Putative ornithine decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ornithine decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6U3_LEIBR

TriTrypDb:

LbrM.12.0300 , LBRM2903_120008000

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6U3

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	7
GO:0006595	polyamine metabolic process	6	7
GO:0006596	polyamine biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009308	amine metabolic process	4	7
GO:0009309	amine biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042401	biogenic amine biosynthetic process	6	7
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006591	ornithine metabolic process	5	1
GO:0009445	putrescine metabolic process	7	1
GO:0009446	putrescine biosynthetic process	8	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0033387	putrescine biosynthetic process from ornithine	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:1901605	alpha-amino acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004586	ornithine decarboxylase activity	5	6
GO:0016829	lyase activity	2	7
GO:0016830	carbon-carbon lyase activity	3	7
GO:0016831	carboxy-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.418
CLV_C14_Caspase3-7	549	553	PF00656	0.535
CLV_C14_Caspase3-7	59	63	PF00656	0.571
CLV_NRD_NRD_1	136	138	PF00675	0.439
CLV_NRD_NRD_1	191	193	PF00675	0.371
CLV_NRD_NRD_1	25	27	PF00675	0.558
CLV_NRD_NRD_1	490	492	PF00675	0.239
CLV_NRD_NRD_1	570	572	PF00675	0.282
CLV_NRD_NRD_1	590	592	PF00675	0.183
CLV_PCSK_FUR_1	568	572	PF00082	0.218
CLV_PCSK_KEX2_1	136	138	PF00082	0.439
CLV_PCSK_KEX2_1	191	193	PF00082	0.371
CLV_PCSK_KEX2_1	24	26	PF00082	0.620
CLV_PCSK_KEX2_1	570	572	PF00082	0.283
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.465
CLV_PCSK_SKI1_1	200	204	PF00082	0.434
CLV_PCSK_SKI1_1	25	29	PF00082	0.568
CLV_PCSK_SKI1_1	320	324	PF00082	0.218
CLV_PCSK_SKI1_1	357	361	PF00082	0.214
CLV_PCSK_SKI1_1	36	40	PF00082	0.613
CLV_PCSK_SKI1_1	379	383	PF00082	0.222
CLV_PCSK_SKI1_1	454	458	PF00082	0.277
CLV_PCSK_SKI1_1	474	478	PF00082	0.183
DEG_APCC_DBOX_1	247	255	PF00400	0.477
DEG_APCC_DBOX_1	453	461	PF00400	0.477
DEG_SPOP_SBC_1	210	214	PF00917	0.507
DOC_CYCLIN_RxL_1	19	29	PF00134	0.616
DOC_MAPK_gen_1	191	198	PF00069	0.336
DOC_MAPK_gen_1	568	575	PF00069	0.418
DOC_MAPK_MEF2A_6	261	268	PF00069	0.414
DOC_PP4_FxxP_1	304	307	PF00568	0.477
DOC_PP4_FxxP_1	364	367	PF00568	0.535
DOC_PP4_MxPP_1	4	7	PF00568	0.670
DOC_USP7_MATH_1	259	263	PF00917	0.535
DOC_USP7_MATH_1	274	278	PF00917	0.421
DOC_USP7_MATH_1	505	509	PF00917	0.528
DOC_USP7_MATH_1	88	92	PF00917	0.621
DOC_WW_Pin1_4	120	125	PF00397	0.618
DOC_WW_Pin1_4	153	158	PF00397	0.462
