Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H6X0_LEIBR

TriTrypDb:

LbrM.12.0570 , LBRM2903_120010600

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.694
CLV_C14_Caspase3-7	704	708	PF00656	0.535
CLV_NRD_NRD_1	177	179	PF00675	0.707
CLV_NRD_NRD_1	188	190	PF00675	0.562
CLV_NRD_NRD_1	232	234	PF00675	0.662
CLV_NRD_NRD_1	235	237	PF00675	0.661
CLV_NRD_NRD_1	250	252	PF00675	0.536
CLV_NRD_NRD_1	360	362	PF00675	0.590
CLV_NRD_NRD_1	45	47	PF00675	0.553
CLV_PCSK_FUR_1	233	237	PF00082	0.532
CLV_PCSK_KEX2_1	176	178	PF00082	0.716
CLV_PCSK_KEX2_1	188	190	PF00082	0.560
CLV_PCSK_KEX2_1	234	236	PF00082	0.672
CLV_PCSK_KEX2_1	359	361	PF00082	0.583
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.672
CLV_PCSK_SKI1_1	236	240	PF00082	0.668
DEG_SPOP_SBC_1	316	320	PF00917	0.601
DEG_SPOP_SBC_1	362	366	PF00917	0.551
DOC_CKS1_1	289	294	PF01111	0.541
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.595
DOC_MAPK_DCC_7	481	491	PF00069	0.483
DOC_PP4_FxxP_1	270	273	PF00568	0.517
DOC_PP4_FxxP_1	289	292	PF00568	0.499
DOC_PP4_FxxP_1	533	536	PF00568	0.546
DOC_USP7_MATH_1	103	107	PF00917	0.719
DOC_USP7_MATH_1	170	174	PF00917	0.723
DOC_USP7_MATH_1	184	188	PF00917	0.565
DOC_USP7_MATH_1	257	261	PF00917	0.722
DOC_USP7_MATH_1	316	320	PF00917	0.618
DOC_USP7_MATH_1	350	354	PF00917	0.552
DOC_USP7_MATH_1	362	366	PF00917	0.551
DOC_USP7_MATH_1	51	55	PF00917	0.664
DOC_USP7_MATH_1	520	524	PF00917	0.654
DOC_USP7_MATH_1	681	685	PF00917	0.493
DOC_USP7_MATH_1	726	730	PF00917	0.640
DOC_USP7_MATH_1	741	745	PF00917	0.726
DOC_WW_Pin1_4	12	17	PF00397	0.556
DOC_WW_Pin1_4	125	130	PF00397	0.664
DOC_WW_Pin1_4	227	232	PF00397	0.624
DOC_WW_Pin1_4	27	32	PF00397	0.508
DOC_WW_Pin1_4	279	284	PF00397	0.611
DOC_WW_Pin1_4	288	293	PF00397	0.575
DOC_WW_Pin1_4	294	299	PF00397	0.513
DOC_WW_Pin1_4	300	305	PF00397	0.529
DOC_WW_Pin1_4	365	370	PF00397	0.664
DOC_WW_Pin1_4	47	52	PF00397	0.616
DOC_WW_Pin1_4	538	543	PF00397	0.511
DOC_WW_Pin1_4	570	575	PF00397	0.508
DOC_WW_Pin1_4	594	599	PF00397	0.507
DOC_WW_Pin1_4	722	727	PF00397	0.770
DOC_WW_Pin1_4	730	735	PF00397	0.761
LIG_14-3-3_CanoR_1	109	113	PF00244	0.655
LIG_14-3-3_CanoR_1	158	162	PF00244	0.532
LIG_14-3-3_CanoR_1	178	184	PF00244	0.688
LIG_14-3-3_CanoR_1	233	239	PF00244	0.599
LIG_14-3-3_CanoR_1	265	274	PF00244	0.597
LIG_14-3-3_CanoR_1	360	369	PF00244	0.553
LIG_14-3-3_CanoR_1	451	457	PF00244	0.635
LIG_14-3-3_CanoR_1	46	51	PF00244	0.588
LIG_14-3-3_CanoR_1	568	574	PF00244	0.670
LIG_14-3-3_CanoR_1	643	651	PF00244	0.507
LIG_14-3-3_CanoR_1	674	682	PF00244	0.649
LIG_AP2alpha_2	85	87	PF02296	0.665
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_Clathr_ClatBox_1	89	93	PF01394	0.516
LIG_CSL_BTD_1	126	129	PF09270	0.523
LIG_CtBP_PxDLS_1	589	593	PF00389	0.648
LIG_FHA_1	18	24	PF00498	0.546
LIG_FHA_1	238	244	PF00498	0.559
LIG_FHA_1	28	34	PF00498	0.513
LIG_FHA_1	300	306	PF00498	0.669
LIG_FHA_1	460	466	PF00498	0.590
LIG_FHA_1	674	680	PF00498	0.470
LIG_FHA_1	714	720	PF00498	0.703
LIG_FHA_2	139	145	PF00498	0.541
LIG_FHA_2	206	212	PF00498	0.612
LIG_FHA_2	220	226	PF00498	0.684
LIG_FHA_2	614	620	PF00498	0.523
LIG_FHA_2	633	639	PF00498	0.534
LIG_Integrin_RGD_1	665	667	PF01839	0.586
LIG_LIR_Apic_2	268	273	PF02991	0.518
LIG_LIR_Apic_2	287	292	PF02991	0.502
LIG_LIR_Gen_1	353	362	PF02991	0.530
LIG_LIR_Gen_1	680	689	PF02991	0.588
LIG_LIR_Gen_1	7	17	PF02991	0.517
LIG_LIR_LC3C_4	684	689	PF02991	0.517
LIG_LIR_Nem_3	353	357	PF02991	0.524
LIG_LIR_Nem_3	680	685	PF02991	0.586
LIG_LIR_Nem_3	7	12	PF02991	0.520
LIG_SH2_CRK	539	543	PF00017	0.518
LIG_SH2_NCK_1	539	543	PF00017	0.492
LIG_SH2_STAP1	324	328	PF00017	0.708
LIG_SH2_STAP1	600	604	PF00017	0.508
LIG_SH2_STAT5	296	299	PF00017	0.645
LIG_SH2_STAT5	392	395	PF00017	0.524
LIG_SH2_STAT5	539	542	PF00017	0.497
LIG_SH2_STAT5	561	564	PF00017	0.495
LIG_SH3_1	487	493	PF00018	0.487
LIG_SH3_2	304	309	PF14604	0.549
LIG_SH3_3	10	16	PF00018	0.590
LIG_SH3_3	197	203	PF00018	0.708
LIG_SH3_3	30	36	PF00018	0.494
LIG_SH3_3	301	307	PF00018	0.562
LIG_SH3_3	487	493	PF00018	0.545
LIG_SH3_3	627	633	PF00018	0.606
LIG_SH3_3	728	734	PF00018	0.677
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.622
LIG_SUMO_SIM_anti_2	353	359	PF11976	0.587
LIG_SUMO_SIM_anti_2	418	428	PF11976	0.527
LIG_TRAF2_1	505	508	PF00917	0.517
LIG_WRC_WIRS_1	274	279	PF05994	0.526
LIG_WRC_WIRS_1	351	356	PF05994	0.525
LIG_WRC_WIRS_1	714	719	PF05994	0.674
MOD_CDC14_SPxK_1	230	233	PF00782	0.539
MOD_CDK_SPK_2	125	130	PF00069	0.527
MOD_CDK_SPxK_1	227	233	PF00069	0.544
MOD_CDK_SPxxK_3	227	234	PF00069	0.542
MOD_CK1_1	108	114	PF00069	0.673
MOD_CK1_1	182	188	PF00069	0.639
MOD_CK1_1	237	243	PF00069	0.683
MOD_CK1_1	245	251	PF00069	0.666
MOD_CK1_1	282	288	PF00069	0.641
MOD_CK1_1	315	321	PF00069	0.681
MOD_CK1_1	339	345	PF00069	0.608
MOD_CK1_1	353	359	PF00069	0.645
MOD_CK1_1	363	369	PF00069	0.628
MOD_CK1_1	419	425	PF00069	0.628
MOD_CK1_1	474	480	PF00069	0.553
MOD_CK1_1	522	528	PF00069	0.721
MOD_CK1_1	54	60	PF00069	0.639
MOD_CK1_1	541	547	PF00069	0.472
MOD_CK1_1	570	576	PF00069	0.566
MOD_CK1_1	578	584	PF00069	0.572
MOD_CK1_1	591	597	PF00069	0.566
MOD_CK1_1	617	623	PF00069	0.630
MOD_CK1_1	628	634	PF00069	0.557
MOD_CK1_1	642	648	PF00069	0.430
MOD_CK1_1	677	683	PF00069	0.620
MOD_CK1_1	7	13	PF00069	0.575
MOD_CK1_1	729	735	PF00069	0.732
MOD_CK1_1	743	749	PF00069	0.601
MOD_CK1_1	99	105	PF00069	0.630
MOD_CK2_1	138	144	PF00069	0.663
MOD_CK2_1	193	199	PF00069	0.700
MOD_CK2_1	205	211	PF00069	0.613
MOD_CK2_1	219	225	PF00069	0.673
MOD_CK2_1	577	583	PF00069	0.528
MOD_CK2_1	613	619	PF00069	0.518
MOD_CK2_1	632	638	PF00069	0.542
MOD_CK2_1	677	683	PF00069	0.466
MOD_Cter_Amidation	231	234	PF01082	0.538
MOD_GlcNHglycan	105	108	PF01048	0.690
MOD_GlcNHglycan	112	115	PF01048	0.616
MOD_GlcNHglycan	119	122	PF01048	0.524
MOD_GlcNHglycan	146	149	PF01048	0.691
MOD_GlcNHglycan	259	262	PF01048	0.728
MOD_GlcNHglycan	314	317	PF01048	0.643
MOD_GlcNHglycan	337	341	PF01048	0.569
MOD_GlcNHglycan	348	351	PF01048	0.504
MOD_GlcNHglycan	418	421	PF01048	0.652
MOD_GlcNHglycan	442	445	PF01048	0.533
MOD_GlcNHglycan	468	471	PF01048	0.648
MOD_GlcNHglycan	497	500	PF01048	0.723
MOD_GlcNHglycan	53	56	PF01048	0.680
MOD_GlcNHglycan	557	560	PF01048	0.490
MOD_GlcNHglycan	57	60	PF01048	0.663
MOD_GlcNHglycan	619	622	PF01048	0.579
MOD_GlcNHglycan	627	630	PF01048	0.550
MOD_GlcNHglycan	679	682	PF01048	0.551
MOD_GlcNHglycan	737	740	PF01048	0.600
MOD_GlcNHglycan	745	748	PF01048	0.529
MOD_GlcNHglycan	769	772	PF01048	0.566
MOD_GSK3_1	134	141	PF00069	0.689
MOD_GSK3_1	178	185	PF00069	0.721
MOD_GSK3_1	237	244	PF00069	0.737
MOD_GSK3_1	257	264	PF00069	0.821
MOD_GSK3_1	273	280	PF00069	0.539
MOD_GSK3_1	312	319	PF00069	0.685
MOD_GSK3_1	329	336	PF00069	0.646
MOD_GSK3_1	339	346	PF00069	0.739
MOD_GSK3_1	361	368	PF00069	0.597
MOD_GSK3_1	4	11	PF00069	0.576
MOD_GSK3_1	419	426	PF00069	0.600
MOD_GSK3_1	42	49	PF00069	0.687
MOD_GSK3_1	508	515	PF00069	0.662
MOD_GSK3_1	51	58	PF00069	0.654
MOD_GSK3_1	537	544	PF00069	0.540
MOD_GSK3_1	551	558	PF00069	0.471
MOD_GSK3_1	575	582	PF00069	0.631
MOD_GSK3_1	590	597	PF00069	0.555
MOD_GSK3_1	613	620	PF00069	0.597
MOD_GSK3_1	624	631	PF00069	0.559
MOD_GSK3_1	66	73	PF00069	0.531
MOD_GSK3_1	669	676	PF00069	0.608
MOD_GSK3_1	677	684	PF00069	0.614
MOD_GSK3_1	722	729	PF00069	0.694
MOD_GSK3_1	730	737	PF00069	0.695
MOD_GSK3_1	99	106	PF00069	0.720
MOD_N-GLC_1	211	216	PF02516	0.540
MOD_N-GLC_1	294	299	PF02516	0.566
MOD_N-GLC_1	316	321	PF02516	0.613
MOD_N-GLC_1	416	421	PF02516	0.528
MOD_N-GLC_1	99	104	PF02516	0.629
MOD_N-GLC_2	446	448	PF02516	0.524
MOD_NEK2_1	142	147	PF00069	0.568
