Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H6W0_LEIBR

TriTrypDb:

LbrM.12.0470 , LBRM2903_120009700

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.433
CLV_C14_Caspase3-7	24	28	PF00656	0.693
CLV_C14_Caspase3-7	328	332	PF00656	0.524
CLV_C14_Caspase3-7	389	393	PF00656	0.529
CLV_C14_Caspase3-7	629	633	PF00656	0.571
CLV_C14_Caspase3-7	703	707	PF00656	0.540
CLV_C14_Caspase3-7	817	821	PF00656	0.604
CLV_C14_Caspase3-7	879	883	PF00656	0.655
CLV_C14_Caspase3-7	886	890	PF00656	0.660
CLV_C14_Caspase3-7	91	95	PF00656	0.532
CLV_C14_Caspase3-7	938	942	PF00656	0.563
CLV_NRD_NRD_1	100	102	PF00675	0.697
CLV_NRD_NRD_1	169	171	PF00675	0.535
CLV_NRD_NRD_1	480	482	PF00675	0.412
CLV_NRD_NRD_1	792	794	PF00675	0.643
CLV_NRD_NRD_1	934	936	PF00675	0.586
CLV_PCSK_FUR_1	478	482	PF00082	0.412
CLV_PCSK_KEX2_1	100	102	PF00082	0.697
CLV_PCSK_KEX2_1	169	171	PF00082	0.535
CLV_PCSK_KEX2_1	480	482	PF00082	0.412
CLV_PCSK_KEX2_1	791	793	PF00082	0.655
CLV_PCSK_KEX2_1	872	874	PF00082	0.574
CLV_PCSK_KEX2_1	934	936	PF00082	0.586
CLV_PCSK_KEX2_1	970	972	PF00082	0.733
CLV_PCSK_PC1ET2_1	872	874	PF00082	0.574
CLV_PCSK_PC1ET2_1	970	972	PF00082	0.733
CLV_PCSK_PC7_1	165	171	PF00082	0.527
CLV_PCSK_PC7_1	96	102	PF00082	0.703
CLV_PCSK_SKI1_1	146	150	PF00082	0.417
CLV_PCSK_SKI1_1	175	179	PF00082	0.348
CLV_PCSK_SKI1_1	453	457	PF00082	0.422
CLV_PCSK_SKI1_1	552	556	PF00082	0.412
CLV_PCSK_SKI1_1	636	640	PF00082	0.538
CLV_PCSK_SKI1_1	652	656	PF00082	0.495
CLV_PCSK_SKI1_1	926	930	PF00082	0.522
CLV_Separin_Metazoa	267	271	PF03568	0.457
CLV_Separin_Metazoa	525	529	PF03568	0.315
CLV_Separin_Metazoa	81	85	PF03568	0.442
DEG_APCC_DBOX_1	452	460	PF00400	0.416
DEG_APCC_DBOX_1	463	471	PF00400	0.409
DEG_APCC_DBOX_1	551	559	PF00400	0.494
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DEG_SCF_FBW7_1	810	817	PF00400	0.556
DEG_SPOP_SBC_1	440	444	PF00917	0.499
DEG_SPOP_SBC_1	824	828	PF00917	0.630
DEG_SPOP_SBC_1	838	842	PF00917	0.524
DOC_ANK_TNKS_1	195	202	PF00023	0.424
DOC_ANK_TNKS_1	410	417	PF00023	0.648
DOC_CKS1_1	811	816	PF01111	0.556
DOC_CYCLIN_RxL_1	549	557	PF00134	0.410
DOC_MAPK_gen_1	634	642	PF00069	0.538
DOC_PP1_RVXF_1	365	372	PF00149	0.501
DOC_PP1_RVXF_1	933	940	PF00149	0.505
DOC_PP4_FxxP_1	811	814	PF00568	0.556
DOC_USP7_MATH_1	109	113	PF00917	0.696
DOC_USP7_MATH_1	124	128	PF00917	0.516
