PriCT_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

primase 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H6X7_LEIBR

TriTrypDb:

LbrM.12.0640 , LBRM2903_120012300

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0003896	DNA primase activity	7	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.330
CLV_MEL_PAP_1	512	518	PF00089	0.275
CLV_NRD_NRD_1	232	234	PF00675	0.399
CLV_NRD_NRD_1	237	239	PF00675	0.387
CLV_NRD_NRD_1	243	245	PF00675	0.377
CLV_NRD_NRD_1	253	255	PF00675	0.412
CLV_NRD_NRD_1	291	293	PF00675	0.211
CLV_NRD_NRD_1	365	367	PF00675	0.343
CLV_NRD_NRD_1	448	450	PF00675	0.371
CLV_NRD_NRD_1	490	492	PF00675	0.367
CLV_NRD_NRD_1	549	551	PF00675	0.304
CLV_NRD_NRD_1	566	568	PF00675	0.493
CLV_PCSK_KEX2_1	243	245	PF00082	0.410
CLV_PCSK_KEX2_1	253	255	PF00082	0.310
CLV_PCSK_KEX2_1	291	293	PF00082	0.306
CLV_PCSK_KEX2_1	364	366	PF00082	0.294
CLV_PCSK_KEX2_1	490	492	PF00082	0.367
CLV_PCSK_KEX2_1	566	568	PF00082	0.406
CLV_PCSK_KEX2_1	92	94	PF00082	0.337
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.337
CLV_PCSK_SKI1_1	132	136	PF00082	0.394
CLV_PCSK_SKI1_1	172	176	PF00082	0.298
CLV_PCSK_SKI1_1	215	219	PF00082	0.391
CLV_PCSK_SKI1_1	307	311	PF00082	0.298
CLV_PCSK_SKI1_1	337	341	PF00082	0.298
CLV_PCSK_SKI1_1	390	394	PF00082	0.491
CLV_PCSK_SKI1_1	412	416	PF00082	0.464
CLV_PCSK_SKI1_1	490	494	PF00082	0.382
DEG_APCC_DBOX_1	363	371	PF00400	0.391
DOC_CYCLIN_RxL_1	129	138	PF00134	0.391
DOC_CYCLIN_RxL_1	169	176	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	538	544	PF00134	0.337
DOC_MAPK_gen_1	364	370	PF00069	0.336
DOC_MAPK_gen_1	550	556	PF00069	0.391
DOC_MAPK_RevD_3	536	552	PF00069	0.391
DOC_PP1_RVXF_1	130	137	PF00149	0.298
DOC_PP1_RVXF_1	297	304	PF00149	0.275
DOC_PP1_RVXF_1	550	557	PF00149	0.253
DOC_PP2B_LxvP_1	160	163	PF13499	0.197
DOC_PP4_FxxP_1	190	193	PF00568	0.275
DOC_USP7_MATH_1	163	167	PF00917	0.391
DOC_USP7_MATH_1	201	205	PF00917	0.467
DOC_USP7_MATH_1	21	25	PF00917	0.308
DOC_USP7_MATH_1	248	252	PF00917	0.281
DOC_USP7_MATH_1	284	288	PF00917	0.253
DOC_USP7_MATH_1	426	430	PF00917	0.666
DOC_USP7_UBL2_3	241	245	PF12436	0.289
DOC_USP7_UBL2_3	450	454	PF12436	0.455
DOC_USP7_UBL2_3	539	543	PF12436	0.275
DOC_WW_Pin1_4	115	120	PF00397	0.258
DOC_WW_Pin1_4	280	285	PF00397	0.419
DOC_WW_Pin1_4	477	482	PF00397	0.436
DOC_WW_Pin1_4	537	542	PF00397	0.391
DOC_WW_Pin1_4	99	104	PF00397	0.420
LIG_14-3-3_CanoR_1	337	345	PF00244	0.275
LIG_14-3-3_CanoR_1	380	389	PF00244	0.540
LIG_14-3-3_CanoR_1	390	395	PF00244	0.525
LIG_14-3-3_CanoR_1	490	496	PF00244	0.314
LIG_14-3-3_CanoR_1	93	99	PF00244	0.197
LIG_Actin_WH2_2	527	545	PF00022	0.337
LIG_AP2alpha_1	190	194	PF02296	0.391
LIG_AP2alpha_2	192	194	PF02296	0.391
LIG_APCC_ABBA_1	133	138	PF00400	0.391
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.391
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BIR_III_2	408	412	PF00653	0.381
LIG_BIR_III_4	473	477	PF00653	0.501
LIG_BRCT_BRCA1_1	49	53	PF00533	0.275
LIG_deltaCOP1_diTrp_1	531	536	PF00928	0.275
LIG_Dynein_DLC8_1	82	88	PF01221	0.197
LIG_EH_1	13	17	PF12763	0.319
LIG_EH1_1	26	34	PF00400	0.310
LIG_eIF4E_1	27	33	PF01652	0.315
LIG_eIF4E_1	306	312	PF01652	0.298
LIG_FHA_1	197	203	PF00498	0.300
LIG_FHA_1	296	302	PF00498	0.388
LIG_FHA_1	37	43	PF00498	0.197
LIG_FHA_1	383	389	PF00498	0.510
LIG_FHA_1	402	408	PF00498	0.422
LIG_FHA_1	494	500	PF00498	0.487
LIG_FHA_1	507	513	PF00498	0.391
LIG_FHA_1	94	100	PF00498	0.268
LIG_FHA_2	1	7	PF00498	0.549
LIG_FHA_2	171	177	PF00498	0.253
LIG_FHA_2	35	41	PF00498	0.197
LIG_FHA_2	370	376	PF00498	0.424
LIG_FHA_2	389	395	PF00498	0.263
LIG_HCF-1_HBM_1	349	352	PF13415	0.309
LIG_LIR_Gen_1	155	163	PF02991	0.275
LIG_LIR_Gen_1	192	203	PF02991	0.306
LIG_LIR_Gen_1	216	225	PF02991	0.337
LIG_LIR_Gen_1	267	277	PF02991	0.395
LIG_LIR_Gen_1	50	60	PF02991	0.296
LIG_LIR_Gen_1	511	520	PF02991	0.275
LIG_LIR_Gen_1	531	541	PF02991	0.155
LIG_LIR_Nem_3	124	128	PF02991	0.391
LIG_LIR_Nem_3	13	19	PF02991	0.308
LIG_LIR_Nem_3	155	160	PF02991	0.275
LIG_LIR_Nem_3	191	197	PF02991	0.309
LIG_LIR_Nem_3	216	220	PF02991	0.225
LIG_LIR_Nem_3	267	273	PF02991	0.395
LIG_LIR_Nem_3	305	309	PF02991	0.299
LIG_LIR_Nem_3	471	475	PF02991	0.475
LIG_LIR_Nem_3	50	56	PF02991	0.296
LIG_LIR_Nem_3	511	516	PF02991	0.275
LIG_LIR_Nem_3	531	536	PF02991	0.155
LIG_LIR_Nem_3	574	580	PF02991	0.413
LIG_LIR_Nem_3	66	72	PF02991	0.393
LIG_LYPXL_yS_3	125	128	PF13949	0.391
LIG_PCNA_yPIPBox_3	331	340	PF02747	0.197
LIG_Pex14_1	565	569	PF04695	0.359
LIG_Pex14_2	190	194	PF04695	0.391
LIG_SH2_CRK	306	310	PF00017	0.298
LIG_SH2_CRK	475	479	PF00017	0.579
LIG_SH2_CRK	569	573	PF00017	0.336
LIG_SH2_GRB2like	571	574	PF00017	0.341
LIG_SH2_SRC	180	183	PF00017	0.275
LIG_SH2_SRC	571	574	PF00017	0.400
LIG_SH2_STAP1	510	514	PF00017	0.275
LIG_SH2_STAP1	544	548	PF00017	0.391
LIG_SH2_STAT3	352	355	PF00017	0.395
LIG_SH2_STAT5	180	183	PF00017	0.275
LIG_SH2_STAT5	381	384	PF00017	0.363
LIG_SH2_STAT5	571	574	PF00017	0.341
LIG_SH2_STAT5	98	101	PF00017	0.391
LIG_SH3_3	180	186	PF00018	0.391
LIG_SH3_3	475	481	PF00018	0.542
LIG_Sin3_3	194	201	PF02671	0.391
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.253
LIG_SUMO_SIM_par_1	396	401	PF11976	0.407
LIG_SxIP_EBH_1	100	110	PF03271	0.378
LIG_TRAF2_1	44	47	PF00917	0.391
LIG_TYR_ITIM	178	183	PF00017	0.275
LIG_UBA3_1	174	179	PF00899	0.197
LIG_UBA3_1	535	543	PF00899	0.268
LIG_WRC_WIRS_1	79	84	PF05994	0.253
LIG_WW_3	502	506	PF00397	0.298
MOD_CDC14_SPxK_1	540	543	PF00782	0.391
MOD_CDK_SPK_2	280	285	PF00069	0.239
MOD_CDK_SPxK_1	537	543	PF00069	0.391
MOD_CK1_1	287	293	PF00069	0.337
MOD_CK1_1	356	362	PF00069	0.197
MOD_CK1_1	537	543	PF00069	0.316
MOD_CK2_1	170	176	PF00069	0.270
MOD_CK2_1	257	263	PF00069	0.333
MOD_CK2_1	355	361	PF00069	0.197
MOD_CK2_1	380	386	PF00069	0.453
MOD_CK2_1	390	396	PF00069	0.359
MOD_GlcNHglycan	165	168	PF01048	0.338
MOD_GlcNHglycan	228	231	PF01048	0.284
