V-type proton ATPase subunit F

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H6W1_LEIBR

TriTrypDb:

LbrM.12.0480 , LBRM2903_120011100

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	11
GO:0098796	membrane protein complex	2	11
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6W1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	6
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11
GO:0022804	active transmembrane transporter activity	3	11
GO:0022853	active monoatomic ion transmembrane transporter activity	4	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	11
GO:0042626	ATPase-coupled transmembrane transporter activity	2	11
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	11
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	11
GO:0140657	ATP-dependent activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	50	52	PF00675	0.358
CLV_NRD_NRD_1	78	80	PF00675	0.466
CLV_PCSK_KEX2_1	50	52	PF00082	0.244
CLV_PCSK_SKI1_1	36	40	PF00082	0.341
DEG_SCF_FBW7_2	62	68	PF00400	0.446
DOC_CKS1_1	62	67	PF01111	0.364
DOC_MAPK_gen_1	79	87	PF00069	0.463
DOC_MAPK_MEF2A_6	79	86	PF00069	0.431
DOC_PP2B_LxvP_1	110	113	PF13499	0.352
DOC_WW_Pin1_4	61	66	PF00397	0.355
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_FHA_1	129	135	PF00498	0.660
LIG_FHA_1	23	29	PF00498	0.352
LIG_LIR_Gen_1	70	78	PF02991	0.274
LIG_SH2_STAT5	58	61	PF00017	0.399
LIG_SH3_3	56	62	PF00018	0.385
LIG_SUMO_SIM_par_1	108	114	PF11976	0.352
LIG_UBA3_1	109	115	PF00899	0.395
MOD_CK2_1	64	70	PF00069	0.464
MOD_GSK3_1	60	67	PF00069	0.451
MOD_NEK2_1	1	6	PF00069	0.727
MOD_Plk_1	20	26	PF00069	0.352
MOD_Plk_4	101	107	PF00069	0.478
MOD_ProDKin_1	61	67	PF00069	0.355
TRG_ENDOCYTIC_2	57	60	PF00928	0.372
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I750	Leptomonas seymouri	83%	99%
A0A0S4JD04	Bodo saltans	53%	100%
A0A1X0NNW5	Trypanosomatidae	71%	96%
A0A3Q8I866	Leishmania donovani	91%	100%
A0A3R7LS82	Trypanosoma rangeli	66%	100%
A1DH48	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	43%	100%
A6RRW0	Botryotinia fuckeliana (strain B05.10)	44%	100%
A7TMI5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	37%	100%
C9ZIT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AGE0	Leishmania infantum	92%	100%
E9ANY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O27037	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	33%	100%
O43046	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
O44091	Drosophila pseudoobscura pseudoobscura	44%	100%
P31478	Manduca sexta	43%	100%
P39111	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P50408	Rattus norvegicus	45%	100%
Q16864	Homo sapiens	45%	100%
Q17029	Anopheles gambiae	43%	100%
Q1HQK8	Aedes aegypti	43%	100%
Q23680	Caenorhabditis elegans	48%	100%
Q24583	Drosophila melanogaster	43%	100%
Q28029	Bos taurus	45%	100%
Q4QGP0	Leishmania major	91%	100%
Q55AH5	Dictyostelium discoideum	44%	100%
Q9D1K2	Mus musculus	45%	100%
Q9I8H3	Xenopus laevis	48%	100%
Q9Y756	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	100%
Q9ZQX4	Arabidopsis thaliana	44%	100%