LeishMANIAdb
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UPF0587 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
UPF0587 protein
Gene product:
Eukaryotic protein of unknown function (DUF866), putative
Species:
Leishmania braziliensis
UniProt:
A4H6V7_LEIBR
TriTrypDb:
LbrM.12.0440 , LBRM2903_120009400 *
Length:
153

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6V7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V7

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_MAPK_gen_1 16 24 PF00069 0.268
DOC_MAPK_gen_1 95 104 PF00069 0.325
DOC_MAPK_JIP1_4 98 104 PF00069 0.325
DOC_MAPK_MEF2A_6 95 104 PF00069 0.325
DOC_PP2B_LxvP_1 70 73 PF13499 0.334
DOC_USP7_MATH_1 136 140 PF00917 0.386
DOC_USP7_UBL2_3 149 153 PF12436 0.517
LIG_BRCT_BRCA1_1 143 147 PF00533 0.379
LIG_BRCT_BRCA1_2 143 149 PF00533 0.325
LIG_FHA_1 17 23 PF00498 0.248
LIG_FHA_1 49 55 PF00498 0.169
LIG_FHA_1 64 70 PF00498 0.266
LIG_LIR_Gen_1 105 113 PF02991 0.379
LIG_LIR_Nem_3 105 111 PF02991 0.379
LIG_LIR_Nem_3 124 130 PF02991 0.285
LIG_Pex14_1 20 24 PF04695 0.326
LIG_SH2_PTP2 38 41 PF00017 0.169
LIG_SH2_SRC 130 133 PF00017 0.315
LIG_SH2_SRC 38 41 PF00017 0.169
LIG_SH2_STAT5 38 41 PF00017 0.248
LIG_SUMO_SIM_par_1 98 103 PF11976 0.350
LIG_TRAF2_1 2 5 PF00917 0.325
LIG_TRAF2_1 80 83 PF00917 0.385
MOD_CK2_1 25 31 PF00069 0.291
MOD_CK2_1 77 83 PF00069 0.387
MOD_GlcNHglycan 79 82 PF01048 0.342
MOD_GlcNHglycan 83 87 PF01048 0.329
MOD_GSK3_1 73 80 PF00069 0.326
MOD_N-GLC_1 16 21 PF02516 0.169
MOD_NEK2_1 147 152 PF00069 0.477
MOD_PIKK_1 121 127 PF00454 0.325
MOD_Plk_1 16 22 PF00069 0.379
MOD_Plk_4 136 142 PF00069 0.266
TRG_DiLeu_BaEn_3 31 37 PF01217 0.370
TRG_ENDOCYTIC_2 38 41 PF00928 0.169
TRG_ER_diLys_1 149 153 PF00400 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P365 Leptomonas seymouri 56% 94%
A0A0S4JVB0 Bodo saltans 37% 96%
A0A1X0NMW8 Trypanosomatidae 43% 97%
A0A3Q8IHN7 Leishmania donovani 82% 95%
A0A422MXW1 Trypanosoma rangeli 47% 97%
A1Z9A2 Drosophila melanogaster 30% 94%
A7SJ66 Nematostella vectensis 29% 96%
C9ZIQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 94%
E9AGC9 Leishmania infantum 82% 95%
E9ANW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 95%
O74797 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 97%
Q290L7 Drosophila pseudoobscura pseudoobscura 27% 94%
Q32P66 Bos taurus 30% 96%
Q3B8G0 Xenopus laevis 28% 96%
Q498R7 Rattus norvegicus 29% 96%
Q8BHG2 Mus musculus 30% 96%
Q9BI88 Caenorhabditis elegans 30% 92%
Q9NWV4 Homo sapiens 30% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS