	0.336
LIG_LIR_Gen_1	535	543	PF02991	0.585
LIG_LIR_Gen_1	644	655	PF02991	0.519
LIG_LIR_Gen_1	718	726	PF02991	0.423
LIG_LIR_Gen_1	830	841	PF02991	0.455
LIG_LIR_Gen_1	845	856	PF02991	0.371
LIG_LIR_LC3C_4	481	484	PF02991	0.306
LIG_LIR_Nem_3	163	169	PF02991	0.496
LIG_LIR_Nem_3	178	183	PF02991	0.477
LIG_LIR_Nem_3	214	220	PF02991	0.562
LIG_LIR_Nem_3	515	521	PF02991	0.420
LIG_LIR_Nem_3	530	536	PF02991	0.381
LIG_LIR_Nem_3	644	650	PF02991	0.438
LIG_LIR_Nem_3	718	722	PF02991	0.419
LIG_LIR_Nem_3	845	851	PF02991	0.485
LIG_MLH1_MIPbox_1	214	218	PF16413	0.488
LIG_PCNA_PIPBox_1	47	56	PF02747	0.487
LIG_Pex14_1	664	668	PF04695	0.406
LIG_Pex14_2	668	672	PF04695	0.387
LIG_PTB_Apo_2	317	324	PF02174	0.323
LIG_PTB_Apo_2	358	365	PF02174	0.333
LIG_PTB_Phospho_1	317	323	PF10480	0.472
LIG_PTB_Phospho_1	358	364	PF10480	0.333
LIG_RPA_C_Fungi	856	868	PF08784	0.363
LIG_SH2_CRK	511	515	PF00017	0.539
LIG_SH2_CRK	518	522	PF00017	0.429
LIG_SH2_GRB2like	359	362	PF00017	0.329
LIG_SH2_NCK_1	431	435	PF00017	0.370
LIG_SH2_PTP2	347	350	PF00017	0.361
LIG_SH2_SRC	494	497	PF00017	0.437
LIG_SH2_SRC	543	546	PF00017	0.704
LIG_SH2_STAP1	374	378	PF00017	0.336
LIG_SH2_STAP1	665	669	PF00017	0.292
LIG_SH2_STAT5	217	220	PF00017	0.415
LIG_SH2_STAT5	317	320	PF00017	0.346
LIG_SH2_STAT5	323	326	PF00017	0.343
LIG_SH2_STAT5	347	350	PF00017	0.361
LIG_SH2_STAT5	616	619	PF00017	0.411
LIG_SH2_STAT5	653	656	PF00017	0.369
LIG_SH2_STAT5	728	731	PF00017	0.437
LIG_SH2_STAT5	856	859	PF00017	0.485
LIG_SH3_3	191	197	PF00018	0.623
LIG_SH3_3	239	245	PF00018	0.444
LIG_SH3_3	569	575	PF00018	0.673
LIG_SH3_4	87	94	PF00018	0.594
LIG_SH3_5	18	22	PF00018	0.588
LIG_SUMO_SIM_anti_2	332	339	PF11976	0.336
LIG_SUMO_SIM_par_1	287	293	PF11976	0.325
LIG_SUMO_SIM_par_1	332	339	PF11976	0.352
LIG_SUMO_SIM_par_1	501	507	PF11976	0.388
LIG_SUMO_SIM_par_1	544	554	PF11976	0.654
LIG_SUMO_SIM_par_1	653	658	PF11976	0.526
LIG_TRAF2_1	120	123	PF00917	0.398
LIG_UBA3_1	234	239	PF00899	0.519
LIG_UBA3_1	301	306	PF00899	0.341
LIG_UBA3_1	337	346	PF00899	0.352
LIG_UBA3_1	832	837	PF00899	0.569
LIG_WRC_WIRS_1	521	526	PF05994	0.488
LIG_WRC_WIRS_1	665	670	PF05994	0.268
LIG_WRC_WIRS_1	739	744	PF05994	0.528
MOD_CK1_1	468	474	PF00069	0.472
MOD_CK1_1	532	538	PF00069	0.512
MOD_CK1_1	844	850	PF00069	0.454
MOD_CK1_1	889	895	PF00069	0.549
MOD_CK2_1	429	435	PF00069	0.352
MOD_CK2_1	489	495	PF00069	0.483
MOD_CK2_1	738	744	PF00069	0.509
MOD_CK2_1	868	874	PF00069	0.514
MOD_CMANNOS	37	40	PF00535	0.522
MOD_Cter_Amidation	57	60	PF01082	0.596
MOD_GlcNHglycan	115	118	PF01048	0.560
MOD_GlcNHglycan	307	310	PF01048	0.418
MOD_GlcNHglycan	491	494	PF01048	0.507
MOD_GlcNHglycan	506	509	PF01048	0.273
MOD_GlcNHglycan	576	579	PF01048	0.624
MOD_GlcNHglycan	583	586	PF01048	0.634
MOD_GlcNHglycan	705	708	PF01048	0.554
MOD_GSK3_1	161	168	PF00069	0.605
MOD_GSK3_1	199	206	PF00069	0.502
MOD_GSK3_1	220	227	PF00069	0.332
MOD_GSK3_1	305	312	PF00069	0.472
MOD_GSK3_1	32	39	PF00069	0.441
MOD_GSK3_1	465	472	PF00069	0.219
MOD_GSK3_1	543	550	PF00069	0.646
MOD_GSK3_1	551	558	PF00069	0.562
MOD_GSK3_1	579	586	PF00069	0.573
MOD_GSK3_1	620	627	PF00069	0.424
MOD_GSK3_1	699	706	PF00069	0.555
MOD_GSK3_1	786	793	PF00069	0.532
