LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4H6T9_LEIBR
TriTrypDb:
LbrM.12.0260 , LBRM2903_120007500 *
Length:
696

Annotations

LeishMANIAdb annotations

This membrane protein has considerable similarity to beta-lactamases found in Streptomyces species. A protein family found in a single copy in parazitic species, while multiple paralogs exist in B.saltans.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 6
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H6T9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6T9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 433 437 PF00656 0.307
CLV_C14_Caspase3-7 474 478 PF00656 0.277
CLV_C14_Caspase3-7 669 673 PF00656 0.783
CLV_NRD_NRD_1 21 23 PF00675 0.423
CLV_NRD_NRD_1 25 27 PF00675 0.417
CLV_NRD_NRD_1 481 483 PF00675 0.559
CLV_NRD_NRD_1 644 646 PF00675 0.619
CLV_PCSK_KEX2_1 21 23 PF00082 0.419
CLV_PCSK_KEX2_1 25 27 PF00082 0.411
CLV_PCSK_KEX2_1 481 483 PF00082 0.559
CLV_PCSK_KEX2_1 644 646 PF00082 0.618
CLV_PCSK_PC7_1 21 27 PF00082 0.346
CLV_PCSK_PC7_1 640 646 PF00082 0.611
CLV_PCSK_SKI1_1 108 112 PF00082 0.594
CLV_PCSK_SKI1_1 317 321 PF00082 0.666
CLV_PCSK_SKI1_1 325 329 PF00082 0.646
CLV_PCSK_SKI1_1 464 468 PF00082 0.460
DEG_APCC_DBOX_1 316 324 PF00400 0.308
DEG_SCF_FBW7_1 116 122 PF00400 0.498
DEG_SCF_FBW7_1 125 132 PF00400 0.342
DEG_SPOP_SBC_1 119 123 PF00917 0.372
DEG_SPOP_SBC_1 85 89 PF00917 0.361
DOC_ANK_TNKS_1 581 588 PF00023 0.624
DOC_CKS1_1 116 121 PF01111 0.483
DOC_CKS1_1 208 213 PF01111 0.441
DOC_CKS1_1 305 310 PF01111 0.503
DOC_CYCLIN_yCln2_LP_2 208 214 PF00134 0.360
DOC_MAPK_DCC_7 22 32 PF00069 0.623
DOC_MAPK_MEF2A_6 25 32 PF00069 0.547
DOC_PP1_SILK_1 687 692 PF00149 0.620
DOC_PP2B_LxvP_1 160 163 PF13499 0.321
DOC_PP2B_LxvP_1 365 368 PF13499 0.239
DOC_PP2B_LxvP_1 456 459 PF13499 0.208
DOC_PP4_FxxP_1 549 552 PF00568 0.610
DOC_USP7_MATH_1 163 167 PF00917 0.392
DOC_USP7_MATH_1 212 216 PF00917 0.460
DOC_USP7_MATH_1 217 221 PF00917 0.399
DOC_USP7_MATH_1 459 463 PF00917 0.351
DOC_USP7_MATH_1 496 500 PF00917 0.299
DOC_USP7_MATH_1 678 682 PF00917 0.636
DOC_USP7_MATH_1 90 94 PF00917 0.347
DOC_WW_Pin1_4 115 120 PF00397 0.478
DOC_WW_Pin1_4 125 130 PF00397 0.356
DOC_WW_Pin1_4 202 207 PF00397 0.370
DOC_WW_Pin1_4 304 309 PF00397 0.474
DOC_WW_Pin1_4 513 518 PF00397 0.469
DOC_WW_Pin1_4 53 58 PF00397 0.530
DOC_WW_Pin1_4 59 64 PF00397 0.388
