NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6V4_LEIBR

TriTrypDb:

LbrM.12.0410 , LBRM2903_120010100

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.668
CLV_C14_Caspase3-7	152	156	PF00656	0.395
CLV_C14_Caspase3-7	209	213	PF00656	0.417
CLV_C14_Caspase3-7	57	61	PF00656	0.499
CLV_NRD_NRD_1	152	154	PF00675	0.407
CLV_NRD_NRD_1	294	296	PF00675	0.508
CLV_NRD_NRD_1	299	301	PF00675	0.536
CLV_NRD_NRD_1	368	370	PF00675	0.623
CLV_NRD_NRD_1	67	69	PF00675	0.579
CLV_PCSK_KEX2_1	108	110	PF00082	0.479
CLV_PCSK_KEX2_1	294	296	PF00082	0.508
CLV_PCSK_KEX2_1	299	301	PF00082	0.536
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.617
CLV_PCSK_PC7_1	295	301	PF00082	0.427
CLV_PCSK_SKI1_1	136	140	PF00082	0.431
CLV_PCSK_SKI1_1	283	287	PF00082	0.422
CLV_PCSK_SKI1_1	303	307	PF00082	0.613
CLV_PCSK_SKI1_1	92	96	PF00082	0.446
DEG_SPOP_SBC_1	243	247	PF00917	0.468
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.533
DOC_MAPK_DCC_7	306	314	PF00069	0.350
DOC_MAPK_gen_1	299	309	PF00069	0.425
DOC_MAPK_RevD_3	282	295	PF00069	0.288
DOC_USP7_MATH_1	119	123	PF00917	0.666
DOC_USP7_MATH_1	225	229	PF00917	0.489
DOC_USP7_MATH_1	243	247	PF00917	0.481
DOC_USP7_MATH_1	258	262	PF00917	0.473
DOC_USP7_MATH_1	320	324	PF00917	0.360
DOC_USP7_MATH_1	54	58	PF00917	0.704
DOC_WW_Pin1_4	184	189	PF00397	0.469
DOC_WW_Pin1_4	277	282	PF00397	0.470
DOC_WW_Pin1_4	307	312	PF00397	0.370
DOC_WW_Pin1_4	325	330	PF00397	0.459
DOC_WW_Pin1_4	73	78	PF00397	0.723
DOC_WW_Pin1_4	81	86	PF00397	0.558
LIG_14-3-3_CanoR_1	35	44	PF00244	0.444
LIG_14-3-3_CterR_2	411	414	PF00244	0.505
LIG_Actin_WH2_2	23	39	PF00022	0.473
LIG_BRCT_BRCA1_1	245	249	PF00533	0.573
LIG_deltaCOP1_diTrp_1	97	105	PF00928	0.354
LIG_FHA_1	172	178	PF00498	0.431
LIG_FHA_1	229	235	PF00498	0.509
LIG_FHA_1	252	258	PF00498	0.407
LIG_FHA_1	78	84	PF00498	0.353
LIG_FHA_1	8	14	PF00498	0.364
LIG_FHA_2	150	156	PF00498	0.392
LIG_FHA_2	50	56	PF00498	0.394
LIG_FHA_2	82	88	PF00498	0.513
LIG_LIR_Apic_2	179	183	PF02991	0.305
LIG_LIR_Gen_1	143	149	PF02991	0.392
LIG_LIR_Gen_1	166	173	PF02991	0.307
LIG_LIR_Gen_1	246	257	PF02991	0.412
LIG_LIR_Gen_1	26	36	PF02991	0.278
LIG_LIR_Gen_1	42	51	PF02991	0.500
LIG_LIR_Gen_1	95	106	PF02991	0.356
LIG_LIR_Nem_3	133	138	PF02991	0.404
LIG_LIR_Nem_3	166	170	PF02991	0.310
LIG_LIR_Nem_3	245	251	PF02991	0.404
LIG_LIR_Nem_3	26	31	PF02991	0.272
LIG_LIR_Nem_3	392	397	PF02991	0.329
LIG_LIR_Nem_3	42	47	PF02991	0.515
LIG_LIR_Nem_3	95	101	PF02991	0.352
LIG_PCNA_yPIPBox_3	24	37	PF02747	0.495
LIG_PDZ_Class_2	409	414	PF00595	0.488
LIG_Pex14_2	101	105	PF04695	0.349
LIG_SH2_CRK	135	139	PF00017	0.426
LIG_SH2_CRK	167	171	PF00017	0.372
LIG_SH2_CRK	180	184	PF00017	0.390
LIG_SH2_CRK	28	32	PF00017	0.261
LIG_SH2_NCK_1	180	184	PF00017	0.446