DOC_USP7_MATH_1	275	279	PF00917	0.572
DOC_USP7_MATH_1	350	354	PF00917	0.579
DOC_USP7_MATH_1	365	369	PF00917	0.455
DOC_USP7_MATH_1	404	408	PF00917	0.622
DOC_USP7_MATH_1	410	414	PF00917	0.587
DOC_USP7_MATH_1	419	423	PF00917	0.557
DOC_USP7_MATH_1	544	548	PF00917	0.433
DOC_USP7_MATH_1	643	647	PF00917	0.769
DOC_USP7_MATH_1	656	660	PF00917	0.538
DOC_USP7_MATH_1	766	770	PF00917	0.643
DOC_USP7_MATH_1	92	96	PF00917	0.540
DOC_WW_Pin1_4	277	282	PF00397	0.625
DOC_WW_Pin1_4	294	299	PF00397	0.509
DOC_WW_Pin1_4	33	38	PF00397	0.613
DOC_WW_Pin1_4	379	384	PF00397	0.525
DOC_WW_Pin1_4	406	411	PF00397	0.547
DOC_WW_Pin1_4	447	452	PF00397	0.545
DOC_WW_Pin1_4	802	807	PF00397	0.727
DOC_WW_Pin1_4	810	815	PF00397	0.636
DOC_WW_Pin1_4	950	955	PF00397	0.605
DOC_WW_Pin1_4	961	966	PF00397	0.612
LIG_14-3-3_CanoR_1	357	363	PF00244	0.635
LIG_14-3-3_CanoR_1	39	45	PF00244	0.440
LIG_14-3-3_CanoR_1	4	8	PF00244	0.690
LIG_14-3-3_CanoR_1	418	426	PF00244	0.555
LIG_14-3-3_CanoR_1	473	478	PF00244	0.363
LIG_14-3-3_CanoR_1	480	488	PF00244	0.357
LIG_14-3-3_CanoR_1	636	641	PF00244	0.626
LIG_14-3-3_CanoR_1	657	665	PF00244	0.473
LIG_14-3-3_CanoR_1	678	686	PF00244	0.670
LIG_14-3-3_CanoR_1	756	762	PF00244	0.753
LIG_14-3-3_CanoR_1	934	940	PF00244	0.647
LIG_BIR_III_2	648	652	PF00653	0.535
LIG_BRCT_BRCA1_1	352	356	PF00533	0.577
LIG_BRCT_BRCA1_1	367	371	PF00533	0.494
LIG_BRCT_BRCA1_1	658	662	PF00533	0.561
LIG_BRCT_BRCA1_1	807	811	PF00533	0.583
LIG_Clathr_ClatBox_1	55	59	PF01394	0.514
LIG_Clathr_ClatBox_1	734	738	PF01394	0.648
LIG_FHA_1	131	137	PF00498	0.569
LIG_FHA_1	256	262	PF00498	0.577
LIG_FHA_1	364	370	PF00498	0.501
LIG_FHA_1	407	413	PF00498	0.627
LIG_FHA_1	440	446	PF00498	0.559
LIG_FHA_1	46	52	PF00498	0.481
LIG_FHA_1	480	486	PF00498	0.422
LIG_FHA_1	551	557	PF00498	0.423
LIG_FHA_1	637	643	PF00498	0.582
LIG_FHA_1	680	686	PF00498	0.539
LIG_FHA_1	729	735	PF00498	0.665
LIG_FHA_1	756	762	PF00498	0.719
LIG_FHA_1	817	823	PF00498	0.712
LIG_FHA_1	833	839	PF00498	0.658
LIG_FHA_2	281	287	PF00498	0.554
LIG_FHA_2	359	365	PF00498	0.677
LIG_FHA_2	481	487	PF00498	0.356
LIG_FHA_2	720	726	PF00498	0.565
LIG_FHA_2	815	821	PF00498	0.599
LIG_FXI_DFP_1	137	141	PF00024	0.541
LIG_GBD_Chelix_1	253	261	PF00786	0.446
LIG_LIR_Apic_2	808	814	PF02991	0.560
LIG_LIR_Apic_2	85	89	PF02991	0.439
LIG_LIR_Gen_1	272	281	PF02991	0.554
LIG_LIR_Gen_1	547	556	PF02991	0.469
LIG_LIR_Nem_3	272	276	PF02991	0.557
LIG_LIR_Nem_3	305	310	PF02991	0.517
LIG_LIR_Nem_3	547	551	PF02991	0.455
LIG_LIR_Nem_3	659	665	PF02991	0.469
LIG_MYND_1	309	313	PF01753	0.524
LIG_NRBOX	550	556	PF00104	0.410
LIG_NRBOX	665	671	PF00104	0.577
LIG_SH2_CRK	454	458	PF00017	0.503
LIG_SH2_CRK	548	552	PF00017	0.390
LIG_SH2_NCK_1	454	458	PF00017	0.503
LIG_SH2_NCK_1	498	502	PF00017	0.461
LIG_SH2_SRC	204	207	PF00017	0.555
LIG_SH2_SRC	498	501	PF00017	0.476
LIG_SH2_SRC	594	597	PF00017	0.548
LIG_SH2_STAP1	832	836	PF00017	0.547
LIG_SH2_STAT3	515	518	PF00017	0.475
LIG_SH2_STAT5	171	174	PF00017	0.456
LIG_SH2_STAT5	204	207	PF00017	0.467
LIG_SH2_STAT5	515	518	PF00017	0.395
LIG_SH2_STAT5	594	597	PF00017	0.548
LIG_SH2_STAT5	812	815	PF00017	0.554
LIG_SH2_STAT5	837	840	PF00017	0.677
LIG_SH3_3	370	376	PF00018	0.581
LIG_SH3_3	494	500	PF00018	0.666
LIG_SH3_3	534	540	PF00018	0.433
LIG_SH3_3	650	656	PF00018	0.574
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.472
LIG_SUMO_SIM_anti_2	441	450	PF11976	0.522
LIG_SUMO_SIM_par_1	295	303	PF11976	0.521
LIG_SUMO_SIM_par_1	53	60	PF11976	0.472
LIG_SUMO_SIM_par_1	552	557	PF11976	0.413
LIG_TRAF2_1	580	583	PF00917	0.480
LIG_TRAF2_1	70	73	PF00917	0.517
LIG_TRAF2_1	722	725	PF00917	0.587
LIG_UBA3_1	555	560	PF00899	0.577
MOD_CDC14_SPxK_1	36	39	PF00782	0.662
MOD_CDC14_SPxK_1	450	453	PF00782	0.353
MOD_CDK_SPK_2	406	411	PF00069	0.537
MOD_CDK_SPxK_1	33	39	PF00069	0.669
MOD_CDK_SPxK_1	447	453	PF00069	0.461
MOD_CDK_SPxxK_3	277	284	PF00069	0.634
MOD_CDK_SPxxK_3	963	970	PF00069	0.561
MOD_CK1_1	112	118	PF00069	0.691
MOD_CK1_1	127	133	PF00069	0.454
MOD_CK1_1	176	182	PF00069	0.503
MOD_CK1_1	297	303	PF00069	0.629
MOD_CK1_1	438	444	PF00069	0.584
MOD_CK1_1	747	753	PF00069	0.629
MOD_CK1_1	769	775	PF00069	0.601
MOD_CK1_1	802	808	PF00069	0.729
MOD_CK1_1	839	845	PF00069	0.599
MOD_CK1_1	890	896	PF00069	0.720
MOD_CK2_1	155	161	PF00069	0.494
MOD_CK2_1	18	24	PF00069	0.721
MOD_CK2_1	358	364	PF00069	0.684
MOD_CK2_1	418	424	PF00069	0.585
MOD_CK2_1	480	486	PF00069	0.355
MOD_CK2_1	57	63	PF00069	0.509
MOD_CK2_1	67	73	PF00069	0.440
MOD_CK2_1	688	694	PF00069	0.585
MOD_CK2_1	718	724	PF00069	0.716
MOD_CK2_1	795	801	PF00069	0.726
MOD_CK2_1	82	88	PF00069	0.425
MOD_CK2_1	839	845	PF00069	0.721
MOD_CK2_1	901	907	PF00069	0.571
MOD_Cter_Amidation	789	792	PF01082	0.731
