Putative 3'-nucleotidase/nuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3 prime nucleotidase/nuclease, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H6V5_LEIBR

TriTrypDb:

LbrM.12.0420 , LBRM2903_120009200

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 23, no: 6
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0009986	cell surface	2	1

Expansion

Sequence features

A4H6V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	30
GO:0006259	DNA metabolic process	4	30
GO:0006308	DNA catabolic process	5	30
GO:0006725	cellular aromatic compound metabolic process	3	30
GO:0006807	nitrogen compound metabolic process	2	30
GO:0008152	metabolic process	1	30
GO:0009056	catabolic process	2	30
GO:0009057	macromolecule catabolic process	4	30
GO:0009987	cellular process	1	30
GO:0019439	aromatic compound catabolic process	4	30
GO:0034641	cellular nitrogen compound metabolic process	3	30
GO:0034655	nucleobase-containing compound catabolic process	4	30
GO:0043170	macromolecule metabolic process	3	30
GO:0044237	cellular metabolic process	2	30
GO:0044238	primary metabolic process	2	30
GO:0044248	cellular catabolic process	3	30
GO:0044260	obsolete cellular macromolecule metabolic process	3	30
GO:0044265	obsolete cellular macromolecule catabolic process	4	30
GO:0044270	cellular nitrogen compound catabolic process	4	30
GO:0046483	heterocycle metabolic process	3	30
GO:0046700	heterocycle catabolic process	4	30
GO:0071704	organic substance metabolic process	2	30
GO:0090304	nucleic acid metabolic process	4	30
GO:1901360	organic cyclic compound metabolic process	3	30
GO:1901361	organic cyclic compound catabolic process	4	30
GO:1901575	organic substance catabolic process	3	30
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006196	AMP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009126	purine nucleoside monophosphate metabolic process	6	1
GO:0009128	purine nucleoside monophosphate catabolic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009158	ribonucleoside monophosphate catabolic process	7	1
GO:0009161	ribonucleoside monophosphate metabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	1
GO:0009169	purine ribonucleoside monophosphate catabolic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046033	AMP metabolic process	7	1
GO:0046434	organophosphate catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	30
GO:0003824	catalytic activity	1	30
GO:0004518	nuclease activity	4	30
GO:0004519	endonuclease activity	5	30
GO:0005488	binding	1	30
GO:0016787	hydrolase activity	2	30
GO:0016788	hydrolase activity, acting on ester bonds	3	30
GO:0043167	ion binding	2	30
GO:0043169	cation binding	3	30
GO:0046872	metal ion binding	4	30
GO:0097159	organic cyclic compound binding	2	30
GO:1901363	heterocyclic compound binding	2	30
GO:0008252	nucleotidase activity	6	1
GO:0008254	3'-nucleotidase activity	7	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.446
CLV_PCSK_KEX2_1	42	44	PF00082	0.450
CLV_PCSK_SKI1_1	287	291	PF00082	0.445
DOC_PP4_FxxP_1	6	9	PF00568	0.388
DOC_USP7_MATH_1	155	159	PF00917	0.317
DOC_USP7_MATH_1	184	188	PF00917	0.307
DOC_USP7_MATH_1	244	248	PF00917	0.244
DOC_USP7_MATH_1	297	301	PF00917	0.372
DOC_USP7_UBL2_3	270	274	PF12436	0.289
DOC_WW_Pin1_4	127	132	PF00397	0.252
DOC_WW_Pin1_4	160	165	PF00397	0.251
DOC_WW_Pin1_4	363	368	PF00397	0.484
LIG_14-3-3_CanoR_1	280	284	PF00244	0.286
LIG_Actin_WH2_2	348	366	PF00022	0.158
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	91	95	PF00533	0.161
LIG_EH1_1	344	352	PF00400	0.258
LIG_FHA_1	306	312	PF00498	0.278
LIG_FHA_1	351	357	PF00498	0.328
LIG_FHA_1	68	74	PF00498	0.311
LIG_GBD_Chelix_1	16	24	PF00786	0.543
LIG_GBD_Chelix_1	288	296	PF00786	0.492
LIG_HCF-1_HBM_1	97	100	PF13415	0.154
