Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6U7_LEIBR

TriTrypDb:

LbrM.12.0340 , LBRM2903_120008500

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H6U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.662
CLV_MEL_PAP_1	546	552	PF00089	0.367
CLV_NRD_NRD_1	255	257	PF00675	0.406
CLV_NRD_NRD_1	565	567	PF00675	0.345
CLV_PCSK_FUR_1	563	567	PF00082	0.336
CLV_PCSK_KEX2_1	219	221	PF00082	0.459
CLV_PCSK_KEX2_1	275	277	PF00082	0.552
CLV_PCSK_KEX2_1	565	567	PF00082	0.341
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.459
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.552
CLV_PCSK_PC7_1	561	567	PF00082	0.337
CLV_PCSK_SKI1_1	199	203	PF00082	0.454
CLV_PCSK_SKI1_1	248	252	PF00082	0.474
CLV_PCSK_SKI1_1	259	263	PF00082	0.428
CLV_PCSK_SKI1_1	272	276	PF00082	0.439
CLV_PCSK_SKI1_1	5	9	PF00082	0.419
CLV_PCSK_SKI1_1	60	64	PF00082	0.338
DEG_APCC_DBOX_1	433	441	PF00400	0.602
DEG_MDM2_SWIB_1	237	244	PF02201	0.618
DEG_SPOP_SBC_1	86	90	PF00917	0.721
DOC_CDC14_PxL_1	218	226	PF14671	0.709
DOC_CKS1_1	6	11	PF01111	0.658
DOC_CYCLIN_RxL_1	57	64	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	97	103	PF00134	0.598
DOC_MAPK_gen_1	225	234	PF00069	0.570
DOC_MAPK_MEF2A_6	225	234	PF00069	0.570
DOC_PP1_RVXF_1	26	32	PF00149	0.546
DOC_PP2B_LxvP_1	101	104	PF13499	0.601
DOC_PP2B_LxvP_1	121	124	PF13499	0.635
DOC_PP2B_LxvP_1	313	316	PF13499	0.634
DOC_PP2B_LxvP_1	586	589	PF13499	0.559
DOC_PP2B_LxvP_1	97	100	PF13499	0.666
DOC_USP7_MATH_1	17	21	PF00917	0.610
DOC_USP7_MATH_1	189	193	PF00917	0.739
DOC_USP7_MATH_1	346	350	PF00917	0.720
DOC_USP7_MATH_1	432	436	PF00917	0.640
DOC_USP7_UBL2_3	275	279	PF12436	0.629
DOC_USP7_UBL2_3	573	577	PF12436	0.634
DOC_WW_Pin1_4	163	168	PF00397	0.644
DOC_WW_Pin1_4	185	190	PF00397	0.719
DOC_WW_Pin1_4	290	295	PF00397	0.744
DOC_WW_Pin1_4	322	327	PF00397	0.688
DOC_WW_Pin1_4	41	46	PF00397	0.662
DOC_WW_Pin1_4	5	10	PF00397	0.611
DOC_WW_Pin1_4	617	622	PF00397	0.656
LIG_14-3-3_CanoR_1	28	32	PF00244	0.547
LIG_14-3-3_CanoR_1	434	438	PF00244	0.622
LIG_14-3-3_CanoR_1	520	530	PF00244	0.344
LIG_BIR_III_2	300	304	PF00653	0.657
LIG_BIR_III_4	82	86	PF00653	0.658
LIG_BRCT_BRCA1_1	496	500	PF00533	0.475
LIG_EH1_1	529	537	PF00400	0.312
LIG_eIF4E_1	530	536	PF01652	0.312
LIG_FHA_1	200	206	PF00498	0.668
LIG_FHA_1	227	233	PF00498	0.684
LIG_FHA_1	360	366	PF00498	0.609
LIG_FHA_1	460	466	PF00498	0.679
LIG_FHA_1	535	541	PF00498	0.388
LIG_FHA_1	6	12	PF00498	0.597
LIG_FHA_2	28	34	PF00498	0.565
LIG_FHA_2	370	376	PF00498	0.720
LIG_FHA_2	621	627	PF00498	0.705
LIG_FHA_2	77	83	PF00498	0.713
LIG_FHA_2	86	92	PF00498	0.640
