Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6X8_LEIBR

TriTrypDb:

LbrM.12.0650 , LBRM2903_120012400

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.539
CLV_NRD_NRD_1	173	175	PF00675	0.590
CLV_NRD_NRD_1	181	183	PF00675	0.550
CLV_NRD_NRD_1	188	190	PF00675	0.661
CLV_NRD_NRD_1	233	235	PF00675	0.670
CLV_NRD_NRD_1	40	42	PF00675	0.505
CLV_NRD_NRD_1	607	609	PF00675	0.581
CLV_PCSK_KEX2_1	108	110	PF00082	0.490
CLV_PCSK_KEX2_1	181	183	PF00082	0.577
CLV_PCSK_KEX2_1	188	190	PF00082	0.684
CLV_PCSK_KEX2_1	291	293	PF00082	0.632
CLV_PCSK_KEX2_1	40	42	PF00082	0.505
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.490
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.515
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.518
CLV_PCSK_PC7_1	287	293	PF00082	0.518
CLV_PCSK_SKI1_1	148	152	PF00082	0.470
CLV_PCSK_SKI1_1	234	238	PF00082	0.516
CLV_PCSK_SKI1_1	291	295	PF00082	0.723
CLV_PCSK_SKI1_1	523	527	PF00082	0.764
CLV_PCSK_SKI1_1	611	615	PF00082	0.583
CLV_PCSK_SKI1_1	68	72	PF00082	0.535
DOC_MAPK_gen_1	437	445	PF00069	0.609
DOC_MAPK_gen_1	605	615	PF00069	0.579
DOC_MAPK_JIP1_4	78	84	PF00069	0.474
DOC_MAPK_MEF2A_6	608	617	PF00069	0.578
DOC_MAPK_MEF2A_6	68	75	PF00069	0.501
DOC_PP2B_LxvP_1	71	74	PF13499	0.495
DOC_USP7_MATH_1	122	126	PF00917	0.593
DOC_USP7_MATH_1	200	204	PF00917	0.601
DOC_USP7_MATH_1	247	251	PF00917	0.562
DOC_USP7_MATH_1	351	355	PF00917	0.761
DOC_USP7_MATH_1	411	415	PF00917	0.621
DOC_USP7_MATH_1	471	475	PF00917	0.642
DOC_USP7_MATH_1	498	502	PF00917	0.775
DOC_USP7_MATH_1	5	9	PF00917	0.526
DOC_USP7_MATH_1	508	512	PF00917	0.610
DOC_USP7_MATH_1	514	518	PF00917	0.546
DOC_USP7_MATH_1	525	529	PF00917	0.551
DOC_USP7_MATH_1	531	535	PF00917	0.727
DOC_USP7_MATH_1	548	552	PF00917	0.507
DOC_USP7_MATH_1	559	563	PF00917	0.712
DOC_USP7_MATH_1	587	591	PF00917	0.752
DOC_USP7_MATH_1	604	608	PF00917	0.475
DOC_USP7_UBL2_3	117	121	PF12436	0.539
DOC_USP7_UBL2_3	175	179	PF12436	0.579
DOC_USP7_UBL2_3	181	185	PF12436	0.580
DOC_USP7_UBL2_3	605	609	PF12436	0.656
DOC_WW_Pin1_4	438	443	PF00397	0.508
DOC_WW_Pin1_4	527	532	PF00397	0.770
DOC_WW_Pin1_4	544	549	PF00397	0.649
LIG_14-3-3_CanoR_1	234	240	PF00244	0.521
LIG_14-3-3_CanoR_1	287	294	PF00244	0.795
LIG_14-3-3_CanoR_1	437	442	PF00244	0.619
LIG_14-3-3_CanoR_1	491	499	PF00244	0.545
LIG_14-3-3_CanoR_1	527	531	PF00244	0.540
LIG_14-3-3_CanoR_1	59	67	PF00244	0.519
LIG_14-3-3_CanoR_1	81	89	PF00244	0.505
LIG_Actin_WH2_2	31	46	PF00022	0.570
LIG_BIR_III_2	484	488	PF00653	0.531
LIG_BIR_III_4	384	388	PF00653	0.517
