LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H6V8_LEIBR
TriTrypDb:
LbrM.12.0450 , LBRM2903_120009500 *
Length:
672

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6V8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 604 608 PF00656 0.677
CLV_NRD_NRD_1 506 508 PF00675 0.628
CLV_NRD_NRD_1 588 590 PF00675 0.828
CLV_NRD_NRD_1 614 616 PF00675 0.534
CLV_PCSK_KEX2_1 506 508 PF00082 0.628
CLV_PCSK_KEX2_1 588 590 PF00082 0.828
CLV_PCSK_KEX2_1 60 62 PF00082 0.582
CLV_PCSK_KEX2_1 614 616 PF00082 0.534
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.582
CLV_PCSK_SKI1_1 144 148 PF00082 0.446
CLV_PCSK_SKI1_1 30 34 PF00082 0.373
CLV_PCSK_SKI1_1 351 355 PF00082 0.598
CLV_PCSK_SKI1_1 446 450 PF00082 0.637
CLV_PCSK_SKI1_1 603 607 PF00082 0.686
CLV_PCSK_SKI1_1 614 618 PF00082 0.454
DEG_APCC_DBOX_1 438 446 PF00400 0.638
DEG_ODPH_VHL_1 286 298 PF01847 0.588
DEG_SPOP_SBC_1 104 108 PF00917 0.693
DOC_CKS1_1 204 209 PF01111 0.774
DOC_CKS1_1 447 452 PF01111 0.628
DOC_CYCLIN_RxL_1 138 151 PF00134 0.436
DOC_CYCLIN_RxL_1 179 190 PF00134 0.439
DOC_CYCLIN_yCln2_LP_2 204 210 PF00134 0.772
DOC_CYCLIN_yCln2_LP_2 422 428 PF00134 0.687
DOC_PP1_RVXF_1 180 187 PF00149 0.435
DOC_PP2B_LxvP_1 286 289 PF13499 0.671
DOC_PP2B_LxvP_1 360 363 PF13499 0.600
DOC_PP2B_LxvP_1 422 425 PF13499 0.605
DOC_PP4_FxxP_1 472 475 PF00568 0.611
DOC_PP4_FxxP_1 571 574 PF00568 0.649
DOC_PP4_FxxP_1 636 639 PF00568 0.623
DOC_USP7_MATH_1 104 108 PF00917 0.724
DOC_USP7_MATH_1 215 219 PF00917 0.647
DOC_USP7_MATH_1 233 237 PF00917 0.652
DOC_USP7_MATH_1 270 274 PF00917 0.698
DOC_USP7_MATH_1 291 295 PF00917 0.696
DOC_USP7_MATH_1 383 387 PF00917 0.834
DOC_USP7_MATH_1 43 47 PF00917 0.680
DOC_USP7_MATH_1 564 568 PF00917 0.670
DOC_USP7_MATH_1 597 601 PF00917 0.681
DOC_USP7_MATH_2 452 458 PF00917 0.508
DOC_WW_Pin1_4 100 105 PF00397 0.782
DOC_WW_Pin1_4 109 114 PF00397 0.670
DOC_WW_Pin1_4 203 208 PF00397 0.770
DOC_WW_Pin1_4 296 301 PF00397 0.824
DOC_WW_Pin1_4 327 332 PF00397 0.785
DOC_WW_Pin1_4 446 451 PF00397 0.449
DOC_WW_Pin1_4 471 476 PF00397 0.612
DOC_WW_Pin1_4 495 500 PF00397 0.580
DOC_WW_Pin1_4 591 596 PF00397 0.588
LIG_14-3-3_CanoR_1 282 287 PF00244 0.637
LIG_14-3-3_CanoR_1 290 300 PF00244 0.581
LIG_14-3-3_CanoR_1 351 360 PF00244 0.856
LIG_14-3-3_CanoR_1 497 503 PF00244 0.622
LIG_14-3-3_CanoR_1 506 516 PF00244 0.468
LIG_14-3-3_CanoR_1 614 620 PF00244 0.610
LIG_14-3-3_CanoR_1 642 650 PF00244 0.625
LIG_BIR_III_4 31 35 PF00653 0.612
LIG_BRCT_BRCA1_1 413 417 PF00533 0.554
LIG_CtBP_PxDLS_1 499 503 PF00389 0.600
LIG_deltaCOP1_diTrp_1 125 132 PF00928 0.700
LIG_deltaCOP1_diTrp_1 423 430 PF00928 0.669
LIG_FHA_1 106 112 PF00498 0.795
LIG_FHA_1 141 147 PF00498 0.697
LIG_FHA_1 22 28 PF00498 0.608
LIG_FHA_1 221 227 PF00498 0.773
LIG_FHA_1 281 287 PF00498 0.606
LIG_FHA_1 336 342 PF00498 0.600