LIG_LIR_Gen_1	211	221	PF02991	0.291
LIG_LIR_Gen_1	91	100	PF02991	0.303
LIG_LIR_Nem_3	211	217	PF02991	0.291
LIG_LIR_Nem_3	322	327	PF02991	0.409
LIG_LIR_Nem_3	91	96	PF02991	0.310
LIG_LYPXL_S_1	255	259	PF13949	0.517
LIG_LYPXL_yS_3	256	259	PF13949	0.301
LIG_Pex14_2	341	345	PF04695	0.479
LIG_SH2_CRK	214	218	PF00017	0.241
LIG_SH2_SRC	327	330	PF00017	0.311
LIG_SH2_STAP1	248	252	PF00017	0.253
LIG_SH2_STAT3	100	103	PF00017	0.312
LIG_SH2_STAT5	361	364	PF00017	0.524
LIG_SH3_3	149	155	PF00018	0.249
LIG_SH3_3	161	167	PF00018	0.227
LIG_SH3_3	19	25	PF00018	0.390
LIG_SH3_3	352	358	PF00018	0.167
LIG_SH3_3	96	102	PF00018	0.269
LIG_SUMO_SIM_par_1	176	181	PF11976	0.250
LIG_SUMO_SIM_par_1	20	26	PF11976	0.564
LIG_WRC_WIRS_1	342	347	PF05994	0.224
MOD_CK1_1	126	132	PF00069	0.312
MOD_CK1_1	213	219	PF00069	0.177
MOD_CK1_1	260	266	PF00069	0.326
MOD_CK1_1	300	306	PF00069	0.364
MOD_CK1_1	88	94	PF00069	0.303
MOD_CK2_1	193	199	PF00069	0.357
MOD_CK2_1	226	232	PF00069	0.321
MOD_CK2_1	327	333	PF00069	0.448
MOD_CK2_1	33	39	PF00069	0.345
MOD_CK2_1	362	368	PF00069	0.527
MOD_GlcNHglycan	125	128	PF01048	0.527
MOD_GlcNHglycan	157	160	PF01048	0.504
MOD_GlcNHglycan	217	220	PF01048	0.538
MOD_GlcNHglycan	329	332	PF01048	0.601
MOD_GSK3_1	123	130	PF00069	0.281
MOD_GSK3_1	134	141	PF00069	0.263
MOD_GSK3_1	224	231	PF00069	0.264
MOD_GSK3_1	234	241	PF00069	0.187
MOD_GSK3_1	81	88	PF00069	0.331
MOD_N-GLC_1	238	243	PF02516	0.447
MOD_N-GLC_1	305	310	PF02516	0.654
MOD_NEK2_1	123	128	PF00069	0.332
MOD_NEK2_1	193	198	PF00069	0.276
MOD_NEK2_1	224	229	PF00069	0.284
MOD_NEK2_1	235	240	PF00069	0.347
MOD_NEK2_1	265	270	PF00069	0.280
MOD_NEK2_1	305	310	PF00069	0.409
MOD_NEK2_1	341	346	PF00069	0.447
MOD_NEK2_1	350	355	PF00069	0.268
MOD_NEK2_1	362	367	PF00069	0.655
MOD_NEK2_1	85	90	PF00069	0.303
MOD_NEK2_2	184	189	PF00069	0.377
MOD_PIKK_1	23	29	PF00454	0.528
MOD_PKA_2	279	285	PF00069	0.307
MOD_Plk_1	210	216	PF00069	0.251
MOD_Plk_1	238	244	PF00069	0.234
MOD_Plk_4	116	122	PF00069	0.253
MOD_Plk_4	134	140	PF00069	0.234
MOD_Plk_4	238	244	PF00069	0.206
MOD_Plk_4	260	266	PF00069	0.257
MOD_Plk_4	287	293	PF00069	0.279
MOD_Plk_4	300	306	PF00069	0.348
MOD_ProDKin_1	127	133	PF00069	0.252
MOD_ProDKin_1	160	166	PF00069	0.251
MOD_ProDKin_1	363	369	PF00069	0.487
MOD_SUMO_rev_2	313	318	PF00179	0.359
MOD_SUMO_rev_2	80	85	PF00179	0.279
TRG_ENDOCYTIC_2	214	217	PF00928	0.276
TRG_ENDOCYTIC_2	256	259	PF00928	0.252
TRG_ENDOCYTIC_2	329	332	PF00928	0.487
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q7	Leptomonas seymouri	39%	100%
A0A0S4JAL3	Bodo saltans	44%	100%
A0A0S4JML7	Bodo saltans	29%	100%
A0A1X0P2K7	Trypanosomatidae	50%	100%
A0A3Q8IBF6	Leishmania donovani	84%	99%
A0A3Q8IEW3	Leishmania donovani	39%	100%
A0A3Q8IFH4	Leishmania donovani	46%	99%
A0A3Q8IK90	Leishmania donovani	46%	100%
A0A3S7X3A6	Leishmania donovani	39%	100%
A0A422N7B0	Trypanosoma rangeli	43%	100%
A4HI96	Leishmania braziliensis	36%	100%
A4HJL3	Leishmania braziliensis	45%	99%
A4I5I0	Leishmania infantum	40%	100%
A4I736	Leishmania infantum	46%	99%
C9ZQH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZQH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZQW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AGC7	Leishmania infantum	84%	99%
E9ANW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
E9B0S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B0S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B231	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
F4JJL3	Arabidopsis thaliana	25%	100%
Q4Q630	Leishmania major	45%	100%
Q4Q7F3	Leishmania major	39%	100%
Q4Q7F4	Leishmania major	38%	100%
Q4QGQ3	Leishmania major	85%	100%
Q66VY6	Leishmania major	47%	100%
Q8LDW6	Arabidopsis thaliana	25%	100%
V5B8Z9	Trypanosoma cruzi	45%	97%