Sulfatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6X3_LEIBR

TriTrypDb:

LbrM.12.0600 , LBRM2903_120011800

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H6X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008484	sulfuric ester hydrolase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.458
CLV_NRD_NRD_1	19	21	PF00675	0.412
CLV_NRD_NRD_1	285	287	PF00675	0.624
CLV_PCSK_KEX2_1	214	216	PF00082	0.533
CLV_PCSK_KEX2_1	411	413	PF00082	0.566
CLV_PCSK_KEX2_1	437	439	PF00082	0.616
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.557
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.488
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.585
CLV_PCSK_SKI1_1	214	218	PF00082	0.603
CLV_PCSK_SKI1_1	438	442	PF00082	0.611
CLV_PCSK_SKI1_1	447	451	PF00082	0.429
CLV_PCSK_SKI1_1	48	52	PF00082	0.488
CLV_Separin_Metazoa	258	262	PF03568	0.399
DEG_APCC_DBOX_1	493	501	PF00400	0.275
DEG_APCC_KENBOX_2	394	398	PF00400	0.307
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DEG_ODPH_VHL_1	442	454	PF01847	0.380
DOC_CKS1_1	319	324	PF01111	0.359
DOC_CKS1_1	413	418	PF01111	0.295
DOC_CYCLIN_yClb1_LxF_4	232	238	PF00134	0.250
DOC_MAPK_gen_1	20	27	PF00069	0.612
DOC_MAPK_gen_1	214	223	PF00069	0.386
DOC_MAPK_gen_1	392	401	PF00069	0.306
DOC_MAPK_gen_1	411	419	PF00069	0.367
DOC_MAPK_MEF2A_6	217	225	PF00069	0.344
DOC_MAPK_MEF2A_6	395	403	PF00069	0.373
DOC_USP7_MATH_1	145	149	PF00917	0.355
DOC_USP7_MATH_1	169	173	PF00917	0.343
DOC_USP7_MATH_1	176	180	PF00917	0.322
DOC_USP7_MATH_1	203	207	PF00917	0.340
DOC_USP7_MATH_1	436	440	PF00917	0.290
DOC_USP7_MATH_1	507	511	PF00917	0.461
DOC_USP7_UBL2_3	51	55	PF12436	0.652
DOC_WW_Pin1_4	101	106	PF00397	0.459
DOC_WW_Pin1_4	136	141	PF00397	0.261
DOC_WW_Pin1_4	20	25	PF00397	0.776
DOC_WW_Pin1_4	287	292	PF00397	0.410
DOC_WW_Pin1_4	318	323	PF00397	0.406
DOC_WW_Pin1_4	412	417	PF00397	0.346
DOC_WW_Pin1_4	481	486	PF00397	0.392
DOC_WW_Pin1_4	503	508	PF00397	0.258
LIG_14-3-3_CanoR_1	20	24	PF00244	0.697
LIG_14-3-3_CanoR_1	286	291	PF00244	0.313
LIG_14-3-3_CanoR_1	351	360	PF00244	0.413
LIG_14-3-3_CanoR_1	390	399	PF00244	0.405
LIG_14-3-3_CanoR_1	438	443	PF00244	0.351
LIG_14-3-3_CanoR_1	447	456	PF00244	0.207
LIG_BRCT_BRCA1_1	233	237	PF00533	0.295
LIG_CtBP_PxDLS_1	24	28	PF00389	0.605
LIG_CtBP_PxDLS_1	416	420	PF00389	0.296
LIG_eIF4E_1	374	380	PF01652	0.331
LIG_FHA_1	226	232	PF00498	0.254
LIG_FHA_1	305	311	PF00498	0.308
LIG_FHA_1	469	475	PF00498	0.388
LIG_FHA_1	87	93	PF00498	0.461