MOD_GlcNHglycan	277	280	PF01048	0.431
MOD_GlcNHglycan	286	289	PF01048	0.407
MOD_GlcNHglycan	293	296	PF01048	0.415
MOD_GlcNHglycan	340	343	PF01048	0.411
MOD_GlcNHglycan	345	348	PF01048	0.411
MOD_GlcNHglycan	357	361	PF01048	0.411
MOD_GlcNHglycan	433	437	PF01048	0.677
MOD_GSK3_1	233	240	PF00069	0.305
MOD_GSK3_1	271	278	PF00069	0.432
MOD_GSK3_1	280	287	PF00069	0.375
MOD_GSK3_1	291	298	PF00069	0.201
MOD_GSK3_1	380	387	PF00069	0.455
MOD_GSK3_1	47	54	PF00069	0.275
MOD_GSK3_1	477	484	PF00069	0.343
MOD_GSK3_1	83	90	PF00069	0.411
MOD_LATS_1	213	219	PF00433	0.391
MOD_N-GLC_1	316	321	PF02516	0.275
MOD_N-GLC_1	521	526	PF02516	0.275
MOD_N-GLC_1	572	577	PF02516	0.354
MOD_NEK2_1	196	201	PF00069	0.429
MOD_NEK2_1	225	230	PF00069	0.231
MOD_NEK2_1	398	403	PF00069	0.339
MOD_NEK2_1	445	450	PF00069	0.560
MOD_NEK2_1	455	460	PF00069	0.539
MOD_NEK2_1	572	577	PF00069	0.354
MOD_NEK2_2	105	110	PF00069	0.391
MOD_PIKK_1	464	470	PF00454	0.527
MOD_PIKK_1	83	89	PF00454	0.197
MOD_PK_1	491	497	PF00069	0.358
MOD_PKA_1	233	239	PF00069	0.386
MOD_PKA_1	291	297	PF00069	0.292
MOD_PKA_1	48	54	PF00069	0.391
MOD_PKA_1	92	98	PF00069	0.309
MOD_PKA_2	232	238	PF00069	0.375
MOD_PKA_2	291	297	PF00069	0.205
MOD_PKA_2	92	98	PF00069	0.309
MOD_Plk_1	170	176	PF00069	0.253
MOD_Plk_1	257	263	PF00069	0.218
MOD_Plk_1	295	301	PF00069	0.197
MOD_Plk_1	316	322	PF00069	0.275
MOD_Plk_1	398	404	PF00069	0.386
MOD_Plk_1	572	578	PF00069	0.366
MOD_Plk_2-3	257	263	PF00069	0.292
MOD_Plk_4	170	176	PF00069	0.253
MOD_Plk_4	384	390	PF00069	0.580
MOD_Plk_4	398	404	PF00069	0.310
MOD_Plk_4	420	426	PF00069	0.466
MOD_Plk_4	572	578	PF00069	0.366
MOD_Plk_4	94	100	PF00069	0.410
MOD_ProDKin_1	115	121	PF00069	0.265
MOD_ProDKin_1	280	286	PF00069	0.419
MOD_ProDKin_1	477	483	PF00069	0.428
MOD_ProDKin_1	537	543	PF00069	0.391
MOD_ProDKin_1	99	105	PF00069	0.428
MOD_SUMO_rev_2	408	414	PF00179	0.530
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.329
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.283
TRG_ENDOCYTIC_2	125	128	PF00928	0.391
TRG_ENDOCYTIC_2	157	160	PF00928	0.337
TRG_ENDOCYTIC_2	180	183	PF00928	0.275
TRG_ENDOCYTIC_2	270	273	PF00928	0.391
TRG_ENDOCYTIC_2	306	309	PF00928	0.298
TRG_ENDOCYTIC_2	475	478	PF00928	0.594
TRG_ENDOCYTIC_2	569	572	PF00928	0.335
TRG_ER_diArg_1	364	366	PF00400	0.353
TRG_ER_diArg_1	456	459	PF00400	0.460
TRG_ER_diArg_1	489	491	PF00400	0.376
TRG_ER_diArg_1	565	567	PF00400	0.411
TRG_NLS_Bipartite_1	233	248	PF00514	0.197
TRG_NLS_MonoExtC_3	243	248	PF00514	0.286
TRG_NLS_MonoExtN_4	241	248	PF00514	0.287
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.197
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T3	Leptomonas seymouri	66%	76%
A0A1X0NMZ0	Trypanosomatidae	46%	76%
A0A3R7JWW2	Trypanosoma rangeli	46%	83%
A0A3S7WS08	Leishmania donovani	81%	100%
E9AGF1	Leishmania infantum	81%	100%
E9ANZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGM9	Leishmania major	81%	100%
V5DG34	Trypanosoma cruzi	45%	97%