DOC_WW_Pin1_4 651 656 PF00397 0.737
LIG_14-3-3_CanoR_1 502 507 PF00244 0.279
LIG_14-3-3_CanoR_1 631 637 PF00244 0.791
LIG_AP2alpha_2 309 311 PF02296 0.332
LIG_BRCT_BRCA1_1 292 296 PF00533 0.327
LIG_BRCT_BRCA1_1 523 527 PF00533 0.191
LIG_Clathr_ClatBox_1 147 151 PF01394 0.349
LIG_FHA_1 120 126 PF00498 0.375
LIG_FHA_1 151 157 PF00498 0.378
LIG_FHA_1 18 24 PF00498 0.641
LIG_FHA_1 314 320 PF00498 0.363
LIG_FHA_1 360 366 PF00498 0.257
LIG_FHA_1 43 49 PF00498 0.479
LIG_FHA_1 518 524 PF00498 0.446
LIG_FHA_1 533 539 PF00498 0.338
LIG_FHA_1 54 60 PF00498 0.473
LIG_FHA_1 86 92 PF00498 0.388
LIG_FHA_2 122 128 PF00498 0.438
LIG_FHA_2 202 208 PF00498 0.509
LIG_FHA_2 352 358 PF00498 0.311
LIG_FHA_2 431 437 PF00498 0.402
LIG_FHA_2 60 66 PF00498 0.531
LIG_LIR_Apic_2 546 552 PF02991 0.604
LIG_LIR_Gen_1 413 420 PF02991 0.367
LIG_LIR_Gen_1 524 534 PF02991 0.290
LIG_LIR_LC3C_4 139 144 PF02991 0.217
LIG_LIR_LC3C_4 535 538 PF02991 0.397
LIG_LIR_Nem_3 183 187 PF02991 0.399
LIG_LIR_Nem_3 280 286 PF02991 0.342
LIG_LIR_Nem_3 413 418 PF02991 0.381
LIG_LIR_Nem_3 423 429 PF02991 0.393
LIG_LIR_Nem_3 524 530 PF02991 0.227
LIG_LIR_Nem_3 70 76 PF02991 0.367
LIG_LYPXL_yS_3 98 101 PF13949 0.399
LIG_NRBOX 137 143 PF00104 0.284
LIG_NRBOX 190 196 PF00104 0.288
LIG_NRBOX 35 41 PF00104 0.267
LIG_PCNA_yPIPBox_3 254 268 PF02747 0.230
LIG_PTB_Apo_2 178 185 PF02174 0.316
LIG_SH2_CRK 415 419 PF00017 0.396
LIG_SH2_CRK 73 77 PF00017 0.364
LIG_SH2_NCK_1 415 419 PF00017 0.378
LIG_SH2_SRC 149 152 PF00017 0.381
LIG_SH2_STAT3 339 342 PF00017 0.286
LIG_SH2_STAT3 548 551 PF00017 0.626
LIG_SH2_STAT5 149 152 PF00017 0.314
LIG_SH2_STAT5 248 251 PF00017 0.331
LIG_SH2_STAT5 260 263 PF00017 0.250
LIG_SH2_STAT5 345 348 PF00017 0.343
LIG_SH2_STAT5 394 397 PF00017 0.376
LIG_SH2_STAT5 426 429 PF00017 0.387
LIG_SH2_STAT5 544 547 PF00017 0.562
LIG_SH2_STAT5 548 551 PF00017 0.604
LIG_SH2_STAT5 622 625 PF00017 0.752
LIG_SH3_2 514 519 PF14604 0.390
LIG_SH3_2 552 557 PF14604 0.722
LIG_SH3_3 113 119 PF00018 0.499
LIG_SH3_3 179 185 PF00018 0.316
LIG_SH3_3 208 214 PF00018 0.432
LIG_SH3_3 282 288 PF00018 0.362
LIG_SH3_3 387 393 PF00018 0.273
LIG_SH3_3 511 517 PF00018 0.518
LIG_SH3_3 549 555 PF00018 0.662
LIG_SH3_3 649 655 PF00018 0.633
LIG_SUMO_SIM_anti_2 139 146 PF11976 0.214
LIG_SUMO_SIM_anti_2 451 457 PF11976 0.366
LIG_SUMO_SIM_anti_2 535 541 PF11976 0.350