DOC_WW_Pin1_4	211	216	PF00397	0.467
DOC_WW_Pin1_4	295	300	PF00397	0.535
DOC_WW_Pin1_4	73	78	PF00397	0.554
LIG_14-3-3_CanoR_1	19	28	PF00244	0.536
LIG_14-3-3_CanoR_1	320	325	PF00244	0.418
LIG_14-3-3_CanoR_1	36	41	PF00244	0.519
LIG_14-3-3_CanoR_1	474	483	PF00244	0.490
LIG_14-3-3_CanoR_1	574	581	PF00244	0.451
LIG_Actin_WH2_2	480	496	PF00022	0.477
LIG_AP2alpha_2	230	232	PF02296	0.377
LIG_BIR_III_2	14	18	PF00653	0.471
LIG_BRCT_BRCA1_1	360	364	PF00533	0.477
LIG_Clathr_ClatBox_1	108	112	PF01394	0.427
LIG_Clathr_ClatBox_1	330	334	PF01394	0.418
LIG_DCNL_PONY_1	1	4	PF03556	0.501
LIG_FHA_1	478	484	PF00498	0.269
LIG_FHA_1	539	545	PF00498	0.477
LIG_FHA_2	130	136	PF00498	0.517
LIG_FHA_2	287	293	PF00498	0.418
LIG_FHA_2	422	428	PF00498	0.477
LIG_FHA_2	443	449	PF00498	0.517
LIG_LIR_Apic_2	301	307	PF02991	0.477
LIG_LIR_Apic_2	361	367	PF02991	0.535
LIG_LIR_Gen_1	323	331	PF02991	0.477
LIG_LIR_Gen_1	408	416	PF02991	0.535
LIG_LIR_Gen_1	443	453	PF02991	0.475
LIG_LIR_Gen_1	524	535	PF02991	0.477
LIG_LIR_Gen_1	602	609	PF02991	0.477
LIG_LIR_Gen_1	625	636	PF02991	0.320
LIG_LIR_Nem_3	123	128	PF02991	0.494
LIG_LIR_Nem_3	187	193	PF02991	0.382
LIG_LIR_Nem_3	229	235	PF02991	0.380
LIG_LIR_Nem_3	323	327	PF02991	0.477
LIG_LIR_Nem_3	408	413	PF02991	0.477
LIG_LIR_Nem_3	443	449	PF02991	0.475
LIG_LIR_Nem_3	516	521	PF02991	0.535
LIG_LIR_Nem_3	524	530	PF02991	0.472
LIG_LIR_Nem_3	602	606	PF02991	0.477
LIG_LIR_Nem_3	625	631	PF02991	0.314
LIG_PCNA_PIPBox_1	288	297	PF02747	0.418
LIG_PCNA_yPIPBox_3	261	272	PF02747	0.470
LIG_PDZ_Class_2	631	636	PF00595	0.289
LIG_Pex14_2	360	364	PF04695	0.477
LIG_SH2_GRB2like	521	524	PF00017	0.477
LIG_SH2_NCK_1	147	151	PF00017	0.511
LIG_SH2_NCK_1	612	616	PF00017	0.383
LIG_SH2_PTP2	324	327	PF00017	0.477
LIG_SH2_STAP1	612	616	PF00017	0.383
LIG_SH2_STAT5	197	200	PF00017	0.397
LIG_SH2_STAT5	233	236	PF00017	0.422
LIG_SH2_STAT5	257	260	PF00017	0.556
LIG_SH2_STAT5	324	327	PF00017	0.503
LIG_SH2_STAT5	402	405	PF00017	0.477
LIG_SH2_STAT5	475	478	PF00017	0.483
LIG_SH2_STAT5	521	524	PF00017	0.502
LIG_SH2_STAT5	612	615	PF00017	0.376
LIG_SH2_STAT5	79	82	PF00017	0.478
LIG_SH3_1	225	231	PF00018	0.347
LIG_SH3_3	151	157	PF00018	0.455
LIG_SH3_3	225	231	PF00018	0.389
LIG_SH3_3	293	299	PF00018	0.535
LIG_SH3_3	63	69	PF00018	0.529
LIG_SUMO_SIM_anti_2	465	471	PF11976	0.477
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.477
LIG_SUMO_SIM_par_1	328	334	PF11976	0.418
LIG_SUMO_SIM_par_1	541	547	PF11976	0.477
LIG_SUMO_SIM_par_1	6	12	PF11976	0.505
LIG_TRAF2_1	132	135	PF00917	0.510
LIG_TYR_ITIM	322	327	PF00017	0.477
LIG_UBA3_1	330	335	PF00899	0.514
LIG_WRC_WIRS_1	527	532	PF05994	0.477