MOD_GSK3_1	866	873	PF00069	0.601
MOD_GSK3_1	881	888	PF00069	0.462
MOD_N-GLC_1	220	225	PF02516	0.481
MOD_N-GLC_1	429	434	PF02516	0.450
MOD_N-GLC_1	568	573	PF02516	0.553
MOD_N-GLC_1	579	584	PF02516	0.606
MOD_N-GLC_1	886	891	PF02516	0.646
MOD_NEK2_1	305	310	PF00069	0.450
MOD_NEK2_1	506	511	PF00069	0.399
MOD_NEK2_1	551	556	PF00069	0.580
MOD_NEK2_1	557	562	PF00069	0.577
MOD_NEK2_1	568	573	PF00069	0.520
MOD_NEK2_1	579	584	PF00069	0.619
MOD_NEK2_1	620	625	PF00069	0.422
MOD_NEK2_1	795	800	PF00069	0.528
MOD_NEK2_1	866	871	PF00069	0.644
MOD_NEK2_1	885	890	PF00069	0.698
MOD_NEK2_1	95	100	PF00069	0.524
MOD_NEK2_2	633	638	PF00069	0.482
MOD_OFUCOSY	29	36	PF10250	0.427
MOD_PIKK_1	429	435	PF00454	0.352
MOD_PIKK_1	455	461	PF00454	0.408
MOD_PIKK_1	543	549	PF00454	0.718
MOD_PIKK_1	699	705	PF00454	0.525
MOD_PIKK_1	786	792	PF00454	0.499
MOD_PIKK_1	822	828	PF00454	0.483
MOD_PK_1	199	205	PF00069	0.593
MOD_PK_1	410	416	PF00069	0.418
MOD_PKA_2	275	281	PF00069	0.572
MOD_PKA_2	455	461	PF00069	0.352
MOD_PKA_2	591	597	PF00069	0.567
MOD_PKA_2	684	690	PF00069	0.485
MOD_PKA_2	80	86	PF00069	0.538
MOD_PKA_2	859	865	PF00069	0.631
MOD_PKA_2	885	891	PF00069	0.758
MOD_PKB_1	408	416	PF00069	0.472
MOD_Plk_1	161	167	PF00069	0.416
MOD_Plk_1	2	8	PF00069	0.581
MOD_Plk_1	220	226	PF00069	0.469
MOD_Plk_1	32	38	PF00069	0.440
MOD_Plk_1	415	421	PF00069	0.370
MOD_Plk_1	543	549	PF00069	0.686
MOD_Plk_1	568	574	PF00069	0.656
MOD_Plk_1	844	850	PF00069	0.539
MOD_Plk_1	886	892	PF00069	0.650
MOD_Plk_2-3	678	684	PF00069	0.373
MOD_Plk_4	161	167	PF00069	0.500
MOD_Plk_4	23	29	PF00069	0.491
MOD_Plk_4	390	396	PF00069	0.336
MOD_Plk_4	501	507	PF00069	0.374
MOD_Plk_4	520	526	PF00069	0.381
MOD_Plk_4	624	630	PF00069	0.427
MOD_Plk_4	664	670	PF00069	0.394
MOD_Plk_4	718	724	PF00069	0.416
MOD_Plk_4	790	796	PF00069	0.534
MOD_ProDKin_1	203	209	PF00069	0.483
MOD_ProDKin_1	267	273	PF00069	0.466
MOD_ProDKin_1	563	569	PF00069	0.532
MOD_ProDKin_1	889	895	PF00069	0.617
MOD_SUMO_for_1	175	178	PF00179	0.536
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.352
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.454
TRG_DiLeu_BaLyEn_6	766	771	PF01217	0.357
TRG_ENDOCYTIC_2	170	173	PF00928	0.578
TRG_ENDOCYTIC_2	217	220	PF00928	0.537
TRG_ENDOCYTIC_2	347	350	PF00928	0.361
TRG_ENDOCYTIC_2	518	521	PF00928	0.460
TRG_ENDOCYTIC_2	536	539	PF00928	0.372
TRG_ENDOCYTIC_2	665	668	PF00928	0.369
TRG_ENDOCYTIC_2	716	719	PF00928	0.390
TRG_ER_diArg_1	126	128	PF00400	0.664
TRG_ER_diArg_1	407	410	PF00400	0.336
TRG_ER_diArg_1	609	612	PF00400	0.484
TRG_NES_CRM1_1	163	178	PF08389	0.534
TRG_NES_CRM1_1	293	307	PF08389	0.336
TRG_NES_CRM1_1	845	859	PF08389	0.399
TRG_NLS_MonoExtN_4	197	202	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT4	Leptomonas seymouri	84%	93%
A0A0S4JAH8	Bodo saltans	31%	71%
A0A0S4JE35	Bodo saltans	57%	98%
A0A1X0NNZ8	Trypanosomatidae	64%	96%
A0A3Q8I989	Leishmania donovani	90%	94%
A0A422MRT7	Trypanosoma rangeli	62%	97%
C9ZHY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	97%
E9AGF3	Leishmania infantum	90%	94%
E9ANZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	94%
Q4QGM7	Leishmania major	90%	100%
V5BP95	Trypanosoma cruzi	69%	100%