LIG_FHA_1 377 383 PF00498 0.581
LIG_FHA_2 478 484 PF00498 0.636
LIG_FHA_2 578 584 PF00498 0.808
LIG_FHA_2 60 66 PF00498 0.817
LIG_FHA_2 616 622 PF00498 0.594
LIG_GBD_Chelix_1 156 164 PF00786 0.394
LIG_LIR_Apic_2 470 475 PF02991 0.615
LIG_LIR_Gen_1 129 140 PF02991 0.672
LIG_LIR_Gen_1 454 464 PF02991 0.591
LIG_LIR_Gen_1 489 500 PF02991 0.636
LIG_LIR_Nem_3 125 130 PF02991 0.713
LIG_LIR_Nem_3 131 135 PF02991 0.566
LIG_LIR_Nem_3 423 429 PF02991 0.673
LIG_LIR_Nem_3 454 459 PF02991 0.593
LIG_LIR_Nem_3 461 466 PF02991 0.484
LIG_LIR_Nem_3 483 487 PF02991 0.674
LIG_LIR_Nem_3 489 495 PF02991 0.536
LIG_LIR_Nem_3 54 59 PF02991 0.666
LIG_LIR_Nem_3 582 587 PF02991 0.814
LIG_MYND_1 545 549 PF01753 0.571
LIG_PDZ_Class_2 667 672 PF00595 0.659
LIG_SH2_CRK 38 42 PF00017 0.635
LIG_SH2_CRK 447 451 PF00017 0.629
LIG_SH2_CRK 492 496 PF00017 0.631
LIG_SH2_CRK 584 588 PF00017 0.834
LIG_SH2_NCK_1 516 520 PF00017 0.609
LIG_SH2_SRC 325 328 PF00017 0.590
LIG_SH2_STAP1 38 42 PF00017 0.635
LIG_SH2_STAP1 516 520 PF00017 0.647
LIG_SH2_STAT3 176 179 PF00017 0.389
LIG_SH2_STAT5 508 511 PF00017 0.600
LIG_SH2_STAT5 661 664 PF00017 0.593
LIG_SH3_3 237 243 PF00018 0.530
LIG_SH3_3 269 275 PF00018 0.849
LIG_SH3_3 294 300 PF00018 0.798
LIG_SH3_3 413 419 PF00018 0.744
LIG_SH3_3 493 499 PF00018 0.652
LIG_SUMO_SIM_anti_2 653 659 PF11976 0.327
LIG_SUMO_SIM_par_1 249 256 PF11976 0.565
LIG_SUMO_SIM_par_1 312 317 PF11976 0.556
LIG_SUMO_SIM_par_1 498 504 PF11976 0.608
LIG_SUMO_SIM_par_1 615 621 PF11976 0.602
LIG_TYR_ITIM 36 41 PF00017 0.619
LIG_UBA3_1 26 30 PF00899 0.468
LIG_WW_3 287 291 PF00397 0.582
MOD_CK1_1 103 109 PF00069 0.726
MOD_CK1_1 148 154 PF00069 0.421
MOD_CK1_1 213 219 PF00069 0.636
MOD_CK1_1 256 262 PF00069 0.587
MOD_CK1_1 273 279 PF00069 0.627
MOD_CK1_1 386 392 PF00069 0.738
MOD_CK1_1 393 399 PF00069 0.726
MOD_CK1_1 4 10 PF00069 0.628
MOD_CK1_1 432 438 PF00069 0.654
MOD_CK1_1 498 504 PF00069 0.550
MOD_CK1_1 538 544 PF00069 0.563
MOD_CK1_1 575 581 PF00069 0.727
MOD_CK1_1 608 614 PF00069 0.706
MOD_CK2_1 235 241 PF00069 0.556
MOD_CK2_1 386 392 PF00069 0.567
MOD_CK2_1 455 461 PF00069 0.587
MOD_CK2_1 477 483 PF00069 0.636
MOD_CK2_1 498 504 PF00069 0.608
MOD_CK2_1 554 560 PF00069 0.808
MOD_CK2_1 577 583 PF00069 0.801
MOD_CK2_1 615 621 PF00069 0.573
MOD_CK2_1 87 93 PF00069 0.594
MOD_GlcNHglycan 11 14 PF01048 0.589
MOD_GlcNHglycan 113 116 PF01048 0.578
MOD_GlcNHglycan 147 150 PF01048 0.687
MOD_GlcNHglycan 215 218 PF01048 0.660
MOD_GlcNHglycan 262 265 PF01048 0.838
MOD_GlcNHglycan 267 271 PF01048 0.802
MOD_GlcNHglycan 316 319 PF01048 0.811
MOD_GlcNHglycan 385 388 PF01048 0.818
MOD_GlcNHglycan 389 392 PF01048 0.735
MOD_GlcNHglycan 408 411 PF01048 0.502
MOD_GlcNHglycan 488 491 PF01048 0.639
MOD_GlcNHglycan 49 52 PF01048 0.517
MOD_GlcNHglycan 541 544 PF01048 0.703
