Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6V9_LEIBR

TriTrypDb:

LbrM.12.0460 , LBRM2903_120009600

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.688
CLV_C14_Caspase3-7	334	338	PF00656	0.691
CLV_C14_Caspase3-7	438	442	PF00656	0.698
CLV_C14_Caspase3-7	560	564	PF00656	0.629
CLV_MEL_PAP_1	618	624	PF00089	0.540
CLV_NRD_NRD_1	142	144	PF00675	0.615
CLV_NRD_NRD_1	434	436	PF00675	0.629
CLV_NRD_NRD_1	483	485	PF00675	0.815
CLV_NRD_NRD_1	488	490	PF00675	0.574
CLV_NRD_NRD_1	547	549	PF00675	0.608
CLV_NRD_NRD_1	584	586	PF00675	0.699
CLV_NRD_NRD_1	587	589	PF00675	0.681
CLV_NRD_NRD_1	697	699	PF00675	0.719
CLV_NRD_NRD_1	701	703	PF00675	0.676
CLV_NRD_NRD_1	716	718	PF00675	0.507
CLV_NRD_NRD_1	74	76	PF00675	0.699
CLV_PCSK_FUR_1	481	485	PF00082	0.723
CLV_PCSK_FUR_1	585	589	PF00082	0.549
CLV_PCSK_FUR_1	698	702	PF00082	0.722
CLV_PCSK_KEX2_1	141	143	PF00082	0.603
CLV_PCSK_KEX2_1	434	436	PF00082	0.629
CLV_PCSK_KEX2_1	480	482	PF00082	0.831
CLV_PCSK_KEX2_1	483	485	PF00082	0.806
CLV_PCSK_KEX2_1	488	490	PF00082	0.528
CLV_PCSK_KEX2_1	546	548	PF00082	0.611
CLV_PCSK_KEX2_1	584	586	PF00082	0.699
CLV_PCSK_KEX2_1	587	589	PF00082	0.681
CLV_PCSK_KEX2_1	699	701	PF00082	0.717
CLV_PCSK_KEX2_1	716	718	PF00082	0.526
CLV_PCSK_KEX2_1	73	75	PF00082	0.702
CLV_PCSK_KEX2_1	83	85	PF00082	0.544
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.659
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.717
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.702
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.544
CLV_PCSK_PC7_1	138	144	PF00082	0.599
CLV_PCSK_PC7_1	484	490	PF00082	0.701
CLV_PCSK_SKI1_1	122	126	PF00082	0.506
CLV_PCSK_SKI1_1	205	209	PF00082	0.407
CLV_PCSK_SKI1_1	534	538	PF00082	0.564
CLV_PCSK_SKI1_1	717	721	PF00082	0.697
CLV_PCSK_SKI1_1	74	78	PF00082	0.670
DEG_SCF_FBW7_1	25	32	PF00400	0.475
DEG_SPOP_SBC_1	225	229	PF00917	0.551
DEG_SPOP_SBC_1	635	639	PF00917	0.565
DOC_ANK_TNKS_1	487	494	PF00023	0.565
DOC_CDC14_PxL_1	188	196	PF14671	0.585
DOC_CKS1_1	26	31	PF01111	0.478
DOC_MAPK_gen_1	296	304	PF00069	0.571
DOC_MAPK_MEF2A_6	24	33	PF00069	0.478
DOC_PP1_RVXF_1	607	613	PF00149	0.526
DOC_PP2B_LxvP_1	15	18	PF13499	0.462
DOC_PP2B_LxvP_1	675	678	PF13499	0.572
DOC_USP7_MATH_1	101	105	PF00917	0.572
DOC_USP7_MATH_1	154	158	PF00917	0.626
DOC_USP7_MATH_1	164	168	PF00917	0.620
DOC_USP7_MATH_1	216	220	PF00917	0.545
DOC_USP7_MATH_1	224	228	PF00917	0.551
DOC_USP7_MATH_1	235	239	PF00917	0.439
DOC_USP7_MATH_1	259	263	PF00917	0.585
DOC_USP7_MATH_1	270	274	PF00917	0.663
DOC_USP7_MATH_1	275	279	PF00917	0.662
DOC_USP7_MATH_1	297	301	PF00917	0.635
DOC_USP7_MATH_1	394	398	PF00917	0.623
DOC_USP7_MATH_1	436	440	PF00917	0.572
DOC_USP7_MATH_1	5	9	PF00917	0.492
DOC_USP7_MATH_1	521	525	PF00917	0.732
DOC_USP7_MATH_1	539	543	PF00917	0.410
DOC_USP7_MATH_1	592	596	PF00917	0.622
DOC_WW_Pin1_4	192	197	PF00397	0.565
DOC_WW_Pin1_4	211	216	PF00397	0.488
DOC_WW_Pin1_4	226	231	PF00397	0.650
DOC_WW_Pin1_4	25	30	PF00397	0.473
DOC_WW_Pin1_4	268	273	PF00397	0.607
DOC_WW_Pin1_4	306	311	PF00397	0.651
DOC_WW_Pin1_4	350	355	PF00397	0.748
DOC_WW_Pin1_4	470	475	PF00397	0.788
DOC_WW_Pin1_4	497	502	PF00397	0.626
DOC_WW_Pin1_4	50	55	PF00397	0.523
DOC_WW_Pin1_4	523	528	PF00397	0.695
DOC_WW_Pin1_4	529	534	PF00397	0.529
DOC_WW_Pin1_4	550	555	PF00397	0.588
DOC_WW_Pin1_4	558	563	PF00397	0.470
DOC_WW_Pin1_4	596	601	PF00397	0.558
DOC_WW_Pin1_4	625	630	PF00397	0.697
DOC_WW_Pin1_4	680	685	PF00397	0.730
LIG_14-3-3_CanoR_1	159	163	PF00244	0.640
LIG_14-3-3_CanoR_1	287	293	PF00244	0.607
LIG_14-3-3_CanoR_1	299	305	PF00244	0.596
LIG_14-3-3_CanoR_1	315	325	PF00244	0.587
LIG_14-3-3_CanoR_1	377	381	PF00244	0.648
LIG_14-3-3_CanoR_1	39	44	PF00244	0.496
LIG_14-3-3_CanoR_1	390	394	PF00244	0.596
LIG_14-3-3_CanoR_1	457	462	PF00244	0.673
LIG_14-3-3_CanoR_1	557	562	PF00244	0.680
LIG_14-3-3_CanoR_1	591	597	PF00244	0.638
LIG_14-3-3_CanoR_1	621	626	PF00244	0.639
LIG_14-3-3_CanoR_1	706	712	PF00244	0.557
LIG_14-3-3_CanoR_1	87	95	PF00244	0.628
LIG_Actin_WH2_2	542	559	PF00022	0.561
LIG_APCC_ABBA_1	461	466	PF00400	0.678
LIG_BRCT_BRCA1_1	355	359	PF00533	0.668
LIG_BRCT_BRCA1_1	527	531	PF00533	0.503
LIG_BRCT_BRCA1_1	618	622	PF00533	0.659
LIG_CtBP_PxDLS_1	17	21	PF00389	0.469
LIG_deltaCOP1_diTrp_1	322	329	PF00928	0.607
LIG_eIF4E_1	50	56	PF01652	0.514
LIG_FHA_1	26	32	PF00498	0.515
LIG_FHA_1	551	557	PF00498	0.558
LIG_FHA_1	61	67	PF00498	0.540
LIG_FHA_1	636	642	PF00498	0.705
LIG_FHA_2	317	323	PF00498	0.644
LIG_FHA_2	332	338	PF00498	0.540
LIG_FHA_2	412	418	PF00498	0.657
LIG_FHA_2	558	564	PF00498	0.694
LIG_FHA_2	659	665	PF00498	0.631
LIG_LIR_Apic_2	42	46	PF02991	0.489
LIG_LIR_Gen_1	109	120	PF02991	0.513
LIG_LIR_Gen_1	300	305	PF02991	0.552
LIG_LIR_Gen_1	619	629	PF02991	0.546
LIG_LIR_Nem_3	109	115	PF02991	0.530
LIG_LIR_Nem_3	238	243	PF02991	0.558
LIG_LIR_Nem_3	300	304	PF02991	0.554
LIG_LIR_Nem_3	328	332	PF02991	0.630
LIG_LIR_Nem_3	356	362	PF02991	0.659
LIG_LIR_Nem_3	619	625	PF02991	0.545
LIG_MYND_1	192	196	PF01753	0.564
LIG_NRBOX	199	205	PF00104	0.521
LIG_NRBOX	8	14	PF00104	0.475
LIG_Pex14_2	359	363	PF04695	0.651
LIG_PTAP_UEV_1	165	170	PF05743	0.545
LIG_PTAP_UEV_1	628	633	PF05743	0.551
LIG_SH2_CRK	112	116	PF00017	0.492
LIG_SH2_CRK	607	611	PF00017	0.526
LIG_SH2_NCK_1	607	611	PF00017	0.526
LIG_SH2_STAT3	472	475	PF00017	0.709
LIG_SH2_STAT5	243	246	PF00017	0.561
LIG_SH2_STAT5	43	46	PF00017	0.491
LIG_SH3_3	160	166	PF00018	0.554
LIG_SH3_3	269	275	PF00018	0.685
LIG_SH3_3	456	462	PF00018	0.619
LIG_SH3_3	524	530	PF00018	0.727
LIG_SH3_3	594	600	PF00018	0.543
LIG_SH3_3	626	632	PF00018	0.597
LIG_SH3_3	662	668	PF00018	0.656
LIG_SUMO_SIM_anti_2	376	385	PF11976	0.656
LIG_WRC_WIRS_1	30	35	PF05994	0.485
MOD_CDC14_SPxK_1	526	529	PF00782	0.532
MOD_CDK_SPK_2	306	311	PF00069	0.621
MOD_CDK_SPK_2	529	534	PF00069	0.614
MOD_CDK_SPxK_1	523	529	PF00069	0.548
MOD_CDK_SPxxK_3	550	557	PF00069	0.563
MOD_CK1_1	103	109	PF00069	0.573
MOD_CK1_1	157	163	PF00069	0.600
MOD_CK1_1	262	268	PF00069	0.738
MOD_CK1_1	283	289	PF00069	0.572
MOD_CK1_1	300	306	PF00069	0.596
MOD_CK1_1	309	315	PF00069	0.612
MOD_CK1_1	352	358	PF00069	0.611
MOD_CK1_1	376	382	PF00069	0.762
MOD_CK1_1	408	414	PF00069	0.547
MOD_CK1_1	473	479	PF00069	0.664
MOD_CK1_1	595	601	PF00069	0.659
MOD_CK1_1	620	626	PF00069	0.559
MOD_CK1_1	68	74	PF00069	0.622
MOD_CK2_1	103	109	PF00069	0.483
MOD_CK2_1	316	322	PF00069	0.654
MOD_CK2_1	411	417	PF00069	0.762
MOD_CK2_1	658	664	PF00069	0.627
MOD_Cter_Amidation	432	435	PF01082	0.616
MOD_DYRK1A_RPxSP_1	529	533	PF00069	0.534
MOD_GlcNHglycan	103	106	PF01048	0.478
MOD_GlcNHglycan	156	159	PF01048	0.697
MOD_GlcNHglycan	165	169	PF01048	0.621
MOD_GlcNHglycan	20	23	PF01048	0.487
MOD_GlcNHglycan	235	238	PF01048	0.523
MOD_GlcNHglycan	261	264	PF01048	0.768
MOD_GlcNHglycan	311	314	PF01048	0.597
MOD_GlcNHglycan	355	358	PF01048	0.626
MOD_GlcNHglycan	408	411	PF01048	0.600
MOD_GlcNHglycan	447	451	PF01048	0.624
MOD_GlcNHglycan	475	478	PF01048	0.607
MOD_GlcNHglycan	629	632	PF01048	0.637
MOD_GlcNHglycan	89	92	PF01048	0.745
MOD_GlcNHglycan	98	101	PF01048	0.635
MOD_GSK3_1	154	161	PF00069	0.634
MOD_GSK3_1	211	218	PF00069	0.636
MOD_GSK3_1	25	32	PF00069	0.575
MOD_GSK3_1	258	265	PF00069	0.653
MOD_GSK3_1	270	277	PF00069	0.617
MOD_GSK3_1	288	295	PF00069	0.576
MOD_GSK3_1	300	307	PF00069	0.644
MOD_GSK3_1	316	323	PF00069	0.502
MOD_GSK3_1	349	356	PF00069	0.593
MOD_GSK3_1	376	383	PF00069	0.648
MOD_GSK3_1	394	401	PF00069	0.528
MOD_GSK3_1	411	418	PF00069	0.476
MOD_GSK3_1	46	53	PF00069	0.560
MOD_GSK3_1	491	498	PF00069	0.569
MOD_GSK3_1	521	528	PF00069	0.722
MOD_GSK3_1	591	598	PF00069	0.557
MOD_GSK3_1	61	68	PF00069	0.562
MOD_GSK3_1	612	619	PF00069	0.626
MOD_GSK3_1	621	628	PF00069	0.672
MOD_GSK3_1	96	103	PF00069	0.640
MOD_LATS_1	37	43	PF00433	0.484
MOD_N-GLC_1	18	23	PF02516	0.481
MOD_N-GLC_1	275	280	PF02516	0.680
MOD_N-GLC_1	415	420	PF02516	0.534
MOD_N-GLC_1	427	432	PF02516	0.628
MOD_N-GLC_1	521	526	PF02516	0.568
MOD_N-GLC_1	68	73	PF02516	0.536
MOD_NEK2_1	31	36	PF00069	0.485
