Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H6W8_LEIBR

TriTrypDb:

LbrM.12.0550 , LBRM2903_120010300

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.540
CLV_NRD_NRD_1	128	130	PF00675	0.531
CLV_NRD_NRD_1	205	207	PF00675	0.524
CLV_PCSK_KEX2_1	128	130	PF00082	0.531
DEG_SPOP_SBC_1	70	74	PF00917	0.514
DOC_CKS1_1	48	53	PF01111	0.520
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.517
DOC_PP1_RVXF_1	126	133	PF00149	0.528
DOC_PP4_FxxP_1	11	14	PF00568	0.681
DOC_USP7_MATH_1	135	139	PF00917	0.682
DOC_USP7_MATH_1	200	204	PF00917	0.538
DOC_USP7_MATH_1	219	223	PF00917	0.531
DOC_USP7_MATH_1	22	26	PF00917	0.594
DOC_USP7_MATH_1	229	233	PF00917	0.535
DOC_USP7_MATH_1	66	70	PF00917	0.682
DOC_USP7_MATH_1	92	96	PF00917	0.801
DOC_USP7_MATH_2	102	108	PF00917	0.687
DOC_USP7_UBL2_3	182	186	PF12436	0.550
DOC_WW_Pin1_4	163	168	PF00397	0.690
DOC_WW_Pin1_4	47	52	PF00397	0.526
DOC_WW_Pin1_4	88	93	PF00397	0.740
DOC_WW_Pin1_4	96	101	PF00397	0.645
LIG_14-3-3_CanoR_1	128	133	PF00244	0.533
LIG_14-3-3_CanoR_1	137	146	PF00244	0.502
LIG_14-3-3_CanoR_1	218	224	PF00244	0.603
LIG_deltaCOP1_diTrp_1	151	160	PF00928	0.664
LIG_FHA_2	194	200	PF00498	0.748
LIG_FHA_2	231	237	PF00498	0.554
LIG_LIR_Gen_1	174	183	PF02991	0.546
LIG_LIR_Nem_3	174	178	PF02991	0.709
LIG_Pex14_1	119	123	PF04695	0.660
LIG_SH3_3	11	17	PF00018	0.636
LIG_SH3_3	29	35	PF00018	0.573
LIG_SH3_4	182	189	PF00018	0.549
LIG_TRAF2_1	167	170	PF00917	0.691
LIG_TRAF2_1	233	236	PF00917	0.680
MOD_CDK_SPK_2	163	168	PF00069	0.690
MOD_CK1_1	163	169	PF00069	0.687
MOD_CK1_1	64	70	PF00069	0.761
MOD_CK2_1	163	169	PF00069	0.687
MOD_CK2_1	22	28	PF00069	0.629
MOD_CK2_1	229	235	PF00069	0.642
MOD_GlcNHglycan	106	109	PF01048	0.706
MOD_GlcNHglycan	124	127	PF01048	0.618
MOD_GlcNHglycan	141	144	PF01048	0.510
MOD_GlcNHglycan	202	205	PF01048	0.569
MOD_GlcNHglycan	68	71	PF01048	0.678
MOD_GSK3_1	104	111	PF00069	0.691
MOD_GSK3_1	124	131	PF00069	0.732
MOD_GSK3_1	135	142	PF00069	0.552
MOD_GSK3_1	156	163	PF00069	0.687
MOD_GSK3_1	225	232	PF00069	0.556
MOD_GSK3_1	40	47	PF00069	0.698
MOD_GSK3_1	61	68	PF00069	0.742
MOD_GSK3_1	69	76	PF00069	0.673
MOD_GSK3_1	82	89	PF00069	0.702
MOD_GSK3_1	92	99	PF00069	0.596
MOD_NEK2_1	160	165	PF00069	0.781
MOD_NEK2_1	44	49	PF00069	0.759
MOD_NEK2_1	86	91	PF00069	0.683
MOD_PIKK_1	219	225	PF00454	0.589
MOD_PIKK_1	235	241	PF00454	0.493
MOD_PKA_1	128	134	PF00069	0.533
MOD_PKA_2	128	134	PF00069	0.533
MOD_PKA_2	136	142	PF00069	0.503
MOD_PKA_2	225	231	PF00069	0.557
MOD_ProDKin_1	163	169	PF00069	0.687
MOD_ProDKin_1	47	53	PF00069	0.528
MOD_ProDKin_1	88	94	PF00069	0.738
MOD_ProDKin_1	96	102	PF00069	0.643
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.700
TRG_ER_diArg_1	128	130	PF00400	0.551
TRG_NLS_MonoExtC_3	205	210	PF00514	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I979	Leishmania donovani	70%	80%
E9AGD7	Leishmania infantum	69%	80%
E9ANX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	88%
Q4QGP3	Leishmania major	65%	100%