GST N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, N-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6V1_LEIBR

TriTrypDb:

LbrM.12.0380 , LBRM2903_120009800

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6V1

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.509
CLV_NRD_NRD_1	166	168	PF00675	0.455
CLV_NRD_NRD_1	265	267	PF00675	0.723
CLV_NRD_NRD_1	304	306	PF00675	0.588
CLV_PCSK_KEX2_1	155	157	PF00082	0.538
CLV_PCSK_KEX2_1	166	168	PF00082	0.516
CLV_PCSK_KEX2_1	265	267	PF00082	0.723
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.457
CLV_PCSK_SKI1_1	16	20	PF00082	0.310
CLV_PCSK_SKI1_1	306	310	PF00082	0.344
CLV_PCSK_SKI1_1	352	356	PF00082	0.310
DEG_APCC_DBOX_1	304	312	PF00400	0.560
DEG_SCF_FBW7_1	276	283	PF00400	0.681
DOC_CYCLIN_RxL_1	233	246	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.496
DOC_MAPK_gen_1	233	243	PF00069	0.653
DOC_MAPK_gen_1	305	311	PF00069	0.346
DOC_MAPK_gen_1	349	359	PF00069	0.527
DOC_MAPK_MEF2A_6	352	359	PF00069	0.492
DOC_MAPK_MEF2A_6	76	84	PF00069	0.628
DOC_MAPK_NFAT4_5	352	360	PF00069	0.519
DOC_MIT_MIM_1	162	172	PF04212	0.431
DOC_PP1_RVXF_1	128	134	PF00149	0.521
DOC_PP1_RVXF_1	236	243	PF00149	0.453
DOC_PP1_RVXF_1	304	311	PF00149	0.358
DOC_PP2B_LxvP_1	355	358	PF13499	0.478
DOC_PP4_FxxP_1	103	106	PF00568	0.438
DOC_USP7_MATH_1	179	183	PF00917	0.438
DOC_USP7_MATH_1	280	284	PF00917	0.538
DOC_USP7_MATH_1	288	292	PF00917	0.633
DOC_USP7_MATH_1	8	12	PF00917	0.219
DOC_USP7_MATH_1	91	95	PF00917	0.596
DOC_WW_Pin1_4	276	281	PF00397	0.644
LIG_14-3-3_CanoR_1	188	198	PF00244	0.695
LIG_14-3-3_CanoR_1	213	218	PF00244	0.547
LIG_14-3-3_CanoR_1	281	285	PF00244	0.640
LIG_14-3-3_CanoR_1	349	355	PF00244	0.475
LIG_Actin_WH2_2	157	174	PF00022	0.470
LIG_deltaCOP1_diTrp_1	121	126	PF00928	0.373
LIG_eIF4E_1	13	19	PF01652	0.447
LIG_FHA_1	126	132	PF00498	0.269
LIG_FHA_1	133	139	PF00498	0.274
LIG_FHA_1	15	21	PF00498	0.463
LIG_FHA_1	298	304	PF00498	0.470
LIG_FHA_1	354	360	PF00498	0.400
LIG_FHA_2	116	122	PF00498	0.453
LIG_FHA_2	127	133	PF00498	0.329
LIG_FHA_2	190	196	PF00498	0.642
LIG_FHA_2	244	250	PF00498	0.663
LIG_FHA_2	315	321	PF00498	0.464
LIG_FHA_2	91	97	PF00498	0.477
LIG_LIR_Gen_1	121	131	PF02991	0.369
LIG_LIR_Nem_3	121	126	PF02991	0.401
LIG_LIR_Nem_3	347	351	PF02991	0.510
LIG_LRP6_Inhibitor_1	367	373	PF00058	0.468
LIG_Rb_LxCxE_1	326	347	PF01857	0.562
LIG_SH2_CRK	23	27	PF00017	0.480
LIG_SH2_CRK	351	355	PF00017	0.554
LIG_SH2_STAP1	134	138	PF00017	0.508
LIG_SH2_STAT5	13	16	PF00017	0.450
LIG_SH2_STAT5	134	137	PF00017	0.511
LIG_SH2_STAT5	170	173	PF00017	0.529
LIG_SH2_STAT5	261	264	PF00017	0.644
LIG_SH2_STAT5	63	66	PF00017	0.320
LIG_SH2_STAT5	73	76	PF00017	0.320
LIG_SH3_3	98	104	PF00018	0.686
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.630
LIG_SUMO_SIM_par_1	80	85	PF11976	0.566
LIG_TRAF2_1	192	195	PF00917	0.594
LIG_UBA3_1	240	245	PF00899	0.640
MOD_CDK_SPK_2	276	281	PF00069	0.644
MOD_CK1_1	189	195	PF00069	0.550
MOD_CK1_1	206	212	PF00069	0.591
MOD_CK1_1	270	276	PF00069	0.632
MOD_CK1_1	287	293	PF00069	0.676
MOD_CK1_1	295	301	PF00069	0.670
MOD_CK1_1	353	359	PF00069	0.400
MOD_CK1_1	90	96	PF00069	0.469
MOD_CK2_1	110	116	PF00069	0.426
MOD_CK2_1	136	142	PF00069	0.511
MOD_CK2_1	189	195	PF00069	0.603
MOD_CK2_1	243	249	PF00069	0.545
MOD_CK2_1	90	96	PF00069	0.478
MOD_GlcNHglycan	138	141	PF01048	0.312
MOD_GlcNHglycan	144	147	PF01048	0.367
MOD_GlcNHglycan	188	191	PF01048	0.531
MOD_GlcNHglycan	276	279	PF01048	0.625
MOD_GlcNHglycan	286	289	PF01048	0.566
MOD_GlcNHglycan	300	303	PF01048	0.548
MOD_GlcNHglycan	84	87	PF01048	0.686
MOD_GlcNHglycan	89	92	PF01048	0.710
MOD_GSK3_1	110	117	PF00069	0.521
MOD_GSK3_1	132	139	PF00069	0.291
MOD_GSK3_1	179	186	PF00069	0.589
MOD_GSK3_1	209	216	PF00069	0.553
MOD_GSK3_1	261	268	PF00069	0.666
MOD_GSK3_1	270	277	PF00069	0.584
MOD_GSK3_1	280	287	PF00069	0.549
MOD_GSK3_1	288	295	PF00069	0.653
MOD_GSK3_1	87	94	PF00069	0.577
MOD_N-GLC_1	38	43	PF02516	0.330
MOD_NEK2_1	1	6	PF00069	0.392
MOD_NEK2_1	114	119	PF00069	0.531
MOD_NEK2_1	126	131	PF00069	0.487
MOD_NEK2_1	171	176	PF00069	0.389
MOD_NEK2_1	274	279	PF00069	0.725
MOD_NEK2_1	323	328	PF00069	0.509
MOD_NEK2_1	339	344	PF00069	0.491
MOD_NEK2_1	64	69	PF00069	0.310
MOD_NEK2_1	80	85	PF00069	0.534
MOD_PIKK_1	115	121	PF00454	0.524
MOD_PIKK_1	8	14	PF00454	0.441
MOD_PK_1	213	219	PF00069	0.608
MOD_PKA_1	136	142	PF00069	0.464
MOD_PKA_1	244	250	PF00069	0.614
MOD_PKA_1	265	271	PF00069	0.717
MOD_PKA_2	206	212	PF00069	0.563
MOD_PKA_2	265	271	PF00069	0.643
MOD_PKA_2	280	286	PF00069	0.450
MOD_PKA_2	288	294	PF00069	0.655
MOD_Plk_1	115	121	PF00069	0.499
MOD_Plk_1	256	262	PF00069	0.604
MOD_Plk_2-3	38	44	PF00069	0.433
MOD_Plk_4	1	7	PF00069	0.384
MOD_Plk_4	110	116	PF00069	0.489
MOD_Plk_4	119	125	PF00069	0.420
MOD_Plk_4	213	219	PF00069	0.581
MOD_Plk_4	280	286	PF00069	0.707
MOD_Plk_4	288	294	PF00069	0.704
MOD_Plk_4	350	356	PF00069	0.519
MOD_ProDKin_1	276	282	PF00069	0.642
MOD_SUMO_rev_2	139	145	PF00179	0.413
TRG_ENDOCYTIC_2	23	26	PF00928	0.436
TRG_ENDOCYTIC_2	351	354	PF00928	0.523
TRG_ER_diArg_1	166	168	PF00400	0.537
TRG_ER_diArg_1	224	227	PF00400	0.673
TRG_ER_diArg_1	265	267	PF00400	0.723
TRG_NLS_Bipartite_1	136	158	PF00514	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY02	Leptomonas seymouri	67%	100%
A0A1X0NNU8	Trypanosomatidae	37%	93%
A0A3R7MZA1	Trypanosoma rangeli	36%	100%
A0A3S7WRV8	Leishmania donovani	83%	100%
C9ZQA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGC3	Leishmania infantum	83%	100%
E9ANW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGQ7	Leishmania major	83%	99%
V5DE18	Trypanosoma cruzi	40%	100%