LIG_LIR_Gen_1	213	222	PF02991	0.593
LIG_LIR_Gen_1	236	245	PF02991	0.642
LIG_LIR_Gen_1	310	319	PF02991	0.634
LIG_LIR_Gen_1	362	371	PF02991	0.675
LIG_LIR_Gen_1	396	406	PF02991	0.552
LIG_LIR_Gen_1	488	496	PF02991	0.597
LIG_LIR_Gen_1	50	57	PF02991	0.530
LIG_LIR_Gen_1	523	533	PF02991	0.277
LIG_LIR_Nem_3	213	218	PF02991	0.587
LIG_LIR_Nem_3	236	240	PF02991	0.730
LIG_LIR_Nem_3	310	314	PF02991	0.657
LIG_LIR_Nem_3	362	366	PF02991	0.690
LIG_LIR_Nem_3	395	401	PF02991	0.652
LIG_LIR_Nem_3	444	448	PF02991	0.626
LIG_LIR_Nem_3	488	492	PF02991	0.602
LIG_LIR_Nem_3	50	56	PF02991	0.529
LIG_LIR_Nem_3	523	529	PF02991	0.351
LIG_MYND_3	21	25	PF01753	0.563
LIG_NRBOX	10	16	PF00104	0.645
LIG_Pex14_1	241	245	PF04695	0.612
LIG_Pex14_1	526	530	PF04695	0.275
LIG_Pex14_2	237	241	PF04695	0.619
LIG_SH2_CRK	311	315	PF00017	0.641
LIG_SH2_CRK	399	403	PF00017	0.610
LIG_SH2_CRK	530	534	PF00017	0.312
LIG_SH2_NCK_1	298	302	PF00017	0.610
LIG_SH2_NCK_1	530	534	PF00017	0.312
LIG_SH2_PTP2	3	6	PF00017	0.758
LIG_SH2_STAP1	311	315	PF00017	0.641
LIG_SH2_STAP1	489	493	PF00017	0.602
LIG_SH2_STAT5	117	120	PF00017	0.623
LIG_SH2_STAT5	245	248	PF00017	0.614
LIG_SH2_STAT5	298	301	PF00017	0.609
LIG_SH2_STAT5	3	6	PF00017	0.652
LIG_SH2_STAT5	458	461	PF00017	0.716
LIG_SH2_STAT5	515	518	PF00017	0.411
LIG_SH2_STAT5	55	58	PF00017	0.696
LIG_SH3_3	136	142	PF00018	0.724
LIG_SH3_3	16	22	PF00018	0.548
LIG_SH3_3	188	194	PF00018	0.747
LIG_SH3_3	198	204	PF00018	0.747
LIG_SH3_3	320	326	PF00018	0.684
LIG_SH3_3	444	450	PF00018	0.650
LIG_SH3_3	81	87	PF00018	0.703
LIG_SH3_3	93	99	PF00018	0.775
LIG_SUMO_SIM_anti_2	229	234	PF11976	0.618
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.225
LIG_TRAF2_1	141	144	PF00917	0.741
LIG_TRAF2_1	340	343	PF00917	0.706
LIG_TRAF2_1	428	431	PF00917	0.693
LIG_TRAF2_2	45	50	PF00917	0.530
LIG_TYR_ITSM	526	533	PF00017	0.275
LIG_UBA3_1	243	251	PF00899	0.551
MOD_CK1_1	163	169	PF00069	0.653
MOD_CK1_1	239	245	PF00069	0.710
MOD_CK1_1	263	269	PF00069	0.614
MOD_CK1_1	284	290	PF00069	0.695
MOD_CK1_1	327	333	PF00069	0.622
MOD_CK1_1	349	355	PF00069	0.737
MOD_CK1_1	419	425	PF00069	0.678
MOD_CK1_1	481	487	PF00069	0.718
MOD_CK1_1	596	602	PF00069	0.607
MOD_CK1_1	620	626	PF00069	0.646
MOD_CK2_1	17	23	PF00069	0.669
MOD_CK2_1	27	33	PF00069	0.579
MOD_CK2_1	43	49	PF00069	0.634
MOD_DYRK1A_RPxSP_1	322	326	PF00069	0.676
MOD_GlcNHglycan	286	289	PF01048	0.447
MOD_GlcNHglycan	352	355	PF01048	0.532
MOD_GlcNHglycan	402	405	PF01048	0.482
MOD_GlcNHglycan	410	413	PF01048	0.571
MOD_GlcNHglycan	418	421	PF01048	0.439
MOD_GlcNHglycan	424	427	PF01048	0.425