LIG_SUMO_SIM_par_1 38 46 PF11976 0.377
LIG_SUMO_SIM_par_1 383 388 PF11976 0.364
LIG_SUMO_SIM_par_1 537 543 PF11976 0.350
LIG_TYR_ITIM 96 101 PF00017 0.503
LIG_TYR_ITSM 411 418 PF00017 0.477
LIG_UBA3_1 58 66 PF00899 0.604
LIG_WRC_WIRS_1 221 226 PF05994 0.341
MOD_CDC14_SPxK_1 516 519 PF00782 0.477
MOD_CDK_SPxK_1 125 131 PF00069 0.373
MOD_CDK_SPxK_1 513 519 PF00069 0.486
MOD_CDK_SPxxK_3 59 66 PF00069 0.414
MOD_CK1_1 121 127 PF00069 0.529
MOD_CK1_1 199 205 PF00069 0.378
MOD_CK1_1 220 226 PF00069 0.426
MOD_CK1_1 227 233 PF00069 0.452
MOD_CK1_1 246 252 PF00069 0.454
MOD_CK1_1 273 279 PF00069 0.406
MOD_CK1_1 335 341 PF00069 0.485
MOD_CK1_1 347 353 PF00069 0.413
MOD_CK1_1 406 412 PF00069 0.331
MOD_CK1_1 430 436 PF00069 0.516
MOD_CK1_1 543 549 PF00069 0.562
MOD_CK1_1 659 665 PF00069 0.749
MOD_CK2_1 197 203 PF00069 0.347
MOD_CK2_1 466 472 PF00069 0.416
MOD_DYRK1A_RPxSP_1 115 119 PF00069 0.458
MOD_GlcNHglycan 153 156 PF01048 0.391
MOD_GlcNHglycan 214 217 PF01048 0.619
MOD_GlcNHglycan 229 232 PF01048 0.510
MOD_GlcNHglycan 237 240 PF01048 0.498
MOD_GlcNHglycan 275 278 PF01048 0.448
MOD_GlcNHglycan 330 333 PF01048 0.580
MOD_GlcNHglycan 354 357 PF01048 0.416
MOD_GlcNHglycan 405 408 PF01048 0.514
MOD_GlcNHglycan 420 423 PF01048 0.582
MOD_GlcNHglycan 436 439 PF01048 0.553
MOD_GlcNHglycan 445 448 PF01048 0.369
MOD_GlcNHglycan 523 526 PF01048 0.570
MOD_GlcNHglycan 570 573 PF01048 0.743
MOD_GlcNHglycan 592 595 PF01048 0.561
MOD_GlcNHglycan 613 616 PF01048 0.788
MOD_GlcNHglycan 625 628 PF01048 0.641
MOD_GlcNHglycan 660 664 PF01048 0.717
MOD_GSK3_1 111 118 PF00069 0.483
MOD_GSK3_1 119 126 PF00069 0.455
MOD_GSK3_1 164 171 PF00069 0.500
MOD_GSK3_1 197 204 PF00069 0.331
MOD_GSK3_1 219 226 PF00069 0.449
MOD_GSK3_1 242 249 PF00069 0.418
MOD_GSK3_1 266 273 PF00069 0.474
MOD_GSK3_1 292 299 PF00069 0.392
MOD_GSK3_1 328 335 PF00069 0.461
MOD_GSK3_1 347 354 PF00069 0.237
MOD_GSK3_1 388 395 PF00069 0.495
MOD_GSK3_1 406 413 PF00069 0.329
MOD_GSK3_1 416 423 PF00069 0.515
MOD_GSK3_1 428 435 PF00069 0.546
MOD_GSK3_1 480 487 PF00069 0.526
MOD_GSK3_1 513 520 PF00069 0.680
MOD_GSK3_1 647 654 PF00069 0.729
MOD_GSK3_1 667 674 PF00069 0.788
MOD_GSK3_1 85 92 PF00069 0.437
MOD_N-GLC_1 111 116 PF02516 0.477
MOD_N-GLC_1 270 275 PF02516 0.554
MOD_N-GLC_1 328 333 PF02516 0.500
MOD_N-GLC_1 59 64 PF02516 0.609
MOD_N-GLC_2 313 315 PF02516 0.506
MOD_NEK2_1 111 116 PF00069 0.567
MOD_NEK2_1 120 125 PF00069 0.555
MOD_NEK2_1 150 155 PF00069 0.468
MOD_NEK2_1 17 22 PF00069 0.573
MOD_NEK2_1 196 201 PF00069 0.294
MOD_NEK2_1 224 229 PF00069 0.381
MOD_NEK2_1 237 242 PF00069 0.413
MOD_NEK2_1 244 249 PF00069 0.383
MOD_NEK2_1 266 271 PF00069 0.494
MOD_NEK2_1 290 295 PF00069 0.333
MOD_NEK2_1 328 333 PF00069 0.493
MOD_NEK2_1 351 356 PF00069 0.370
MOD_NEK2_1 403 408 PF00069 0.502
MOD_NEK2_1 41 46 PF00069 0.407
MOD_NEK2_1 410 415 PF00069 0.463
MOD_NEK2_1 443 448 PF00069 0.479
MOD_NEK2_1 623 628 PF00069 0.707
MOD_NEK2_2 106 111 PF00069 0.469
MOD_PIKK_1 237 243 PF00454 0.525
MOD_PIKK_1 517 523 PF00454 0.523
MOD_PIKK_1 667 673 PF00454 0.751
MOD_PIKK_1 678 684 PF00454 0.705
MOD_PKA_2 480 486 PF00069 0.524
MOD_PKA_2 501 507 PF00069 0.320
MOD_PKA_2 646 652 PF00069 0.548
MOD_PKB_1 645 653 PF00069 0.540
MOD_Plk_1 111 117 PF00069 0.676
MOD_Plk_1 270 276 PF00069 0.545
MOD_Plk_1 347 353 PF00069 0.340
MOD_Plk_1 471 477 PF00069 0.365
MOD_Plk_1 79 85 PF00069 0.465
MOD_Plk_4 175 181 PF00069 0.534
MOD_Plk_4 220 226 PF00069 0.402
MOD_Plk_4 292 298 PF00069 0.412
MOD_Plk_4 347 353 PF00069 0.428
MOD_Plk_4 410 416 PF00069 0.475
MOD_Plk_4 532 538 PF00069 0.343
MOD_Plk_4 540 546 PF00069 0.372
MOD_Plk_4 79 85 PF00069 0.450
MOD_ProDKin_1 115 121 PF00069 0.613
MOD_ProDKin_1 125 131 PF00069 0.428
MOD_ProDKin_1 202 208 PF00069 0.461
MOD_ProDKin_1 304 310 PF00069 0.617
MOD_ProDKin_1 513 519 PF00069 0.596
MOD_ProDKin_1 53 59 PF00069 0.680
MOD_ProDKin_1 651 657 PF00069 0.694
TRG_DiLeu_BaEn_1 619 624 PF01217 0.610
TRG_DiLeu_BaLyEn_6 26 31 PF01217 0.608
TRG_DiLeu_BaLyEn_6 54 59 PF01217 0.608
TRG_ENDOCYTIC_2 415 418 PF00928 0.482
TRG_ENDOCYTIC_2 72 75 PF00928 0.450
TRG_ENDOCYTIC_2 98 101 PF00928 0.540
TRG_ER_diArg_1 21 23 PF00400 0.648
TRG_ER_diArg_1 24 26 PF00400 0.661
TRG_ER_diArg_1 644 646 PF00400 0.744
TRG_NES_CRM1_1 136 151 PF08389 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZA5 Leptomonas seymouri 42% 99%
A0A0S4JQ75 Bodo saltans 29% 100%
A0A1X0NMU7 Trypanosomatidae 30% 100%
A0A3S7WRU5 Leishmania donovani 64% 100%
A0A422NUF1 Trypanosoma rangeli 28% 100%
E9AGB3 Leishmania infantum 64% 100%
E9ANV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 99%
Q4QGR9 Leishmania major 62% 100%
V5BD98 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS