WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6W6_LEIBR

TriTrypDb:

LbrM.12.0530 , LBRM2903_120010900

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.607
CLV_C14_Caspase3-7	434	438	PF00656	0.656
CLV_C14_Caspase3-7	952	956	PF00656	0.745
CLV_NRD_NRD_1	127	129	PF00675	0.655
CLV_NRD_NRD_1	264	266	PF00675	0.526
CLV_NRD_NRD_1	292	294	PF00675	0.591
CLV_NRD_NRD_1	349	351	PF00675	0.627
CLV_NRD_NRD_1	465	467	PF00675	0.610
CLV_NRD_NRD_1	554	556	PF00675	0.717
CLV_NRD_NRD_1	599	601	PF00675	0.806
CLV_NRD_NRD_1	725	727	PF00675	0.512
CLV_NRD_NRD_1	738	740	PF00675	0.419
CLV_NRD_NRD_1	744	746	PF00675	0.506
CLV_NRD_NRD_1	896	898	PF00675	0.655
CLV_NRD_NRD_1	927	929	PF00675	0.682
CLV_NRD_NRD_1	945	947	PF00675	0.818
CLV_NRD_NRD_1	958	960	PF00675	0.618
CLV_PCSK_FUR_1	365	369	PF00082	0.577
CLV_PCSK_FUR_1	943	947	PF00082	0.569
CLV_PCSK_KEX2_1	264	266	PF00082	0.600
CLV_PCSK_KEX2_1	291	293	PF00082	0.602
CLV_PCSK_KEX2_1	329	331	PF00082	0.482
CLV_PCSK_KEX2_1	349	351	PF00082	0.619
CLV_PCSK_KEX2_1	367	369	PF00082	0.396
CLV_PCSK_KEX2_1	460	462	PF00082	0.580
CLV_PCSK_KEX2_1	554	556	PF00082	0.729
CLV_PCSK_KEX2_1	744	746	PF00082	0.584
CLV_PCSK_KEX2_1	758	760	PF00082	0.618
CLV_PCSK_KEX2_1	896	898	PF00082	0.650
CLV_PCSK_KEX2_1	927	929	PF00082	0.688
CLV_PCSK_KEX2_1	945	947	PF00082	0.818
CLV_PCSK_KEX2_1	958	960	PF00082	0.618
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.630
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.395
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.555
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.577
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.550
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.591
CLV_PCSK_SKI1_1	231	235	PF00082	0.790
CLV_PCSK_SKI1_1	404	408	PF00082	0.415
CLV_PCSK_SKI1_1	600	604	PF00082	0.751
CLV_PCSK_SKI1_1	634	638	PF00082	0.526
CLV_PCSK_SKI1_1	65	69	PF00082	0.466
CLV_PCSK_SKI1_1	85	89	PF00082	0.730
DEG_APCC_DBOX_1	554	562	PF00400	0.742
DEG_SCF_FBW7_1	666	673	PF00400	0.753
DEG_SCF_FBW7_1	87	92	PF00400	0.767
DEG_SCF_FBW7_2	224	230	PF00400	0.547
DEG_SPOP_SBC_1	762	766	PF00917	0.590
DOC_ANK_TNKS_1	711	718	PF00023	0.621
DOC_ANK_TNKS_1	936	943	PF00023	0.786
DOC_CKS1_1	224	229	PF01111	0.544
DOC_CKS1_1	657	662	PF01111	0.751
DOC_CKS1_1	667	672	PF01111	0.694
DOC_CYCLIN_RxL_1	62	71	PF00134	0.488
DOC_MAPK_gen_1	551	560	PF00069	0.689
DOC_MAPK_gen_1	69	77	PF00069	0.579
DOC_MAPK_gen_1	927	934	PF00069	0.548
DOC_MAPK_MEF2A_6	927	936	PF00069	0.730
DOC_PP2B_LxvP_1	26	29	PF13499	0.523
DOC_PP2B_LxvP_1	686	689	PF13499	0.754
DOC_PP4_FxxP_1	702	705	PF00568	0.723
DOC_PP4_FxxP_1	845	848	PF00568	0.632
DOC_USP7_MATH_1	180	184	PF00917	0.789
DOC_USP7_MATH_1	303	307	PF00917	0.402
DOC_USP7_MATH_1	36	40	PF00917	0.390
DOC_USP7_MATH_1	385	389	PF00917	0.624
DOC_USP7_MATH_1	662	666	PF00917	0.767
DOC_USP7_MATH_1	670	674	PF00917	0.722
DOC_USP7_MATH_1	682	686	PF00917	0.462
DOC_USP7_MATH_1	89	93	PF00917	0.774
DOC_USP7_UBL2_3	102	106	PF12436	0.812
DOC_USP7_UBL2_3	529	533	PF12436	0.622
DOC_USP7_UBL2_3	74	78	PF12436	0.639
DOC_WW_Pin1_4	223	228	PF00397	0.729
DOC_WW_Pin1_4	231	236	PF00397	0.683
DOC_WW_Pin1_4	567	572	PF00397	0.700
DOC_WW_Pin1_4	591	596	PF00397	0.648
DOC_WW_Pin1_4	617	622	PF00397	0.713
DOC_WW_Pin1_4	637	642	PF00397	0.483
DOC_WW_Pin1_4	643	648	PF00397	0.601
DOC_WW_Pin1_4	653	658	PF00397	0.635
DOC_WW_Pin1_4	666	671	PF00397	0.689
DOC_WW_Pin1_4	85	90	PF00397	0.705
DOC_WW_Pin1_4	881	886	PF00397	0.687
DOC_WW_Pin1_4	915	920	PF00397	0.762
LIG_14-3-3_CanoR_1	128	134	PF00244	0.648
LIG_14-3-3_CanoR_1	182	188	PF00244	0.760
LIG_14-3-3_CanoR_1	518	525	PF00244	0.563
LIG_14-3-3_CanoR_1	605	609	PF00244	0.756
LIG_14-3-3_CanoR_1	763	771	PF00244	0.536
LIG_14-3-3_CanoR_1	776	780	PF00244	0.500
LIG_14-3-3_CanoR_1	927	933	PF00244	0.713
LIG_Actin_WH2_2	462	479	PF00022	0.637
LIG_Actin_WH2_2	621	636	PF00022	0.608
LIG_BRCT_BRCA1_1	172	176	PF00533	0.649
LIG_BRCT_BRCA1_1	378	382	PF00533	0.644
LIG_BRCT_BRCA1_1	395	399	PF00533	0.331
LIG_BRCT_BRCA1_1	698	702	PF00533	0.761
LIG_Clathr_ClatBox_1	807	811	PF01394	0.542
LIG_FHA_1	200	206	PF00498	0.622
LIG_FHA_1	568	574	PF00498	0.521
LIG_FHA_1	628	634	PF00498	0.540
LIG_FHA_1	681	687	PF00498	0.758
LIG_FHA_1	836	842	PF00498	0.550
LIG_FHA_1	900	906	PF00498	0.645
LIG_FHA_1	929	935	PF00498	0.765
LIG_FHA_2	580	586	PF00498	0.708
LIG_FHA_2	604	610	PF00498	0.762
LIG_FHA_2	776	782	PF00498	0.570
LIG_FHA_2	959	965	PF00498	0.791
LIG_LIR_Apic_2	54	59	PF02991	0.392
LIG_LIR_Apic_2	699	705	PF02991	0.740
LIG_LIR_Apic_2	843	849	PF02991	0.547
LIG_LIR_Apic_2	964	969	PF02991	0.726
LIG_LIR_Nem_3	43	49	PF02991	0.333
LIG_LIR_Nem_3	61	67	PF02991	0.484
LIG_LRP6_Inhibitor_1	691	697	PF00058	0.542
LIG_PCNA_yPIPBox_3	535	548	PF02747	0.733
LIG_PCNA_yPIPBox_3	622	634	PF02747	0.608
LIG_Pex14_2	395	399	PF04695	0.610
LIG_REV1ctd_RIR_1	843	847	PF16727	0.610
LIG_SH2_CRK	867	871	PF00017	0.785
LIG_SH2_GRB2like	46	49	PF00017	0.356
LIG_SH2_NCK_1	851	855	PF00017	0.612
LIG_SH2_PTP2	728	731	PF00017	0.567
LIG_SH2_STAT5	46	49	PF00017	0.331
LIG_SH2_STAT5	728	731	PF00017	0.567
LIG_SH3_1	654	660	PF00018	0.757
LIG_SH3_3	615	621	PF00018	0.655
LIG_SH3_3	654	660	PF00018	0.757
LIG_SH3_3	879	885	PF00018	0.507
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.744
LIG_SUMO_SIM_par_1	201	207	PF11976	0.541
LIG_SUMO_SIM_par_1	358	364	PF11976	0.473
LIG_TRAF2_1	280	283	PF00917	0.414
LIG_TRAF2_1	381	384	PF00917	0.590
LIG_TRAF2_1	536	539	PF00917	0.588