LIG_BRCT_BRCA1_1	225	229	PF00533	0.537
LIG_BRCT_BRCA1_1	413	417	PF00533	0.672
LIG_BRCT_BRCA1_1	461	465	PF00533	0.671
LIG_BRCT_BRCA1_1	548	552	PF00533	0.622
LIG_FHA_1	11	17	PF00498	0.580
LIG_FHA_1	222	228	PF00498	0.534
LIG_FHA_1	295	301	PF00498	0.691
LIG_FHA_1	394	400	PF00498	0.567
LIG_FHA_1	438	444	PF00498	0.580
LIG_FHA_2	278	284	PF00498	0.713
LIG_FHA_2	579	585	PF00498	0.689
LIG_FHA_2	94	100	PF00498	0.485
LIG_Integrin_RGD_1	197	199	PF01839	0.516
LIG_LIR_Apic_2	110	114	PF02991	0.477
LIG_LIR_Gen_1	160	167	PF02991	0.536
LIG_LIR_Nem_3	160	164	PF02991	0.535
LIG_LIR_Nem_3	389	393	PF02991	0.523
LIG_SH2_STAP1	161	165	PF00017	0.460
LIG_SH2_STAP1	502	506	PF00017	0.688
LIG_SH3_3	89	95	PF00018	0.636
LIG_SH3_4	605	612	PF00018	0.658
LIG_SxIP_EBH_1	437	449	PF03271	0.643
LIG_TRAF2_1	125	128	PF00917	0.539
LIG_TRAF2_1	166	169	PF00917	0.456
LIG_WRC_WIRS_1	47	52	PF05994	0.602
MOD_CDK_SPxK_1	544	550	PF00069	0.531
MOD_CK1_1	211	217	PF00069	0.643
MOD_CK1_1	223	229	PF00069	0.777
MOD_CK1_1	230	236	PF00069	0.610
MOD_CK1_1	238	244	PF00069	0.621
MOD_CK1_1	286	292	PF00069	0.616
MOD_CK1_1	322	328	PF00069	0.533
MOD_CK1_1	361	367	PF00069	0.655
MOD_CK1_1	392	398	PF00069	0.545
MOD_CK1_1	415	421	PF00069	0.493
MOD_CK1_1	455	461	PF00069	0.628
MOD_CK1_1	463	469	PF00069	0.661
MOD_CK1_1	517	523	PF00069	0.622
MOD_CK1_1	534	540	PF00069	0.581
MOD_CK1_1	541	547	PF00069	0.674
MOD_CK1_1	579	585	PF00069	0.689
MOD_CK2_1	122	128	PF00069	0.646
MOD_CK2_1	130	136	PF00069	0.538
MOD_CK2_1	18	24	PF00069	0.488
MOD_CK2_1	214	220	PF00069	0.750
MOD_CK2_1	3	9	PF00069	0.531
MOD_CK2_1	308	314	PF00069	0.651
MOD_CK2_1	578	584	PF00069	0.664
MOD_CK2_1	604	610	PF00069	0.577
MOD_CK2_1	93	99	PF00069	0.500
MOD_DYRK1A_RPxSP_1	527	531	PF00069	0.589
MOD_GlcNHglycan	118	121	PF01048	0.545
MOD_GlcNHglycan	142	145	PF01048	0.443
MOD_GlcNHglycan	210	213	PF01048	0.577
MOD_GlcNHglycan	269	272	PF01048	0.743
MOD_GlcNHglycan	288	291	PF01048	0.702
MOD_GlcNHglycan	321	324	PF01048	0.545
MOD_GlcNHglycan	360	363	PF01048	0.670
MOD_GlcNHglycan	365	368	PF01048	0.758
MOD_GlcNHglycan	370	373	PF01048	0.655
MOD_GlcNHglycan	417	420	PF01048	0.688
MOD_GlcNHglycan	421	424	PF01048	0.748
MOD_GlcNHglycan	426	429	PF01048	0.565
MOD_GlcNHglycan	448	451	PF01048	0.574
MOD_GlcNHglycan	454	457	PF01048	0.563
MOD_GlcNHglycan	462	465	PF01048	0.597
MOD_GlcNHglycan	469	472	PF01048	0.527
MOD_GlcNHglycan	473	476	PF01048	0.504
MOD_GlcNHglycan	5	8	PF01048	0.429
MOD_GlcNHglycan	510	513	PF01048	0.768
MOD_GlcNHglycan	533	536	PF01048	0.751