MOD_CK1_1	394	400	PF00069	0.447
MOD_CK1_1	434	440	PF00069	0.507
MOD_CK1_1	564	570	PF00069	0.418
MOD_CK1_1	611	617	PF00069	0.381
MOD_CK2_1	129	135	PF00069	0.533
MOD_CK2_1	280	286	PF00069	0.477
MOD_CK2_1	493	499	PF00069	0.477
MOD_GlcNHglycan	220	223	PF01048	0.530
MOD_GlcNHglycan	276	279	PF01048	0.311
MOD_GlcNHglycan	341	344	PF01048	0.285
MOD_GlcNHglycan	403	406	PF01048	0.290
MOD_GlcNHglycan	440	443	PF01048	0.294
MOD_GSK3_1	120	127	PF00069	0.490
MOD_GSK3_1	205	212	PF00069	0.449
MOD_GSK3_1	32	39	PF00069	0.543
MOD_GSK3_1	394	401	PF00069	0.480
MOD_GSK3_1	41	48	PF00069	0.665
MOD_GSK3_1	434	441	PF00069	0.490
MOD_GSK3_1	560	567	PF00069	0.438
MOD_N-GLC_1	216	221	PF02516	0.515
MOD_N-GLC_1	351	356	PF02516	0.335
MOD_N-GLC_1	421	426	PF02516	0.227
MOD_N-GLC_1	46	51	PF02516	0.537
MOD_NEK2_1	111	116	PF00069	0.554
MOD_NEK2_1	421	426	PF00069	0.477
MOD_NEK2_1	476	481	PF00069	0.449
MOD_NEK2_1	526	531	PF00069	0.477
MOD_NEK2_1	573	578	PF00069	0.518
MOD_NEK2_2	386	391	PF00069	0.475
MOD_PIKK_1	111	117	PF00454	0.584
MOD_PIKK_1	414	420	PF00454	0.418
MOD_PIKK_1	500	506	PF00454	0.431
MOD_PIKK_1	99	105	PF00454	0.458
MOD_PKA_1	191	197	PF00069	0.369
MOD_PKA_2	191	197	PF00069	0.376
MOD_PKA_2	493	499	PF00069	0.491
MOD_PKA_2	573	579	PF00069	0.454
MOD_Plk_1	216	222	PF00069	0.559
MOD_Plk_1	421	427	PF00069	0.427
MOD_Plk_1	442	448	PF00069	0.477
MOD_Plk_1	464	470	PF00069	0.477
MOD_Plk_1	561	567	PF00069	0.481
MOD_Plk_1	89	95	PF00069	0.506
MOD_Plk_2-3	286	292	PF00069	0.495
MOD_Plk_4	286	292	PF00069	0.418
MOD_Plk_4	320	326	PF00069	0.484
MOD_Plk_4	370	376	PF00069	0.414
MOD_Plk_4	398	404	PF00069	0.418
MOD_Plk_4	421	427	PF00069	0.477
MOD_Plk_4	464	470	PF00069	0.477
MOD_Plk_4	505	511	PF00069	0.545
MOD_Plk_4	538	544	PF00069	0.477
MOD_Plk_4	574	580	PF00069	0.477
MOD_Plk_4	6	12	PF00069	0.513
MOD_ProDKin_1	120	126	PF00069	0.620
MOD_ProDKin_1	153	159	PF00069	0.470
MOD_ProDKin_1	211	217	PF00069	0.475
MOD_ProDKin_1	295	301	PF00069	0.535
MOD_ProDKin_1	73	79	PF00069	0.547
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.574
TRG_ENDOCYTIC_2	141	144	PF00928	0.412
TRG_ENDOCYTIC_2	257	260	PF00928	0.535
TRG_ENDOCYTIC_2	324	327	PF00928	0.477
TRG_ENDOCYTIC_2	410	413	PF00928	0.477
TRG_ENDOCYTIC_2	527	530	PF00928	0.493
TRG_ER_diArg_1	190	192	PF00400	0.373
TRG_ER_diArg_1	25	27	PF00400	0.717
TRG_ER_diArg_1	568	571	PF00400	0.481
TRG_NLS_MonoExtC_3	23	29	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I681	Leptomonas seymouri	63%	88%
A0A3S5H6K6	Leishmania donovani	70%	90%
E9AGB5	Leishmania infantum	70%	90%
E9ANV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	89%
P27116	Leishmania donovani	70%	90%
Q4QGR5	Leishmania major	70%	100%