MOD_NEK2_1	325	330	PF00069	0.671
MOD_NEK2_1	537	542	PF00069	0.533
MOD_NEK2_1	556	561	PF00069	0.607
MOD_NEK2_1	617	622	PF00069	0.579
MOD_NEK2_1	89	94	PF00069	0.628
MOD_PIKK_1	510	516	PF00454	0.568
MOD_PIKK_1	537	543	PF00454	0.533
MOD_PKA_2	158	164	PF00069	0.560
MOD_PKA_2	376	382	PF00069	0.647
MOD_PKA_2	389	395	PF00069	0.593
MOD_PKA_2	436	442	PF00069	0.532
MOD_PKA_2	556	562	PF00069	0.571
MOD_PKA_2	569	575	PF00069	0.482
MOD_PKA_2	612	618	PF00069	0.675
MOD_PKA_2	620	626	PF00069	0.615
MOD_Plk_1	116	122	PF00069	0.494
MOD_Plk_1	275	281	PF00069	0.684
MOD_Plk_1	398	404	PF00069	0.566
MOD_Plk_1	427	433	PF00069	0.708
MOD_Plk_1	521	527	PF00069	0.584
MOD_Plk_1	68	74	PF00069	0.536
MOD_Plk_2-3	331	337	PF00069	0.533
MOD_Plk_4	116	122	PF00069	0.494
MOD_Plk_4	124	130	PF00069	0.412
MOD_Plk_4	275	281	PF00069	0.659
MOD_Plk_4	320	326	PF00069	0.454
MOD_Plk_4	39	45	PF00069	0.504
MOD_Plk_4	398	404	PF00069	0.560
MOD_Plk_4	5	11	PF00069	0.464
MOD_Plk_4	637	643	PF00069	0.704
MOD_ProDKin_1	192	198	PF00069	0.563
MOD_ProDKin_1	211	217	PF00069	0.491
MOD_ProDKin_1	226	232	PF00069	0.647
MOD_ProDKin_1	25	31	PF00069	0.475
MOD_ProDKin_1	268	274	PF00069	0.606
MOD_ProDKin_1	306	312	PF00069	0.650
MOD_ProDKin_1	350	356	PF00069	0.745
MOD_ProDKin_1	470	476	PF00069	0.790
MOD_ProDKin_1	497	503	PF00069	0.629
MOD_ProDKin_1	50	56	PF00069	0.525
MOD_ProDKin_1	523	529	PF00069	0.689
MOD_ProDKin_1	550	556	PF00069	0.577
MOD_ProDKin_1	558	564	PF00069	0.468
MOD_ProDKin_1	596	602	PF00069	0.559
MOD_ProDKin_1	625	631	PF00069	0.697
MOD_ProDKin_1	680	686	PF00069	0.726
MOD_SUMO_rev_2	411	421	PF00179	0.494
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.445
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.514
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.563
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.472
TRG_ENDOCYTIC_2	112	115	PF00928	0.497
TRG_ENDOCYTIC_2	607	610	PF00928	0.528
TRG_ER_diArg_1	141	143	PF00400	0.603
TRG_ER_diArg_1	434	437	PF00400	0.633
TRG_ER_diArg_1	481	484	PF00400	0.835
TRG_ER_diArg_1	545	548	PF00400	0.598
TRG_ER_diArg_1	584	587	PF00400	0.704
TRG_ER_diArg_1	698	701	PF00400	0.720
TRG_ER_diArg_1	74	76	PF00400	0.699
TRG_NLS_Bipartite_1	698	717	PF00514	0.708
TRG_NLS_MonoCore_2	479	484	PF00514	0.635
TRG_NLS_MonoCore_2	698	703	PF00514	0.718
TRG_NLS_MonoExtC_3	479	484	PF00514	0.659
TRG_NLS_MonoExtC_3	711	716	PF00514	0.693
TRG_NLS_MonoExtN_4	698	703	PF00514	0.717
TRG_NLS_MonoExtN_4	712	717	PF00514	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRY8	Leishmania donovani	69%	100%
E9AGD2	Leishmania infantum	69%	100%
E9ANX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QGP8	Leishmania major	68%	100%