MOD_NEK2_1	157	162	PF00069	0.596
MOD_NEK2_1	277	282	PF00069	0.759
MOD_NEK2_1	440	445	PF00069	0.690
MOD_NEK2_1	465	470	PF00069	0.653
MOD_NEK2_1	495	500	PF00069	0.530
MOD_NEK2_1	599	604	PF00069	0.649
MOD_NEK2_1	66	71	PF00069	0.723
MOD_NEK2_1	8	13	PF00069	0.572
MOD_NEK2_2	4	9	PF00069	0.511
MOD_NEK2_2	669	674	PF00069	0.484
MOD_NEK2_2	681	686	PF00069	0.471
MOD_PIKK_1	59	65	PF00454	0.687
MOD_PIKK_1	70	76	PF00454	0.634
MOD_PK_1	234	240	PF00069	0.530
MOD_PKA_1	188	194	PF00069	0.673
MOD_PKA_1	234	240	PF00069	0.594
MOD_PKA_1	360	366	PF00069	0.548
MOD_PKA_1	46	52	PF00069	0.564
MOD_PKA_2	108	114	PF00069	0.651
MOD_PKA_2	142	148	PF00069	0.706
MOD_PKA_2	157	163	PF00069	0.540
MOD_PKA_2	188	194	PF00069	0.673
MOD_PKA_2	234	240	PF00069	0.610
MOD_PKA_2	330	336	PF00069	0.589
MOD_PKA_2	360	366	PF00069	0.618
MOD_PKA_2	440	446	PF00069	0.652
MOD_PKA_2	567	573	PF00069	0.668
MOD_PKA_2	642	648	PF00069	0.483
MOD_PKA_2	673	679	PF00069	0.482
MOD_PKB_1	176	184	PF00069	0.554
MOD_PKB_1	359	367	PF00069	0.548
MOD_Plk_1	316	322	PF00069	0.565
MOD_Plk_1	395	401	PF00069	0.505
MOD_Plk_1	416	422	PF00069	0.687
MOD_Plk_1	507	513	PF00069	0.552
MOD_Plk_1	613	619	PF00069	0.547
MOD_Plk_1	689	695	PF00069	0.467
MOD_Plk_2-3	614	620	PF00069	0.523
MOD_Plk_4	29	35	PF00069	0.531
MOD_Plk_4	350	356	PF00069	0.684
MOD_Plk_4	4	10	PF00069	0.530
MOD_Plk_4	419	425	PF00069	0.532
MOD_Plk_4	508	514	PF00069	0.533
MOD_Plk_4	541	547	PF00069	0.515
MOD_Plk_4	600	606	PF00069	0.661
MOD_ProDKin_1	12	18	PF00069	0.556
MOD_ProDKin_1	125	131	PF00069	0.665
MOD_ProDKin_1	227	233	PF00069	0.624
MOD_ProDKin_1	27	33	PF00069	0.511
MOD_ProDKin_1	279	285	PF00069	0.614
MOD_ProDKin_1	288	294	PF00069	0.574
MOD_ProDKin_1	300	306	PF00069	0.529
MOD_ProDKin_1	365	371	PF00069	0.667
MOD_ProDKin_1	47	53	PF00069	0.611
MOD_ProDKin_1	538	544	PF00069	0.511
MOD_ProDKin_1	570	576	PF00069	0.508
MOD_ProDKin_1	594	600	PF00069	0.509
MOD_ProDKin_1	722	728	PF00069	0.771
MOD_ProDKin_1	730	736	PF00069	0.759
MOD_SUMO_rev_2	225	231	PF00179	0.716
TRG_DiLeu_BaEn_1	683	688	PF01217	0.451
TRG_DiLeu_LyEn_5	301	306	PF01217	0.553
TRG_ENDOCYTIC_2	655	658	PF00928	0.613
TRG_ER_diArg_1	176	178	PF00400	0.706
TRG_ER_diArg_1	233	236	PF00400	0.604
TRG_ER_diArg_1	358	361	PF00400	0.534
TRG_NLS_MonoCore_2	232	237	PF00514	0.533
TRG_NLS_MonoExtN_4	231	238	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I993	Leishmania donovani	53%	100%
E9AGD5	Leishmania infantum	53%	100%
E9ANX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4QGP5	Leishmania major	50%	96%