MOD_GlcNHglycan	466	469	PF01048	0.501
MOD_GlcNHglycan	91	95	PF01048	0.487
MOD_GSK3_1	152	159	PF00069	0.715
MOD_GSK3_1	185	192	PF00069	0.690
MOD_GSK3_1	259	266	PF00069	0.645
MOD_GSK3_1	346	353	PF00069	0.703
MOD_GSK3_1	39	46	PF00069	0.650
MOD_GSK3_1	472	479	PF00069	0.774
MOD_GSK3_1	481	488	PF00069	0.674
MOD_GSK3_1	521	528	PF00069	0.344
MOD_GSK3_1	591	598	PF00069	0.602
MOD_GSK3_1	599	606	PF00069	0.658
MOD_GSK3_1	85	92	PF00069	0.816
MOD_LATS_1	197	203	PF00433	0.642
MOD_N-GLC_1	290	295	PF02516	0.439
MOD_N-GLC_1	594	599	PF02516	0.400
MOD_N-GLC_2	131	133	PF02516	0.459
MOD_NEK2_1	160	165	PF00069	0.657
MOD_NEK2_1	260	265	PF00069	0.690
MOD_NEK2_1	341	346	PF00069	0.621
MOD_NEK2_1	348	353	PF00069	0.626
MOD_NEK2_1	39	44	PF00069	0.648
MOD_NEK2_1	433	438	PF00069	0.575
MOD_NEK2_1	482	487	PF00069	0.561
MOD_NEK2_1	505	510	PF00069	0.312
MOD_NEK2_1	578	583	PF00069	0.631
MOD_PIKK_1	134	140	PF00454	0.734
MOD_PIKK_1	189	195	PF00454	0.738
MOD_PIKK_1	39	45	PF00454	0.643
MOD_PIKK_1	620	626	PF00454	0.646
MOD_PIKK_1	67	73	PF00454	0.694
MOD_PK_1	494	500	PF00069	0.475
MOD_PKA_2	27	33	PF00069	0.540
MOD_PKA_2	379	385	PF00069	0.623
MOD_PKA_2	433	439	PF00069	0.599
MOD_PKA_2	471	477	PF00069	0.608
MOD_Plk_1	327	333	PF00069	0.658
MOD_Plk_1	494	500	PF00069	0.475
MOD_Plk_2-3	281	287	PF00069	0.636
MOD_Plk_4	236	242	PF00069	0.608
MOD_Plk_4	27	33	PF00069	0.555
MOD_Plk_4	393	399	PF00069	0.534
MOD_Plk_4	525	531	PF00069	0.275
MOD_Plk_4	534	540	PF00069	0.312
MOD_ProDKin_1	163	169	PF00069	0.641
MOD_ProDKin_1	185	191	PF00069	0.719
MOD_ProDKin_1	290	296	PF00069	0.743
MOD_ProDKin_1	322	328	PF00069	0.690
MOD_ProDKin_1	41	47	PF00069	0.655
MOD_ProDKin_1	5	11	PF00069	0.609
MOD_ProDKin_1	617	623	PF00069	0.658
MOD_SUMO_rev_2	342	346	PF00179	0.651
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.680
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.706
TRG_ENDOCYTIC_2	3	6	PF00928	0.706
TRG_ENDOCYTIC_2	311	314	PF00928	0.643
TRG_ENDOCYTIC_2	398	401	PF00928	0.606
TRG_ENDOCYTIC_2	445	448	PF00928	0.620
TRG_ENDOCYTIC_2	489	492	PF00928	0.604
TRG_ENDOCYTIC_2	530	533	PF00928	0.328
TRG_ER_diArg_1	179	182	PF00400	0.679
TRG_ER_diArg_1	452	455	PF00400	0.624
TRG_ER_diArg_1	561	564	PF00400	0.610
TRG_ER_diArg_1	565	568	PF00400	0.613
TRG_ER_diLys_1	630	633	PF00400	0.722
TRG_NES_CRM1_1	431	444	PF08389	0.586
TRG_NES_CRM1_1	576	592	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL0	Leptomonas seymouri	51%	100%
A0A3S7WS03	Leishmania donovani	71%	98%
E9AGB8	Leishmania infantum	70%	99%
E9ANV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	97%
Q4QGR2	Leishmania major	71%	100%