LIG_TRAF2_1	607	610	PF00917	0.736
LIG_TRAF2_1	707	710	PF00917	0.542
LIG_TRAF2_1	778	781	PF00917	0.511
LIG_UBA3_1	543	551	PF00899	0.697
LIG_WW_1	848	851	PF00397	0.507
LIG_WW_3	847	851	PF00397	0.741
MOD_CDC14_SPxK_1	228	231	PF00782	0.790
MOD_CDK_SPK_2	567	572	PF00069	0.700
MOD_CDK_SPxK_1	225	231	PF00069	0.787
MOD_CDK_SPxK_1	666	672	PF00069	0.791
MOD_CDK_SPxxK_3	231	238	PF00069	0.563
MOD_CK1_1	100	106	PF00069	0.675
MOD_CK1_1	109	115	PF00069	0.671
MOD_CK1_1	178	184	PF00069	0.735
MOD_CK1_1	225	231	PF00069	0.562
MOD_CK1_1	656	662	PF00069	0.703
MOD_CK1_1	680	686	PF00069	0.781
MOD_CK1_1	835	841	PF00069	0.528
MOD_CK1_1	872	878	PF00069	0.642
MOD_CK1_1	930	936	PF00069	0.790
MOD_CK2_1	109	115	PF00069	0.691
MOD_CK2_1	277	283	PF00069	0.412
MOD_CK2_1	603	609	PF00069	0.739
MOD_CK2_1	668	674	PF00069	0.641
MOD_CK2_1	704	710	PF00069	0.532
MOD_CK2_1	775	781	PF00069	0.515
MOD_CK2_1	889	895	PF00069	0.715
MOD_Cter_Amidation	724	727	PF01082	0.521
MOD_GlcNHglycan	167	170	PF01048	0.612
MOD_GlcNHglycan	182	185	PF01048	0.631
MOD_GlcNHglycan	307	310	PF01048	0.636
MOD_GlcNHglycan	495	498	PF01048	0.691
MOD_GlcNHglycan	579	582	PF01048	0.739
MOD_GlcNHglycan	691	694	PF01048	0.650
MOD_GlcNHglycan	698	701	PF01048	0.714
MOD_GlcNHglycan	827	831	PF01048	0.686
MOD_GlcNHglycan	871	874	PF01048	0.769
MOD_GlcNHglycan	99	102	PF01048	0.802
MOD_GSK3_1	176	183	PF00069	0.652
MOD_GSK3_1	563	570	PF00069	0.660
MOD_GSK3_1	573	580	PF00069	0.647
MOD_GSK3_1	604	611	PF00069	0.729
MOD_GSK3_1	643	650	PF00069	0.612
MOD_GSK3_1	652	659	PF00069	0.745
MOD_GSK3_1	662	669	PF00069	0.742
MOD_GSK3_1	676	683	PF00069	0.721
MOD_GSK3_1	85	92	PF00069	0.724
MOD_GSK3_1	881	888	PF00069	0.677
MOD_GSK3_1	911	918	PF00069	0.727
MOD_GSK3_1	923	930	PF00069	0.775
MOD_GSK3_1	945	952	PF00069	0.754
MOD_GSK3_1	97	104	PF00069	0.657
MOD_N-GLC_1	832	837	PF02516	0.633
MOD_N-GLC_2	832	834	PF02516	0.667
MOD_NEK2_1	176	181	PF00069	0.745
MOD_NEK2_1	189	194	PF00069	0.473
MOD_NEK2_1	573	578	PF00069	0.790
MOD_NEK2_1	603	608	PF00069	0.782
MOD_NEK2_1	642	647	PF00069	0.535
MOD_NEK2_1	677	682	PF00069	0.730
MOD_NEK2_1	743	748	PF00069	0.524
MOD_NEK2_1	793	798	PF00069	0.496
MOD_PIKK_1	376	382	PF00454	0.593
MOD_PIKK_1	414	420	PF00454	0.457
MOD_PIKK_1	501	507	PF00454	0.707
MOD_PIKK_1	517	523	PF00454	0.689
MOD_PIKK_1	793	799	PF00454	0.544
MOD_PIKK_1	911	917	PF00454	0.771
MOD_PK_1	129	135	PF00069	0.751
MOD_PKA_1	554	560	PF00069	0.737
MOD_PKA_1	927	933	PF00069	0.729
MOD_PKA_1	945	951	PF00069	0.811
MOD_PKA_1	958	964	PF00069	0.616
MOD_PKA_2	456	462	PF00069	0.400
MOD_PKA_2	517	523	PF00069	0.604
MOD_PKA_2	554	560	PF00069	0.712
MOD_PKA_2	604	610	PF00069	0.757
MOD_PKA_2	743	749	PF00069	0.534
MOD_PKA_2	762	768	PF00069	0.312
MOD_PKA_2	775	781	PF00069	0.496