LIG_FHA_2	163	169	PF00498	0.428
LIG_FHA_2	21	27	PF00498	0.709
LIG_FHA_2	329	335	PF00498	0.475
LIG_FHA_2	448	454	PF00498	0.280
LIG_FHA_2	54	60	PF00498	0.654
LIG_GBD_Chelix_1	332	340	PF00786	0.540
LIG_LIR_Gen_1	118	128	PF02991	0.310
LIG_LIR_Gen_1	396	403	PF02991	0.326
LIG_LIR_Gen_1	460	469	PF02991	0.382
LIG_LIR_Nem_3	118	123	PF02991	0.291
LIG_LIR_Nem_3	206	212	PF02991	0.309
LIG_LIR_Nem_3	312	317	PF02991	0.310
LIG_LIR_Nem_3	396	401	PF02991	0.285
LIG_LIR_Nem_3	460	464	PF02991	0.376
LIG_LYPXL_S_1	208	212	PF13949	0.443
LIG_LYPXL_yS_3	209	212	PF13949	0.233
LIG_Pex14_2	341	345	PF04695	0.343
LIG_SH2_CRK	319	323	PF00017	0.360
LIG_SH2_CRK	413	417	PF00017	0.350
LIG_SH2_GRB2like	93	96	PF00017	0.458
LIG_SH2_NCK_1	319	323	PF00017	0.360
LIG_SH2_STAP1	432	436	PF00017	0.392
LIG_SH2_STAT3	369	372	PF00017	0.282
LIG_SH2_STAT5	170	173	PF00017	0.328
LIG_SH2_STAT5	356	359	PF00017	0.450
LIG_SH2_STAT5	369	372	PF00017	0.302
LIG_SH2_STAT5	374	377	PF00017	0.250
LIG_SH2_STAT5	386	389	PF00017	0.382
LIG_SH2_STAT5	432	435	PF00017	0.302
LIG_SH2_STAT5	6	9	PF00017	0.702
LIG_SH2_STAT5	93	96	PF00017	0.444
LIG_SH3_3	125	131	PF00018	0.410
LIG_SH3_3	288	294	PF00018	0.416
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.350
LIG_SUMO_SIM_par_1	108	113	PF11976	0.318
LIG_SUMO_SIM_par_1	414	420	PF11976	0.297
LIG_SUMO_SIM_par_1	83	89	PF11976	0.203
LIG_WW_3	184	188	PF00397	0.298
MOD_CDK_SPK_2	101	106	PF00069	0.392
MOD_CK1_1	138	144	PF00069	0.259
MOD_CK1_1	150	156	PF00069	0.451
MOD_CK1_1	179	185	PF00069	0.315
MOD_CK1_1	19	25	PF00069	0.694
MOD_CK1_1	236	242	PF00069	0.328
MOD_CK1_1	289	295	PF00069	0.460
MOD_CK1_1	320	326	PF00069	0.479
MOD_CK1_1	363	369	PF00069	0.300
MOD_CK1_1	506	512	PF00069	0.400
MOD_CK2_1	162	168	PF00069	0.395
MOD_CK2_1	20	26	PF00069	0.710
MOD_CK2_1	252	258	PF00069	0.459
MOD_CK2_1	260	266	PF00069	0.461
MOD_CK2_1	362	368	PF00069	0.388
MOD_CK2_1	390	396	PF00069	0.356
MOD_CK2_1	46	52	PF00069	0.631
MOD_CK2_1	53	59	PF00069	0.614
MOD_Cter_Amidation	409	412	PF01082	0.478
MOD_GlcNHglycan	115	118	PF01048	0.561
MOD_GlcNHglycan	125	128	PF01048	0.660
MOD_GlcNHglycan	140	143	PF01048	0.616
MOD_GlcNHglycan	164	168	PF01048	0.595
MOD_GlcNHglycan	171	174	PF01048	0.481
MOD_GlcNHglycan	181	184	PF01048	0.481
MOD_GlcNHglycan	199	202	PF01048	0.583
MOD_GlcNHglycan	238	241	PF01048	0.679
MOD_GlcNHglycan	265	270	PF01048	0.615
MOD_GlcNHglycan	297	300	PF01048	0.661
MOD_GlcNHglycan	353	356	PF01048	0.498
MOD_GlcNHglycan	362	365	PF01048	0.456