MOD_GlcNHglycan	102	105	PF01048	0.795
MOD_GlcNHglycan	114	117	PF01048	0.545
MOD_GlcNHglycan	129	132	PF01048	0.709
MOD_GlcNHglycan	174	178	PF01048	0.486
MOD_GlcNHglycan	21	24	PF01048	0.684
MOD_GlcNHglycan	302	305	PF01048	0.602
MOD_GlcNHglycan	325	328	PF01048	0.706
MOD_GlcNHglycan	352	355	PF01048	0.723
MOD_GlcNHglycan	379	382	PF01048	0.751
MOD_GlcNHglycan	412	415	PF01048	0.831
MOD_GlcNHglycan	421	424	PF01048	0.794
MOD_GlcNHglycan	430	433	PF01048	0.810
MOD_GlcNHglycan	491	495	PF01048	0.571
MOD_GlcNHglycan	601	604	PF01048	0.517
MOD_GlcNHglycan	626	629	PF01048	0.730
MOD_GlcNHglycan	658	661	PF01048	0.557
MOD_GlcNHglycan	689	693	PF01048	0.702
MOD_GlcNHglycan	69	72	PF01048	0.382
MOD_GlcNHglycan	731	734	PF01048	0.645
MOD_GlcNHglycan	746	749	PF01048	0.635
MOD_GlcNHglycan	762	765	PF01048	0.556
MOD_GlcNHglycan	807	810	PF01048	0.582
MOD_GlcNHglycan	827	830	PF01048	0.749
MOD_GlcNHglycan	90	93	PF01048	0.520
MOD_GlcNHglycan	916	919	PF01048	0.621
MOD_GSK3_1	276	283	PF00069	0.585
MOD_GSK3_1	3	10	PF00069	0.636
MOD_GSK3_1	33	40	PF00069	0.592
MOD_GSK3_1	406	413	PF00069	0.703
MOD_GSK3_1	435	442	PF00069	0.614
MOD_GSK3_1	443	450	PF00069	0.543
MOD_GSK3_1	469	476	PF00069	0.423
MOD_GSK3_1	626	633	PF00069	0.577
MOD_GSK3_1	684	691	PF00069	0.576
MOD_GSK3_1	696	703	PF00069	0.647
MOD_GSK3_1	795	802	PF00069	0.725
MOD_GSK3_1	810	817	PF00069	0.577
MOD_GSK3_1	832	839	PF00069	0.586
MOD_GSK3_1	856	863	PF00069	0.642
MOD_GSK3_1	88	95	PF00069	0.584
MOD_GSK3_1	885	892	PF00069	0.707
MOD_GSK3_1	935	942	PF00069	0.657
MOD_GSK3_1	946	953	PF00069	0.610
MOD_GSK3_1	96	103	PF00069	0.716
MOD_LATS_1	597	603	PF00433	0.520
MOD_LATS_1	876	882	PF00433	0.555
MOD_N-GLC_1	350	355	PF02516	0.551
MOD_N-GLC_1	766	771	PF02516	0.618
MOD_N-GLC_1	860	865	PF02516	0.563
MOD_NEK2_1	276	281	PF00069	0.604
MOD_NEK2_1	356	361	PF00069	0.561
MOD_NEK2_1	363	368	PF00069	0.521
MOD_NEK2_1	386	391	PF00069	0.653
MOD_NEK2_1	626	631	PF00069	0.718
MOD_NEK2_1	7	12	PF00069	0.706
MOD_NEK2_1	82	87	PF00069	0.578
MOD_NEK2_1	856	861	PF00069	0.563
MOD_NEK2_1	928	933	PF00069	0.495
MOD_NEK2_2	832	837	PF00069	0.547
MOD_PIKK_1	130	136	PF00454	0.416
MOD_PIKK_1	220	226	PF00454	0.453
MOD_PIKK_1	45	51	PF00454	0.545
MOD_PIKK_1	8	14	PF00454	0.698
MOD_PIKK_1	860	866	PF00454	0.725
MOD_PIKK_1	893	899	PF00454	0.571
MOD_PKA_1	100	106	PF00069	0.685