MOD_PKA_2	793	799	PF00069	0.321
MOD_PKA_2	849	855	PF00069	0.699
MOD_PKA_2	927	933	PF00069	0.723
MOD_PKA_2	944	950	PF00069	0.753
MOD_PKA_2	958	964	PF00069	0.745
MOD_PKB_1	943	951	PF00069	0.653
MOD_Plk_1	608	614	PF00069	0.649
MOD_Plk_1	717	723	PF00069	0.611
MOD_Plk_1	826	832	PF00069	0.644
MOD_Plk_1	899	905	PF00069	0.625
MOD_Plk_2-3	277	283	PF00069	0.412
MOD_Plk_2-3	57	63	PF00069	0.561
MOD_Plk_2-3	710	716	PF00069	0.580
MOD_Plk_4	199	205	PF00069	0.540
MOD_Plk_4	51	57	PF00069	0.412
MOD_Plk_4	556	562	PF00069	0.692
MOD_Plk_4	662	668	PF00069	0.665
MOD_Plk_4	682	688	PF00069	0.684
MOD_Plk_4	900	906	PF00069	0.602
MOD_ProDKin_1	223	229	PF00069	0.723
MOD_ProDKin_1	231	237	PF00069	0.683
MOD_ProDKin_1	567	573	PF00069	0.703
MOD_ProDKin_1	591	597	PF00069	0.650
MOD_ProDKin_1	617	623	PF00069	0.707
MOD_ProDKin_1	637	643	PF00069	0.490
MOD_ProDKin_1	653	659	PF00069	0.635
MOD_ProDKin_1	666	672	PF00069	0.689
MOD_ProDKin_1	85	91	PF00069	0.708
MOD_ProDKin_1	881	887	PF00069	0.681
MOD_ProDKin_1	915	921	PF00069	0.764
MOD_SUMO_for_1	68	71	PF00179	0.618
MOD_SUMO_for_1	757	760	PF00179	0.496
MOD_SUMO_rev_2	314	320	PF00179	0.608
MOD_SUMO_rev_2	325	331	PF00179	0.495
MOD_SUMO_rev_2	388	395	PF00179	0.581
MOD_SUMO_rev_2	396	406	PF00179	0.291
MOD_SUMO_rev_2	434	441	PF00179	0.601
MOD_SUMO_rev_2	470	479	PF00179	0.581
MOD_SUMO_rev_2	594	603	PF00179	0.597
MOD_SUMO_rev_2	620	628	PF00179	0.626
TRG_DiLeu_BaEn_1	710	715	PF01217	0.531
TRG_DiLeu_BaEn_2	505	511	PF01217	0.608
TRG_DiLeu_BaEn_3	538	544	PF01217	0.676
TRG_DiLeu_BaEn_4	815	821	PF01217	0.626
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.595
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.523
TRG_ENDOCYTIC_2	46	49	PF00928	0.331
TRG_ENDOCYTIC_2	64	67	PF00928	0.561
TRG_ENDOCYTIC_2	728	731	PF00928	0.556
TRG_ENDOCYTIC_2	867	870	PF00928	0.786
TRG_ER_diArg_1	255	258	PF00400	0.540
TRG_ER_diArg_1	263	265	PF00400	0.593
TRG_ER_diArg_1	553	555	PF00400	0.491
TRG_ER_diArg_1	719	722	PF00400	0.526
TRG_ER_diArg_1	743	745	PF00400	0.565
TRG_ER_diArg_1	896	898	PF00400	0.721
TRG_ER_diArg_1	943	946	PF00400	0.816
TRG_ER_diArg_1	957	959	PF00400	0.620
TRG_NLS_MonoExtC_3	287	292	PF00514	0.665
TRG_NLS_MonoExtN_4	102	109	PF00514	0.716
TRG_NLS_MonoExtN_4	288	295	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	812	816	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	896	900	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL16	Leptomonas seymouri	55%	93%
A0A3S7WRX9	Leishmania donovani	84%	100%
C9ZIR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AGD9	Leishmania infantum	84%	100%
E9ANX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QGP1	Leishmania major	84%	100%
V5AMQ0	Trypanosoma cruzi	32%	100%