MOD_GlcNHglycan	408	411	PF01048	0.515
MOD_GlcNHglycan	62	66	PF01048	0.503
MOD_GSK3_1	146	153	PF00069	0.416
MOD_GSK3_1	16	23	PF00069	0.720
MOD_GSK3_1	175	182	PF00069	0.342
MOD_GSK3_1	197	204	PF00069	0.312
MOD_GSK3_1	221	228	PF00069	0.363
MOD_GSK3_1	236	243	PF00069	0.305
MOD_GSK3_1	282	289	PF00069	0.375
MOD_GSK3_1	417	424	PF00069	0.485
MOD_GSK3_1	477	484	PF00069	0.439
MOD_GSK3_1	503	510	PF00069	0.408
MOD_N-GLC_1	162	167	PF02516	0.623
MOD_N-GLC_1	192	197	PF02516	0.558
MOD_N-GLC_1	295	300	PF02516	0.544
MOD_N-GLC_1	478	483	PF02516	0.647
MOD_N-GLC_1	94	99	PF02516	0.667
MOD_NEK2_1	115	120	PF00069	0.282
MOD_NEK2_1	123	128	PF00069	0.358
MOD_NEK2_1	2	7	PF00069	0.722
MOD_NEK2_1	221	226	PF00069	0.309
MOD_NEK2_1	27	32	PF00069	0.709
MOD_NEK2_1	317	322	PF00069	0.502
MOD_NEK2_1	336	341	PF00069	0.327
MOD_NEK2_1	360	365	PF00069	0.277
MOD_NEK2_1	401	406	PF00069	0.242
MOD_NEK2_1	428	433	PF00069	0.286
MOD_NEK2_2	176	181	PF00069	0.351
MOD_NEK2_2	507	512	PF00069	0.280
MOD_OFUCOSY	275	281	PF10250	0.520
MOD_PIKK_1	240	246	PF00454	0.412
MOD_PIKK_1	252	258	PF00454	0.314
MOD_PIKK_1	320	326	PF00454	0.485
MOD_PIKK_1	390	396	PF00454	0.396
MOD_PIKK_1	447	453	PF00454	0.371
MOD_PKA_1	286	292	PF00069	0.403
MOD_PKA_2	19	25	PF00069	0.646
MOD_PKA_2	260	266	PF00069	0.415
MOD_PKA_2	27	33	PF00069	0.588
MOD_PKB_1	388	396	PF00069	0.397
MOD_Plk_1	192	198	PF00069	0.299
MOD_Plk_1	336	342	PF00069	0.292
MOD_Plk_1	421	427	PF00069	0.391
MOD_Plk_4	115	121	PF00069	0.316
MOD_Plk_4	176	182	PF00069	0.278
MOD_Plk_4	2	8	PF00069	0.763
MOD_Plk_4	221	227	PF00069	0.375
MOD_Plk_4	233	239	PF00069	0.401
MOD_Plk_4	309	315	PF00069	0.402
MOD_Plk_4	336	342	PF00069	0.326
MOD_Plk_4	454	460	PF00069	0.291
MOD_ProDKin_1	101	107	PF00069	0.449
MOD_ProDKin_1	136	142	PF00069	0.257
MOD_ProDKin_1	20	26	PF00069	0.777
MOD_ProDKin_1	287	293	PF00069	0.412
MOD_ProDKin_1	318	324	PF00069	0.406
MOD_ProDKin_1	412	418	PF00069	0.350
MOD_ProDKin_1	481	487	PF00069	0.385
MOD_ProDKin_1	503	509	PF00069	0.263
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.279
TRG_ENDOCYTIC_2	209	212	PF00928	0.280
TRG_NES_CRM1_1	453	468	PF08389	0.352
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I453	Leptomonas seymouri	64%	99%
A0A1X0NM85	Trypanosomatidae	34%	87%
A0A3Q8IHP7	Leishmania donovani	80%	100%
A0A422NA33	Trypanosoma rangeli	36%	97%
E9AGE7	Leishmania infantum	80%	100%
E9ANY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGN3	Leishmania major	79%	100%
V5AZS1	Trypanosoma cruzi	35%	94%