MOD_PKA_1	480	486	PF00069	0.355
MOD_PKA_2	100	106	PF00069	0.706
MOD_PKA_2	18	24	PF00069	0.562
MOD_PKA_2	25	31	PF00069	0.674
MOD_PKA_2	255	261	PF00069	0.446
MOD_PKA_2	3	9	PF00069	0.757
MOD_PKA_2	356	362	PF00069	0.566
MOD_PKA_2	410	416	PF00069	0.821
MOD_PKA_2	428	434	PF00069	0.807
MOD_PKA_2	479	485	PF00069	0.472
MOD_PKA_2	624	630	PF00069	0.700
MOD_PKA_2	656	662	PF00069	0.485
MOD_PKA_2	718	724	PF00069	0.556
MOD_PKA_2	755	761	PF00069	0.688
MOD_PKA_2	777	783	PF00069	0.677
MOD_PKB_1	425	433	PF00069	0.730
MOD_PKB_1	478	486	PF00069	0.355
MOD_PKB_1	634	642	PF00069	0.532
MOD_PKB_1	793	801	PF00069	0.726
MOD_Plk_1	173	179	PF00069	0.362
MOD_Plk_1	490	496	PF00069	0.598
MOD_Plk_1	832	838	PF00069	0.709
MOD_Plk_1	856	862	PF00069	0.564
MOD_Plk_2-3	155	161	PF00069	0.494
MOD_Plk_2-3	54	60	PF00069	0.492
MOD_Plk_4	365	371	PF00069	0.618
MOD_Plk_4	443	449	PF00069	0.580
MOD_Plk_4	57	63	PF00069	0.513
MOD_Plk_4	757	763	PF00069	0.550
MOD_Plk_4	928	934	PF00069	0.476
MOD_ProDKin_1	277	283	PF00069	0.627
MOD_ProDKin_1	294	300	PF00069	0.509
MOD_ProDKin_1	33	39	PF00069	0.613
MOD_ProDKin_1	379	385	PF00069	0.527
MOD_ProDKin_1	406	412	PF00069	0.548
MOD_ProDKin_1	447	453	PF00069	0.535
MOD_ProDKin_1	802	808	PF00069	0.729
MOD_ProDKin_1	810	816	PF00069	0.635
MOD_ProDKin_1	950	956	PF00069	0.605
MOD_ProDKin_1	961	967	PF00069	0.608
MOD_SUMO_rev_2	667	676	PF00179	0.472
TRG_DiLeu_BaEn_4	155	161	PF01217	0.363
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.503
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.518
TRG_ENDOCYTIC_2	454	457	PF00928	0.508
TRG_ENDOCYTIC_2	548	551	PF00928	0.396
TRG_ER_diArg_1	100	102	PF00400	0.697
TRG_ER_diArg_1	169	171	PF00400	0.535
TRG_ER_diArg_1	246	249	PF00400	0.413
TRG_ER_diArg_1	426	429	PF00400	0.644
TRG_ER_diArg_1	477	480	PF00400	0.455
TRG_ER_diArg_1	791	793	PF00400	0.655
TRG_ER_diArg_1	910	913	PF00400	0.643
TRG_ER_diArg_1	933	935	PF00400	0.581
TRG_NES_CRM1_1	518	530	PF08389	0.360
TRG_NES_CRM1_1	845	857	PF08389	0.714
TRG_NLS_MonoExtC_3	969	975	PF00514	0.760
TRG_NLS_MonoExtN_4	967	974	PF00514	0.729
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I101	Leptomonas seymouri	35%	93%
A0A3S5H6K8	Leishmania donovani	67%	90%
E9AGD3	Leishmania infantum	67%	90%
E9ANX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	89%
Q4QGP7	Leishmania major	66%	100%