Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6V2_LEIBR

TriTrypDb:

LbrM.12.0390 , LBRM2903_120009900

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H6V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.644
CLV_NRD_NRD_1	163	165	PF00675	0.367
CLV_NRD_NRD_1	305	307	PF00675	0.451
CLV_NRD_NRD_1	91	93	PF00675	0.611
CLV_PCSK_KEX2_1	163	165	PF00082	0.367
CLV_PCSK_KEX2_1	268	270	PF00082	0.365
CLV_PCSK_KEX2_1	305	307	PF00082	0.451
CLV_PCSK_KEX2_1	45	47	PF00082	0.330
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.369
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.345
CLV_PCSK_PC7_1	301	307	PF00082	0.464
CLV_PCSK_PC7_1	41	47	PF00082	0.278
CLV_PCSK_SKI1_1	52	56	PF00082	0.417
DEG_SPOP_SBC_1	167	171	PF00917	0.707
DEG_SPOP_SBC_1	7	11	PF00917	0.578
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.302
DOC_MAPK_gen_1	131	140	PF00069	0.589
DOC_PP1_RVXF_1	50	57	PF00149	0.468
DOC_PP2B_LxvP_1	220	223	PF13499	0.698
DOC_PP2B_LxvP_1	4	7	PF13499	0.591
DOC_USP7_MATH_1	167	171	PF00917	0.712
DOC_USP7_MATH_1	245	249	PF00917	0.641
DOC_USP7_MATH_1	7	11	PF00917	0.641
DOC_WW_Pin1_4	114	119	PF00397	0.302
DOC_WW_Pin1_4	176	181	PF00397	0.715
LIG_14-3-3_CanoR_1	58	63	PF00244	0.338
LIG_BIR_III_2	258	262	PF00653	0.577
LIG_BRCT_BRCA1_1	103	107	PF00533	0.302
LIG_BRCT_BRCA1_1	110	114	PF00533	0.302
LIG_BRCT_BRCA1_1	277	281	PF00533	0.606
LIG_deltaCOP1_diTrp_1	204	209	PF00928	0.640
LIG_FHA_1	130	136	PF00498	0.561
LIG_FHA_1	160	166	PF00498	0.557
LIG_FHA_1	186	192	PF00498	0.717
LIG_FHA_1	334	340	PF00498	0.619
LIG_FHA_2	156	162	PF00498	0.519
LIG_FHA_2	255	261	PF00498	0.699
LIG_FHA_2	283	289	PF00498	0.679
LIG_Integrin_RGD_1	286	288	PF01839	0.423
LIG_LIR_Nem_3	146	152	PF02991	0.547
LIG_RPA_C_Fungi	152	164	PF08784	0.345
LIG_SH2_NCK_1	36	40	PF00017	0.360
LIG_SH2_STAP1	49	53	PF00017	0.465
LIG_SH3_3	210	216	PF00018	0.444
LIG_SH3_3	238	244	PF00018	0.534
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.216
LIG_SUMO_SIM_par_1	57	64	PF11976	0.216
LIG_TYR_ITIM	34	39	PF00017	0.357
MOD_CK1_1	108	114	PF00069	0.240
MOD_CK1_1	169	175	PF00069	0.629
MOD_CK1_1	176	182	PF00069	0.587
MOD_CK1_1	232	238	PF00069	0.653
MOD_CK1_1	61	67	PF00069	0.363
MOD_CK2_1	16	22	PF00069	0.365
MOD_CK2_1	290	296	PF00069	0.784
MOD_GlcNHglycan	10	13	PF01048	0.581
MOD_GlcNHglycan	103	106	PF01048	0.302
MOD_GlcNHglycan	247	250	PF01048	0.675
MOD_GlcNHglycan	292	295	PF01048	0.582
MOD_GSK3_1	101	108	PF00069	0.216
MOD_GSK3_1	155	162	PF00069	0.390
MOD_GSK3_1	166	173	PF00069	0.579
MOD_GSK3_1	174	181	PF00069	0.584
MOD_GSK3_1	2	9	PF00069	0.535
MOD_GSK3_1	225	232	PF00069	0.663
MOD_GSK3_1	282	289	PF00069	0.584
MOD_GSK3_1	54	61	PF00069	0.312
MOD_GSK3_1	64	71	PF00069	0.273
MOD_N-GLC_1	282	287	PF02516	0.518
MOD_NEK2_1	129	134	PF00069	0.484
MOD_NEK2_1	16	21	PF00069	0.437
MOD_NEK2_1	281	286	PF00069	0.521
MOD_PIKK_1	225	231	PF00454	0.619
MOD_PIKK_1	269	275	PF00454	0.583
MOD_PK_1	58	64	PF00069	0.216
MOD_PKA_2	16	22	PF00069	0.426
MOD_PKA_2	40	46	PF00069	0.316
MOD_Plk_1	333	339	PF00069	0.477
MOD_Plk_4	108	114	PF00069	0.258
MOD_Plk_4	334	340	PF00069	0.348
MOD_Plk_4	58	64	PF00069	0.393
MOD_ProDKin_1	114	120	PF00069	0.302
MOD_ProDKin_1	176	182	PF00069	0.644
MOD_SUMO_for_1	320	323	PF00179	0.615
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.461
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.319
TRG_ENDOCYTIC_2	36	39	PF00928	0.356
TRG_ER_diArg_1	163	165	PF00400	0.441
TRG_ER_diArg_1	305	307	PF00400	0.557
TRG_ER_diArg_1	86	89	PF00400	0.471
TRG_NES_CRM1_1	204	215	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL14	Leptomonas seymouri	37%	100%
A0A3S7WRY6	Leishmania donovani	67%	100%
E9AGC4	Leishmania infantum	67%	100%
E9ANW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QGQ6	Leishmania major	67%	94%