SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6U2_LEIBR

TriTrypDb:

LbrM.12.0290 , LBRM2903_120007900

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6U2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.610
CLV_NRD_NRD_1	128	130	PF00675	0.511
CLV_NRD_NRD_1	228	230	PF00675	0.569
CLV_NRD_NRD_1	29	31	PF00675	0.551
CLV_NRD_NRD_1	528	530	PF00675	0.483
CLV_NRD_NRD_1	549	551	PF00675	0.392
CLV_PCSK_FUR_1	30	34	PF00082	0.553
CLV_PCSK_KEX2_1	127	129	PF00082	0.576
CLV_PCSK_KEX2_1	228	230	PF00082	0.570
CLV_PCSK_KEX2_1	29	31	PF00082	0.552
CLV_PCSK_KEX2_1	32	34	PF00082	0.559
CLV_PCSK_KEX2_1	528	530	PF00082	0.483
CLV_PCSK_KEX2_1	549	551	PF00082	0.393
CLV_PCSK_KEX2_1	553	555	PF00082	0.391
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.558
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.410
CLV_PCSK_PC7_1	549	555	PF00082	0.410
CLV_PCSK_SKI1_1	209	213	PF00082	0.357
CLV_PCSK_SKI1_1	229	233	PF00082	0.232
CLV_PCSK_SKI1_1	554	558	PF00082	0.375
CLV_PCSK_SKI1_1	561	565	PF00082	0.350
CLV_PCSK_SKI1_1	87	91	PF00082	0.549
DEG_SPOP_SBC_1	178	182	PF00917	0.494
DOC_CKS1_1	96	101	PF01111	0.404
DOC_CYCLIN_RxL_1	206	213	PF00134	0.390
DOC_CYCLIN_RxL_1	476	488	PF00134	0.389
DOC_MAPK_MEF2A_6	87	95	PF00069	0.484
DOC_PP2B_LxvP_1	232	235	PF13499	0.450
DOC_USP7_MATH_1	140	144	PF00917	0.709
DOC_USP7_MATH_1	165	169	PF00917	0.563
DOC_USP7_MATH_1	177	181	PF00917	0.608
DOC_USP7_MATH_1	205	209	PF00917	0.448
DOC_USP7_MATH_1	227	231	PF00917	0.318
DOC_USP7_MATH_1	23	27	PF00917	0.624
DOC_USP7_MATH_1	403	407	PF00917	0.548
DOC_USP7_MATH_1	496	500	PF00917	0.513
DOC_USP7_MATH_1	510	514	PF00917	0.528
DOC_USP7_MATH_1	522	526	PF00917	0.681
DOC_USP7_MATH_1	527	531	PF00917	0.677
DOC_USP7_UBL2_3	150	154	PF12436	0.473
DOC_WW_Pin1_4	167	172	PF00397	0.752
DOC_WW_Pin1_4	201	206	PF00397	0.406
DOC_WW_Pin1_4	340	345	PF00397	0.572
DOC_WW_Pin1_4	424	429	PF00397	0.438
DOC_WW_Pin1_4	95	100	PF00397	0.405
LIG_14-3-3_CanoR_1	209	218	PF00244	0.376
LIG_14-3-3_CanoR_1	228	232	PF00244	0.540
LIG_14-3-3_CanoR_1	3	12	PF00244	0.553
LIG_14-3-3_CanoR_1	33	37	PF00244	0.625
LIG_14-3-3_CanoR_1	338	344	PF00244	0.502
LIG_14-3-3_CanoR_1	359	363	PF00244	0.365
LIG_14-3-3_CanoR_1	516	522	PF00244	0.538
LIG_14-3-3_CanoR_1	523	527	PF00244	0.535
LIG_14-3-3_CanoR_1	528	537	PF00244	0.490
LIG_14-3-3_CanoR_1	71	77	PF00244	0.642
LIG_14-3-3_CanoR_1	87	92	PF00244	0.405
LIG_BIR_II_1	1	5	PF00653	0.727
LIG_BRCT_BRCA1_1	181	185	PF00533	0.628
LIG_BRCT_BRCA1_1	286	290	PF00533	0.342
LIG_deltaCOP1_diTrp_1	355	363	PF00928	0.292
LIG_EH1_1	475	483	PF00400	0.443
LIG_FHA_1	219	225	PF00498	0.399
LIG_FHA_1	256	262	PF00498	0.434
LIG_FHA_1	373	379	PF00498	0.385
LIG_FHA_1	425	431	PF00498	0.305
LIG_FHA_1	466	472	PF00498	0.487
LIG_FHA_1	88	94	PF00498	0.531
LIG_FHA_1	96	102	PF00498	0.364
LIG_FHA_2	287	293	PF00498	0.428
LIG_LIR_Apic_2	251	257	PF02991	0.467
LIG_LIR_Gen_1	361	369	PF02991	0.279
LIG_LIR_Gen_1	52	59	PF02991	0.500
LIG_LIR_Nem_3	361	366	PF02991	0.400
LIG_LIR_Nem_3	52	56	PF02991	0.505
LIG_LIR_Nem_3	559	563	PF02991	0.511
LIG_NRBOX	88	94	PF00104	0.561
LIG_REV1ctd_RIR_1	370	380	PF16727	0.346
LIG_SH2_CRK	254	258	PF00017	0.564
LIG_SH2_CRK	507	511	PF00017	0.516
LIG_SH2_CRK	560	564	PF00017	0.463
LIG_SH2_NCK_1	254	258	PF00017	0.447
LIG_SH2_NCK_1	36	40	PF00017	0.652
LIG_SH2_SRC	36	39	PF00017	0.649
LIG_SH2_SRC	505	508	PF00017	0.485
LIG_SH2_STAP1	114	118	PF00017	0.519
LIG_SH2_STAP1	388	392	PF00017	0.372
LIG_SH2_STAT5	100	103	PF00017	0.504
LIG_SH2_STAT5	117	120	PF00017	0.405
LIG_SH2_STAT5	200	203	PF00017	0.411
LIG_SH2_STAT5	254	257	PF00017	0.454
LIG_SH2_STAT5	422	425	PF00017	0.438
LIG_SH2_STAT5	505	508	PF00017	0.516
LIG_SH2_STAT5	562	565	PF00017	0.472
LIG_SH3_3	127	133	PF00018	0.353
LIG_SH3_3	420	426	PF00018	0.439
LIG_SH3_3	454	460	PF00018	0.615
LIG_SH3_3	468	474	PF00018	0.389
LIG_SUMO_SIM_anti_2	487	494	PF11976	0.442
LIG_SUMO_SIM_par_1	260	266	PF11976	0.421
LIG_SUMO_SIM_par_1	487	494	PF11976	0.350
LIG_TRAF2_1	380	383	PF00917	0.427
LIG_TRAF2_1	539	542	PF00917	0.429
LIG_WRC_WIRS_1	160	165	PF05994	0.476
LIG_WRC_WIRS_1	430	435	PF05994	0.292
MOD_CDK_SPxxK_3	167	174	PF00069	0.732
MOD_CK1_1	13	19	PF00069	0.707
MOD_CK1_1	164	170	PF00069	0.746
MOD_CK1_1	25	31	PF00069	0.648
MOD_CK1_1	284	290	PF00069	0.395
MOD_CK1_1	306	312	PF00069	0.692
MOD_CK1_1	339	345	PF00069	0.721
MOD_CK1_1	346	352	PF00069	0.617
MOD_CK1_1	530	536	PF00069	0.686
MOD_CK1_1	63	69	PF00069	0.701
MOD_CK1_1	79	85	PF00069	0.557
MOD_CK2_1	139	145	PF00069	0.710
MOD_CK2_1	286	292	PF00069	0.426
MOD_CK2_1	330	336	PF00069	0.580
MOD_GlcNHglycan	15	18	PF01048	0.720
MOD_GlcNHglycan	163	166	PF01048	0.542
MOD_GlcNHglycan	175	178	PF01048	0.550
MOD_GlcNHglycan	283	286	PF01048	0.378
MOD_GlcNHglycan	352	355	PF01048	0.547
MOD_GlcNHglycan	445	449	PF01048	0.582
MOD_GlcNHglycan	454	457	PF01048	0.585
MOD_GlcNHglycan	498	501	PF01048	0.576
MOD_GlcNHglycan	532	535	PF01048	0.757
MOD_GlcNHglycan	537	540	PF01048	0.702
MOD_GSK3_1	11	18	PF00069	0.642
MOD_GSK3_1	135	142	PF00069	0.582
MOD_GSK3_1	155	162	PF00069	0.633
MOD_GSK3_1	163	170	PF00069	0.613
MOD_GSK3_1	173	180	PF00069	0.686
MOD_GSK3_1	201	208	PF00069	0.413
MOD_GSK3_1	248	255	PF00069	0.487
MOD_GSK3_1	28	35	PF00069	0.741
MOD_GSK3_1	303	310	PF00069	0.505
MOD_GSK3_1	332	339	PF00069	0.668
MOD_GSK3_1	342	349	PF00069	0.562
MOD_GSK3_1	368	375	PF00069	0.324
MOD_GSK3_1	382	389	PF00069	0.414
MOD_GSK3_1	45	52	PF00069	0.442
MOD_GSK3_1	491	498	PF00069	0.380
MOD_GSK3_1	58	65	PF00069	0.647
MOD_GSK3_1	67	74	PF00069	0.654
MOD_N-GLC_1	140	145	PF02516	0.520
MOD_N-GLC_1	274	279	PF02516	0.353
MOD_N-GLC_1	336	341	PF02516	0.507
MOD_N-GLC_2	281	283	PF02516	0.322
MOD_NEK2_1	123	128	PF00069	0.368
MOD_NEK2_1	15	20	PF00069	0.731
MOD_NEK2_1	159	164	PF00069	0.520
MOD_NEK2_1	22	27	PF00069	0.659
MOD_NEK2_1	274	279	PF00069	0.469
MOD_NEK2_1	286	291	PF00069	0.461
MOD_NEK2_1	305	310	PF00069	0.412
MOD_NEK2_1	386	391	PF00069	0.404
MOD_NEK2_2	76	81	PF00069	0.529
MOD_PIKK_1	252	258	PF00454	0.507
MOD_PIKK_1	263	269	PF00454	0.341
MOD_PIKK_1	346	352	PF00454	0.465
MOD_PIKK_1	517	523	PF00454	0.709
MOD_PKA_1	32	38	PF00069	0.689
MOD_PKA_1	549	555	PF00069	0.502
MOD_PKA_2	173	179	PF00069	0.708
MOD_PKA_2	218	224	PF00069	0.417
MOD_PKA_2	227	233	PF00069	0.402
MOD_PKA_2	28	34	PF00069	0.531
MOD_PKA_2	303	309	PF00069	0.562
MOD_PKA_2	337	343	PF00069	0.504
MOD_PKA_2	358	364	PF00069	0.490
MOD_PKA_2	515	521	PF00069	0.511
MOD_PKA_2	522	528	PF00069	0.506
MOD_PKA_2	549	555	PF00069	0.392
MOD_PKA_2	70	76	PF00069	0.620
MOD_Plk_1	155	161	PF00069	0.466
MOD_Plk_1	336	342	PF00069	0.537
MOD_Plk_1	382	388	PF00069	0.348
MOD_Plk_2-3	382	388	PF00069	0.464
MOD_Plk_4	118	124	PF00069	0.415
MOD_Plk_4	155	161	PF00069	0.466
MOD_Plk_4	236	242	PF00069	0.565
MOD_Plk_4	286	292	PF00069	0.426
MOD_Plk_4	343	349	PF00069	0.504
MOD_Plk_4	358	364	PF00069	0.357
MOD_Plk_4	368	374	PF00069	0.312
MOD_Plk_4	87	93	PF00069	0.525
MOD_ProDKin_1	167	173	PF00069	0.754
MOD_ProDKin_1	201	207	PF00069	0.412
MOD_ProDKin_1	340	346	PF00069	0.571
MOD_ProDKin_1	424	430	PF00069	0.431
MOD_ProDKin_1	95	101	PF00069	0.403
TRG_DiLeu_BaEn_2	428	434	PF01217	0.448
TRG_ENDOCYTIC_2	560	563	PF00928	0.376
TRG_ER_diArg_1	127	129	PF00400	0.470
TRG_ER_diArg_1	227	229	PF00400	0.316
TRG_ER_diArg_1	548	550	PF00400	0.465
TRG_ER_diArg_1	80	83	PF00400	0.551
TRG_NES_CRM1_1	473	488	PF08389	0.329
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U7	Leptomonas seymouri	49%	100%
A0A1X0NNV4	Trypanosomatidae	37%	100%
A0A3Q8I958	Leishmania donovani	71%	100%
A4HV71	Leishmania infantum	71%	84%
C9ZQA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ANV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QGR6	Leishmania major	71%	98%
V5BD95	Trypanosoma cruzi	34%	100%