MOD_GlcNHglycan	541	544	PF01048	0.557
MOD_GlcNHglycan	561	564	PF01048	0.625
MOD_GlcNHglycan	567	570	PF01048	0.602
MOD_GlcNHglycan	581	584	PF01048	0.477
MOD_GSK3_1	100	107	PF00069	0.608
MOD_GSK3_1	223	230	PF00069	0.785
MOD_GSK3_1	235	242	PF00069	0.561
MOD_GSK3_1	273	280	PF00069	0.545
MOD_GSK3_1	389	396	PF00069	0.668
MOD_GSK3_1	411	418	PF00069	0.741
MOD_GSK3_1	455	462	PF00069	0.598
MOD_GSK3_1	463	470	PF00069	0.553
MOD_GSK3_1	498	505	PF00069	0.663
MOD_GSK3_1	517	524	PF00069	0.508
MOD_GSK3_1	527	534	PF00069	0.615
MOD_GSK3_1	537	544	PF00069	0.641
MOD_GSK3_1	548	555	PF00069	0.564
MOD_GSK3_1	575	582	PF00069	0.626
MOD_GSK3_1	583	590	PF00069	0.590
MOD_N-GLC_1	531	536	PF02516	0.597
MOD_NEK2_1	16	21	PF00069	0.471
MOD_NEK2_1	229	234	PF00069	0.515
MOD_NEK2_1	319	324	PF00069	0.617
MOD_NEK2_1	393	398	PF00069	0.543
MOD_NEK2_1	417	422	PF00069	0.669
MOD_NEK2_1	43	48	PF00069	0.523
MOD_NEK2_1	457	462	PF00069	0.667
MOD_NEK2_1	467	472	PF00069	0.456
MOD_NEK2_1	526	531	PF00069	0.591
MOD_NEK2_1	536	541	PF00069	0.669
MOD_NEK2_1	552	557	PF00069	0.519
MOD_NEK2_1	576	581	PF00069	0.614
MOD_NEK2_1	588	593	PF00069	0.599
MOD_NEK2_1	82	87	PF00069	0.604
MOD_PIKK_1	122	128	PF00454	0.545
MOD_PIKK_1	322	328	PF00454	0.450
MOD_PIKK_1	339	345	PF00454	0.638
MOD_PK_1	235	241	PF00069	0.525
MOD_PKA_2	104	110	PF00069	0.501
MOD_PKA_2	286	292	PF00069	0.683
MOD_PKA_2	393	399	PF00069	0.593
MOD_PKA_2	43	49	PF00069	0.601
MOD_PKA_2	508	514	PF00069	0.693
MOD_PKA_2	526	532	PF00069	0.508
MOD_PKA_2	576	582	PF00069	0.613
MOD_PKA_2	77	83	PF00069	0.552
MOD_PKB_1	332	340	PF00069	0.595
MOD_Plk_1	412	418	PF00069	0.494
MOD_Plk_1	502	508	PF00069	0.788
MOD_Plk_1	531	537	PF00069	0.639
MOD_Plk_1	57	63	PF00069	0.555
MOD_Plk_2-3	130	136	PF00069	0.530
MOD_Plk_2-3	308	314	PF00069	0.630
MOD_Plk_4	421	427	PF00069	0.494
MOD_Plk_4	93	99	PF00069	0.500
MOD_ProDKin_1	438	444	PF00069	0.507
MOD_ProDKin_1	527	533	PF00069	0.770
MOD_ProDKin_1	544	550	PF00069	0.539
MOD_SUMO_rev_2	110	119	PF00179	0.508
TRG_DiLeu_BaEn_1	160	165	PF01217	0.535
TRG_DiLeu_BaEn_1	24	29	PF01217	0.446
TRG_DiLeu_BaEn_4	220	226	PF01217	0.560
TRG_ENDOCYTIC_2	161	164	PF00928	0.461
TRG_ER_diArg_1	188	191	PF00400	0.560
TRG_NLS_MonoCore_2	178	183	PF00514	0.496
TRG_NLS_MonoExtC_3	178	183	PF00514	0.479
TRG_NLS_MonoExtN_4	177	184	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E7	Leptomonas seymouri	40%	97%
A0A3S7WRY5	Leishmania donovani	70%	100%
E9AGF2	Leishmania infantum	69%	100%
E9ANZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QGM8	Leishmania major	68%	100%