LIG_SH2_NCK_1	349	353	PF00017	0.457
LIG_SH2_SRC	167	170	PF00017	0.312
LIG_SH2_SRC	349	352	PF00017	0.454
LIG_SH2_STAP1	44	48	PF00017	0.494
LIG_SH2_STAT5	169	172	PF00017	0.306
LIG_SH2_STAT5	251	254	PF00017	0.274
LIG_SH3_2	376	381	PF14604	0.360
LIG_SH3_3	331	337	PF00018	0.572
LIG_SH3_3	373	379	PF00018	0.444
LIG_SUMO_SIM_par_1	29	34	PF11976	0.322
LIG_SUMO_SIM_par_1	79	84	PF11976	0.452
LIG_SUMO_SIM_par_1	92	97	PF11976	0.279
LIG_TRAF2_1	84	87	PF00917	0.421
LIG_UBA3_1	284	288	PF00899	0.242
MOD_CDC14_SPxK_1	280	283	PF00782	0.272
MOD_CDK_SPxK_1	277	283	PF00069	0.310
MOD_CK1_1	137	143	PF00069	0.308
MOD_CK1_1	187	193	PF00069	0.378
MOD_CK1_1	210	216	PF00069	0.673
MOD_CK1_1	228	234	PF00069	0.512
MOD_CK1_1	239	245	PF00069	0.406
MOD_CK2_1	258	264	PF00069	0.437
MOD_CK2_1	39	45	PF00069	0.601
MOD_CK2_1	49	55	PF00069	0.411
MOD_CK2_1	81	87	PF00069	0.522
MOD_GlcNHglycan	110	113	PF01048	0.549
MOD_GlcNHglycan	120	124	PF01048	0.557
MOD_GlcNHglycan	139	142	PF01048	0.367
MOD_GlcNHglycan	157	160	PF01048	0.512
MOD_GlcNHglycan	180	183	PF01048	0.363
MOD_GlcNHglycan	228	231	PF01048	0.428
MOD_GlcNHglycan	238	241	PF01048	0.312
MOD_GlcNHglycan	275	278	PF01048	0.477
MOD_GlcNHglycan	322	325	PF01048	0.404
MOD_GlcNHglycan	340	343	PF01048	0.616
MOD_GlcNHglycan	73	76	PF01048	0.679
MOD_GSK3_1	238	245	PF00069	0.542
MOD_GSK3_1	271	278	PF00069	0.476
MOD_GSK3_1	39	46	PF00069	0.374
MOD_GSK3_1	69	76	PF00069	0.648
MOD_GSK3_1	77	84	PF00069	0.597
MOD_LATS_1	269	275	PF00433	0.478
MOD_NEK2_1	149	154	PF00069	0.388
MOD_NEK2_1	178	183	PF00069	0.373
MOD_NEK2_1	36	41	PF00069	0.447
MOD_PIKK_1	99	105	PF00454	0.555
MOD_PKA_1	108	114	PF00069	0.492
MOD_PKA_2	108	114	PF00069	0.614
MOD_Plk_1	258	264	PF00069	0.430
MOD_Plk_1	99	105	PF00069	0.428
MOD_Plk_2-3	259	265	PF00069	0.487
MOD_Plk_4	23	29	PF00069	0.286
MOD_Plk_4	244	250	PF00069	0.399
MOD_Plk_4	43	49	PF00069	0.402
MOD_ProDKin_1	184	190	PF00069	0.479
MOD_ProDKin_1	277	283	PF00069	0.461
MOD_ProDKin_1	307	313	PF00069	0.356
MOD_ProDKin_1	325	331	PF00069	0.475
MOD_ProDKin_1	73	79	PF00069	0.712
MOD_ProDKin_1	81	87	PF00069	0.552
TRG_DiLeu_BaEn_4	99	105	PF01217	0.428
TRG_ENDOCYTIC_2	135	138	PF00928	0.363
TRG_ENDOCYTIC_2	144	147	PF00928	0.312
TRG_ENDOCYTIC_2	167	170	PF00928	0.312
TRG_ENDOCYTIC_2	28	31	PF00928	0.266
TRG_ENDOCYTIC_2	44	47	PF00928	0.503
TRG_ER_diArg_1	299	301	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D9	Leptomonas seymouri	50%	100%
A0A1X0NR33	Trypanosomatidae	33%	100%
A0A3S7WRX1	Leishmania donovani	73%	100%
A0A422NA30	Trypanosoma rangeli	37%	100%
C9ZUI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGC6	Leishmania infantum	72%	100%
E9ANW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QGQ4	Leishmania major	72%	100%
V5BTJ4	Trypanosoma cruzi	36%	100%