Alanine transaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alanine aminotransferase

Species:

Leishmania braziliensis

UniProt:

A4H6X6_LEIBR

TriTrypDb:

LbrM.12.0630 , LBRM2903_120012200

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006522	alanine metabolic process	6	13
GO:0006524	alanine catabolic process	5	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009058	biosynthetic process	2	13
GO:0009063	amino acid catabolic process	4	13
GO:0009078	pyruvate family amino acid metabolic process	5	13
GO:0009080	pyruvate family amino acid catabolic process	6	13
GO:0009987	cellular process	1	13
GO:0016054	organic acid catabolic process	4	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0042851	L-alanine metabolic process	7	13
GO:0042853	L-alanine catabolic process	6	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044248	cellular catabolic process	3	13
GO:0044281	small molecule metabolic process	2	13
GO:0044282	small molecule catabolic process	3	13
GO:0046395	carboxylic acid catabolic process	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901565	organonitrogen compound catabolic process	4	13
GO:1901575	organic substance catabolic process	3	13
GO:1901605	alpha-amino acid metabolic process	4	13
GO:1901606	alpha-amino acid catabolic process	5	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	6	4
GO:0047635	alanine-oxo-acid transaminase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.363
CLV_NRD_NRD_1	317	319	PF00675	0.291
CLV_NRD_NRD_1	371	373	PF00675	0.393
CLV_PCSK_KEX2_1	278	280	PF00082	0.350
CLV_PCSK_KEX2_1	317	319	PF00082	0.291
CLV_PCSK_KEX2_1	371	373	PF00082	0.377
CLV_PCSK_SKI1_1	104	108	PF00082	0.263
CLV_PCSK_SKI1_1	161	165	PF00082	0.338
CLV_PCSK_SKI1_1	260	264	PF00082	0.467
CLV_PCSK_SKI1_1	384	388	PF00082	0.237
CLV_PCSK_SKI1_1	439	443	PF00082	0.282
DEG_APCC_DBOX_1	103	111	PF00400	0.363
DEG_APCC_DBOX_1	438	446	PF00400	0.291
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_CDC14_PxL_1	79	87	PF14671	0.357
DOC_CYCLIN_yClb5_NLxxxL_5	322	331	PF00134	0.445
DOC_MAPK_gen_1	278	284	PF00069	0.439
DOC_MAPK_MEF2A_6	161	168	PF00069	0.297
DOC_PP2B_LxvP_1	289	292	PF13499	0.291
DOC_PP2B_PxIxI_1	228	234	PF00149	0.333
DOC_WW_Pin1_4	225	230	PF00397	0.291
DOC_WW_Pin1_4	355	360	PF00397	0.291
LIG_14-3-3_CanoR_1	279	285	PF00244	0.345
LIG_14-3-3_CanoR_1	396	403	PF00244	0.424
LIG_14-3-3_CanoR_1	46	52	PF00244	0.415
LIG_Actin_WH2_2	188	204	PF00022	0.213
LIG_BRCT_BRCA1_1	47	51	PF00533	0.391
LIG_EH1_1	24	32	PF00400	0.416
LIG_EH1_1	294	302	PF00400	0.213
LIG_eIF4E_1	25	31	PF01652	0.436
LIG_eIF4E_1	49	55	PF01652	0.466
LIG_FAT_LD_1	297	305	PF03623	0.213
LIG_FHA_1	226	232	PF00498	0.318
LIG_FHA_1	239	245	PF00498	0.349
LIG_FHA_1	297	303	PF00498	0.296
LIG_FHA_1	410	416	PF00498	0.248
LIG_FHA_1	467	473	PF00498	0.208
LIG_FHA_2	144	150	PF00498	0.355
LIG_LIR_Gen_1	375	386	PF02991	0.276
LIG_LIR_Gen_1	48	59	PF02991	0.411
LIG_LIR_Gen_1	487	496	PF02991	0.266
LIG_LIR_Nem_3	283	287	PF02991	0.314
LIG_LIR_Nem_3	364	370	PF02991	0.231
LIG_LIR_Nem_3	373	377	PF02991	0.270
LIG_LIR_Nem_3	48	54	PF02991	0.432
LIG_LIR_Nem_3	487	491	PF02991	0.394
LIG_Pex14_2	121	125	PF04695	0.355
LIG_SH2_CRK	374	378	PF00017	0.208
LIG_SH2_CRK	56	60	PF00017	0.372
LIG_SH2_STAP1	117	121	PF00017	0.319
LIG_SH2_STAP1	185	189	PF00017	0.303
LIG_SH2_STAP1	218	222	PF00017	0.363
LIG_SH2_STAT3	185	188	PF00017	0.303
LIG_SH2_STAT3	49	52	PF00017	0.294
LIG_SH2_STAT5	117	120	PF00017	0.316
LIG_SH2_STAT5	200	203	PF00017	0.452
LIG_SH2_STAT5	295	298	PF00017	0.440
LIG_SH2_STAT5	321	324	PF00017	0.319
LIG_SH2_STAT5	367	370	PF00017	0.382
LIG_SH2_STAT5	56	59	PF00017	0.378
LIG_SH3_3	172	178	PF00018	0.291
LIG_SH3_3	192	198	PF00018	0.355
LIG_SH3_3	234	240	PF00018	0.304
LIG_SH3_3	271	277	PF00018	0.213
LIG_SH3_3	448	454	PF00018	0.291
LIG_SH3_3	77	83	PF00018	0.360
LIG_SUMO_SIM_anti_2	446	454	PF11976	0.294
LIG_SUMO_SIM_par_1	261	268	PF11976	0.445
LIG_SUMO_SIM_par_1	298	308	PF11976	0.364
LIG_TYR_ITIM	54	59	PF00017	0.370
LIG_UBA3_1	300	309	PF00899	0.438
LIG_UBA3_1	377	382	PF00899	0.291
LIG_WRC_WIRS_1	281	286	PF05994	0.303
LIG_WW_3	358	362	PF00397	0.397
MOD_CDC14_SPxK_1	358	361	PF00782	0.363
MOD_CDK_SPK_2	225	230	PF00069	0.291
MOD_CDK_SPxK_1	355	361	PF00069	0.363
MOD_CK1_1	225	231	PF00069	0.453
MOD_CK1_1	303	309	PF00069	0.300
MOD_CK1_1	411	417	PF00069	0.439
MOD_CK1_1	50	56	PF00069	0.529
MOD_CK2_1	280	286	PF00069	0.363
MOD_CK2_1	377	383	PF00069	0.341
MOD_Cter_Amidation	315	318	PF01082	0.319
MOD_GlcNHglycan	185	188	PF01048	0.488
MOD_GlcNHglycan	224	227	PF01048	0.333
MOD_GlcNHglycan	446	450	PF01048	0.335
MOD_GlcNHglycan	455	458	PF01048	0.252
MOD_GSK3_1	111	118	PF00069	0.285
MOD_GSK3_1	150	157	PF00069	0.288
MOD_GSK3_1	183	190	PF00069	0.323
MOD_GSK3_1	296	303	PF00069	0.298
MOD_GSK3_1	333	340	PF00069	0.267
MOD_N-GLC_2	342	344	PF02516	0.319
MOD_NEK2_1	300	305	PF00069	0.330
MOD_NEK2_1	322	327	PF00069	0.327
MOD_NEK2_1	444	449	PF00069	0.293
MOD_NEK2_1	467	472	PF00069	0.339
MOD_NEK2_2	365	370	PF00069	0.213
MOD_NEK2_2	461	466	PF00069	0.333
MOD_PK_1	337	343	PF00069	0.303
MOD_PKA_2	45	51	PF00069	0.434
MOD_PKA_2	467	473	PF00069	0.291
MOD_Plk_1	363	369	PF00069	0.303
MOD_Plk_4	296	302	PF00069	0.338
MOD_Plk_4	365	371	PF00069	0.277
MOD_Plk_4	467	473	PF00069	0.291
MOD_Plk_4	50	56	PF00069	0.446
MOD_ProDKin_1	225	231	PF00069	0.291
MOD_ProDKin_1	355	361	PF00069	0.291
MOD_SUMO_rev_2	33	40	PF00179	0.481
TRG_DiLeu_BaEn_1	259	264	PF01217	0.355
TRG_DiLeu_BaEn_1	383	388	PF01217	0.445
TRG_DiLeu_BaEn_1	487	492	PF01217	0.259
TRG_ENDOCYTIC_2	321	324	PF00928	0.346
TRG_ENDOCYTIC_2	374	377	PF00928	0.256
TRG_ENDOCYTIC_2	56	59	PF00928	0.376
TRG_ER_diArg_1	277	279	PF00400	0.449
TRG_ER_diArg_1	370	372	PF00400	0.213
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P4	Leptomonas seymouri	23%	100%
A0A0N1I393	Leptomonas seymouri	24%	100%
A0A0P0VI36	Oryza sativa subsp. japonica	23%	100%
A0A0S4IKK8	Bodo saltans	59%	100%
A0A0S4IU18	Bodo saltans	49%	98%
A0A0S4KND1	Bodo saltans	54%	100%
A0A1X0NME9	Trypanosomatidae	67%	100%
A0A1X0P7X4	Trypanosomatidae	25%	100%
A0A3Q8I9A2	Leishmania donovani	81%	100%
A0A3Q8INT3	Leishmania donovani	24%	100%
A0A3R7LIW3	Trypanosoma rangeli	67%	100%
A0A3S5IQG1	Trypanosoma rangeli	22%	100%
A0A3S5IRA0	Trypanosoma rangeli	24%	100%
A2CC97	Prochlorococcus marinus (strain MIT 9303)	24%	100%
A4HPA3	Leishmania braziliensis	24%	100%
A4IDL0	Leishmania infantum	24%	100%
A4IFH5	Bos taurus	40%	100%
B8IZX8	Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB)	25%	100%
C4Z4Y1	Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4)	24%	100%
C4ZG66	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	24%	100%
C6C2Z3	Musicola paradisiaca (strain Ech703)	22%	100%
C9ZIU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	99%
E9AGF0	Leishmania infantum	81%	100%
E9ANZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AT13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F4I7I0	Arabidopsis thaliana	44%	92%
O58489	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O67781	Aquifex aeolicus (strain VF5)	26%	100%
P04694	Rattus norvegicus	24%	100%
P0A959	Escherichia coli (strain K12)	25%	100%
P0A960	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P0A961	Shigella flexneri	25%	100%
P14909	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	23%	100%
P16524	Bacillus subtilis (strain 168)	24%	100%
P17735	Homo sapiens	23%	100%
P23034	Bacillus sp. (strain YM-2)	25%	100%
P24298	Homo sapiens	43%	100%
P25409	Rattus norvegicus	40%	100%
P33447	Trypanosoma cruzi	24%	100%
P34106	Panicum miliaceum	46%	100%
P52892	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	98%
P52893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	84%
P52894	Hordeum vulgare	46%	100%
P53001	Bacillus subtilis (strain 168)	24%	100%
P58350	Rhizobium meliloti (strain 1021)	25%	100%
P63499	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
P71348	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
P9WQ90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQ91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q06191	Rhizobium meliloti	24%	100%
Q10334	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	98%
Q28DB5	Xenopus tropicalis	38%	95%
Q4J8X2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	22%	100%
Q4Q1I5	Leishmania major	25%	93%
Q4QGN0	Leishmania major	82%	100%
Q54K95	Dictyostelium discoideum	23%	100%
Q54MJ7	Dictyostelium discoideum	45%	93%
Q58874	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q58CZ9	Bos taurus	24%	100%
Q59228	Geobacillus stearothermophilus	24%	100%
Q5F4K8	Pinus pinaster	24%	100%
Q60013	Streptomyces virginiae	25%	100%
Q6GM82	Xenopus laevis	39%	92%
Q6NYL5	Danio rerio	41%	91%
Q795M6	Bacillus subtilis (strain 168)	25%	100%
Q7V4Z3	Prochlorococcus marinus (strain MIT 9313)	24%	100%
Q82DR2	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	26%	100%
Q8BGT5	Mus musculus	42%	95%
Q8DTM1	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	23%	100%
Q8QZR1	Mus musculus	24%	100%
Q8QZR5	Mus musculus	41%	100%
Q8TD30	Homo sapiens	42%	95%
Q93703	Caenorhabditis elegans	23%	100%
Q972A2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	23%	100%
Q9HUI9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	100%
Q9LDV4	Arabidopsis thaliana	45%	92%
Q9LR30	Arabidopsis thaliana	43%	100%
Q9S7E9	Arabidopsis thaliana	42%	100%
Q9SIE1	Arabidopsis thaliana	24%	100%
Q9SIV0	Arabidopsis thaliana	22%	100%
Q9ST02	Hordeum vulgare	25%	100%
Q9ST03	Hordeum vulgare	25%	90%
Q9SUR6	Arabidopsis thaliana	22%	100%
Q9V0L2	Pyrococcus abyssi (strain GE5 / Orsay)	23%	100%
Q9X0Y2	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	25%	100%
V5BGG8	Trypanosoma cruzi	24%	100%
V5BJS7	Trypanosoma cruzi	65%	99%