MOD_GlcNHglycan 550 553 PF01048 0.793
MOD_GlcNHglycan 566 569 PF01048 0.534
MOD_GlcNHglycan 6 9 PF01048 0.608
MOD_GlcNHglycan 82 85 PF01048 0.803
MOD_GlcNHglycan 89 92 PF01048 0.744
MOD_GSK3_1 17 24 PF00069 0.589
MOD_GSK3_1 206 213 PF00069 0.527
MOD_GSK3_1 255 262 PF00069 0.826
MOD_GSK3_1 266 273 PF00069 0.684
MOD_GSK3_1 274 281 PF00069 0.548
MOD_GSK3_1 292 299 PF00069 0.803
MOD_GSK3_1 300 307 PF00069 0.668
MOD_GSK3_1 314 321 PF00069 0.606
MOD_GSK3_1 383 390 PF00069 0.570
MOD_GSK3_1 43 50 PF00069 0.572
MOD_GSK3_1 491 498 PF00069 0.579
MOD_GSK3_1 535 542 PF00069 0.631
MOD_GSK3_1 554 561 PF00069 0.672
MOD_GSK3_1 575 582 PF00069 0.720
MOD_GSK3_1 597 604 PF00069 0.688
MOD_GSK3_1 605 612 PF00069 0.593
MOD_GSK3_1 98 105 PF00069 0.795
MOD_N-GLC_1 210 215 PF02516 0.531
MOD_NEK2_1 220 225 PF00069 0.709
MOD_NEK2_1 314 319 PF00069 0.714
MOD_NEK2_1 429 434 PF00069 0.658
MOD_NEK2_1 553 558 PF00069 0.806
MOD_NEK2_1 559 564 PF00069 0.702
MOD_NEK2_1 605 610 PF00069 0.719
MOD_NEK2_1 622 627 PF00069 0.329
MOD_NEK2_1 650 655 PF00069 0.335
MOD_PIKK_1 253 259 PF00454 0.578
MOD_PIKK_1 432 438 PF00454 0.401
MOD_PKA_1 69 75 PF00069 0.845
MOD_PKA_2 281 287 PF00069 0.639
MOD_PKA_2 376 382 PF00069 0.582
MOD_PKA_2 43 49 PF00069 0.502
MOD_PKA_2 538 544 PF00069 0.586
MOD_PKA_2 80 86 PF00069 0.719
MOD_PKB_1 537 545 PF00069 0.565
MOD_Plk_1 130 136 PF00069 0.659
MOD_Plk_1 210 216 PF00069 0.535
MOD_Plk_1 454 460 PF00069 0.588
MOD_Plk_1 622 628 PF00069 0.597
MOD_Plk_2-3 455 461 PF00069 0.587
MOD_Plk_2-3 601 607 PF00069 0.667
MOD_Plk_4 1 7 PF00069 0.558
MOD_Plk_4 235 241 PF00069 0.648
MOD_Plk_4 246 252 PF00069 0.540
MOD_Plk_4 455 461 PF00069 0.587
MOD_Plk_4 477 483 PF00069 0.636
MOD_Plk_4 491 497 PF00069 0.409
MOD_Plk_4 51 57 PF00069 0.657
MOD_ProDKin_1 100 106 PF00069 0.783
MOD_ProDKin_1 109 115 PF00069 0.670
MOD_ProDKin_1 203 209 PF00069 0.772
MOD_ProDKin_1 296 302 PF00069 0.825
MOD_ProDKin_1 327 333 PF00069 0.777
MOD_ProDKin_1 446 452 PF00069 0.448
MOD_ProDKin_1 471 477 PF00069 0.617
MOD_ProDKin_1 495 501 PF00069 0.570
MOD_ProDKin_1 591 597 PF00069 0.583
TRG_DiLeu_BaEn_1 461 466 PF01217 0.600
TRG_DiLeu_BaEn_4 63 69 PF01217 0.587
TRG_ENDOCYTIC_2 38 41 PF00928 0.629
TRG_ENDOCYTIC_2 492 495 PF00928 0.639
TRG_ENDOCYTIC_2 584 587 PF00928 0.835
TRG_ER_diArg_1 505 507 PF00400 0.619
TRG_ER_diArg_1 537 540 PF00400 0.816
TRG_ER_diArg_1 587 589 PF00400 0.831
TRG_ER_diArg_1 614 616 PF00400 0.534
TRG_NES_CRM1_1 31 45 PF08389 0.376
TRG_Pf-PMV_PEXEL_1 507 511 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.669

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WRW8 Leishmania donovani 70% 100%
E9AGD1 Leishmania infantum 70% 100%
E9ANX1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
Q4QGP9 Leishmania major 68% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS